LOCUS       NM_194344               4549 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus SH3 domain and tetratricopeptide repeats 1 (Sh3tc1),
            transcript variant 1, mRNA.
ACCESSION   NM_194344 XM_993641
VERSION     NM_194344.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4549)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4549)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Kitamura,H., Nakagawa,T., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of FLJ
            genes: the complete nucleotide sequences of 110 mouse
            FLJ-homologous cDnas identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (2), 127-135 (2004)
   PUBMED   15449545
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY201660.1, AK159089.1, AK150064.1 and BY513538.1.
            
            On May 30, 2007 this sequence version replaced NM_194344.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Variants 1 and 2 both encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK159089.1, AK150064.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-225               BY201660.1         2-226
            226-718             AK159089.1         5-497
            719-3951            AK150064.1         497-3729
            3952-4546           AK159089.1         3731-4325
            4547-4549           BY513538.1         241-243
FEATURES             Location/Qualifiers
     source          1..4549
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 18.6 cM"
     gene            1..4549
                     /gene="Sh3tc1"
                     /gene_synonym="4631428G15"
                     /note="SH3 domain and tetratricopeptide repeats 1"
                     /db_xref="GeneID:231147"
                     /db_xref="MGI:MGI:2678949"
     exon            1..330
                     /gene="Sh3tc1"
                     /gene_synonym="4631428G15"
                     /inference="alignment:Splign:2.1.0"
     exon            331..561
                     /gene="Sh3tc1"
                     /gene_synonym="4631428G15"
                     /inference="alignment:Splign:2.1.0"
     CDS             378..4418
                     /gene="Sh3tc1"
                     /gene_synonym="4631428G15"
                     /codon_start=1
                     /product="SH3 domain and tetratricopeptide
                     repeat-containing protein 1"
                     /protein_id="NP_919325.2"
                     /db_xref="CCDS:CCDS19234.2"
                     /db_xref="GeneID:231147"
                     /db_xref="MGI:MGI:2678949"
                     /translation="MRSFREEEEEATSEELFTMGRGPEEPRGSCSPEDQIQSVSMGLP
                     TGQERTGSAEAEATVRGDVAPPRIVVGLAAEPPPSQMTVYPTDLTLQLLAVRRKSGLR
                     SPSLQQALRSRLRLLENDSREVARVLGELSARLLSIHSDQDRIVVTFKTFEEIWKFST
                     YHALGFTHHCLENLLVDQTFWLLSPSEEEETAILMYVNKDALKQTHKNLLTQEGSIFV
                     LCPDHRVRRTIGPKGAGKGPQTLRRASGVPLGVAILETDSSSPTPNMSSNVEAAEAEP
                     EPLTPFHQWTLRVPWDPIDESMSGPGTPDAQLMRFGLASAIADFQGSGPEEMSFSVGD
                     VIEILGAQVPGLPWCVGRHMASGQVGFVRTGLVSMQGPASDLESAIFLSEEERSFFRS
                     EGHFSDEDARRLLSRTSGTDVCTTCSLDWLEEAEGEQLEQREMSLPHLNPEPHGTLQM
                     VKNILEKCKACPDHPEAPVSWSLGGVSRRASSLDLEEPRFCLDPEDDWTDPEPLDSLL
