LOCUS       NM_021506               5084 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus SH3 domain containing ring finger 1 (Sh3rf1), mRNA.
ACCESSION   NM_021506
VERSION     NM_021506.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5084)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5084)
  AUTHORS   Yao,M., Meng,M., Yang,X., Wang,S., Zhang,H., Zhang,F., Shi,L.,
            Zhang,Y., Zhang,X. and Xu,Z.
  TITLE     POSH regulates assembly of the NMDAR/PSD-95/Shank complex and
            synaptic function
  JOURNAL   Cell Rep 39 (1), 110642 (2022)
   PUBMED   35385725
  REMARK    GeneRIF: POSH regulates assembly of the NMDAR/PSD-95/Shank complex
            and synaptic function.
REFERENCE   3  (bases 1 to 5084)
  AUTHORS   Goodwani,S., Fernandez,C., Acton,P.J., Buggia-Prevot,V.,
            McReynolds,M.L., Ma,J., Hu,C.H., Hamby,M.E., Jiang,Y., Le,K.,
            Soth,M.J., Jones,P. and Ray,W.J.
  TITLE     Dual Leucine Zipper Kinase Is Constitutively Active in the Adult
            Mouse Brain and Has Both Stress-Induced and Homeostatic Functions
  JOURNAL   Int J Mol Sci 21 (14), 4849 (2020)
   PUBMED   32659913
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5084)
  AUTHORS   West,R.J.H., Ugbode,C., Gao,F.B. and Sweeney,S.T.
  TITLE     The pro-apoptotic JNK scaffold POSH/SH3RF1 mediates
            CHMP2BIntron5-associated toxicity in animal models of
            frontotemporal dementia
  JOURNAL   Hum Mol Genet 27 (8), 1382-1395 (2018)
   PUBMED   29432529
  REMARK    GeneRIF: The pro-apoptotic JNK scaffold protein POSH mediates
            CHMP2BIntron5-associated toxicity in animal models of
            frontotemporal dementia.
REFERENCE   5  (bases 1 to 5084)
  AUTHORS   Cunningham,C.A., Cardwell,L.N., Guan,Y., Teixeiro,E. and
            Daniels,M.A.
  TITLE     POSH Regulates CD4+ T Cell Differentiation and Survival
  JOURNAL   J Immunol 196 (10), 4003-4013 (2016)
   PUBMED   27084103
  REMARK    GeneRIF: this study shows that POSH is essential for the
            integration of cell-type-specific signals that regulate the
            differentiation, survival, and function of T cells
REFERENCE   6  (bases 1 to 5084)
  AUTHORS   Xu,Z., Sproul,A., Wang,W., Kukekov,N. and Greene,L.A.
  TITLE     Siah1 interacts with the scaffold protein POSH to promote JNK
            activation and apoptosis
  JOURNAL   J Biol Chem 281 (1), 303-312 (2006)
   PUBMED   16230351
  REMARK    GeneRIF: Siah1 is a binding partner for POSH (plenty of SH3s), a
            scaffold component of the apoptotic JNK pathway
REFERENCE   7  (bases 1 to 5084)
  AUTHORS   Okazaki,N., F-Kikuno,R., Ohara,R., Inamoto,S., Koseki,H.,
            Hiraoka,S., Saga,Y., Seino,S., Nishimura,M., Kaisho,T., Hoshino,K.,
            Kitamura,H., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: IV. The complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (3), 205-218 (2004)
   PUBMED   15368895
REFERENCE   8  (bases 1 to 5084)
  AUTHORS   Figueroa,C., Tarras,S., Taylor,J. and Vojtek,A.B.
  TITLE     Akt2 negatively regulates assembly of the POSH-MLK-JNK signaling
            complex
  JOURNAL   J Biol Chem 278 (48), 47922-47927 (2003)
   PUBMED   14504284
REFERENCE   9  (bases 1 to 5084)
  AUTHORS   Figueroa,C. and Vojtek,A.B.
  TITLE     Akt negatively regulates translation of the ternary complex factor
            Elk-1
  JOURNAL   Oncogene 22 (36), 5554-5561 (2003)
   PUBMED   12944902
REFERENCE   10 (bases 1 to 5084)
  AUTHORS   Tapon,N., Nagata,K., Lamarche,N. and Hall,A.
