LOCUS       NM_001024539            3974 bp    mRNA    linear   ROD 07-AUG-2024
DEFINITION  Mus musculus SHC (Src homology 2 domain containing) transforming
            protein 2 (Shc2), mRNA.
ACCESSION   NM_001024539 XM_001478068 XM_001478431
VERSION     NM_001024539.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3974)
  AUTHORS   Sasner,M., Preuss,C., Pandey,R.S., Uyar,A., Garceau,D.,
            Kotredes,K.P., Williams,H., Oblak,A.L., Lin,P.B., Perkins,B.,
            Soni,D., Ingraham,C., Lee-Gosselin,A., Lamb,B.T., Howell,G.R. and
            Carter,G.W.
  TITLE     In vivo validation of late-onset Alzheimer's disease genetic risk
            factors
  JOURNAL   Alzheimers Dement 20 (7), 4970-4984 (2024)
   PUBMED   38687251
REFERENCE   2  (bases 1 to 3974)
  AUTHORS   Kakizawa,S., Kishimoto,Y., Yamamoto,S., Onga,K., Yasuda,K.,
            Miyamoto,Y., Watanabe,M., Sakai,R. and Mori,N.
  TITLE     Functional maintenance of calcium store by ShcB adaptor protein in
            cerebellar Purkinje cells
  JOURNAL   Sci Rep 10 (1), 14475 (2020)
   PUBMED   32879382
  REMARK    GeneRIF: Functional maintenance of calcium store by ShcB adaptor
            protein in cerebellar Purkinje cells.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3974)
  AUTHORS   Hawley,S.P., Wills,M.K., Rabalski,A.J., Bendall,A.J. and Jones,N.
  TITLE     Expression patterns of ShcD and Shc family adaptor proteins during
            mouse embryonic development
  JOURNAL   Dev Dyn 240 (1), 221-231 (2011)
   PUBMED   21117147
REFERENCE   4  (bases 1 to 3974)
  AUTHORS   Miyamoto,Y., Chen,L., Sato,M., Sokabe,M., Nabeshima,T., Pawson,T.,
            Sakai,R. and Mori,N.
  TITLE     Hippocampal synaptic modulation by the phosphotyrosine adapter
            protein ShcC/N-Shc via interaction with the NMDA receptor
  JOURNAL   J Neurosci 25 (7), 1826-1835 (2005)
   PUBMED   15716419
REFERENCE   5  (bases 1 to 3974)
  AUTHORS   Liu,H.Y. and Meakin,S.O.
  TITLE     ShcB and ShcC activation by the Trk family of receptor tyrosine
            kinases
  JOURNAL   J Biol Chem 277 (29), 26046-26056 (2002)
   PUBMED   12006576
REFERENCE   6  (bases 1 to 3974)
  AUTHORS   Sakai,R., Henderson,J.T., O'Bryan,J.P., Elia,A.J., Saxton,T.M. and
            Pawson,T.
  TITLE     The mammalian ShcB and ShcC phosphotyrosine docking proteins
            function in the maturation of sensory and sympathetic neurons
  JOURNAL   Neuron 28 (3), 819-833 (2000)
   PUBMED   11163269
REFERENCE   7  (bases 1 to 3974)
  AUTHORS   Luzi,L., Confalonieri,S., Di Fiore,P.P. and Pelicci,P.G.
  TITLE     Evolution of Shc functions from nematode to human
  JOURNAL   Curr Opin Genet Dev 10 (6), 668-674 (2000)
   PUBMED   11088019
  REMARK    Review article
REFERENCE   8  (bases 1 to 3974)
  AUTHORS   Puttagunta,R., Gordon,L.A., Meyer,G.E., Kapfhamer,D.,
            Lamerdin,J.E., Kantheti,P., Portman,K.M., Chung,W.K., Jenne,D.E.,
            Olsen,A.S. and Burmeister,M.
  TITLE     Comparative maps of human 19p13.3 and mouse chromosome 10 allow
            identification of sequences at evolutionary breakpoints
  JOURNAL   Genome Res 10 (9), 1369-1380 (2000)
   PUBMED   10984455
REFERENCE   9  (bases 1 to 3974)
  AUTHORS   Pelicci,G., Dente,L., De Giuseppe,A., Verducci-Galletti,B.,
            Giuli,S., Mele,S., Vetriani,C., Giorgio,M., Pandolfi,P.P.,
            Cesareni,G. and Pelicci,P.G.
  TITLE     A family of Shc related proteins with conserved PTB, CH1 and SH2
            regions
  JOURNAL   Oncogene 13 (3), 633-641 (1996)
   PUBMED   8760305
REFERENCE   10 (bases 1 to 3974)
  AUTHORS   O'Bryan,J.P., Songyang,Z., Cantley,L., Der,C.J. and Pawson,T.
