LOCUS       NM_025340               1747 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus SHANK-associated RH domain interacting protein
            (Sharpin), mRNA.
ACCESSION   NM_025340
VERSION     NM_025340.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1747)
  AUTHORS   Zhang,Y., Xu,X., Wang,Y., Wang,Y., Zhou,X. and Pan,L.
  TITLE     Mechanistic insights into the homo-dimerization of HOIL-1L and
            SHARPIN
  JOURNAL   Biochem Biophys Res Commun 689, 149239 (2023)
   PUBMED   37976837
  REMARK    GeneRIF: Mechanistic insights into the homo-dimerization of HOIL-1L
            and SHARPIN.
REFERENCE   2  (bases 1 to 1747)
  AUTHORS   Anderton,H., Chopin,M., Dawson,C.A., Nutt,S.L., Whitehead,L.,
            Silke,N., Lalaloui,N. and Silke,J.
  TITLE     Langerhans cells are an essential cellular intermediary in chronic
            dermatitis
  JOURNAL   Cell Rep 39 (10), 110922 (2022)
   PUBMED   35675765
REFERENCE   3  (bases 1 to 1747)
  AUTHORS   Chun,N., Ang,R.L., Chan,M., Fairchild,R.L., Baldwin,W.M. 3rd,
            Horwitz,J.K., Gelles,J.D., Chipuk,J.E., Kelliher,M.A., Pavlov,V.I.,
            Li,Y., Homann,D., Heeger,P.S. and Ting,A.T.
  TITLE     T cell-derived tumor necrosis factor induces cytotoxicity by
            activating RIPK1-dependent target cell death
  JOURNAL   JCI Insight 6 (24), e148643 (2021)
   PUBMED   34752416
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1747)
  AUTHORS   Ang,R.L., Chan,M., Legarda,D., Sundberg,J.P., Sun,S.C.,
            Gillespie,V.L., Chun,N., Heeger,P.S., Xiong,H., Lira,S.A. and
            Ting,A.T.
  TITLE     Immune dysregulation in SHARPIN-deficient mice is dependent on
            CYLD-mediated cell death
  JOURNAL   Proc Natl Acad Sci U S A 118 (50) (2021)
   PUBMED   34887354
  REMARK    GeneRIF: Immune dysregulation in SHARPIN-deficient mice is
            dependent on CYLD-mediated cell death.
REFERENCE   5  (bases 1 to 1747)
  AUTHORS   Gomez-Diaz,C., Jonsson,G., Schodl,K., Deszcz,L., Bestehorn,A.,
            Eislmayr,K., Almagro,J., Kavirayani,A., Seida,M., Fennell,L.M.,
            Hagelkruys,A., Kovarik,P., Penninger,J.M. and Ikeda,F.
  TITLE     The ubiquitin ligase HOIL-1L regulates immune responses by
            interacting with linear ubiquitin chains
  JOURNAL   iScience 24 (11), 103241 (2021)
   PUBMED   34755089
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1747)
  AUTHORS   Gijbels,M.J., Zurcher,C., Kraal,G., Elliott,G.R., HogenEsch,H.,
            Schijff,G., Savelkoul,H.F. and Bruijnzeel,P.L.
  TITLE     Pathogenesis of skin lesions in mice with chronic proliferative
            dermatitis (cpdm/cpdm)
  JOURNAL   Am J Pathol 148 (3), 941-950 (1996)
   PUBMED   8774148
REFERENCE   7  (bases 1 to 1747)
  AUTHORS   Gijbels,M.J., HogenEsch,H., Bruijnzeel,P.L., Elliott,G.R. and
            Zurcher,C.
  TITLE     Maintenance of donor phenotype after full-thickness skin
            transplantation from mice with chronic proliferative dermatitis
            (cpdm/cpdm) to C57BL/Ka and nude mice and vice versa
  JOURNAL   J Invest Dermatol 105 (6), 769-773 (1995)
   PUBMED   7490470
REFERENCE   8  (bases 1 to 1747)
  AUTHORS   Gijbels,M.J., HogenEsch,H., Blauw,B., Roholl,P. and Zurcher,C.
  TITLE     Ultrastructure of epidermis of mice with chronic proliferative
            dermatitis
  JOURNAL   Ultrastruct Pathol 19 (2), 107-111 (1995)
   PUBMED   7792947
REFERENCE   9  (bases 1 to 1747)
  AUTHORS   Gallardo Torres,H.I., Gijbels,M.J., HegnEsch,H. and Kraal,G.
  TITLE     Chronic proliferative dermatitis in mice: neutrophil-endothelium
            interactions and the role of adhesion molecules
  JOURNAL   Pathobiology 63 (6), 341-347 (1995)
   PUBMED   8738473
REFERENCE   10 (bases 1 to 1747)
  AUTHORS   HogenEsch,H., Gijbels,M.J., Offerman,E., van Hooft,J., van
            Bekkum,D.W. and Zurcher,C.
  TITLE     A spontaneous mutation characterized by chronic proliferative
            dermatitis in C57BL mice
  JOURNAL   Am J Pathol 143 (3), 972-982 (1993)
   PUBMED   8362989
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BI729629.1 and BC016203.1.
