LOCUS       NM_001146299            4784 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus SH3 domain containing ring finger 2 (Sh3rf2),
            transcript variant 1, mRNA.
ACCESSION   NM_001146299
VERSION     NM_001146299.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4784)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4784)
  AUTHORS   Yang,X., Sun,D., Xiang,H., Wang,S., Huang,Y., Li,L., Cheng,X.,
            Liu,H., Hu,F., Cheng,Y., Ma,T., Hu,M., Tian,H., Tian,S., Zhou,Y.,
            Zhang,P., Zhang,X.J., Ji,Y.X., Hu,Y., Li,H. and She,Z.G.
  TITLE     Hepatocyte SH3RF2 Deficiency Is a Key Aggravator for NAFLD
  JOURNAL   Hepatology 74 (3), 1319-1338 (2021)
   PUBMED   33894019
  REMARK    GeneRIF: Hepatocyte SH3RF2 Deficiency Is a Key Aggravator for
            NAFLD.
REFERENCE   3  (bases 1 to 4784)
  AUTHORS   Wang,S., Tan,N., Zhu,X., Yao,M., Wang,Y., Zhang,X. and Xu,Z.
  TITLE     Sh3rf2 Haploinsufficiency Leads to Unilateral Neuronal Development
            Deficits and Autistic-Like Behaviors in Mice
  JOURNAL   Cell Rep 25 (11), 2963-2971 (2018)
   PUBMED   30540932
  REMARK    GeneRIF: Sh3rf2 haploinsufficiency is a highly penetrant risk
            factor for Autism spectrum disorders.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK033601.1, AK029168.1 and AC122848.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK033601.1, BC145060.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2092              AK033601.1         45-2136
            2093-3415           AK029168.1         1998-3320
            3416-4784           AC122848.3         91078-92446
FEATURES             Location/Qualifiers
     source          1..4784
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 22.21 cM"
     gene            1..4784
                     /gene="Sh3rf2"
                     /gene_synonym="2310046K19; 9130023G24Rik; Ppp1r39; RNF158"
                     /note="SH3 domain containing ring finger 2"
                     /db_xref="GeneID:269016"
                     /db_xref="MGI:MGI:2444628"
     exon            1..486
                     /gene="Sh3rf2"
                     /gene_synonym="2310046K19; 9130023G24Rik; Ppp1r39; RNF158"
                     /inference="alignment:Splign:2.1.0"
     CDS             109..2316
                     /gene="Sh3rf2"
                     /gene_synonym="2310046K19; 9130023G24Rik; Ppp1r39; RNF158"
                     /EC_number="2.3.2.27"
                     /note="isoform 1 is encoded by transcript variant 1;
                     putative E3 ubiquitin-protein ligase SH3RF2; SH3
                     domain-containing RING finger protein 2; protein
                     phosphatase 1 regulatory subunit 39; RING finger protein
                     158; RING-type E3 ubiquitin transferase SH3RF2"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase SH3RF2 isoform 1"
                     /protein_id="NP_001139771.1"
                     /db_xref="CCDS:CCDS50265.1"
                     /db_xref="GeneID:269016"
                     /db_xref="MGI:MGI:2444628"
                     /translation="MDDLTLLDLLECPVCFEKLDVTAKVLPCQHTFCKPCLQRIFKAH
                     KELRCPECRTLVFCSIEALPANLLLVRLLDGVRSGQSSWKGGSFRRPRILTLQDNRKA
                     KSSPRSLQASPFRLVPSVRIHMDGVPRAKALCNYRGKNPGDLKFNKGDVILLRRQLDE
