LOCUS       NM_001113331            3569 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus src homology 2 domain-containing transforming protein
            C1 (Shc1), transcript variant 1, mRNA.
ACCESSION   NM_001113331
VERSION     NM_001113331.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3569)
  AUTHORS   Jiang,Y., Xu,L., Zhu,X., Zhu,X., Xu,X. and Li,J.
  TITLE     Hyperglycemic stress induces oxidative damage of enteric glial
            cells by triggering redoxosomes/p66SHC activation
  JOURNAL   Redox Rep 29 (1), 2324234 (2024)
   PUBMED   38444386
  REMARK    GeneRIF: Hyperglycemic stress induces oxidative damage of enteric
            glial cells by triggering redoxosomes/p66SHC activation.
REFERENCE   2  (bases 1 to 3569)
  AUTHORS   Castro,C.F.G., Nardiello,C., Hadzic,S., Kojonazarov,B., Kraut,S.,
            Gierhardt,M., Schaffer,J., Bednorz,M., Quanz,K., Heger,J.,
            Korfei,M., Wilhelm,J., Hecker,M., Bartkuhn,M., Arnhold,S.,
            Guenther,A., Seeger,W., Schulz,R., Weissmann,N., Sommer,N. and
            Pak,O.
  TITLE     The Role of the Redox Enzyme p66Shc in Biological Aging of the Lung
  JOURNAL   Aging Dis 15 (2), 911-926 (2024)
   PUBMED   37548932
  REMARK    GeneRIF: The Role of the Redox Enzyme p66Shc in Biological Aging of
            the Lung.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3569)
  AUTHORS   Potes,Y., Bermejo-Millo,J.C., Mendes,C., Castelao-Baptista,J.P.,
            Diaz-Luis,A., Perez-Martinez,Z., Solano,J.J., Sardao,V.A.,
            Oliveira,P.J., Caballero,B., Coto-Montes,A. and Vega-Naredo,I.
  TITLE     p66Shc signaling and autophagy impact on C2C12 myoblast
            differentiation during senescence
  JOURNAL   Cell Death Dis 15 (3), 200 (2024)
   PUBMED   38459002
  REMARK    GeneRIF: p66Shc signaling and autophagy impact on C2C12 myoblast
            differentiation during senescence.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3569)
  AUTHORS   Lopresti,L., Capitani,N., Tatangelo,V., Tangredi,C.,
            Boncompagni,G., Frezzato,F., Visentin,A., Marotta,G., Ciofini,S.,
            Gozzetti,A., Bocchia,M., Trentin,L., Baldari,C.T. and Patrussi,L.
  TITLE     p66Shc deficiency in CLL cells enhances PD-L1 expression and
            suppresses immune synapse formation
  JOURNAL   Front Cell Dev Biol 12, 1297116 (2024)
   PUBMED   38389706
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3569)
  AUTHORS   Zhang,Y., Huang,C.Z., Chen,H.Z., Nie,Y. and Hu,M.Q.
  TITLE     [Study of senescence protein p66Shc on myocardial tissue repair in
            adult mice]
  JOURNAL   Sheng Li Xue Bao 75 (6), 946-952 (2023)
   PUBMED   38151356
  REMARK    GeneRIF: [Study of senescence protein p66[Shc] on myocardial tissue
            repair in adult mice].
REFERENCE   6  (bases 1 to 3569)
  AUTHORS   Galisteo,M.L., Dikic,I., Batzer,A.G., Langdon,W.Y. and
            Schlessinger,J.
  TITLE     Tyrosine phosphorylation of the c-cbl proto-oncogene protein
            product and association with epidermal growth factor (EGF) receptor
            upon EGF stimulation
  JOURNAL   J Biol Chem 270 (35), 20242-20245 (1995)
   PUBMED   7657591
REFERENCE   7  (bases 1 to 3569)
  AUTHORS   VanderKuur,J., Allevato,G., Billestrup,N., Norstedt,G. and
            Carter-Su,C.
  TITLE     Growth hormone-promoted tyrosyl phosphorylation of SHC proteins and
            SHC association with Grb2
  JOURNAL   J Biol Chem 270 (13), 7587-7593 (1995)
   PUBMED   7535773
REFERENCE   8  (bases 1 to 3569)
  AUTHORS   Ravichandran,K.S., Lorenz,U., Shoelson,S.E. and Burakoff,S.J.