  TITLE     A mammalian adaptor protein with conserved Src homology 2 and
            phosphotyrosine-binding domains is related to Shc and is
            specifically expressed in the brain
  JOURNAL   Proc Natl Acad Sci U S A 93 (7), 2729-2734 (1996)
   PUBMED   8610109
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB646065.1, AK032878.1 and BC059866.1.
            
            On or before Mar 13, 2008 this sequence version replaced
            XM_001478068.1, XM_001478431.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7974084.11303.1,
                                           SRR14995048.1800901.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-434               BB646065.1         2-435
            435-2392            AK032878.1         120-2077
            2393-3974           BC059866.1         2269-3850
FEATURES             Location/Qualifiers
     source          1..3974
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 39.72 cM"
     gene            1..3974
                     /gene="Shc2"
                     /gene_synonym="6720466E06; SCK; ShcB; Sli"
                     /note="SHC (Src homology 2 domain containing) transforming
                     protein 2"
                     /db_xref="GeneID:216148"
                     /db_xref="MGI:MGI:106180"
     exon            1..470
                     /gene="Shc2"
                     /gene_synonym="6720466E06; SCK; ShcB; Sli"
                     /inference="alignment:Splign:2.1.0"
     CDS             69..1790
                     /gene="Shc2"
                     /gene_synonym="6720466E06; SCK; ShcB; Sli"
                     /note="protein Sck; protein Sli; SH2 domain protein C2;
                     SHC-transforming protein B; src homology 2
                     domain-containing-transforming protein C2"
                     /codon_start=1
                     /product="SHC-transforming protein 2"
                     /protein_id="NP_001019710.1"
                     /db_xref="CCDS:CCDS48620.1"
                     /db_xref="GeneID:216148"
                     /db_xref="MGI:MGI:106180"
                     /translation="MTQGPGGRAAPEPEAPTTFCALLPRMPQWKFAAPGSFLGRGPAA
                     TRVAGVAEAQPEPGVPALAAVLGACEPRCAAPCPLPALGRCRGSGTRGARVTPDVADE
                     WVRKGGFIHKPAHGWLHPDARVLGPGVSYIVRYMGCIEVLRSMRSLDFNTRTQVTREA
                     INRLHEAVPGVRGSWKKKAPNKALASILGKSNLRFAGMSISVNISVDGLNLSVPATRQ
                     IIANHHMQSISFASGGDTDMTDYVAYVAKDPINQRACHILECCEGLAQSVISTVGQAF
                     ELRFKQYLHSPPKAVVPPERLTGLEELAWGDDDAAADHNYYNSIPGKEPPLGGLVDSR
                     LAVTQPCALATLGGLGQGMTPVWRDARGLPWDMGPSGAAPPGDGYVQADARGPHDYEE
                     HLYVNTQGLDAVELEDTAEAPLQFEDSPKKDLFDMRPFEDALKLHACSVAAGITAASP
                     PLEDQWPSPPTRRAPIAPTEEQLRQEPWYHGRMSRRAAEKLLRADGDFLVRDSVTNPG
                     QYVLTGMHAGQPKHLLLVDPEGVVRTKDVLFESISHLIDYHLKNGLPIVAAESELHLR
                     GVVSREP"
     exon            471..541
                     /gene="Shc2"
                     /gene_synonym="6720466E06; SCK; ShcB; Sli"
                     /inference="alignment:Splign:2.1.0"
     exon            542..602
                     /gene="Shc2"
                     /gene_synonym="6720466E06; SCK; ShcB; Sli"
                     /inference="alignment:Splign:2.1.0"
     exon            603..722
                     /gene="Shc2"
                     /gene_synonym="6720466E06; SCK; ShcB; Sli"
                     /inference="alignment:Splign:2.1.0"
     exon            723..776
                     /gene="Shc2"
                     /gene_synonym="6720466E06; SCK; ShcB; Sli"
                     /inference="alignment:Splign:2.1.0"
     exon            777..828
                     /gene="Shc2"
                     /gene_synonym="6720466E06; SCK; ShcB; Sli"
                     /inference="alignment:Splign:2.1.0"