                     QVLNAPGYGAHFRSLYDISLPWLSTALYGFDDEEELAERLAQARGVAKKVDLSMALAR
                     LCLLLGRLCARKLKLSQARVYFEEALGALEGSFGDLSLVAAVYSSLTTVYLKQKNAEK
                     CVQVAPKAAALLLGTPGHSCNADAELLKYALRRVICGLSPQAEARACFLLARHYTHLK
                     QPEEALPYLERLLRLNRDAGSPQASWPEDCYLLLADIYGRKCLPHLALSCLRVSSLWT
                     RCSLPGSLRSVDLVLQNVPGPNSQRRAGHSLPSQIAYYLRQALASLAPGTGQALRGPL
                     YASLAQLYSHHQQYSQAIAFMSQAAEADTAAGVHPVVDRLVALAWLHMLCGNSLVAMD
                     ILKCISDAAVANKDQECVMMNMVAMALKRMGRTRQAAEGYFRALHMAYAQGHLQSQAV
                     VLANFGALCLQAGARSLAQHYLREAVGLFSQVPSGVCGRDFTQVLLWLGQLCTRRALP
                     QQAKCYYEWAFLVAVETDHLESQLQAVQKLCLFYSKVMPNEVRCVIYHEFQLALARKT
                     ANKVLEGQLLEAISQLYLSLGTERAYKSALDYTKRSLGIFIDLQQKEKEARAWLQAGK
                     IYYILRQNELVDLYIQVAQNAALYTGDPKLGLELFEAAGDIFFNGTWEREKAVSFYRD
                     RALPLAVTVGDQEVELRLCNKLVALLSALEAPQEGLEFAHEALALSITLGDRLNERVA
                     YHRLATLHHRLGHGELAEHFFLKALSLCSSPLEFDEETLYYVKVYLVLGDIIFYDLKD
                     PFDAAGYYQLALAAAVDLGHKKAQLKIYTRLATIYHHFLVDREMSLFFYQKARTFASE
                     LNLRRTNLVPQRFCGRAPWLAPGHPS"
     exon            562..636
                     /gene="Sh3tc1"
                     /gene_synonym="4631428G15"
                     /inference="alignment:Splign:2.1.0"
     exon            637..764
                     /gene="Sh3tc1"
                     /gene_synonym="4631428G15"
                     /inference="alignment:Splign:2.1.0"
     exon            765..870
                     /gene="Sh3tc1"
                     /gene_synonym="4631428G15"
                     /inference="alignment:Splign:2.1.0"
     exon            871..1017
                     /gene="Sh3tc1"
                     /gene_synonym="4631428G15"
                     /inference="alignment:Splign:2.1.0"
     exon            1018..1228
                     /gene="Sh3tc1"
                     /gene_synonym="4631428G15"
                     /inference="alignment:Splign:2.1.0"
     exon            1229..1305
                     /gene="Sh3tc1"
                     /gene_synonym="4631428G15"
                     /inference="alignment:Splign:2.1.0"
     exon            1306..1501
                     /gene="Sh3tc1"
                     /gene_synonym="4631428G15"
                     /inference="alignment:Splign:2.1.0"
     exon            1502..1635
                     /gene="Sh3tc1"
                     /gene_synonym="4631428G15"
                     /inference="alignment:Splign:2.1.0"
     exon            1636..1677
                     /gene="Sh3tc1"
                     /gene_synonym="4631428G15"
                     /inference="alignment:Splign:2.1.0"
     exon            1678..3357
                     /gene="Sh3tc1"
                     /gene_synonym="4631428G15"
                     /inference="alignment:Splign:2.1.0"
     exon            3358..3538
                     /gene="Sh3tc1"
                     /gene_synonym="4631428G15"
                     /inference="alignment:Splign:2.1.0"
     exon            3539..3689
                     /gene="Sh3tc1"
                     /gene_synonym="4631428G15"
                     /inference="alignment:Splign:2.1.0"
     exon            3690..3812
                     /gene="Sh3tc1"
                     /gene_synonym="4631428G15"