  TITLE     Interaction of Shc with Grb2 regulates association of Grb2 with
            mSOS
  JOURNAL   Mol Cell Biol 15 (2), 593-600 (1995)
   PUBMED   7529871
REFERENCE   9  (bases 1 to 3569)
  AUTHORS   Suen,K.L., Bustelo,X.R., Pawson,T. and Barbacid,M.
  TITLE     Molecular cloning of the mouse grb2 gene: differential interaction
            of the Grb2 adaptor protein with epidermal growth factor and nerve
            growth factor receptors
  JOURNAL   Mol Cell Biol 13 (9), 5500-5512 (1993)
   PUBMED   7689150
REFERENCE   10 (bases 1 to 3569)
  AUTHORS   Pelicci,G., Lanfrancone,L., Grignani,F., McGlade,J., Cavallo,F.,
            Forni,G., Nicoletti,I., Grignani,F., Pawson,T. and Pelicci,P.G.
  TITLE     A novel transforming protein (SHC) with an SH2 domain is implicated
            in mitogenic signal transduction
  JOURNAL   Cell 70 (1), 93-104 (1992)
   PUBMED   1623525
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB656759.1, AK049357.1, BB458154.2 and BQ031241.1.
            
            On Aug 13, 2009 this sequence version replaced NM_001113331.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK155158.1, SRR7345562.953553.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-642               BB656759.1         1-642
            643-2455            AK049357.1         218-2030
            2456-2456           BB458154.2         380-380
            2457-3306           AK049357.1         2031-2880
            3307-3539           AK049357.1         2882-3114
            3540-3569           BQ031241.1         1-30                c
FEATURES             Location/Qualifiers
     source          1..3569
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 39.11 cM"
     gene            1..3569
                     /gene="Shc1"
                     /gene_synonym="p66; p66shc; Shc; ShcA"
                     /note="src homology 2 domain-containing transforming
                     protein C1"
                     /db_xref="GeneID:20416"
                     /db_xref="MGI:MGI:98296"
     exon            1..725
                     /gene="Shc1"
                     /gene_synonym="p66; p66shc; Shc; ShcA"
                     /inference="alignment:Splign:2.1.0"
     CDS             231..1970
                     /gene="Shc1"
                     /gene_synonym="p66; p66shc; Shc; ShcA"
                     /note="isoform a is encoded by transcript variant 1;
                     SHC-transforming protein 1; SH2 domain protein C1;
                     SHC-transforming protein A"
                     /codon_start=1
                     /product="SHC-transforming protein 1 isoform a"
                     /protein_id="NP_001106802.1"
                     /db_xref="CCDS:CCDS50962.1"
                     /db_xref="GeneID:20416"
                     /db_xref="MGI:MGI:98296"
                     /translation="MDLLPPKPKYNPLRNESLSSLEEGASGSTPPEELPSPSASSLGP
                     ILPPLPGDDSPTTLCSFFPRMSNLKLANPAGGRLGPKGEPGKAAEDGEGSAGAALRDS
                     GLLPLLQDMNKLSGGGGRRTRVEGGQLGGEEWTRHGSFVNKPTRGWLHPNDKVMGPGV
                     SYLVRYMGCVEVLQSMRALDFNTRTQVTREAISLVCEAVPGAKGATRRRKPCSRPLSS
                     ILGRSNLKFAGMPITLTVSTSSLNLMAADCKQIIANHHMQSISFASGGDPDTAEYVAY
                     VAKDPVNQRACHILECPEGLAQDVISTIGQAFELRFKQYLRNPPKLVTPHDRMAGFDG
                     SAWDEEEEEPPDHQYYNDFPGKEPPLGGVVDMRLREGAARPTLPSAQMSSHLGATLPI
                     GQHAAGDHEVRKQMLPPPPCPGRELFDDPSYVNIQNLDKARQAGGGAGPPNPSLNGSA
                     PRDLFDMKPFEDALRVPPPPQSMSMAEQLQGEPWFHGKLSRREAEALLQLNGDFLVRE