                     NWYQGEINGVSGIFPASSVEVIKQLPQPPPLCRALYNFDLRDKDKSENQDCLTFLKDD
                     VITVISRVDENWAEGKLGDKVGIFPILFVEPNVSARHLLENKGHQLSRTRHLSLMSSP
                     SRGKATNTSSLRKSPGSRRKGSGQFSMTTALNTLNRTVHSPEGHQMVEISTPMLISSN
                     SPSVLTQHGDKADFPTSSTGQVSSSQPAPASPGHSTAMVSVPSSQQHLSNNMFVALHT
                     YSAHRPEELDLQKGEGIRVLGKYQDGWLKGLSLLTGRTGIFPSDYVIPVFSSTARKTS
                     SFPDSRSPTVCTTWALSTSSVSSQGSFAEGDPRQSGPFKSVFVPTAVVNPSRSTPGPG
                     SSGQGSLRKVRSSMRKNGSLQRPVQSGIPTFMVGSLRCSPTMVIRPQRFQFYPPQGMT
                     PSPTPIMVEMGSKSIYTGEPALTCINRGSKTRIHSAGNSIIMEGKETPIKSEPPPKPP
                     ASAPPSILVKPENSKNGTEKQVKTVRFQNYSPPPTKHSASSPTSGKHDHPATLKGSQH
                     EAVSSGGEMTILFAHRSGCHSGQQTDLRRKSAFGKTMPLLSTASATQTLFPSK"
     exon            487..756
                     /gene="Sh3rf2"
                     /gene_synonym="2310046K19; 9130023G24Rik; Ppp1r39; RNF158"
                     /inference="alignment:Splign:2.1.0"
     exon            757..852
                     /gene="Sh3rf2"
                     /gene_synonym="2310046K19; 9130023G24Rik; Ppp1r39; RNF158"
                     /inference="alignment:Splign:2.1.0"
     exon            853..1173
                     /gene="Sh3rf2"
                     /gene_synonym="2310046K19; 9130023G24Rik; Ppp1r39; RNF158"
                     /inference="alignment:Splign:2.1.0"
     exon            1174..1265
                     /gene="Sh3rf2"
                     /gene_synonym="2310046K19; 9130023G24Rik; Ppp1r39; RNF158"
                     /inference="alignment:Splign:2.1.0"
     exon            1266..1436
                     /gene="Sh3rf2"
                     /gene_synonym="2310046K19; 9130023G24Rik; Ppp1r39; RNF158"
                     /inference="alignment:Splign:2.1.0"
     exon            1437..1681
                     /gene="Sh3rf2"
                     /gene_synonym="2310046K19; 9130023G24Rik; Ppp1r39; RNF158"
                     /inference="alignment:Splign:2.1.0"
     exon            1682..2040
                     /gene="Sh3rf2"
                     /gene_synonym="2310046K19; 9130023G24Rik; Ppp1r39; RNF158"
                     /inference="alignment:Splign:2.1.0"
     exon            2041..4784
                     /gene="Sh3rf2"
                     /gene_synonym="2310046K19; 9130023G24Rik; Ppp1r39; RNF158"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2364..2369
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sh3rf2"
                     /gene_synonym="2310046K19; 9130023G24Rik; Ppp1r39; RNF158"
                     /note="hexamer: AATACA"
     polyA_site      2385
                     /gene="Sh3rf2"
                     /gene_synonym="2310046K19; 9130023G24Rik; Ppp1r39; RNF158"
                     /note="major polyA site"
     regulatory      3925..3930
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sh3rf2"
                     /gene_synonym="2310046K19; 9130023G24Rik; Ppp1r39; RNF158"
                     /note="hexamer: AATAAA"
     regulatory      3930..3935
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sh3rf2"
                     /gene_synonym="2310046K19; 9130023G24Rik; Ppp1r39; RNF158"
                     /note="hexamer: AATGAA"
     polyA_site      3946
                     /gene="Sh3rf2"
