LOCUS       NM_001033306            2762 bp    mRNA    linear   ROD 11-OCT-2023
DEFINITION  Mus musculus src homology 2 domain-containing transforming protein
            B (Shb), mRNA.
ACCESSION   NM_001033306 XM_001474892
VERSION     NM_001033306.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2762)
  AUTHORS   Galazo MJ, Sweetser DA and Macklis JD.
  TITLE     Tle4 controls both developmental acquisition and early post-natal
            maturation of corticothalamic projection neuron identity
  JOURNAL   Cell Rep 42 (8), 112957 (2023)
   PUBMED   37561632
REFERENCE   2  (bases 1 to 2762)
  AUTHORS   Bedogni F and Hevner RF.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2762)
  AUTHORS   Jamalpour M, Bergquist E and Welsh M.
  TITLE     Absence of the Shb gene in mixed-lineage leukemia MLL-AF9 cells
            increases latency in mice despite higher proliferation rates in
            vitro
  JOURNAL   Exp Cell Res 397 (2), 112368 (2020)
   PUBMED   33220260
  REMARK    GeneRIF: Absence of the Shb gene in mixed-lineage leukemia MLL-AF9
            cells increases latency in mice despite higher proliferation rates
            in vitro.
REFERENCE   4  (bases 1 to 2762)
  AUTHORS   He Q, Li X, He L, Li Y, Betsholtz C and Welsh M.
  TITLE     Pericyte dysfunction due to Shb gene deficiency increases B16F10
            melanoma lung metastasis
  JOURNAL   Int J Cancer 147 (9), 2634-2644 (2020)
   PUBMED   32441314
  REMARK    GeneRIF: Pericyte dysfunction due to Shb gene deficiency increases
            B16F10 melanoma lung metastasis.
REFERENCE   5  (bases 1 to 2762)
  AUTHORS   He Q, Li X, Singh K, Luo Z, Meija-Cordova M, Jamalpour M, Lindahl
            B, Kriz V, Vuolteenaho R, Ulvmar M and Welsh M.
  TITLE     The Cdh5-CreERT2 transgene causes conditional Shb gene deletion in
            hematopoietic cells with consequences for immune cell responses to
            tumors
  JOURNAL   Sci Rep 9 (1), 7548 (2019)
   PUBMED   31101877
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2762)
  AUTHORS   Holmqvist K, Cross M, Riley D and Welsh M.
  TITLE     The Shb adaptor protein causes Src-dependent cell spreading and
            activation of focal adhesion kinase in murine brain endothelial
            cells
  JOURNAL   Cell Signal 15 (2), 171-179 (2003)
   PUBMED   12464388
  REMARK    GeneRIF: Shb binds directly to FAK and regulates its
            phosphorylation leading to enhanced cell spreading in a
            Src-dependent manner.
REFERENCE   7  (bases 1 to 2762)
  AUTHORS   Cross MJ, Lu L, Magnusson P, Nyqvist D, Holmqvist K, Welsh M and
            Claesson-Welsh L.
  TITLE     The Shb adaptor protein binds to tyrosine 766 in the FGFR-1 and
            regulates the Ras/MEK/MAPK pathway via FRS2 phosphorylation in
            endothelial cells
  JOURNAL   Mol Biol Cell 13 (8), 2881-2893 (2002)
   PUBMED   12181353
REFERENCE   8  (bases 1 to 2762)
  AUTHORS   Anneren C.
  TITLE     Dual role of the tyrosine kinase GTK and the adaptor protein SHB in
            beta-cell growth: enhanced beta-cell replication after 60%
            pancreatectomy and increased sensitivity to streptozotocin
  JOURNAL   J Endocrinol 172 (1), 145-153 (2002)
   PUBMED   11786382
REFERENCE   9  (bases 1 to 2762)
  AUTHORS   Lavergne C, Mares J, Karlsson T, Breant B and Welsh M.
  TITLE     Control of SHB gene expression by protein phosphorylation
  JOURNAL   Cell Signal 8 (1), 55-58 (1996)
   PUBMED   8777141
REFERENCE   10 (bases 1 to 2762)
  AUTHORS   Welsh M, Mares J, Karlsson T, Lavergne C, Breant B and
            Claesson-Welsh L.