                     STTTPGQYVLTGLQSGQPKHLLLVDPEGVVRTKDHRFESVSHLISYHMDNHLPIISAG
                     SELCLQQPVDRKV"
     exon            726..796
                     /gene="Shc1"
                     /gene_synonym="p66; p66shc; Shc; ShcA"
                     /inference="alignment:Splign:2.1.0"
     exon            797..860
                     /gene="Shc1"
                     /gene_synonym="p66; p66shc; Shc; ShcA"
                     /inference="alignment:Splign:2.1.0"
     exon            861..980
                     /gene="Shc1"
                     /gene_synonym="p66; p66shc; Shc; ShcA"
                     /inference="alignment:Splign:2.1.0"
     exon            981..1034
                     /gene="Shc1"
                     /gene_synonym="p66; p66shc; Shc; ShcA"
                     /inference="alignment:Splign:2.1.0"
     exon            1035..1086
                     /gene="Shc1"
                     /gene_synonym="p66; p66shc; Shc; ShcA"
                     /inference="alignment:Splign:2.1.0"
     exon            1087..1213
                     /gene="Shc1"
                     /gene_synonym="p66; p66shc; Shc; ShcA"
                     /inference="alignment:Splign:2.1.0"
     exon            1214..1400
                     /gene="Shc1"
                     /gene_synonym="p66; p66shc; Shc; ShcA"
                     /inference="alignment:Splign:2.1.0"
     exon            1401..1470
                     /gene="Shc1"
                     /gene_synonym="p66; p66shc; Shc; ShcA"
                     /inference="alignment:Splign:2.1.0"
     exon            1471..1602
                     /gene="Shc1"
                     /gene_synonym="p66; p66shc; Shc; ShcA"
                     /inference="alignment:Splign:2.1.0"
     exon            1603..1841
                     /gene="Shc1"
                     /gene_synonym="p66; p66shc; Shc; ShcA"
                     /inference="alignment:Splign:2.1.0"
     exon            1842..3554
                     /gene="Shc1"
                     /gene_synonym="p66; p66shc; Shc; ShcA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3519..3524
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Shc1"
                     /gene_synonym="p66; p66shc; Shc; ShcA"
                     /note="hexamer: ATTAAA"
     polyA_site      3540
                     /gene="Shc1"
                     /gene_synonym="p66; p66shc; Shc; ShcA"
                     /note="major polyA site"
ORIGIN      
        1 agccagtaga ggtttcctag ctgggctgtg caaggatgtg ctctcaaact gtctaggtct
       61 gagttgggag agcagaggtc acttgtcctt cgcctcccca ggtcatctgt tatcaccggg
      121 ctgccgaggt cagactaggc taagggcctg gggatgcccc ctgcctggcc cccttgcctg
      181 aattggcagg ggggccgggc tgggcagcag cccctcttct caccccagcc atggatcttc
      241 taccccccaa gccgaagtac aacccacttc ggaatgagtc tctgtcatcg ctggaggagg
      301 gggcttcggg gtctacccct ccggaggagc taccttcccc atcagcttca tccctgggac
      361 ccattctgcc tcctctgccg ggggacgata gtccgactac cctgtgttcc ttctttcccc
      421 ggatgagcaa cctgaagctg gccaatcctg ctggggggcg cctggggcct aaaggggagc
      481 caggaaaggc tgctgaagat ggggaaggga gtgcaggggc agcccttcgg gactcaggcc
      541 tcttgcccct cctccaggac atgaacaagc tgagtggagg cggcgggcgc aggactcggg
      601 tagaaggggg ccagctgggg ggcgaggagt ggaccagaca cgggagcttt gtcaataagc
      661 ccacacgagg ctggctgcat cccaacgaca aagtcatggg acctggggtt tcctacttgg
      721 ttcggtacat gggctgtgtg gaggtcttac agtcaatgcg agcccttgac ttcaataccc
