LOCUS       NM_021423               7380 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus SH3 and multiple ankyrin repeat domains 3 (Shank3),
            mRNA.
ACCESSION   NM_021423 XM_001002893
VERSION     NM_021423.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7380)
  AUTHORS   Kshetri,R., Beavers,J.O., Hyde,R., Ewa,R., Schwertman,A.,
            Porcayo,S. and Richardson,B.D.
  TITLE     Behavioral decline in Shank3Deltaex4-22 mice during early adulthood
            parallels cerebellar granule cell glutamatergic synaptic changes
  JOURNAL   Mol Autism 15 (1), 52 (2024)
   PUBMED   39633421
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7380)
  AUTHORS   Fischer,I., Shohat,S., Leichtmann-Bardoogo,Y., Nayak,R., Wiener,G.,
            Rosh,I., Shemen,A., Tripathi,U., Rokach,M., Bar,E., Hussein,Y.,
            Castro,A.C., Chen,G., Soffer,A., Schokoroy-Trangle,S.,
            Elad-Sfadia,G., Assaf,Y., Schroeder,A., Monteiro,P., Stern,S.,
            Maoz,B.M. and Barak,B.
  TITLE     Shank3 mutation impairs glutamate signaling and myelination in ASD
            mouse model and human iPSC-derived OPCs
  JOURNAL   Sci Adv 10 (41), eadl4573 (2024)
   PUBMED   39392881
  REMARK    GeneRIF: Shank3 mutation impairs glutamate signaling and
            myelination in ASD mouse model and human iPSC-derived OPCs.
REFERENCE   3  (bases 1 to 7380)
  AUTHORS   Gora,C., Dudas,A., Vaugrente,O., Drobecq,L., Pecnard,E., Lefort,G.
            and Pellissier,L.P.
  TITLE     Deciphering autism heterogeneity: a molecular stratification
            approach in four mouse models
  JOURNAL   Transl Psychiatry 14 (1), 416 (2024)
   PUBMED   39366951
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7380)
  AUTHORS   Bacova,Z., Jurkovicova-Tarabova,B., Havranek,T., Mihalj,D.,
            Borbelyova,V., Pirnik,Z., Mravec,B., Ostatnikova,D. and Bakos,J.
  TITLE     Shank3 deficiency alters midbrain GABAergic neuron morphology,
            GABAergic markers and synaptic activity in primary striatal neurons
  JOURNAL   Mol Brain 17 (1), 71 (2024)
   PUBMED   39334399
  REMARK    GeneRIF: Shank3 deficiency alters midbrain GABAergic neuron
            morphology, GABAergic markers and synaptic activity in primary
            striatal neurons.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7380)
  AUTHORS   Landen,J.G., Vandendoren,M., Killmer,S., Bedford,N.L. and
            Nelson,A.C.
  TITLE     Huddling substates in mice facilitate dynamic changes in body
            temperature and are modulated by Shank3b and Trpm8 mutation
  JOURNAL   Commun Biol 7 (1), 1186 (2024)
   PUBMED   39304735
  REMARK    GeneRIF: Huddling substates in mice facilitate dynamic changes in
            body temperature and are modulated by Shank3b and Trpm8 mutation.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 7380)
  AUTHORS   Olson,P.A., Tkatch,T., Hernandez-Lopez,S., Ulrich,S., Ilijic,E.,
            Mugnaini,E., Zhang,H., Bezprozvanny,I. and Surmeier,D.J.
  TITLE     G-protein-coupled receptor modulation of striatal CaV1.3 L-type
            Ca2+ channels is dependent on a Shank-binding domain
  JOURNAL   J Neurosci 25 (5), 1050-1062 (2005)
   PUBMED   15689540
  REMARK    GeneRIF: Shank promotes the assembly of a signaling complex at
            corticostriatal synapses that enables key GPCRs to regulate L-type
            Ca2+ channels and the integration of glutamatergic synaptic events.
REFERENCE   7  (bases 1 to 7380)
  AUTHORS   Schuetz,G., Rosario,M., Grimm,J., Boeckers,T.M., Gundelfinger,E.D.
            and Birchmeier,W.