                     /gene_synonym="2310046K19; 9130023G24Rik; Ppp1r39; RNF158"
     polyA_site      3960
                     /gene="Sh3rf2"
                     /gene_synonym="2310046K19; 9130023G24Rik; Ppp1r39; RNF158"
     regulatory      4519..4524
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sh3rf2"
                     /gene_synonym="2310046K19; 9130023G24Rik; Ppp1r39; RNF158"
                     /note="hexamer: AGTAAA"
     polyA_site      4541
                     /gene="Sh3rf2"
                     /gene_synonym="2310046K19; 9130023G24Rik; Ppp1r39; RNF158"
ORIGIN      
        1 aggcagggag ttctgatgct cccaaaagac cagctctacc ccctcggctc gctgccccta
       61 caatgtggat cctgcttctc caggttggga ctggagtttt aaaataaaat ggatgatttg
      121 acgttacttg atctcctgga gtgccctgtg tgctttgaaa agctcgatgt cacagccaaa
      181 gttctcccct gccagcacac cttctgcaaa ccatgtctac agaggatttt caaggcccac
      241 aaggagctga ggtgcccgga atgcaggact ctggtgttct gcagcatcga ggctctgcca
      301 gccaacctgt tgctcgtgcg tttgctggat ggtgtgcgtt ccggacagag ctcgtggaaa
      361 ggaggctcct tccgaaggcc tcggatactg accttgcagg acaacaggaa agccaagagc
      421 agccccagaa gtctacaggc tagccctttc cggctggtgc ccagtgtcag gatccacatg
      481 gatggggtgc ctcgagccaa ggccttgtgc aactacagag ggaagaatcc tggcgacctg
      541 aagtttaata aaggcgatgt catcctcctt cggagacagc ttgatgagaa ctggtaccag
      601 ggggagatta atggcgtcag cgggatcttc ccggccagct ctgtggaagt catcaaacag
      661 ctgccccaac cacccccact ctgcagagcc ctctacaact ttgaccttcg agacaaggat
      721 aagagtgaga accaggactg cctgaccttc ctcaaggatg atgtcatcac agtgatcagc
      781 cgtgtagatg agaactgggc agagggaaag ctcggagata aagtgggcat cttccccatc
      841 ttgtttgtag agccaaacgt ctcggcaaga cacctcctag agaacaaagg acatcagtta
      901 tcacgcacaa gacacctgtc cctgatgtcc tccccatcca gaggcaaagc gaccaacaca
      961 tcctcgctcc gaaagagccc agggtccagg aggaagggat ctgggcagtt ctccatgact
     1021 acagctttga acacactcaa ccgtacagtc cattctcctg aaggccacca gatggtggaa
     1081 atcagcaccc cgatgctcat cagctctaac agcccctctg tgctcaccca acatggggac
     1141 aaggcagact tccctaccag ctctacagga caggtcagca gttctcagcc tgcacctgcc
     1201 tccccgggac attccacagc catggtcagt gtgcccagct cccagcaaca cctttcaaat
     1261 aacatgtttg tagccctaca cacttactca gcccatagac ccgaagagct ggacctgcag
     1321 aagggagaag gcatcagggt tctgggcaag taccaggatg gctggctgaa gggcctctcc
     1381 ttactcactg gacgaactgg catctttcca agcgactatg tcatcccagt cttcagttca
     1441 acagctagaa agacatctag ttttcctgat tcccggagcc ccactgtctg caccacatgg
     1501 gcgttatcca cctcctctgt gtcctcccag ggtagctttg cagaaggtga tccccggcaa
     1561 agtggaccct tcaaatctgt ctttgtgccc actgccgtag ttaacccttc gaggagcaca
     1621 cctggcccag ggtcttctgg acaagggtct cttaggaaag tgcggagcag catgagaaaa
     1681 aatggatccc tgcagagacc agttcaatct gggatcccca ctttcatggt gggctccctc
     1741 aggtgcagtc ctaccatggt gatccggcct cagaggttcc agttttatcc gccacagggg
     1801 atgacccctt ccccgacacc gataatggtg gagatggggt ctaaatctat ttacactggg
     1861 gagcctgccc tgacctgcat caacagaggt agcaagacca ggatccactc agcaggcaat
     1921 tccatcatca tggaaggcaa agaaacgccc atcaagagtg aaccgccacc caagccgcct
     1981 gcatctgcgc caccctccat cctcgtgaaa ccagaaaatt caaagaatgg cactgaaaag
     2041 caagtcaaaa ccgtgagatt tcagaattac agccctccgc ccaccaaaca ctctgcctcc
     2101 agtcccacct ctggaaagca cgaccatcca gccaccttga aggggtccca gcatgaagca