                     /inference="alignment:Splign:2.1.0"
     exon            3813..3963
                     /gene="Sh3tc1"
                     /gene_synonym="4631428G15"
                     /inference="alignment:Splign:2.1.0"
     exon            3964..4160
                     /gene="Sh3tc1"
                     /gene_synonym="4631428G15"
                     /inference="alignment:Splign:2.1.0"
     exon            4161..4549
                     /gene="Sh3tc1"
                     /gene_synonym="4631428G15"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4530..4535
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sh3tc1"
                     /gene_synonym="4631428G15"
                     /note="hexamer: AGTAAA"
     polyA_site      4548
                     /gene="Sh3tc1"
                     /gene_synonym="4631428G15"
                     /note="major polyA site"
ORIGIN      
        1 accacagagc acggggctgg cagtgggcag gcagggacag ggcctggctc tggtccacaa
       61 ggagctaatg atcaactggc cactggagtc cttgccgcag cacctcagcc tgccttgggt
      121 ctccaggccc ctaggctcag ggaggaagtg gggcaggaag cagggggcgg tggcagtact
      181 gagcagtcag ccggctgtgg gcggactctg cctgtccagg ccagctggag acagcccgta
      241 ggccagtcag caaggagccg agccagtagt ggccacctgg cacctgcatt cctgagcctg
      301 ggaggaagct gtctgaagaa ctgatcacag aaggccagca acatgcccag ctcttggcct
      361 tgaggccact gtgcgtcatg aggagcttca gggaggagga ggaggaggcg acttctgagg
      421 agctgttcac catggggcgg ggccctgagg agcctcgggg aagctgtagc cctgaagacc
      481 agattcagag tgtatccatg ggcttgccca ctggccagga gagaacaggg tctgcggagg
      541 ctgaggcaac agtgagaggt gatgtggctc ctccccgcat cgtggtcggg ctggctgctg
      601 aaccccctcc cagtcaaatg acagtgtatc caacagacct gaccctgcaa ctgttggctg
      661 tgaggcggaa gagtggactg cggagcccca gcctgcagca ggccctgcgc agccggctcc
      721 gcctgctgga gaacgatagc cgggaagtgg cccgtgtgct tggagaactg tcagccaggc
      781 tgctgtctat ccacagtgac caggaccgga tcgtggtgac atttaagact tttgaagaaa
      841 tctggaagtt ttctacctat catgctcttg gcttcacaca ccactgcctg gagaacctgc
      901 tggtagacca gaccttctgg ctgctttccc ccagtgagga ggaggagact gccatcctca
      961 tgtatgtaaa caaggatgcc ttgaagcaga cacacaagaa cctcctcaca caggaagggt
     1021 ccatctttgt tctgtgtcct gaccaccgag taagaaggac gataggaccc aaaggtgcag
     1081 ggaagggtcc ccagaccctc agacgggctt cgggagtccc tctgggagtg gcaatcctgg
     1141 aaacagactc ctcatcaccc acacccaaca tgtcctccaa tgtggaagca gcagaggccg
     1201 aaccagagcc cttgactcca tttcaccagt ggactctcag ggtcccatgg gatcccatcg
     1261 atgaatccat gagtggacct gggacacctg atgcccagct catgaggttt ggcctggcct
     1321 ctgcgatagc tgacttccag ggctcaggcc ccgaagagat gtccttcagc gttggtgatg
     1381 tcatcgagat cctcggtgcc caggtgcctg gcctgccctg gtgtgtgggc cggcacatgg
     1441 cctctggcca ggtgggcttt gtgaggactg gcctcgtcag catgcagggc ccggcatctg
     1501 acctggaaag tgccattttc ctcagtgagg aagaaaggtc attcttcaga agtgagggcc
     1561 acttctcaga cgaagatgcc cggcggctcc tgagcaggac atctggcaca gatgtgtgca
     1621 ccacatgcag cctggactgg ttagaagaag ctgagggcga acagctggag caacgagaaa
     1681 tgtctctgcc tcacctgaac ccagaaccac atgggactct gcagatggta aagaacattt
     1741 tagaaaagtg caaggcctgc cctgaccacc ccgaagcccc ggtgtcctgg agccttggag
     1801 gggtgtccag aagagcgagt tcactggacc ttgaggagcc ccgcttctgc ctggatcctg
     1861 aggatgactg gacagacccc gagcctctgg actcactgct gcaggtcctg aatgcccctg