  TITLE     The neuronal scaffold protein Shank3 mediates signaling and
            biological function of the receptor tyrosine kinase Ret in
            epithelial cells
  JOURNAL   J Cell Biol 167 (5), 945-952 (2004)
   PUBMED   15569713
  REMARK    GeneRIF: These results demonstrate that the Shank3 adaptor protein
            can mediate cellular signaling, and provide a molecular mechanism
            for the biological divergence between the Ret9 and Ret51 isoform.
REFERENCE   8  (bases 1 to 7380)
  AUTHORS   Okazaki,N., F-Kikuno,R., Ohara,R., Inamoto,S., Koseki,H.,
            Hiraoka,S., Saga,Y., Seino,S., Nishimura,M., Kaisho,T., Hoshino,K.,
            Kitamura,H., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: IV. The complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (3), 205-218 (2004)
   PUBMED   15368895
REFERENCE   9  (bases 1 to 7380)
  AUTHORS   Uemura,T., Mori,H. and Mishina,M.
  TITLE     Direct interaction of GluRdelta2 with Shank scaffold proteins in
            cerebellar Purkinje cells
  JOURNAL   Mol Cell Neurosci 26 (2), 330-341 (2004)
   PUBMED   15207857
REFERENCE   10 (bases 1 to 7380)
  AUTHORS   Bolis,A., Corbetta,S., Cioce,A. and de Curtis,I.
  TITLE     Differential distribution of Rac1 and Rac3 GTPases in the
            developing mouse brain: implications for a role of Rac3 in Purkinje
            cell differentiation
  JOURNAL   Eur J Neurosci 18 (9), 2417-2424 (2003)
   PUBMED   14622142
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC137513.3 and AC122401.3.
            
            On Jun 21, 2019 this sequence version replaced NM_021423.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB231013.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-312               AC137513.3         25999-26310         c
            313-516             AC137513.3         25500-25703         c
            517-588             AC137513.3         24443-24514         c
            589-697             AC137513.3         22690-22798         c
            698-849             AC137513.3         22464-22615         c
            850-1017            AC137513.3         22211-22378         c
            1018-1134           AC137513.3         22005-22121         c
            1135-1212           AC137513.3         21524-21601         c
            1213-1279           AC137513.3         20462-20528         c
            1280-1550           AC137513.3         4545-4815           c
            1551-1744           AC137513.3         1699-1892           c
            1745-1858           AC137513.3         645-758             c
            1859-1934           AC122401.3         163686-163761       c
            1935-2017           AC122401.3         163396-163478       c
            2018-2142           AC122401.3         162885-163009       c
            2143-2275           AC122401.3         162643-162775       c
            2276-2356           AC122401.3         161650-161730       c
            2357-2380           AC122401.3         157066-157089       c
            2381-2511           AC122401.3         151874-152004       c
            2512-2596           AC122401.3         151226-151310       c
            2597-4853           AC122401.3         145222-147478       c
            4854-7380           AC122401.3         134843-137369       c
FEATURES             Location/Qualifiers
     source          1..7380
