LOCUS       NM_011367               1407 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Mus musculus sex hormone binding globulin (Shbg), mRNA.
ACCESSION   NM_011367 XM_001006589
VERSION     NM_011367.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1407)
  AUTHORS   Xie,X., Sun,L., Duan,Y., Lv,Z., Yao,X., Wang,C., Chen,X., Tian,S.,
            Yan,L., Shao,Y., Luo,H. and Liu,J.
  TITLE     SRSF2 in Sertoli cells is essential for testicular development and
            spermatogenesis in mice
  JOURNAL   FASEB J 37 (5), e22918 (2023)
   PUBMED   37039821
REFERENCE   2  (bases 1 to 1407)
  AUTHORS   Brianso-Llort,L., Fuertes-Rioja,L., Ramos-Perez,L.,
            Salcedo-Allende,M.T., Hernandez,C., Simo,R. and Selva,D.M.
  TITLE     Transforming growth factor-beta 1: A new factor reducing hepatic
            SHBG production in liver fibrosis
  JOURNAL   J Cell Physiol 237 (9), 3598-3613 (2022)
   PUBMED   35762039
  REMARK    GeneRIF: Transforming growth factor-beta 1: A new factor reducing
            hepatic SHBG production in liver fibrosis.
REFERENCE   3  (bases 1 to 1407)
  AUTHORS   Yamazaki,H., Kushiyama,A., Sakoda,H., Fujishiro,M., Yamamotoya,T.,
            Nakatsu,Y., Kikuchi,T., Kaneko,S., Tanaka,H. and Asano,T.
  TITLE     Protective Effect of Sex Hormone-Binding Globulin against Metabolic
            Syndrome: In Vitro Evidence Showing Anti-Inflammatory and Lipolytic
            Effects on Adipocytes and Macrophages
  JOURNAL   Mediators Inflamm 2018, 3062319 (2018)
   PUBMED   30046278
  REMARK    GeneRIF: SHBG suppresses inflammation and lipid accumulation in
            macrophages and adipocytes, which might be among the mechanisms
            underlying the protective effect of SHBG, that is, its actions
            which reduce the incidence of metabolic syndrome
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1407)
  AUTHORS   Li,Y., Zhang,L., Hu,Y., Chen,M., Han,F., Qin,Y., Chen,M., Cui,X.,
            Duo,S., Tang,F. and Gao,F.
  TITLE     beta-Catenin directs the transformation of testis Sertoli cells to
            ovarian granulosa-like cells by inducing Foxl2 expression
  JOURNAL   J Biol Chem 292 (43), 17577-17586 (2017)
   PUBMED   28900034
REFERENCE   5  (bases 1 to 1407)
  AUTHORS   Zhang,L., Chen,M., Wen,Q., Li,Y., Wang,Y., Wang,Y., Qin,Y., Cui,X.,
            Yang,L., Huff,V. and Gao,F.
  TITLE     Reprogramming of Sertoli cells to fetal-like Leydig cells by Wt1
            ablation
  JOURNAL   Proc Natl Acad Sci U S A 112 (13), 4003-4008 (2015)
   PUBMED   25775596
REFERENCE   6  (bases 1 to 1407)
  AUTHORS   Remmers,E.F., Goldmuntz,E.A., Cash,J.M., Crofford,L.J.,
            Misiewicz-Poltorak,B., Zha,H. and Wilder,R.L.
  TITLE     Genetic map of nine polymorphic loci comprising a single linkage
            group on rat chromosome 10: evidence for linkage conservation with
            human chromosome 17 and mouse chromosome 11
  JOURNAL   Genomics 14 (3), 618-623 (1992)
   PUBMED   1358809
REFERENCE   7  (bases 1 to 1407)
  AUTHORS   Pownall,S., Kozak,C.A., Schappert,K., Sarkar,M., Hull,E.,
            Schachter,H. and Marth,J.D.
  TITLE     Molecular cloning and characterization of the mouse
            UDP-N-acetylglucosamine:alpha-3-D-mannoside
            beta-1,2-N-acetylglucosaminyltransferase I gene
  JOURNAL   Genomics 12 (4), 699-704 (1992)
   PUBMED   1533386
REFERENCE   8  (bases 1 to 1407)
  AUTHORS   Moore,S.K., Appella,E., Villar,C.J. and Kozak,C.A.
  TITLE     Mapping of the mouse 86-kDa heat-shock protein expressed gene
            (Hsp86-1) on chromosome 12 and related genes on chromosomes 3, 4,
            9, and 11
  JOURNAL   Genomics 10 (4), 1019-1029 (1991)
   PUBMED   1916807
REFERENCE   9  (bases 1 to 1407)
  AUTHORS   Joseph,D.R., Adamson,M.C. and Kozak,C.A.
  TITLE     Genetic mapping of the gene for androgen-binding protein/sex
            hormone-binding globulin to mouse chromosome 11
  JOURNAL   Cytogenet Cell Genet 56 (2), 122-124 (1991)
   PUBMED   2013230
REFERENCE   10 (bases 1 to 1407)
  AUTHORS   Hearne,C.M., McAleer,M.A., Love,J.M., Aitman,T.J., Cornall,R.J.,
            Ghosh,S., Knight,A.M., Prins,J.B. and Todd,J.A.
  TITLE     Additional microsatellite markers for mouse genome mapping
  JOURNAL   Mamm Genome 1 (4), 273-282 (1991)
   PUBMED   1794058
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK010959.1, BC120785.1 and AL731687.13.