  TITLE     Shb is a ubiquitously expressed Src homology 2 protein
  JOURNAL   Oncogene 9 (1), 19-27 (1994)
   PUBMED   8302579
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL772376.6, BY739915.1 and BC058986.1.
            
            [WARNING] On Jan 19, 2024 this sequence was replaced by
            NM_001033306.2.
            
            On Jul 8, 2009 this sequence version replaced XM_001474892.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC058986.1, SRR7974084.17183.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                AL772376.6         176024-176040       c
            18-498              BY739915.1         2-482
            499-2480            BC058986.1         1-1982
            2481-2481           AL772376.6         68751-68751         c
            2482-2762           BC058986.1         1984-2264
FEATURES             Location/Qualifiers
     source          1..2762
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 24.0 cM"
     gene            1..2762
                     /gene="Shb"
                     /note="src homology 2 domain-containing transforming
                     protein B"
                     /db_xref="GeneID:230126"
                     /db_xref="MGI:MGI:98294"
     exon            1..1267
                     /gene="Shb"
                     /inference="alignment:Splign:2.1.0"
     CDS             569..2080
                     /gene="Shb"
                     /codon_start=1
                     /product="SH2 domain-containing adapter protein B"
                     /protein_id="NP_001028478.1"
                     /db_xref="CCDS:CCDS51173.1"
                     /db_xref="GeneID:230126"
                     /db_xref="MGI:MGI:98294"
                     /translation="MAKWLNKYFSLGNSKTKSPPQPPRPDYREQRRRGERREQPPQAV
                     PQACSASSASCGSAAACFSASSGSLPDDSGSTSDLIRAYRAQKERDFEDPYNGPGSSL
                     RKLRAMCRLDYCGGGGGGDPGGGQRAFTAAAGAAGCCCAAAGAGAAASSSSSSGSPHL
                     YRSSSERRPTTPAEVRYISPKHRLIKVESASAAGDPPGGVCSGGRTWSPTTCGGKKLL
                     NKCSAEETGAGQKDKVTIADDYSDPFDAKSDLKSKAGKGESAGYMEPYEAQRIMTEFQ
                     RQESVRSQHKGIQLYDTPYEPEGQSVDSDSESTVSLRLRESKLPQDDDRPADEYDQPW
                     EWNRVTIPALAAQFNGNEKRQSSPSPSRDRRRQLRAPGGGFKPIKHGSPEFCGILGER
                     VDPTIPLEKQIWYHGAISRSDAENLLRLCKECSYLVRNSQTSKHDYSLSLKSNQGFMH
                     MKLAKTKEKYVLGQNSPPFDSVPEVIHYYTTRKLPIKGAEHLSLLYPVAVRTL"
     exon            1268..1388
                     /gene="Shb"
                     /inference="alignment:Splign:2.1.0"
     exon            1389..1604
                     /gene="Shb"
                     /inference="alignment:Splign:2.1.0"
     exon            1605..1776
                     /gene="Shb"
                     /inference="alignment:Splign:2.1.0"
     exon            1777..1896
                     /gene="Shb"
                     /inference="alignment:Splign:2.1.0"
     exon            1897..2744
                     /gene="Shb"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcgggttct ggcggccgag tgtcacacac gcggcggctc gggaggcggc agcagaggca
       61 gcggcagagc caggcgccgc cgggacgggc aggggcgcgc gggctccgcc aggcgccggc
      121 cgcctccctc attcgttcgc ttgttttccg acccgcagtg gggccgggct cgcccccgtg