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 44.96 cM"
     gene            1..7380
                     /gene="Shank3"
                     /gene_synonym="proSAP2; Spank-2"
                     /note="SH3 and multiple ankyrin repeat domains 3"
                     /db_xref="GeneID:58234"
                     /db_xref="MGI:MGI:1930016"
     exon            1..312
                     /gene="Shank3"
                     /gene_synonym="proSAP2; Spank-2"
                     /inference="alignment:Splign:2.1.0"
     exon            313..516
                     /gene="Shank3"
                     /gene_synonym="proSAP2; Spank-2"
                     /inference="alignment:Splign:2.1.0"
     exon            517..588
                     /gene="Shank3"
                     /gene_synonym="proSAP2; Spank-2"
                     /inference="alignment:Splign:2.1.0"
     exon            589..697
                     /gene="Shank3"
                     /gene_synonym="proSAP2; Spank-2"
                     /inference="alignment:Splign:2.1.0"
     exon            698..849
                     /gene="Shank3"
                     /gene_synonym="proSAP2; Spank-2"
                     /inference="alignment:Splign:2.1.0"
     exon            850..1017
                     /gene="Shank3"
                     /gene_synonym="proSAP2; Spank-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1018..1134
                     /gene="Shank3"
                     /gene_synonym="proSAP2; Spank-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1135..1212
                     /gene="Shank3"
                     /gene_synonym="proSAP2; Spank-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1213..1279
                     /gene="Shank3"
                     /gene_synonym="proSAP2; Spank-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1280..1550
                     /gene="Shank3"
                     /gene_synonym="proSAP2; Spank-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1551..1744
                     /gene="Shank3"
                     /gene_synonym="proSAP2; Spank-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1745..1858
                     /gene="Shank3"
                     /gene_synonym="proSAP2; Spank-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1859..1934
                     /gene="Shank3"
                     /gene_synonym="proSAP2; Spank-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1935..2017
                     /gene="Shank3"
                     /gene_synonym="proSAP2; Spank-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2018..2142
                     /gene="Shank3"
                     /gene_synonym="proSAP2; Spank-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2143..2275
                     /gene="Shank3"
                     /gene_synonym="proSAP2; Spank-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2276..2356
                     /gene="Shank3"
                     /gene_synonym="proSAP2; Spank-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2357..2380
                     /gene="Shank3"
                     /gene_synonym="proSAP2; Spank-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2381..2511
                     /gene="Shank3"
                     /gene_synonym="proSAP2; Spank-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2512..2596