            
            On Jul 8, 2009 this sequence version replaced NM_011367.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U85644.1, AK010959.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164140, SAMN01164143
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                AK010959.1         1-15
            16-1375             BC120785.1         1-1360
            1376-1407           AL731687.13        108943-108974       c
FEATURES             Location/Qualifiers
     source          1..1407
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 42.86 cM"
     gene            1..1407
                     /gene="Shbg"
                     /gene_synonym="ABP"
                     /note="sex hormone binding globulin"
                     /db_xref="GeneID:20415"
                     /db_xref="MGI:MGI:98295"
     exon            1..157
                     /gene="Shbg"
                     /gene_synonym="ABP"
                     /inference="alignment:Splign:2.1.0"
     CDS             44..1255
                     /gene="Shbg"
                     /gene_synonym="ABP"
                     /note="SBP; sex steroid-binding protein; testis-specific
                     androgen-binding protein"
                     /codon_start=1
                     /product="sex hormone-binding globulin precursor"
                     /protein_id="NP_035497.1"
                     /db_xref="CCDS:CCDS24899.1"
                     /db_xref="GeneID:20415"
                     /db_xref="MGI:MGI:98295"
                     /translation="MEKRDSVALHWRLLLLLLLLMPPPTHQGRALRHIDPIQSAQDPP
                     AKYLSNGPGQEPVMVMTIDLTKISKPHSSFEFRTWDPEGVIFYGDTNTEDDWFLLGLR
                     AGQLEIQLHNAWARLTVGFGPRLDDGRWHPVELKMNGDSLLLWVDGKEMLCLRQISAS
                     LADHSQRSMRIALGGLLLPTSKLRFPLVPALDGCIRRDIWLGHQAQLSASPRTSLGNC
                     DVDLQPGLFFPPGTHAEFSLQDIPQPHADPWTFSLELGFKLVDGSGQLLALGTGTNSS
                     WLNIHLQNQSVVLSSEAEPKVVLPLDVGLPLQLTLDRVKVVLSQGPKMEVLSMSLLRP
                     ASLWRLWSHPQGHLSLGALPGESSSASFCLSDFWVQGQRLDIDQALSRSQDIWTHSCP
                     QRPSNDTRTSH"
     exon            158..249
                     /gene="Shbg"
                     /gene_synonym="ABP"
                     /inference="alignment:Splign:2.1.0"
     exon            250..439
                     /gene="Shbg"
                     /gene_synonym="ABP"
                     /inference="alignment:Splign:2.1.0"
     exon            440..601
                     /gene="Shbg"
                     /gene_synonym="ABP"
                     /inference="alignment:Splign:2.1.0"
     exon            602..761
                     /gene="Shbg"
                     /gene_synonym="ABP"
                     /inference="alignment:Splign:2.1.0"
     exon            762..898
                     /gene="Shbg"
                     /gene_synonym="ABP"
                     /inference="alignment:Splign:2.1.0"
     exon            899..1106
                     /gene="Shbg"
                     /gene_synonym="ABP"
                     /inference="alignment:Splign:2.1.0"
     exon            1107..1407
                     /gene="Shbg"
                     /gene_synonym="ABP"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggttttcaga tagtctgagc cactgggtgg atagctgcta actatggaga agagagactc
       61 tgtggccttg cattggcgac tgcttctgct gttgctacta ctgatgccgc ctcccaccca
      121 ccagggacgg gccctgagac acattgaccc tatccagagt gcccaggacc ctcctgctaa
      181 gtacctcagc aatggcccag gacaagagcc tgtcatggtt atgaccattg acctcaccaa
      241 aatcagcaaa ccccattcct cctttgagtt tcgaacctgg gatccagagg gagtgatttt
      301 ttatggggac accaacactg aagatgactg gttcctgctg ggactgcgag ctggccagct
      361 tgaaatccag ctacacaatg cctgggctcg gctcacagta ggctttggtc ctcggctgga
      421 cgatgggaga tggcacccgg tggagctgaa gatgaacggg gattcactgc tgctgtgggt
      481 ggatgggaag gagatgctat gcctgagaca aatctctgca tccctggctg accactccca
      541 gcgcagcatg aggattgcac taggggggct cctcctccct acttccaaac ttcggtttcc
      601 gctcgtgcct gccctggacg gctgtattcg gcgagatatc tggctgggcc accaggccca
      661 gctctcagcc tctccccgca ctagcctggg aaactgtgat gtggacctgc aacctggact
      721 gttcttccct ccagggaccc acgcagaatt cagtctccaa gacattcccc agcctcatgc
      781 agacccctgg accttttctc tggagctagg atttaagctg gtggatggct caggacaact
      841 ccttgctctt ggaacaggaa caaattcttc ttggcttaac attcacctcc aaaaccaaag
      901 cgtggttctg tcttccgagg cagaacctaa ggtagtttta cccttggacg tgggactccc
      961 tcttcagctg acgctggata gagtcaaagt ggtcttgagc caaggaccaa agatggaagt
     1021 cctttctatg tctcttttga gacctgcctc cctctggaga ctctggtccc accctcaggg
     1081 ccatctctcc cttggggctt taccaggaga gagttcttct gcttccttct gcctgagtga
     1141 cttttgggta caaggacaga gactggacat agaccaggcc ctgagcagaa gccaggacat
     1201 ctggactcac agctgccccc agagacctag caacgatacc cgcacctccc actagcccct
     1261 tctgagaagc agacaaggtg gtacacatct ttaaagccag gagaggtgaa gttgggagaa
     1321 tcgggacttc aagattatcc ttggctacat aacatgtttg agaccagccc aggctacatg
     1381 aaaccctgtc tttaaaaata aaaaaag
//