  TITLE     A new rac target POSH is an SH3-containing scaffold protein
            involved in the JNK and NF-kappaB signalling pathways
  JOURNAL   EMBO J 17 (5), 1395-1404 (1998)
   PUBMED   9482736
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC134339.6 and AC117196.3.
            
            On Sep 1, 2022 this sequence version replaced NM_021506.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK173185.1, SRR17784645.570505.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-79                AC134339.6         64218-64296         c
            80-566              AC134339.6         62246-62732         c
            567-842             AC117196.3         40662-40937
            843-938             AC117196.3         41366-41461
            939-1241            AC117196.3         60843-61145
            1242-1352           AC117196.3         65181-65291
            1353-1537           AC117196.3         73031-73215
            1538-1708           AC117196.3         74518-74688
            1709-1968           AC117196.3         83951-84210
            1969-2327           AC117196.3         85452-85810
            2328-2680           AC117196.3         96020-96372
            2681-5084           AC117196.3         105112-107515
FEATURES             Location/Qualifiers
     source          1..5084
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 30.94 cM"
     gene            1..5084
                     /gene="Sh3rf1"
                     /gene_synonym="2200003J05Rik; Posh; Sh3md2"
                     /note="SH3 domain containing ring finger 1"
                     /db_xref="GeneID:59009"
                     /db_xref="MGI:MGI:1913066"
     exon            1..79
                     /gene="Sh3rf1"
                     /gene_synonym="2200003J05Rik; Posh; Sh3md2"
                     /inference="alignment:Splign:2.1.0"
     exon            80..566
                     /gene="Sh3rf1"
                     /gene_synonym="2200003J05Rik; Posh; Sh3md2"
                     /inference="alignment:Splign:2.1.0"
     CDS             174..2849
                     /gene="Sh3rf1"
                     /gene_synonym="2200003J05Rik; Posh; Sh3md2"
                     /EC_number="2.3.2.27"
                     /note="SH3 multiple domains 2; plenty of SH3 domains;
                     putative E3 ubiquitin-protein ligase SH3RF1; plenty of
                     SH3s; SH3 multiple domains protein 2; SH3
                     domain-containing RING finger protein 1; RING-type E3
                     ubiquitin transferase SH3RF1"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase SH3RF1"
                     /protein_id="NP_067481.2"
                     /db_xref="CCDS:CCDS40348.1"
                     /db_xref="GeneID:59009"
                     /db_xref="MGI:MGI:1913066"
                     /translation="MDESALLDLLECPVCLERLDASAKVLPCQHTFCKRCLLGIVGSR
                     NELRCPECRTLVGSGVDELPSNILLVRLLDGIKQRPWKPGPGGGGGTTCTNTLRAQGS
                     TVVNCGSKDLQSSQCGQQPRVQAWSPPVRGIPQLPCAKALYNYEGKEPGDLKFSKGDI
                     IILRRQVDENWYHGEVSGVHGFFPTNFVQIIKPLPQPPPQCKALYDFEVKDKEADKDC
                     LPFAKDDVLTVIRRVDENWAEGMLADKIGIFPISYVEFNSAAKQLIEWDKPPVPGVDT
                     AECPSATAQSTSASKHPDTKKNTRKRHSFTSLTMANKSSQGSQNRHSMEISPPVLISS
                     SNPTAAARISELSGLSCSAPSQVHISTTGLIVTPPPSSPVTTGPAFTFPSDVPYQAAL