                     /gene="Shank3"
                     /gene_synonym="proSAP2; Spank-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2597..4853
                     /gene="Shank3"
                     /gene_synonym="proSAP2; Spank-2"
                     /inference="alignment:Splign:2.1.0"
     exon            4854..7380
                     /gene="Shank3"
                     /gene_synonym="proSAP2; Spank-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7359..7364
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Shank3"
                     /gene_synonym="proSAP2; Spank-2"
                     /note="hexamer: AATAAA"
     polyA_site      7380
                     /gene="Shank3"
                     /gene_synonym="proSAP2; Spank-2"
                     /note="major polyA site"
ORIGIN      
        1 aggcgccgct cgaagccggg gccgatgcag ctaaaccgtg ccgccgtcgc cgccgccgct
       61 gcgcctgcgg agcccccgga gccgctgtcc cccgcgctgg ccccggcccc ggcccccccc
      121 ggccccctcc cgcgtagcgc ggtcggcggg gctcttgcgg ggggtcaggg ggggccaggg
      181 cgccgcgcgg agtccccgtg cgctcctctc tccgccggga acagtccggg cccgggcgct
      241 agcaccggga tggacggccc cggggccagc gccgtggtcg tgcgcgtcgg catcccggac
      301 ctgcaacaaa cgaagtgcct gcgtctggac ccaaccgcgc ccgtgtgggc cgccaagcag
      361 cgtgtgctct gcgccctcaa tcatagcctt caagacgcgc tcaactacgg gctattccag
      421 cctccctccc ggggtcgcgc cggcaagttc ctggatgaag agcggctctt acaggactac
      481 ccgcctaacc tggacacgcc cctgccctat ctggagttcc gatacaagcg gagagtttat
      541 gcccagaacc tcatagatga caagcagttt gcaaagctac acacaaaggc aaacctgaag
      601 aagttcatgg actatgtcca gctacacagc acagataagg tggcccgcct gctggacaag
      661 gggctggacc ccaatttcca tgaccctgac tcaggagagt gccctctgag ccttgcggca
      721 cagttggaca acgccactga cctcctgaag gttctccgca acggcggtgc tcatctggac
      781 ttccggaccc gagatgggct gacagccgtc cactgtgcta cccgccagcg gaacgcaggg
      841 gcattgacga ccctgctgga cctgggggct tcgcctgact acaaggacag ccgcggcctg
      901 acgcccctgt accatagtgc cctagggggc ggggatgccc tctgttgcga gctgcttctc
      961 catgatcatg cacagctggg gaccactgat gagaatggtt ggcaagagat ccatcaggcc
     1021 tgtcgctttg gacacgtgca gcacctggag caccttttgt tctatggggc caacatgggt
     1081 gctcagaatg cctcgggaaa cacagccctg cacatctgtg ccctctacaa ccaggagagt
     1141 tgcgcgcgcg tcctgctttt ccgtggtgcc aacaaggacg tccgcaatta caacagccag
     1201 acagccttcc aggtggccat tattgcaggg aactttgagc ttgccgaggt aatcaagacc
     1261 cacaaagact ccgatgtcgt accattcagg gaaaccccca gctatgcaaa gcgacggcgt
     1321 ctggctggcc cgagtggcct ggcatcccca cggcccttac agcgctcagc cagtgatatc
     1381 aacctgaaag gtgatcagcc cgcagcttct ccagggccca ctctccgaag cctccctcat
     1441 caactcttgc tccagaggct tcaggaggag aaagaccgtg acagggatgg tgaactggag
     1501 aatgacatca gcggcccctc agcaggcagg ggtggccaca acaagatcag ccccagtggg
     1561 cccggcggat ccggccccgc gcccggcccc ggcccggcgt ctcccgcgcc ccccgcgccg
     1621 ccgccccggg gcccgaagcg gaaactttac agtgccgtcc ccggccgcaa gttcatcgct
     1681 gtgaaggcgc acagcccgca gggcgagggc gagatcccgc tgcaccgcgg cgaggccgtg
     1741 aaggtgctca gcattgggga gggcggtttc tgggagggaa ccgtgaaggg ccgaacaggc
     1801 tggttcccag ctgactgtgt ggaagaagtg cagatgcgac agtatgacac ccggcatgaa
     1861 accagagagg accggacgaa gcgtctcttc cgccactaca ctgtgggttc ctatgacagc
     1921 ctcacttcac acagcgatta tgtcatcgat gataaggtgg ctatcctgca gaaaagggac
     1981 catgaggggt ttggctttgt tctccgggga gccaaagcag agacccccat tgaggagttt