      181 cactcgagaa gcccgcagct ggccgcggct cgcacggggc aggggcgcgc tccgcgaggg
      241 tgggggcgct gggtgcgggc gtgcgcggcg gggggcgcct ggccttccgc tctaggcggc
      301 ccgggtccct atgagacacg tctgtgcggg gcgcgagatc caaagctcgg tcggcgcgcg
      361 gcaggggcgg agggctgtgc agcagcggcc ggagccaggc ggcggccggc aggaggcggc
      421 ggctgcgaga acttgaactt ggcgaccggt gccccgcacg ccccccaccg gggcaggggc
      481 gttgcgggac tgggcgacag cgttgtcccc cgaatggccg cggcggcgga ccgggctcgc
      541 gcgccgcggc cctaggcggc ccttcgccat ggccaagtgg ctgaacaagt acttcagctt
      601 gggcaacagc aagactaaga gtccgccgca gccgccgagg ccggactacc gggagcagcg
      661 gcgccggggc gagcgacgag agcagccccc gcaggccgtg ccgcaggcct gctcggcgtc
      721 ctcggcgtcc tgtgggtcgg ccgccgcctg cttctcggcc tcgtcgggct ctctgcccga
      781 cgacagcggc agcacgagtg acctcatccg cgcctaccgc gcgcagaagg agcgcgactt
      841 cgaggacccg tacaacgggc cgggctcgtc gctgcgcaaa ctgcgagcta tgtgccgcct
      901 ggactactgc ggcggcggcg gcggcgggga ccccggcggg ggccagcgcg ccttcacggc
      961 ggcagcggga gctgcgggct gctgctgcgc ggcggcggga gcgggcgccg ccgcgtcctc
     1021 gtcctcatcc tccggctccc cgcacctcta ccgcagcagc agcgagcggc ggccgacgac
     1081 gccggcggag gtgcgctaca tctcccctaa gcaccgactc atcaaagtgg agagcgcgag
     1141 cgctgcgggg gaccctccgg gaggcgtgtg ctctggcggc cgtacctgga gcccgacgac
     1201 ctgcggaggc aaaaaactgc tcaacaagtg ctccgccgag gagaccggag ctggtcagaa
     1261 agataaggtg accatagctg atgactactc cgatcccttt gatgccaaga gcgacctcaa
     1321 gagcaaagca ggaaagggtg agagcgctgg ctacatggag ccctacgaag cccagaggat
     1381 catgacagaa ttccagaggc aagagagcgt ccggtcacag cacaaaggca tccagttgta
     1441 cgacaccccg tacgagccgg aaggccagag cgtggactca gactcagaga gcactgtgag
     1501 ccttcggctg cgggagagca agctacccca ggatgacgac aggcctgctg atgagtacga
     1561 ccagccgtgg gaatggaacc gggtcaccat ccccgccctg gcagcccagt ttaacggcaa
     1621 tgaaaagcgg cagtcctccc catcaccttc tcgggaccga cggcgccagc tccgtgcccc
     1681 gggaggaggc ttcaagccca tcaagcacgg gagccccgag ttctgtggga ttctggggga
     1741 gagagtggat cccaccatcc cactggagaa acagatatgg tatcacgggg ccatcagcag
     1801 aagtgatgct gagaacctgc tgcgactctg taaggagtgc agctaccttg tccggaacag
     1861 ccagaccagc aaacatgact actccctctc cctgaagagt aaccagggct tcatgcacat
     1921 gaaactggcc aagaccaaag agaagtatgt tctgggtcag aacagccccc cttttgacag
     1981 cgtcccggaa gtcatccact actacaccac caggaagctg cccatcaaag gggccgagca
     2041 cttgtccctc ctctacccag tggctgtgcg gactctgtga aaagaccagc ctcaccctgc
     2101 tctgagacca agcctgttcc ttggaggagc tggcagggca ccgaccagct gtctgtgctg
     2161 ccagcagtgt ccagtgtgtg ttgtgtgtat ggtactagca caccactgca tgtcttagaa
     2221 tgctgtcgcc acttacaggg ttggagaagg cctggatgaa gagggcagcc cgcggccaca
     2281 ccaccccagc ccctacccca ccccctcctc gagtttctgt gaattaaagt ctttgcaatc
     2341 caaagagatg ccttccaggg tgaacaaaag tggagctgct ccagcggtgg gcggggccca
     2401 gcagtgggtg gggcccagcg gtaggtgggg cggagctctg gcctgtatct ctttgttttc
     2461 cagttgtcag gaactcacct gtgtatgggc aaggtttttc ccattggtgc tgggagccca
     2521 ggaggccctg ggagccaccc catctggtct gtgtctgtgt cactgggtgt gcatattgag
     2581 tgtacacaaa agagaccatg tcataagcca gagtaagccc ccatctcctt ttagatgtac
     2641 actctgtaac cgttagatgt caaggaacaa ttgtgcagac aaagaggatg caattattta
     2701 tgaatatgat agggtgtgta aataaaatag tcatttaata tataaaaaaa aaaaaaaaaa
     2761 aa
//
