LOCUS       NM_172788               5796 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus SH3 domain containing ring finger 3 (Sh3rf3), mRNA.
ACCESSION   NM_172788 XM_001472021 XM_001472224
VERSION     NM_172788.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5796)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5796)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5796)
  AUTHORS   Xu,C., Graf,L.F., Fazli,L., Coleman,I.M., Mauldin,D.E., Li,D.,
            Nelson,P.S., Gleave,M., Plymate,S.R., Cox,M.E., Torok-Storb,B.J.
            and Knudsen,B.S.
  TITLE     Regulation of global gene expression in the bone marrow
            microenvironment by androgen: androgen ablation increases
            insulin-like growth factor binding protein-5 expression
  JOURNAL   Prostate 67 (15), 1621-1629 (2007)
   PUBMED   17823924
  REMARK    GeneRIF: Androgen suppressive therapy increases IGFBP5 in the bone
            marrow microenvironment and thereby may facilitate the progression
            of prostate cancer.
REFERENCE   4  (bases 1 to 5796)
  AUTHORS   Amaar,Y.G., Tapia,B., Chen,S.T., Baylink,D.J. and Mohan,S.
  TITLE     Identification and characterization of novel IGFBP5 interacting
            protein: evidence IGFBP5-IP is a potential regulator of osteoblast
            cell proliferation
  JOURNAL   Am J Physiol Cell Physiol 290 (3), C900-C906 (2006)
   PUBMED   16269403
  REMARK    GeneRIF: Insulin-like growth factor binding protein 5 interacting
            protein (IGFBP5-IP) may act as intracellular mediator of growth
            promoting actions of IGFBP5 and perhaps other osteoregulatory
            agents in bone cells.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK133071.1, BC057304.1, BF470772.1 and CD741846.1.
            
            On or before Mar 12, 2008 this sequence version replaced
            XM_001472021.1, XM_001472224.1, NM_172788.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660811.2178.1, AK029202.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-768               AK133071.1         1-768
            769-4456            BC057304.1         25-3712
            4457-4711           BF470772.1         14-268
            4712-5779           BC057304.1         3967-5034
            5780-5796           CD741846.1         1-17                c
FEATURES             Location/Qualifiers
     source          1..5796
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 29.41 cM"
     gene            1..5796
                     /gene="Sh3rf3"
                     /gene_synonym="4831416G18Rik; Igfbp5-ip; Sh3md4; Sh3rf31"
                     /note="SH3 domain containing ring finger 3"
                     /db_xref="GeneID:237353"
                     /db_xref="MGI:MGI:2444637"
     exon            1..768
                     /gene="Sh3rf3"
                     /gene_synonym="4831416G18Rik; Igfbp5-ip; Sh3md4; Sh3rf31"
                     /inference="alignment:Splign:2.1.0"
     CDS             217..2853
                     /gene="Sh3rf3"
                     /gene_synonym="4831416G18Rik; Igfbp5-ip; Sh3md4; Sh3rf31"
                     /EC_number="2.3.2.27"
                     /note="insulin-like growth factor binding protein 5
                     interacting protein; SH3 domain-containing RING finger
                     protein 3; plenty of SH3s 2; SH3 multiple domains protein
                     4; SH3 multiple domains 4"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase SH3RF3"
                     /protein_id="NP_766376.2"
                     /db_xref="CCDS:CCDS35906.2"
                     /db_xref="GeneID:237353"