     2041 acacccacac ctgccttccc tgcactccaa taccttgagt ctgtagatgt ggaaggtgtg
     2101 gcctggaggg ctggacttcg aactggggac ttcctcattg aggtgaacgg agtgaatgtc
     2161 gtgaaggttg gacacaagca agtggtgggt ctcatccgtc agggtggcaa ccgcctggtc
     2221 atgaaggttg tgtctgtgac caggaaaccc gaggaggatg gtgctcggcg cagagcccca
     2281 ccacccccaa agagggctcc cagcaccacg ctgaccctgc ggtccaagtc catgacggct
     2341 gagctcgagg aacttgcttc cattcggaga agaaaagggg agaagttgga tgagatcctg
     2401 gcagttgccg cggagccgac actgaggccg gacattgcag atgctgactc gagggcggcc
     2461 actgtcaagc agcggcccac cagccggagg atcacccctg ctgagatcag ctcattgttt
     2521 gagcgccagg gcctcccagg cccagagaag ctgccgggct ctctgcggaa ggggattcca
     2581 cggaccaaat ctgtagggga ggatgagaag ctggcatccc tactggaagg gcgcttccca
     2641 cgcagcacgt caatgcagga cacagtgcgt gaaggtcgag gcattccacc cccgccgcag
     2701 accgccccgc cacccccacc cgcgccctac tacttcgact ccgggccacc ccccaccttc
     2761 tcaccgccgc caccaccggg ccgggcctat gacactgtgc gctccagctt caaaccaggc
     2821 ctggaggctc gtctgggtgc gggggccgcc ggcctgtatg atccgagcac gcctctgggc
     2881 ccgctgccct accctgagcg tcagaagcgt gcgcgctcca tgatcatact gcaggactct
     2941 gcgccagaag tgggtgatgt cccccggcct gcgcctgccg ccacaccgcc tgagcgcccc
     3001 aagcgccggc ctcggccgtc aggccctgat agtccctatg ccaacctggg cgccttcagt
     3061 gccagcctct tcgctccgtc gaaaccacag cgccgcaaga gcccgctggt gaagcagctt
     3121 caggtggagg acgctcagga gcgcgcggcc ctggccgtgg gtagcccggg accagtgggc
     3181 ggaagctttg cacgagaacc ctctccgacg caccgcgggc cccggccagg cagccttgac
     3241 tacagctctg gagaaggcct aggccttacc ttcggcggcc ctagccctgg cccagtcaag
     3301 gagcggcgcc tggaggagcg acgccgttcc actgtgttcc tctctgtggg tgccatcgag
     3361 ggcagccctc ccagcgcgga tctgccatcc ctacaaccct cccgctccat tgatgagcgc
     3421 ctcctgggga caggcgccac cactggccgc gatttgctac tcccctcccc tgtctctgct
     3481 ctgaagccat tggtcggtgg tcccagcctt gggccctcag gctccacctt catccaccct
     3541 ctcactggca aacccttgga tcctagctca cccttagctc ttgctctggc tgcccgggag
     3601 cgggctctgg cctcgcaaac accttcccgg tcccccacac ctgtgcacag ccccgatgct
     3661 gaccgccctg gacccctctt tgtggatgtg caaacccgag actctgagag aggaccgttg
     3721 gcttccccag ccttctcccc tcggagtcca gcgtggattc cagtgcctgc tcggagagag
     3781 gcagagaagc cccctcggga agagcggaag tcaccagagg acaagaagtc catgatcctc
     3841 agcgtcttgg acacgtcctt gcaacggcca gctggcctca ttgttgtgca tgccaccagc
     3901 aatgggcagg agcccagcag gctgggggct gaagaggagc gccccggtac tccggagctg
     3961 gccccagccc ccatgcaggc agcagctgtg gcagagccca tgccaagccc ccgggcccag
     4021 ccccctggca gcatcccagc agatcccggg ccaggtcaag gcagctcaga ggaggagcca
     4081 gagctggtat tcgctgtgaa cctgccacct gctcagctgt cctccagcga tgaggagacc
     4141 agagaggagc tggcccgcat agggctagtg ccaccccctg aagagtttgc caatgggatc
     4201 ctgctgacca ccccgccccc agggccgggc cccttgccca ccacggtacc cagcccggcc
     4261 tcagggaagc ccagcagcga gctgccccct gcccctgagt ctgcagctga ctctggagta
     4321 gaggaggctg acactcgaag ctccagtgac ccccacctgg agaccacaag caccatttcc
     4381 acagtgtcca gcatgtccac cctgagctcg gagagtgggg aactcacgga cacccacacc
     4441 tcctttgccg atggacacac ttttctactc gagaagccac cagtgcctcc caagcccaag
     4501 ctcaagtccc cgctggggaa ggggccggtg accttcaggg acccgctgct gaagcaatcc
     4561 tcggacagtg agctcatggc ccagcagcac catgctgcct ctactgggtt ggcttctgct
     4621 gctgggcccg cccgccctcg ctacctcttc cagagaaggt ccaagctgtg gggggacccc