            
            On Jan 16, 2008 this sequence version replaced NM_025340.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB052763.1, AK003578.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-59                BI729629.1         2-60
            60-1747             BC016203.1         1-1688
FEATURES             Location/Qualifiers
     source          1..1747
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 35.75 cM"
     gene            1..1747
                     /gene="Sharpin"
                     /gene_synonym="0610041B22Rik; cpdm; RBCKL1; SIPL1"
                     /note="SHANK-associated RH domain interacting protein"
                     /db_xref="GeneID:106025"
                     /db_xref="MGI:MGI:1913331"
     exon            1..630
                     /gene="Sharpin"
                     /gene_synonym="0610041B22Rik; cpdm; RBCKL1; SIPL1"
                     /inference="alignment:Splign:2.1.0"
     exon            631..805
                     /gene="Sharpin"
                     /gene_synonym="0610041B22Rik; cpdm; RBCKL1; SIPL1"
                     /inference="alignment:Splign:2.1.0"
     exon            806..940
                     /gene="Sharpin"
                     /gene_synonym="0610041B22Rik; cpdm; RBCKL1; SIPL1"
                     /inference="alignment:Splign:2.1.0"
     exon            941..1082
                     /gene="Sharpin"
                     /gene_synonym="0610041B22Rik; cpdm; RBCKL1; SIPL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1083..1191
                     /gene="Sharpin"
                     /gene_synonym="0610041B22Rik; cpdm; RBCKL1; SIPL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1192..1345
                     /gene="Sharpin"
                     /gene_synonym="0610041B22Rik; cpdm; RBCKL1; SIPL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1346..1458
                     /gene="Sharpin"
                     /gene_synonym="0610041B22Rik; cpdm; RBCKL1; SIPL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1459..1587
                     /gene="Sharpin"
                     /gene_synonym="0610041B22Rik; cpdm; RBCKL1; SIPL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1588..1733
                     /gene="Sharpin"
                     /gene_synonym="0610041B22Rik; cpdm; RBCKL1; SIPL1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1713..1718
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sharpin"
                     /gene_synonym="0610041B22Rik; cpdm; RBCKL1; SIPL1"
                     /note="hexamer: ATTAAA"
     polyA_site      1733
                     /gene="Sharpin"
                     /gene_synonym="0610041B22Rik; cpdm; RBCKL1; SIPL1"
                     /note="major polyA site"
ORIGIN      
        1 cctcttccta gagtggtcca cggttacgaa gagcctctgc tgtgcttatg tgtgtttgtg
       61 tgcattggtg cctggttcct tccgggaact ggtattgtct tgtgtagggc agcagctgtc
      121 gttcgttcga acctttaaga aaagttcatc cttgccttct ttttgtgacc ggtgaccggt
      181 ctgtgacact gtctcgggtc ctgctgaaag gtgactagct tggccggacc gtgcctggag
      241 atctgggacc attcctatcg cttagcgagc catcaggctc tggtagtgcg cagcatcggg
      301 tccttcttgt tctccaagct ctggggcatc cggaaccgag gctcacagtc cgagtttctg
      361 gccggcggaa gtactcgaca gttctctatc acggaagcac tctcggagag tcaggactcc
      421 gccggatcag aaatgtcgcc gcccgccggc ggtgcggcag tggctgcaga ccctgcctca
      481 cctgtggtgc tcctggcagt gcacgcggcg gtcaggcccc tgggcgctgg acaggatgcc
      541 gaagcgcagc cgcggaagct gcaattgata gcggaccctg agcggcctgg acgcttccgg
      601 ctaggactgt taggcaccga gcctggggcg gtcagtttag aatggccctt ggaggctatt
      661 tgttacaccg tccgtgggcc taaccaacac gagctgcagc ctccccctgg aggtcctgga
      721 accttcagcg tgcacttcct cgaccccgag gaagcacagc agtgggcagc actggtgcga
      781 gatgccaccg cagaaggaca aaatggcagt ggcagcccag ccccagcccc agccccagca
      841 atgtgcccca tttctccacc atgttcttct atggctcaaa tacctaaagc aacccaacct
      901 gaggtggatc ttcctcaaag ttctggaaac ttcaaaaaag aagagctggc tacacgcctg
      961 tcccaggcca ttgcaggtgg ggatgagaaa gcagcggccc aagtggcagc agtcctggcg
     1021 cagcatcatg tggctctcaa tgtccagctc atggaggcct ggttcccacc aggtcccata
     1081 aggctacaag tcacagttga agacgccaca tcggttttgt cctcttcatc gtctgcccat
     1141 gtctcactga agatccaccc acattgctcc attgcagccc ttcaggatca ggtgttctca
     1201 gagttcggtt tcccaccagc tgtgcagcgc tgggtcattg ggcggtgcct gtgtatgcct
     1261 gaacgaagcc ttgcttccta tggggtctct caagatggag accctgcttt tctttacttg
     1321 ctctcggccc ccagagaagt ttcaggacaa agccttcaaa actccaagat ggaccggaaa
     1381 ttaggcttgt ttcctcagtc actggggctg cctcatgacc tccagccgtc cagttccagt
     1441 ctcccaagtc cctctcagcc tggctggtct tgcccttcct gcactttcat caatgcctca
     1501 aaccgccctg gctgtgagat gtgtagcacc caaaggccct gtgcttggga tcctcttgct
     1561 gcagcttcca cctagaagcc accaaaggtt acagagaata tggccctcct gtcacaggcc
     1621 caaccaccac cacttgaact ttgcagggga ctgatgcttg ttggggacag agatgccagt
     1681 gttaaacaac aggggctaca tacaagctag taattaaaga cacatacgag ccaaaaaaaa
     1741 aaaaaaa
//