                     /db_xref="MGI:MGI:2444637"
                     /translation="MLLGASWLCASKAAATAARGEGEDRQGEQQRGAQARTEEDMDES
                     SLLDLLECSVCLERLDTTAKVLPCQHTFCRRCLESIVCSRHELRCPECRILVGCGVDE
                     LPANILLVRLLDGIRQRPRTGASPGSSPPARPGPGTFSALAGGAGGATGSPPCSPVFL
                     SAAAGSSTSSLCDVATNRSVPVAKTLSQLPYAKALYSYEGKEPGDLKFNKGDIIILRR
                     KVDENWYHGELQGMHGFLPASYIQCVRPLPQALPQGKALYDFEMKDRDQDKDCLTFTK
                     DEVLTVIRRVDDNWAEGMLGDKIGIFPLLYVELNDSAKQLIEMDKLCPAATTAYNYDA
                     LLSSDPSTVASVAPGPTLSSSGAVSAFQRRVDSKKNAKKRHSFTALSVTHKSSQAASH
                     RHSMEISAPVLISSSDPRAAARIGELAHLSCTVPTQDSSSAGPVPTALPRAAAVAGEQ
                     GMSPKVQLPLNVYLALYAYKPQKNDELELRKGEMYRVLEKCQDGWFKGASLKTGVSGV
                     FPGNYVTPVSRVPGGGAGLPWNNVLGGSPLAKGMATIMHPGGGSLSSPATAARSALPL
                     TTLQDHMQHPATSLPTGSCLRHSAQPTASQAGDTTIPTATHASAQALDRPTATVSPLR
                     TQTSPSRLPSTGLRPRSVASPQHGQQSPAQMCPRPAIPFTSAASAITPPNVSAANLSG
                     EVGGTPISGLSTPSLINTGFKPDDKKNEKKEKKSGLLKLLAGASTKKKSRSPPSVSPT
                     HDPQSAMDTSLQGAMGPEVSPLTVHGRAGSCPIESEMQGAIGLEPLHRKAGSLDLNFS
                     LSPSRQATLSMASIRPEPKPLPRERYRVVVSYPPQSEAEIELKEGDIVFVHKKHEDGW
                     FKGTLQRNGRTGLFPGSFVESF"
     exon            769..1044
                     /gene="Sh3rf3"
                     /gene_synonym="4831416G18Rik; Igfbp5-ip; Sh3md4; Sh3rf31"
                     /inference="alignment:Splign:2.1.0"
     exon            1045..1140
                     /gene="Sh3rf3"
                     /gene_synonym="4831416G18Rik; Igfbp5-ip; Sh3md4; Sh3rf31"
                     /inference="alignment:Splign:2.1.0"
     exon            1141..1500
                     /gene="Sh3rf3"
                     /gene_synonym="4831416G18Rik; Igfbp5-ip; Sh3md4; Sh3rf31"
                     /inference="alignment:Splign:2.1.0"
     exon            1501..1601
                     /gene="Sh3rf3"
                     /gene_synonym="4831416G18Rik; Igfbp5-ip; Sh3md4; Sh3rf31"
                     /inference="alignment:Splign:2.1.0"
     exon            1602..1772
                     /gene="Sh3rf3"
                     /gene_synonym="4831416G18Rik; Igfbp5-ip; Sh3md4; Sh3rf31"
                     /inference="alignment:Splign:2.1.0"
     exon            1773..2029
                     /gene="Sh3rf3"
                     /gene_synonym="4831416G18Rik; Igfbp5-ip; Sh3md4; Sh3rf31"
                     /inference="alignment:Splign:2.1.0"
     exon            2030..2349
                     /gene="Sh3rf3"
                     /gene_synonym="4831416G18Rik; Igfbp5-ip; Sh3md4; Sh3rf31"
                     /inference="alignment:Splign:2.1.0"
     exon            2350..2684
                     /gene="Sh3rf3"
                     /gene_synonym="4831416G18Rik; Igfbp5-ip; Sh3md4; Sh3rf31"
                     /inference="alignment:Splign:2.1.0"
     exon            2685..5781
                     /gene="Sh3rf3"
                     /gene_synonym="4831416G18Rik; Igfbp5-ip; Sh3md4; Sh3rf31"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5762..5767
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sh3rf3"
                     /gene_synonym="4831416G18Rik; Igfbp5-ip; Sh3md4; Sh3rf31"
                     /note="hexamer: AATAAA"
     polyA_site      5779
                     /gene="Sh3rf3"
                     /gene_synonym="4831416G18Rik; Igfbp5-ip; Sh3md4; Sh3rf31"
                     /note="major polyA site"
ORIGIN      
        1 gaactccggt gcctgcctcg cgggcaggct cggcgtgtca ctttgcaaat cgtggaggct