     2161 gtctcctcgg gaggagagat gaccattcta tttgcccacc gaagtggctg ccactccggg
     2221 caacaaacag accttcggag aaagtcagcc tttggcaaga ccatgccctt attgtccact
     2281 gcttcagcca cacagacctt gtttcccagc aaatgattct tcgggtggct tttcttagac
     2341 acaaaagagg tgaattgcat ataaatacag cctgcctcca ctacagacat actactgttc
     2401 tttgaaggtt gagtctcctt aatgtccctt tttagtccac aggaatggga aggcaggaat
     2461 tccaggttgg ccttctcttt ctttttagcc ctgactgtcc tagaactcac tctgtagacg
     2521 aggctggtct tgaacttaga gatctgcctg cctttgcctc cctagtactg ggattaaaag
     2581 catgcagcac aaccaaccag catgtttcta aacttagtgg tttactacgg ccaaccccac
     2641 tgcttaagcc aaagaataag aaaagcatcc atacctgtgc ctccaggatt caggattttg
     2701 cctctcttcc tatgcgctca atatagaaca tctttgtagc ctaaaaaaca gccagtgtgt
     2761 ggcagtagtg aaattgctct cagggcctct ttgacctcat cgtcatcccc ctttcttctc
     2821 accacactag aacaatctct gccatctgct aaggccatat catcttcact ccacagagtc
     2881 acaacaacag ctgcaaaggg agagtttgag ggaaggatat gagatggtcc attttgaaca
     2941 ttctgagaac ccactgaaac ggaagagagt gactttctga gtttgctgac tccaaagcca
     3001 gagagcctga tgctgactac caaatgctca aagatgatca tgcattaagc ttcttggccc
     3061 gattcttccc atatatttct tcacagtaga taagcaggga gcacggagag acagataaag
     3121 gatgtgtatg gtattataga cttttcatcc ttcttctcaa aacaaagtgt gcttggaggg
     3181 cacttgacca ggcagcgggt ttagatctct attctgcctg taacccagta tattttgttc
     3241 tccttggttc ctagtcatgt ggggaaggga actagtttcc cttatgggac aatggagggg
     3301 agggcagagg agggtgcttc ttagagaact gttaccaaag aaagtggaca gagaagaaaa
     3361 gggagatagg aggaacagag gaggaatggt gcatgaaaca aatatggaca agaaggagct
     3421 gaaaggcggg aagagtagag ttctcaggaa agaatataaa caggtctggt tgaagcaatg
     3481 tttacactga cagaaggtgg gaaaaggacc agattctgcc gtggagaaag ggtcaaaact
     3541 agatgactcc atccagatgg gctggaagga gcaggtccag ccagggtgcc ttgtgaacag
     3601 ggtgagggag aggtgggagg cagctctgcg aaccagacag ctctgcaaac cagggccacg
     3661 atctaagaca gcccattagc tctcattaaa tgtaattgtt gtgacttaac attcatcaca
     3721 tgtccatcta tgtggacact ttaatgcata aatgccgttt gctactaagg ctgggtgcca
     3781 cttaaaaaaa aaaaaaaaga caggtctaat tagacgtttc ctacaggcag ttcttgcagg
     3841 tctctggatt gtgaacatac atctcttacc cacccacaca cttggcaaac ggaattatct
     3901 gtaggctttt ccagacatta atagaataaa atgaaaccat aatccagcca aggaatacga
     3961 tacatgtgtc agagtttttg aagtggtggc gtctacaagt agtatgttgt tcctgcgctt
     4021 gtgtgagata gtggttcatg tgtatgccat gaaatcagca tgcacatctc tgccttcttg
     4081 aagtcaggac agccattaag atggagaagt aagacactca caaggacagc aggacactat
     4141 gatttgtcca agtatgagta gctatgcctc acctttaccc cagaaaacca ttctcattaa
     4201 gaatagcagc ccactctata cccagtatgg cagacataca ccataatgag ccaactaaat
     4261 gtttagccca ttcttccacg gcaggaggtc cagttatttt ttttttaatg tttgtggcta
     4321 tcaaacaggt tgtttagagg acaacagagg ggcatgccta tgaaatgata acctcccaaa
     4381 gaaataagca tagttccaag gatggccacc tccatagcac caaaccttcc atccattccc
     4441 agaactgaat gcttcccaga gcatcctgta tcttgtagag ctttgtgagt gcttgaacgg
     4501 gatgagctgc tatttctaag taaaagttga tttcacaagc accttctgtt cctttattct
     4561 accaacatgt gtccggcgtt tacctccgtg ctagccagac acagcaatga gaacagcaca
     4621 ctcatcctct gatgcacttc ctgcaaaact gtgtagggca actatgactg ttcccattag
     4681 agagccaagg aaacggaagc ttaaaactgg ccacaaactg gctgaggcaa gcgtgggaac
     4741 ccaagctacc tggtgacgta gcccagctgg agactgtagt gtac
//