     exon            829..955
                     /gene="Shc2"
                     /gene_synonym="6720466E06; SCK; ShcB; Sli"
                     /inference="alignment:Splign:2.1.0"
     exon            956..1121
                     /gene="Shc2"
                     /gene_synonym="6720466E06; SCK; ShcB; Sli"
                     /inference="alignment:Splign:2.1.0"
     exon            1122..1185
                     /gene="Shc2"
                     /gene_synonym="6720466E06; SCK; ShcB; Sli"
                     /inference="alignment:Splign:2.1.0"
     exon            1186..1350
                     /gene="Shc2"
                     /gene_synonym="6720466E06; SCK; ShcB; Sli"
                     /inference="alignment:Splign:2.1.0"
     exon            1351..1661
                     /gene="Shc2"
                     /gene_synonym="6720466E06; SCK; ShcB; Sli"
                     /inference="alignment:Splign:2.1.0"
     exon            1662..1795
                     /gene="Shc2"
                     /gene_synonym="6720466E06; SCK; ShcB; Sli"
                     /inference="alignment:Splign:2.1.0"
     exon            1796..3961
                     /gene="Shc2"
                     /gene_synonym="6720466E06; SCK; ShcB; Sli"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2371..2376
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Shc2"
                     /gene_synonym="6720466E06; SCK; ShcB; Sli"
                     /note="hexamer: ATTAAA"
     polyA_site      2393
                     /gene="Shc2"
                     /gene_synonym="6720466E06; SCK; ShcB; Sli"
                     /note="major polyA site"
     regulatory      3090..3095
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Shc2"
                     /gene_synonym="6720466E06; SCK; ShcB; Sli"
                     /note="hexamer: GATAAA"
     polyA_site      3115
                     /gene="Shc2"
                     /gene_synonym="6720466E06; SCK; ShcB; Sli"
                     /note="major polyA site"
     regulatory      3930..3935
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Shc2"
                     /gene_synonym="6720466E06; SCK; ShcB; Sli"
                     /note="hexamer: ATTAAA"
     regulatory      3934..3939
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Shc2"
                     /gene_synonym="6720466E06; SCK; ShcB; Sli"
                     /note="hexamer: AATAAA"
     polyA_site      3947
                     /gene="Shc2"
                     /gene_synonym="6720466E06; SCK; ShcB; Sli"
     polyA_site      3951
                     /gene="Shc2"
                     /gene_synonym="6720466E06; SCK; ShcB; Sli"
ORIGIN      
        1 atcactcggc ggggaggagc gcacggctct ggaccaggct cagccggggc tcctcggcgg
       61 ccgcggccat gacgcagggt ccgggtggcc gcgcggcccc cgagcccgag gcgcccacca
      121 ccttctgcgc actgctgccg cggatgccgc agtggaagtt cgcagcgccg ggtagcttcc
      181 tgggccgcgg tcccgcggcg acgcgcgtgg cgggggtggc agaggcgcag ccggagcccg
      241 gggtccccgc gctggccgct gtgttgggcg cttgcgaacc gcgctgcgcc gcgccctgtc
      301 cgctgcccgc gctcggccgc tgccggggct cggggacgcg gggcgcgcgg gtgactccgg
      361 atgtcgctga cgagtgggtg cgcaagggcg gcttcattca caagccggcg cacggctggt
      421 tgcatcccga tgccagggtc ctggggcccg gggtctctta catcgttcgg tacatgggct
      481 gcattgaggt gcttcgatcc atgcgctccc tggatttcaa cacccgaaca caggtgacga
      541 gggaagccat caatcggctc catgaggctg tgcccggtgt ccggggctcc tggaagaaga
      601 aggcccccaa caaggctctg gcctccatct tggggaaaag caacctgcgc ttcgccggca
      661 tgagcatctc agtcaacatc tccgtggacg gccttaactt gtctgttccc gccacccgcc
      721 agatcatcgc caaccatcat atgcagtcta tttccttcgc ctcgggtggt gacacggaca
      781 tgactgatta cgtggcctat gtggccaagg accccatcaa ccagagagcc tgccacatct
      841 tggaatgctg tgaaggtctt gcccagagcg tcatcagcac cgtagggcaa gcctttgagc
      901 tgcgcttcaa gcaatacctg cacagtccgc ccaaggcggt agtgccccct gaaaggctga