       61 agtgcctcgg gctgtcagca cgcgccgcgc ggggaccgaa ccctgtttat tgacggcgac
      121 tgcccgggct aggcgcaaat gcccgctctc ctcggcgggc cgggctctgg ctgctagact
      181 taggcggctc gctgggcccg cgctggcgcc tcccccatgc tgcttggggc gtcctggctg
      241 tgcgcgtcca aggcggcggc caccgcagct cggggcgagg gcgaggacag gcagggtgag
      301 cagcagaggg gggcccaggc gaggactgaa gaggatatgg acgaatcatc gctgctggat
      361 ttgctggaat gctctgtgtg cctggagcgc ctggacacta cggccaaggt gttgccatgc
      421 cagcacacct tctgccgacg ctgtctggag agcatcgtgt gctcgcgcca cgaactacgt
      481 tgtcccgagt gccgcatcct ggtgggctgc ggtgtggacg agctgcccgc caacatactg
      541 ctagtgcgcc tgctggatgg catccgccag aggccccgca cgggtgccag cccggggagc
      601 agccctcccg cgcgcccggg ccccggtacg ttctcagcgc tcgctggtgg cgctggaggg
      661 gcgacaggca gtcccccgtg ttctccggtc tttctctcag cggccgcagg cagctctacc
      721 tccagtttgt gcgacgtggc gactaatagg agtgtgccag tggctaagac tctatcccag
      781 cttccctatg ccaaggcgct ctacagctac gaggggaaag aacctggtga cctcaagttc
      841 aacaaagggg acatcatcat cctgagacgc aaggttgacg agaactggta ccacggcgag
      901 ctgcagggca tgcacggttt cctcccagcc agctacatcc agtgtgtgag gcccttgccg
      961 caggctctgc cccaaggcaa agcactttat gattttgaga tgaaggacag agaccaagac
     1021 aaagattgtc tgaccttcac taaggacgaa gttttaactg tgatccggag agtggatgat
     1081 aattgggctg aaggcatgct aggagacaag atcggcatct tccctctcct gtacgtggag
     1141 ctcaatgact ctgccaagca actcattgag atggacaagc tgtgccctgc tgccaccact
     1201 gcctacaact atgatgccct cttgtcctct gaccccagca cagtagccag tgtggcccct
     1261 ggtcccaccc taagtagctc aggggcagtc agtgcctttc aacgacgtgt ggacagcaag
     1321 aagaatgcca agaagcgcca ctccttcact gcgctcagcg tgacgcacaa atcctcacag
     1381 gctgccagtc acaggcactc catggaaatt agtgctccgg tgctgatcag ctccagcgac
     1441 ccgcgtgccg cagccaggat tggggagctt gcccatctgt cctgcactgt ccccacccag
     1501 gactcctctt ccgctggacc tgtccccaca gccctcccac gagctgctgc agtggctgga
     1561 gaacagggca tgtctcccaa agtccagctg cccctcaacg tgtacctggc tctctatgca
     1621 tacaagcccc agaagaatga tgagctggag ctacgcaagg gggagatgta ccgtgtgctc
     1681 gagaagtgcc aggacggctg gttcaaggga gcctcactaa aaacaggcgt ctcgggggta
     1741 ttccccggga actatgtgac gcccgtctcc agagttcctg gaggaggggc tgggttaccc
     1801 tggaataatg tccttggagg gtctccactg gccaagggca tggccaccat tatgcaccct
     1861 ggaggtggaa gtctgagcag cccagccact gccgccaggt ctgccctgcc tctcaccaca
     1921 ctacaggatc acatgcagca cccagccacc tcccttccaa ccggcagctg ccttcggcac
     1981 tcagcccaac caacagccag ccaggccggg gataccacca tcccaacagc tacccatgcc
     2041 tctgcccagg ccctggaccg gccaactgcc accgtgtcac ccctgcgcac tcagacttct
     2101 ccatcccgcc tgcccagcac cggcctgaga ccccgctctg tggcgtcccc acagcatggc
     2161 cagcagtccc cggcacagat gtgtccccgg ccagccatcc ccttcacatc agcggcctcc
     2221 gccatcacac cccccaatgt cagtgcagcc aatctgagcg gggaggtcgg agggacaccc
     2281 atcagcggcc tgtccacacc cagcctcatc aacacgggct tcaagccaga tgacaagaaa
     2341 aacgaaaaga aggagaaaaa gagcggcctg ctgaagctgc tggctggggc ctcgaccaag
     2401 aagaagtcac gctccccgcc atctgtatct ccaacccatg acccccagtc ggccatggat
     2461 acctcacttc agggtgccat gggccccgaa gtgtccccat tgaccgtcca tggcagggca
     2521 ggttcctgcc ccatagagag tgagatgcag ggtgccattg ggttggagcc actgcacagg
     2581 aaagcaggct ccttggatct gaatttctct ttgtccccgt ctcggcaagc aactctgtcc
     2641 atggcttcca ttcgccctga acctaagcca ctgcccagag agaggtaccg tgtggtggtc
     2701 tcctaccctc cacagagtga agcggagatc gagctaaagg aaggtgatat cgtcttcgtg
     2761 cacaagaagc atgaagacgg ctggttcaag gggacactgc agcggaatgg ccgcacaggt
     2821 ctcttcccag gcagctttgt ggagagcttc tgaggaccac tgctcatggc tagcttctgt
     2881 tgtcctggag agagcagagg atgcccgcct tatcaccaaa gtccgagcga ggttctttct