                     GSMNPPLPPPPLLAATVLASTPSGATAAVAAAAAAAAAGMGPRPVMGSSEQIAHLRPQ
                     TRPSVYVAIYPYTPRKEDELELRKGEMFLVFERCQDGWYKGTSMHTSKIGVFPGNYVA
                     PVTRAVTNASQAKVSMSTAGQASRGVTMVSPSTAGGPTQKPQGNGVAGNPSVVPTAVV
                     SAAHIQTSPQAKVLLHMSGQMTVNQARNAVRTVAAHSQERPTAAVTPIQVQNAACLGP
                     ASVGLPHHSLASQPLPPMAGPAAHGAAVSISRTNAPMACAAGASLASPNMTSAVLETE
                     PSGRTVTILPGLPTSPESAASACGNSSAGKPDKDSKKEKKGLLKLLSGASTKRKPRVS
                     PPASPTLDVELGAGEAPLQGAVGPELPLGGSHGRVGSCPTDGDGPVAAGTAALAQDAF
                     HRKTSSLDSAVPIAPPPRQACSSLGPVMNEARPVVCERHRVVVSYPPQSEAELELKEG
                     DIVFVHKKREDGWFKGTLQRNGKTGLFPGSFVENI"
     exon            567..842
                     /gene="Sh3rf1"
                     /gene_synonym="2200003J05Rik; Posh; Sh3md2"
                     /inference="alignment:Splign:2.1.0"
     exon            843..938
                     /gene="Sh3rf1"
                     /gene_synonym="2200003J05Rik; Posh; Sh3md2"
                     /inference="alignment:Splign:2.1.0"
     exon            939..1241
                     /gene="Sh3rf1"
                     /gene_synonym="2200003J05Rik; Posh; Sh3md2"
                     /inference="alignment:Splign:2.1.0"
     exon            1242..1352
                     /gene="Sh3rf1"
                     /gene_synonym="2200003J05Rik; Posh; Sh3md2"
                     /inference="alignment:Splign:2.1.0"
     exon            1353..1537
                     /gene="Sh3rf1"
                     /gene_synonym="2200003J05Rik; Posh; Sh3md2"
                     /inference="alignment:Splign:2.1.0"
     exon            1538..1708
                     /gene="Sh3rf1"
                     /gene_synonym="2200003J05Rik; Posh; Sh3md2"
                     /inference="alignment:Splign:2.1.0"
     exon            1709..1968
                     /gene="Sh3rf1"
                     /gene_synonym="2200003J05Rik; Posh; Sh3md2"
                     /inference="alignment:Splign:2.1.0"
     exon            1969..2327
                     /gene="Sh3rf1"
                     /gene_synonym="2200003J05Rik; Posh; Sh3md2"
                     /inference="alignment:Splign:2.1.0"
     exon            2328..2680
                     /gene="Sh3rf1"
                     /gene_synonym="2200003J05Rik; Posh; Sh3md2"
                     /inference="alignment:Splign:2.1.0"
     exon            2681..5084
                     /gene="Sh3rf1"
                     /gene_synonym="2200003J05Rik; Posh; Sh3md2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5061..5066
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sh3rf1"
                     /gene_synonym="2200003J05Rik; Posh; Sh3md2"
                     /note="hexamer: ATTAAA"
     polyA_site      5084
                     /gene="Sh3rf1"
                     /gene_synonym="2200003J05Rik; Posh; Sh3md2"
                     /note="major polyA site"
ORIGIN      
        1 acacgggcag cgggctcggc ggggctgcat ctaccagcgc tgcggggccg cgaacaaagg
       61 cgagcagcgg aggcgcgaga gcaaagtctg aaatggatgt tacatgaatc actttaaggg
      121 ctgcgcacaa ctatgaacgt tctgaagccg ttttctcact aaagtcactc aagatggatg
      181 agtctgcctt gttggacctt ctggagtgcc ctgtgtgtct agaacgcctg gatgcttccg
      241 caaaggtctt accctgccag catacctttt gcaaacgctg tttgctgggg attgtgggtt
