LOCUS       NP_035497                403 aa            linear   ROD 27-APR-2025
DEFINITION  sex hormone-binding globulin precursor [Mus musculus].
ACCESSION   NP_035497 XP_001006589
VERSION     NP_035497.1
DBSOURCE    REFSEQ: accession NM_011367.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 403)
  AUTHORS   Xie,X., Sun,L., Duan,Y., Lv,Z., Yao,X., Wang,C., Chen,X., Tian,S.,
            Yan,L., Shao,Y., Luo,H. and Liu,J.
  TITLE     SRSF2 in Sertoli cells is essential for testicular development and
            spermatogenesis in mice
  JOURNAL   FASEB J 37 (5), e22918 (2023)
   PUBMED   37039821
REFERENCE   2  (residues 1 to 403)
  AUTHORS   Brianso-Llort,L., Fuertes-Rioja,L., Ramos-Perez,L.,
            Salcedo-Allende,M.T., Hernandez,C., Simo,R. and Selva,D.M.
  TITLE     Transforming growth factor-beta 1: A new factor reducing hepatic
            SHBG production in liver fibrosis
  JOURNAL   J Cell Physiol 237 (9), 3598-3613 (2022)
   PUBMED   35762039
  REMARK    GeneRIF: Transforming growth factor-beta 1: A new factor reducing
            hepatic SHBG production in liver fibrosis.
REFERENCE   3  (residues 1 to 403)
  AUTHORS   Yamazaki,H., Kushiyama,A., Sakoda,H., Fujishiro,M., Yamamotoya,T.,
            Nakatsu,Y., Kikuchi,T., Kaneko,S., Tanaka,H. and Asano,T.
  TITLE     Protective Effect of Sex Hormone-Binding Globulin against Metabolic
            Syndrome: In Vitro Evidence Showing Anti-Inflammatory and Lipolytic
            Effects on Adipocytes and Macrophages
  JOURNAL   Mediators Inflamm 2018, 3062319 (2018)
   PUBMED   30046278
  REMARK    GeneRIF: SHBG suppresses inflammation and lipid accumulation in
            macrophages and adipocytes, which might be among the mechanisms
            underlying the protective effect of SHBG, that is, its actions
            which reduce the incidence of metabolic syndrome
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 403)
  AUTHORS   Li,Y., Zhang,L., Hu,Y., Chen,M., Han,F., Qin,Y., Chen,M., Cui,X.,
            Duo,S., Tang,F. and Gao,F.
  TITLE     beta-Catenin directs the transformation of testis Sertoli cells to
            ovarian granulosa-like cells by inducing Foxl2 expression
  JOURNAL   J Biol Chem 292 (43), 17577-17586 (2017)
   PUBMED   28900034
REFERENCE   5  (residues 1 to 403)
  AUTHORS   Zhang,L., Chen,M., Wen,Q., Li,Y., Wang,Y., Wang,Y., Qin,Y., Cui,X.,
            Yang,L., Huff,V. and Gao,F.
  TITLE     Reprogramming of Sertoli cells to fetal-like Leydig cells by Wt1
            ablation
  JOURNAL   Proc Natl Acad Sci U S A 112 (13), 4003-4008 (2015)
   PUBMED   25775596
REFERENCE   6  (residues 1 to 403)
  AUTHORS   Remmers,E.F., Goldmuntz,E.A., Cash,J.M., Crofford,L.J.,
            Misiewicz-Poltorak,B., Zha,H. and Wilder,R.L.
  TITLE     Genetic map of nine polymorphic loci comprising a single linkage
            group on rat chromosome 10: evidence for linkage conservation with
            human chromosome 17 and mouse chromosome 11
  JOURNAL   Genomics 14 (3), 618-623 (1992)
   PUBMED   1358809
REFERENCE   7  (residues 1 to 403)
  AUTHORS   Pownall,S., Kozak,C.A., Schappert,K., Sarkar,M., Hull,E.,
            Schachter,H. and Marth,J.D.