      781 ggactcaggt caccagggag gccatcagtt tggtgtgtga agctgtgcct ggtgccaaag
      841 gggcgacaag gaggagaaag ccttgtagcc gcccactcag ctccatcctg gggaggagta
      901 acctgaagtt tgctggaatg ccaatcactc tcactgtgtc taccagcagc cttaacctca
      961 tggcagccga ctgcaaacag atcattgcca accatcacat gcaatctatc tctttcgcgt
     1021 ccggtgggga tccggacaca gctgagtatg ttgcctatgt tgccaaagac cctgtgaatc
     1081 agagagcctg ccatatcctg gagtgtcctg aagggcttgc tcaggatgtc atcagcacca
     1141 tcgggcaggc ctttgagttg cgcttcaaac agtatctcag gaatccaccg aagctggtca
     1201 ccccccatga caggatggct ggctttgatg gctcagcttg ggatgaggag gaagaagagc
     1261 cccctgacca tcagtactac aatgactttc cagggaagga accccctctt ggtggggtgg
     1321 tagatatgag gcttcgggaa ggggctgctc gacccactct gcctagtgcc cagatgtcca
     1381 gccacttggg agctacactg cctatagggc agcatgctgc aggagaccat gaagtccgta
     1441 aacagatgtt gcctccgccg ccttgcccag gcagagaact cttcgatgac ccctcctatg
     1501 tcaacatcca gaatctagac aaggcccggc aggctggggg tggggctggg cccccaaatc
     1561 cttctcttaa tggcagtgca ccccgagacc tttttgacat gaagcccttt gaagatgcac
     1621 ttcgggtgcc acccccaccg cagtccatgt ccatggctga gcagctgcaa ggggagccct
     1681 ggttccacgg gaagctgagc cggagggagg ccgaggcgct gctgcagctc aatggtgact
     1741 tcttggtgcg agagagcacg accacgcctg gccagtatgt gctcactggc ctgcagagtg
     1801 ggcagcccaa gcacttgctg ctggtggacc ctgaaggtgt ggttcggaca aaggatcacc
     1861 gctttgagag tgtcagtcac ctgatcagct accacatgga caatcacttg cccatcatct
     1921 ctgcgggcag cgaactgtgc ctacagcaac ccgtggatcg gaaagtgtga tccttctcag
     1981 cttctccaac aggatgctct ccatttccgt ctcccgtatt ctctaacttg tgggacctct
     2041 gttttgtggg tctggccttg ggtgggaact gggagcaacg aggacatggg tttagtgccc
     2101 acttgagaga gagaaaaaga gggtttcagt aaggagcctg gggtagcatc ctgcctctgg
     2161 ccaaacttca ccaaagtatt aatgtgcaga gtggtccctt gtctgggcct tgcctgtgcc
     2221 aacctgatgc ccttcccccc caaagggtgg gttcttataa tggaaaatgc cctgtgatga
     2281 taggcccagt ggagcaactg ccctttgggg gaagggaaat aattatacct ctggtttact
     2341 cctgggtctt cagggtaccc cagatcccgc ataacatatc ccactccctc tgcttcccct
     2401 taaactttgt gcctttgact atcataggtc tgcagatact taatgcagag ttctcaggcc
     2461 cttcacgtgt ggacaggggt tactgccacc ttggcttctg gagccctgtc ctattcagca
     2521 ccccttcctg tgtctaggga gaatagggac aggagtggcc gctatctgct ctgcctttcg
     2581 gatgtgcagc ccttaagaga ttgccccaag cctgaatatg gtggcgcacg cctttaatca
     2641 cagcactcag gaggcagaga caggaggaat tgtgaggcca tccgatctac aacagagtga
     2701 gttccaggac agccagggct atggagagag aacctgtctc caaaaaccaa aaagagcgat
     2761 taccccagag ccttcttcct gatggtagcg gggaggggca ggactggacc catcttgctc
     2821 agtgcctcct gacctcaatg cctttcctcc aaggggtctg tatacatttc tcaagcctgc
     2881 tcctcccatg tttgcatgtg tgttatagtc tacagccaaa gtatagccct cactgtaacc
     2941 ccatcctgcc tccctccttt gggataggtg tgtgcgtctg acttgggcct ccagggtgtg
     3001 tacagtcagt gtgggttttg tggaggcaat aagactgaag cagtagacaa tccccaatac
     3061 catttgcagg tctggaactg cactctcttt tttaaaaaac atgtatacat tttagggctg
     3121 tagatttatt ttcctggttt tgtttttcat tgctgacttt tgagcacaga attatgataa
     3181 tcaattacat ttatacatca cctcgatgac ttttccaaac ttttattttt ttttttaaac
     3241 aactgttggg attttactcc ctggccttaa ctaggacagg attgtacccc actcctcccc
     3301 cccccctttt tctttttcgc caagacaact gagcagaaat ttggctgagc agtgttgtgg
     3361 gactatgatg tgatagtttt agatcctacc ttctgctttc gggcagctgc agccagcaca
     3421 gaaaccttgc aagctcactc tgtgtgtagg ctttctggac aaggaatggt cgccaaattt
     3481 ttggtttgga tgtcttatac caaagggaaa tagtcttcat taaagttcgt atttctttta
     3541 cctcggcctc tcaaaaaaaa aaaaaaaaa
//