     4681 gtggagagtc gggggctccc tgggcctgaa gatgacaaac caactgtgat cagtgagctc
     4741 agctcccgtc tgcagcagct gaataaagac acacgctcct tgggggagga accagttggt
     4801 ggcctgggca gcctgctgga ccctgctaag aagtcaccca ttgcagcagc tcggctcttc
     4861 agcagcctcg gtgagctgag caccatctca gcgcagcgca gcccgggggg cccgggcgga
     4921 ggggcctcct actcggtgcg gcccagcggc cggtaccccg tggcgagacg agccccgagc
     4981 ccagtgaaac ccgcatcgct ggagcgggtg gaggggctgg gggcgggcgt gggaggcgcg
     5041 gggcggccct tcggcctcac gcctcccacc atcctcaagt cgtccagcct ctccatcccg
     5101 cacgaaccca aggaagtgcg cttcgtggtg cgaagtgtga gtgcgcgcag ccgctccccc
     5161 tcaccatctc cgctgccctc gccttctccc ggctctggcc ccagtgccgg cccgcgtcgg
     5221 ccatttcaac agaagcccct gcagctctgg agcaagttcg atgtgggcga ctggctggag
     5281 agcatccact taggcgagca ccgagaccgc ttcgaggacc atgagatcga aggcgcacac
     5341 ctgcctgcgc tcaccaagga agacttcgtg gagctgggcg tcacacgcgt tggccaccgc
     5401 atgaacatcg agcgtgcgct caggcagctg gatggcagct gacgccccac tccctctcct
     5461 gttcctgctg cgccctgccg gcagggcccc cacccctact ccaggccgca ggctcggctc
     5521 gccccctacc acggcgcccg ggccaggaat gttgcatgaa tcgtcctgtt tgctgttgct
     5581 tggagacttg ccctgtacat tgcttagtgc cctcccctgc cgctgaaccc cacccagcac
     5641 acagtaaggg cgcggaccag gggggctggg tggaaggggg tgggggcagg gtgctctggc
     5701 ctgaccactt cctccatagc tcctggtggc cattcttcca gagggggaac ctagtccagc
     5761 atgcgaggtc aggacacgcc ttggtgactc ggggggaggg gggagacatt ggggttctcg
     5821 ataggggcca aggagccccc tgttttacat attttaatcc actctatatt tggaaagaga
     5881 aaaggaacaa atatctctgt ccgtaatagt tcccgccctc ttcccctcta gtcctctcgc
     5941 tggtcccgcc acagctgccc agtcttccat ctctggcccc tcactgccac cccatacagg
     6001 gcaggggaca ctccagctgg cctggggtta gccagggtcc tggcagccca ccctggggac
     6061 cccggctcag ccccccttcc ctcgctgagc tatagtatgc cccacccacc ctttaggtgc
     6121 tgctcagggg gacgggtggc aggcattgcc tgctgggcac tagcagggcc aggtggcctg
     6181 ggaaattatt gccctggggc tgggccccgg taacccaaac cccagccatc atcttcacag
     6241 ggtctctccc acaggagggg tctaaccttt cccacttctt gggcaactac agcagagaag
     6301 cctccctgcc tcgcacccca aagactcccc aattcctgcc ctgtgtgtgt gtgtgcgcca
     6361 cataatgtgt gtgcacgcct gtgtgcttgt gaaaactggg tgtggctgag cgcatgggtg
     6421 ccctgtgtgt gcttgactgt gcagtggtcc ccaggggctg ttctggatgg gtgggaggtg
     6481 gcggcagaag cttgcacagg gtgcatgcat gggtgtgtgc ccgggaaggg gccctgtcct
     6541 gctggtgggt cctgctgttc tctcagcctg tcccctcctc cccaaacctc acccagctta
     6601 agcagggatt cttcgtgaat cctttcagct tcgggaggcc tcaagggctc cccccgcagg
     6661 cagtacccct tcgggcttct aagggaattg tggggaccac taaaatcagg ccacaacagc
     6721 ccttggagag aggcaaagac tcctgagggt cccctggccc ccttactgtg actcctcaca
     6781 ctcagcaatg acctgtgggg tggggggccc tggggcattt ttaaacatcg ggtttggagt
     6841 ctggactaag ctccatccac gtcactcaca agtttctgtt tctatttcta gcttttttta
     6901 ataaaaaata aataaataaa taaatatata aataaatata tatatatata aaagacagaa
     6961 aacaggtgtt ttcatggccc aggggcttgg cacgccggtc tgtgcccacc tgccccaccc
     7021 tggcccatcg gccccattcc ttagacacag agtcacaccc actaaccctc tcaccaacag
     7081 agcaggtcac acacacagca gcagtcactg taacagactg ccacatacac agtctcacat
     7141 ttacctgtgg gtttttggtt ctgttcaatt tgggttttta actttacagg gtcagttccg
     7201 cttctccccc cccccctttt gtatggagtt ccatctgggg ggctttcaac cccctgctcc
     7261 agtcctgagg cctcctgacc ctgacgttgt gatacacccc acagagatct atgtttctta
     7321 tattattatt attaataata attattataa tattatgtaa taaatttata agaaatgaaa
//