     1921 gttatggggc ccacttccgg agcctgtacg atatctcact tccctggctg agcaccgcac
     1981 tctatggctt tgatgatgaa gaagagctgg ctgaacgatt ggcacaggcc cgaggagttg
     2041 ccaagaaagt cgacttgagc atggccctgg caaggctctg cctcctgctg gggcgtctgt
     2101 gtgcccgaaa gctcaaacta tcccaggccc gggtgtactt tgaagaggca ctgggagctc
     2161 tggaggggag ttttggggac ctctccctgg tggcggcagt gtatagcagc ctgactactg
     2221 tgtacctaaa gcagaagaac gcagagaagt gtgtgcaggt ggcacccaaa gcagcggcac
     2281 tgctcctggg gacacccggc cactcctgca acgcagatgc ggagctgctg aagtatgcgc
     2341 tgcgcagggt catctgtggc ctcagcccac aggccgaggc ccgggcctgc ttcctgctgg
     2401 ccaggcacta cacccacctc aaacagcctg aggaggccct gccatacctg gagagactgc
     2461 ttcgcctcaa cagggatgca gggagcccac aggcctcatg gcctgaagac tgttacctgc
     2521 ttctggctga catttatggc cggaaatgcc tgccccatct ggcgttgagc tgcctcagag
     2581 tgtcctcact gtggacaagg tgctctctgc ctggctcctt gaggagtgtg gacctggtac
     2641 tccagaatgt tcctgggcca aacagccaaa ggagggcagg tcatagcctt ccctcccaga
     2701 ttgcttacta cctcagacag gcattggcct ctctggctcc tggcacagga caggcactgc
     2761 gtgggccgct ctatgccagc ctggctcaac tgtacagtca ccaccagcag tacagccagg
     2821 ccattgcctt catgtctcag gctgcagaag ctgacactgc agctggggtc caccctgtcg
     2881 tggaccgctt ggtggccctc gcctggttgc acatgctttg tgggaacagc ttagtagcca
     2941 tggacatcct gaagtgcatc tcagatgcag ccgtggccaa taaggaccag gagtgtgtta
     3001 tgatgaacat ggtggccatg gccctgaaga ggatgggcag gacccgacag gctgctgaag
     3061 gctacttccg agctctgcac atggcctatg cacagggcca cctgcagagc caggcagtgg
     3121 tcctggctaa ctttggggcc ctgtgtctgc aagctggtgc acgcagcttg gcccagcact
     3181 acctgcgcga ggctgtgggg ctcttctccc aggtgcccag tggcgtgtgt ggccgggact
     3241 tcacccaggt gctcctgtgg ttgggccaac tgtgcacacg ccgggccctc ccgcagcagg
     3301 ctaagtgcta ctacgagtgg gcctttctgg tggccgtgga gacagaccat ctggagagtc
     3361 agttacaggc tgtgcagaag ctgtgcctct tctacagcaa ggtgatgccc aatgaggtgc
     3421 gatgtgtcat ctaccacgag ttccaactgg cactggcacg caagaccgcc aacaaggtgc
     3481 tggagggaca gctgctggag gccatcagcc agctctacct gtcgctgggc actgagcggg
     3541 cctacaagtc ggctctggat tacactaaac ggagcctggg gattttcatc gacctgcagc
     3601 agaaggagaa ggaggcacgc gcctggctgc aggcagggaa gatctactat atcctgcgtc
     3661 agaatgagct ggtggactta tacatccagg tggcacagaa tgcagccctg tatactgggg
     3721 accccaagct gggcctggaa ctgtttgagg cagcagggga cattttcttc aatgggacct
     3781 gggagcggga gaaagctgtg tccttctacc gggaccgggc actgcccctg gctgtgactg
     3841 taggagacca ggaagtggaa ctgcgcctgt gcaacaagct ggtggccctt ctgtccgcgc
     3901 tggaggcacc ccaggagggc ctggagtttg cccatgaggc cttggcactc agcatcaccc
     3961 taggtgaccg cctgaatgag cgagtggcct accacaggct agccaccctg caccaccggc
     4021 tgggccacgg ggaactggct gagcacttct tcctcaaggc cctgtcactc tgcagctcgc
     4081 ccctggaatt cgatgaggag accctgtact atgtgaaggt ctacctggtg ctgggtgaca
     4141 tcatcttcta tgacctgaag gacccgtttg atgcagctgg gtattaccag ctggcactgg
     4201 cagcagccgt ggacctgggc cacaagaaag cccagctgaa gatctacacc cgcctggcta
     4261 ccatctacca ccacttcctc gtggaccgtg agatgtccct cttcttctac cagaaagcaa
     4321 ggacctttgc ctcagaactg aacctccgca ggaccaacct ggtgccccag cgcttctgtg
     4381 gccgggcacc ctggctggcc cctggccacc catcctgaca acctgagaag gggcatatac
     4441 aaggggactc ttcctcttct tggggtgtgg gcaacttatt attattatta ttttgctgag
     4501 ggttgggggg aactgaagga ccaaacagta gtaaatattt ttcagcaac
//