  TITLE     Molecular cloning and characterization of the mouse
            UDP-N-acetylglucosamine:alpha-3-D-mannoside
            beta-1,2-N-acetylglucosaminyltransferase I gene
  JOURNAL   Genomics 12 (4), 699-704 (1992)
   PUBMED   1533386
REFERENCE   8  (residues 1 to 403)
  AUTHORS   Moore,S.K., Appella,E., Villar,C.J. and Kozak,C.A.
  TITLE     Mapping of the mouse 86-kDa heat-shock protein expressed gene
            (Hsp86-1) on chromosome 12 and related genes on chromosomes 3, 4,
            9, and 11
  JOURNAL   Genomics 10 (4), 1019-1029 (1991)
   PUBMED   1916807
REFERENCE   9  (residues 1 to 403)
  AUTHORS   Joseph,D.R., Adamson,M.C. and Kozak,C.A.
  TITLE     Genetic mapping of the gene for androgen-binding protein/sex
            hormone-binding globulin to mouse chromosome 11
  JOURNAL   Cytogenet Cell Genet 56 (2), 122-124 (1991)
   PUBMED   2013230
REFERENCE   10 (residues 1 to 403)
  AUTHORS   Hearne,C.M., McAleer,M.A., Love,J.M., Aitman,T.J., Cornall,R.J.,
            Ghosh,S., Knight,A.M., Prins,J.B. and Todd,J.A.
  TITLE     Additional microsatellite markers for mouse genome mapping
  JOURNAL   Mamm Genome 1 (4), 273-282 (1991)
   PUBMED   1794058
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK010959.1, BC120785.1 and AL731687.13.
            
            On May 4, 2006 this sequence version replaced XP_001006589.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U85644.1, AK010959.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164140, SAMN01164143
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..403
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 42.86 cM"
     Protein         1..403
                     /product="sex hormone-binding globulin precursor"
                     /note="SBP; sex steroid-binding protein; testis-specific
                     androgen-binding protein"
                     /calculated_mol_wt=41328
     sig_peptide     1..30
                     /note="/evidence=ECO:0000250; propagated from
                     UniProtKB/Swiss-Prot (P97497.1)"
                     /calculated_mol_wt=3506
     mat_peptide     31..403
                     /product="Sex hormone-binding globulin.
                     /id=PRO_0000032558"
                     /note="propagated from UniProtKB/Swiss-Prot (P97497.1)"
                     /calculated_mol_wt=41328
     Region          76..206
                     /region_name="Laminin_G_1"
                     /note="Laminin G domain; pfam00054"
                     /db_xref="CDD:395008"
     Region          225..369
                     /region_name="LamG"
                     /note="Laminin G domain; Laminin G-like domains are
                     usually Ca++ mediated receptors that can have binding
                     sites for steroids, beta1 integrins, heparin, sulfatides,
                     fibulin-1, and alpha-dystroglycans. Proteins that contain
                     LamG domains serve a variety of...; cl22861"
                     /db_xref="CDD:473984"
     Site            274
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P97497.1)"
     Site            284
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P97497.1)"
     Site            397
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P97497.1)"
     CDS             1..403
                     /gene="Shbg"
                     /gene_synonym="ABP"
                     /coded_by="NM_011367.2:44..1255"
                     /db_xref="CCDS:CCDS24899.1"
                     /db_xref="GeneID:20415"
                     /db_xref="MGI:MGI:98295"
ORIGIN      
        1 mekrdsvalh wrllllllll mpppthqgra lrhidpiqsa qdppakylsn gpgqepvmvm
       61 tidltkiskp hssfefrtwd pegvifygdt nteddwfllg lragqleiql hnawarltvg
      121 fgprlddgrw hpvelkmngd slllwvdgke mlclrqisas ladhsqrsmr ialgglllpt
      181 sklrfplvpa ldgcirrdiw lghqaqlsas prtslgncdv dlqpglffpp gthaefslqd
      241 ipqphadpwt fslelgfklv dgsgqllalg tgtnsswlni hlqnqsvvls seaepkvvlp
      301 ldvglplqlt ldrvkvvlsq gpkmevlsms llrpaslwrl wshpqghlsl galpgesssa
      361 sfclsdfwvq gqrldidqal srsqdiwths cpqrpsndtr tsh
//