     2941 aaagcaccgg ccagaaacaa gccgatgatt cacgtgaagt ccttattgga agcacacatg
     3001 ggccatggcg tgtttgtgaa gataggccat atcctcatgt gacatcctac tggaagcaca
     3061 tgtgagtgtc ctgcaagacc acgccatgag tctgagtgag cagtagcaca gaaaatgtta
     3121 cccacatgga caaaggcgct gctctgtcac ccagcggcta aagcgttatt gtgtaaggtt
     3181 gggagcccgg gagggtatag agttgggcca tgtgctaggg ctgacagcaa gaagagcatc
     3241 ttccctgcct gccctgggta ccattcctct atatacctct gtcacctacc accaggcctc
     3301 accgccaggg cattcatggt tcaggagcct catagaaggg ctgtgagcct cccaaggtgt
     3361 ccagtggggt cctgtggggc actggagcag aaccctcttg tctttgtctc ctactgggat
     3421 aatgaggtgc accgtccagt tcctccgccg ctgtcttcac actgcttcct tcttacggca
     3481 caccttttta atgtacaact cttagacttt atatatttct aataggtcag acgctgcata
     3541 tttttcatac atctggtgct gattttttgt aaaaccaacc tgggtaagtg tcaagggggg
     3601 aaaaaaagaa gtaacatcaa aggaaagttt tctatatttc ccagatgaag tttggagcat
     3661 attgaggaat tcctatctgt aatatcacaa tgctggctgg tgctccatgc agcgagaggg
     3721 agggtctgtg gagagggtgc atggagtcgg agcgtcttcc caaacggctg gaaatagcta
     3781 acccacaagc tccatctaga tgagagtgat tgctatgact aaaaaactgg aaacaaatga
     3841 aggagtgggt tctgcctttg tgtgtggcag aaaatgcaca tagacagaca gacagacaca
     3901 tacacatata tacacacaca gacagacaga cacacacaca tatacacaga caacacacac
     3961 actcacacag acacacacac acacacagac acacacacat acatagacaa cacacacaca
     4021 ctcacacata cacacacaca gacacacaga cacacacaca gacacacact gaccccagaa
     4081 gcttcctttg attgctttaa agagaatgac taaaaatagc attctgaaag cacgtctttc
     4141 taccaaaatg cagcttttac aacagctcag atccactctc ttgcaaagga tttttttttc
     4201 cttttcaaaa ataaatagct tgccctctga ggccaggcaa aactcatctg ctagagacca
     4261 aaggtacagt gataacacaa gcctgatgct tgtctataga cttacagggc ctgcagacgc
     4321 tggaaaggaa tgagggctgg tctctgactc tgaggcctta cgtatattca ctgtcacaac
     4381 agcttgctgc ccaggaggct agcctgatgg ctatcaggag gtgtgagtgt cacactctaa
     4441 gaacactttt tttttttcaa aaatttctca aaaaaaatag caatttgtga gcctctgggt
     4501 acatttttat aaaatcatgc agccctgtat caagtctttg gtagcagagg ctatcactga
     4561 ttttcataat aaaataaaga gcacttatgc tcaacgtttc tgtctgggga tatgactaac
     4621 tagttgtgac tgccgggtgg ctaccacatg gatgtaatca cacccagacg gtctcaccct
     4681 cccccaggtg atagcaccct tattggacat agaaaactgt tgtgagccaa agagacgctc
     4741 tatctcagac atagggaccc ctgtatgcag gctcggtgac aaccacatga tatctactca
     4801 gtgtcactgc taaatgactt gcccatccat gcacaaaaga tctaggtatg gttccgtgct
     4861 gccaccatgg aggtaacaca gatctacatc ctgggtgagg catgttttca gtggaaccag
     4921 agctaactcc agatcccaga caatgaagca agtccctttc ccttctaaac aaggtcaact
     4981 ctgagtcaac agaacagact tcacttggaa ctgtcttcct ttcttgcact ggctgcctcg
     5041 tgatagagga agtagcagcc tcacagaaag cagaggaaag catcaaggta ccgtggaaaa
     5101 catcagctga atcctctcct agcaaagttt acactgcgac cagcatgggg agggaagcag
     5161 ggccctgggg ctcattctca ggtggggctt ttgagacaca caatgaaccc catggtctga
     5221 gtattctgaa cactcccaag cccttgagcc ttcaaaaatc atgttttcca cagccaatga
     5281 cagaaaagag gtacctttcc taaggtcatc ttcccttgag gacacacgtc tgtggcacca
     5341 aaatgaagcc agcacctcat ctagaacctt cacattccgt cctggccagc agcatgtgcc
     5401 ccttactcat acacttgtat ttggtggcca cgtgggtttc actccttagt tctcagccct
     5461 tcagatagac ggtcagcaag gagacaggac agtctagcct ccagaggact gatggatctc
     5521 gagagacaag atggtccata gtgaggcgta aatacaaggc ggagcacccc aaaatcagcc
     5581 cagtagatgt ggaagccctt gtactttgca caacacacac cgagacagac agacagaaag
     5641 acacgtgcac acgtgtgctc ccaaccccac atatgttttt attatacacc aatgtcagtg
     5701 tgtgatttta gatgaattga cagtagtggc catctctgat gcctgtgttt ctgagtcttt
     5761 aaataaagat gaacatggag aaaaaaaaaa aaaaaa
//