      961 ctgggctgga ggagttggcc tggggagatg atgacgctgc tgcagaccac aattactaca
     1021 acagcattcc gggaaaggag ccacccctgg gcgggctggt ggactccaga ctggctgtca
     1081 cacagccctg tgcgctggcg acactcgggg gccttggaca gggaatgaca ccagtatgga
     1141 gagatgcccg tggcttgcct tgggacatgg gcccctctgg agcagcccca ccgggggatg
     1201 gctacgtgca ggcagatgcc cgagggccac atgactacga ggagcacctg tatgtcaata
     1261 cccagggcct ggatgctgtg gagcttgagg acaccgccga ggcacctctg cagtttgagg
     1321 acagccccaa gaaggacctg tttgacatgc gaccctttga agatgccctg aagttgcacg
     1381 cgtgctcagt ggcagccggc atcactgcag cctcaccccc tctggaagac cagtggccca
     1441 gtccccctac ccgcagggcc cccattgcac ccacagagga gcaattgagg caggagccct
     1501 ggtaccacgg acgaatgagc cgtcgggctg cagagaagct gcttcgggcc gatggggact
     1561 tccttgtgag agacagcgtc accaacccgg ggcagtatgt cctcacgggc atgcatgcgg
     1621 ggcagcccaa gcacctgctg ctggtggacc ccgagggtgt ggtgcggacg aaagatgtgt
     1681 tgtttgagag catcagccac ctcatagact atcacctgaa gaatgggctg cctatcgtgg
     1741 ctgctgagag cgagctgcat ctgcggggag tggtctctcg ggagccatga gccaggtgac
     1801 agtcctcagc ccaacttcta cccctagatg cccttgctga ggcctttctc tcagatcctg
     1861 aagccacgag aaccagaatg gttaccacct ctccttccac acgagccctc gggaagccgc
     1921 ctttcccagc tgtgctcgct cagctggctg ggcccgtgag acagagtcag ggtcaagcct
     1981 ctgctcccac ctgagcccca accctgaagg gtgagggctg tacaaaccaa agacagaccg
     2041 agtcgccttt aacgaagaca tccaaatgca ggccccgtac ctctggtccc agtgcgagta
     2101 gggacatcag gctgtgtcca cagtgatgtg gacagctctg tgtgggcagg ggtagtgtcc
     2161 tgccctagct gggctctgag gacctagatg cactgttgct tttgggggtg attaaggtgc
     2221 ttttgggtct cagatccctg atgggggagc agcccagggg ctcgcctggc atgtagggta
     2281 tccaggtgag tcagaggcag gggaacctca gtgaggtgtg gtatccactc agcacttccc
     2341 agctgtcacc tgcctggacc ttcaactgta attaaacaca gggttgagcg tgagcctgct
     2401 gtgtctgcta gggattccca ggtgggcaac cgaggcaagg gggaagcttt gtgaagcccc
     2461 agggctagag cagacggcta ggtgggactg tggggtctgg actcccccct gcaccccacc
     2521 ccctgttcac caacagtgaa caagcctcta gttttactcc aagataaatt agcctctctc
     2581 cctgtttggt gtttccccag tcccttcttg gcaacactgt ggcttaccta gggattcttg
     2641 cacactgggc ccctggggag gactgggctc ctctgtgtgg ttctggagta cctgccaggg
     2701 ccagcatggg agtaaaagct tccttctgcc tcaagcatga gacatcatta aggtcaaagt
     2761 tacaggtcac cttgatgctc tcttcttcca aatacagaaa ggctcagagt cccaccccca
     2821 ccacccacct tgccattccc cacggaagtg gaaacttaca tggtttcttt agaaagtcag
     2881 ttgtgttgga tgttgttttg ttgaggcaga catgtaaagg agtgttttcc tgaagcagac
     2941 acaggcaaaa ggacgttttg ctaaggtaga cgacgtgtga agggacaagg tagacgtgtg
     3001 aagggatgtt tctgttgaag tggacacagg tgggaggatg ttttgcttga ggtagccaca
     3061 tgaagaaatg tttcactgaa gcagacacag ataaaaaatg ttttgttaaa gcaaacgtgt
     3121 aaaaggacta tgatgttcac aaggacccaa cagatggtgg acaacactag atgatattgg
     3181 tactcctcgt tattctttaa tggtcattgc cggtcatgac tttataagaa agaaacatac
     3241 taaacaactt ctggtggtgt tctggcggct tcttgccgct tccacagact tgggcccatt
     3301 ggcagagtga tgtcagctga cacagactca cctggaggac acgtggtact tagagagagg
     3361 ataaatagga cccaaaggaa agtaacagag gcttaaatat ctagctctgt aacacatcct
     3421 tgggctccag tcttagtttt tgctgatctt tacatcattg agagaggcac ggcagaaaac
     3481 ttttcctggt gtccctgctg gtcctggtcc ctcctgctga ctcgtgccaa tgtggccgag
     3541 gcctgacttt ttctgctggg tcatgccacc actgctgatt catgtttgca atcctgacac
     3601 tactgaactg gactgctggt gtacatcctg acaacacaga tgggacttgc tccaaagaac
     3661 tatttctaga caggtccact tcccctgtat cttaatattt cttttccact acctctggtg
     3721 ggtggtgggc tagaatagag gttaagacat ttaaggcatt tattaaaaat agggtttaaa
     3781 tgggcttgag aaatggctca ggggttaaga gctcttccag aggtcctgag ttcaatttcc
     3841 agcagccaca tggttgctca taaccatctg taatggggtc caatggcctt tctggtgtgt
     3901 ctgaagatag ctacagtgta ctcatataca ttaaataaat aaataaataa atcttaaaaa
     3961 aaaaaaaaaa aaaa
//