      301 cccggaatga actcagatgt cccgaatgcc ggactcttgt tggctctggg gtcgacgagc
      361 tccccagtaa catcctactg gtcagacttc tggatggcat caagcagagg ccttggaaac
      421 ccggccctgg tgggggcggc gggaccacct gcacaaacac attaagggcg cagggcagca
      481 ctgtggttaa ttgtggctcg aaagatctgc agagctccca gtgtggacag cagcctcggg
      541 tgcaagcctg gagcccccca gtgaggggaa tacctcagtt accgtgtgcc aaagcattat
      601 ataactacga aggaaaagag cccggagacc ttaagttcag caaaggcgac atcatcattc
      661 tgcgccgaca ggtggatgag aattggtacc acggggaagt cagcggggtc cacggctttt
      721 tccccaccaa cttcgtgcag atcatcaaac ctttacctca gcccccgcct cagtgcaaag
      781 cactttacga ctttgaagtg aaagacaagg aagctgacaa agattgcctt cccttcgcaa
      841 aggacgacgt actgaccgtg atccgcagag tggatgaaaa ctgggctgaa ggaatgctgg
      901 cagataaaat aggaatattt ccaatttcat acgtggagtt taactcagct gccaagcagc
      961 tgatagagtg ggataagcct cccgtgccag gagtggacac ggcagaatgc ccctcagcga
     1021 cggcgcagag cacctctgcc tcaaagcacc ccgacaccaa gaagaacacc aggaagcgac
     1081 actccttcac ctccctcacc atggccaaca agtcttccca ggggtcccag aaccgccact
     1141 ccatggagat cagccctcct gtgctcatca gttccagcaa ccccacagcc gcagcccgca
     1201 tcagcgaact gtccgggctc tcctgcagcg ccccgtctca ggtccatata agcaccactg
     1261 ggttaattgt gaccccaccc cctagcagcc cggtgacaac tggccctgcg ttcacgttcc
     1321 cttcagatgt cccctaccaa gctgcccttg gaagtatgaa tcctccactt cccccacccc
     1381 ctctcctggc ggccaccgta ctcgcctcca ccccgtcagg cgctactgct gctgttgctg
     1441 ctgctgctgc cgccgccgct gctggaatgg gacccaggcc tgtgatgggg tcctctgaac
     1501 agattgcaca tttacggcct cagactcgtc ccagtgtata tgttgctata tatccgtaca
     1561 ctccccggaa ggaagacgaa ctggagctga ggaaagggga gatgtttttg gtgtttgagc
     1621 gttgccagga cggctggtac aaagggacat cgatgcatac cagcaagata ggcgttttcc
     1681 ctggcaacta tgtggcgccc gtcacaaggg cggtgacgaa tgcctcccaa gctaaagtct
     1741 ctatgtctac tgcgggtcaa gcaagtcgcg gggtgaccat ggtcagccct tccactgcag
     1801 gaggacctac acagaagccc caaggaaacg gcgtggccgg aaatcccagc gtcgtcccca
     1861 cggctgtggt gtcagcagct catatccaga caagtcctca ggctaaggtc ctgctgcaca
     1921 tgtctgggca gatgacagtc aatcaggccc gcaatgctgt gaggacagtt gcagcacata
     1981 gccaggaacg ccccacggca gcagtgactc ccatccaggt ccagaatgcc gcctgcctcg
     2041 gtcctgcatc cgtgggcctg ccccatcatt ctctggcctc ccaacctctg cctccaatgg
     2101 cgggtcctgc tgcccacggt gctgccgtca gcatcagtcg aaccaatgcc cccatggcct
     2161 gcgctgcagg ggcttctctg gcctccccaa atatgaccag tgccgtgttg gagacagagc
     2221 ccagtggtcg cacagtgacc atcctccctg gactccccac atctccagag agtgctgcat
     2281 cagcgtgtgg gaacagttca gctgggaaac cagacaagga cagtaagaaa gaaaaaaagg
     2341 gcctactgaa gctgctttct ggtgcctcca ccaaacgcaa gccccgagtc tcccctccag
     2401 catcacctac cctggatgtg gagctgggtg ctggggaggc tcccttgcag ggagcagtag
     2461 gtcctgagct gccgctaggg ggcagccacg gcagagtggg gtcatgcccc acagatggtg
     2521 atggtccagt ggccgctgga acagcagccc tagcccagga tgccttccac cgcaagacaa
     2581 gctccctgga ctccgcagtg cccattgctc caccacctcg ccaggcctgc tcctccctgg
     2641 gcccagtcat gaatgaggcc cggcctgttg tttgtgaaag gcacagggtg gtggtttcct
     2701 accctcctca gagtgaggcc gaacttgaac tcaaggaagg agatattgtg tttgttcata
     2761 agaaacgaga ggacggctgg ttcaaaggca cgttacagag gaatgggaag actggccttt
     2821 tcccagggag ctttgtggaa aacatctgag aagacgggac acggagaaag cttatcatca
     2881 caccacgtgt gactaaagag cacaaagcag tttcatagaa agagcacatc tgtggacttc
     2941 cagatcttca agaaccgagc agaagatggg cacctgactc cagagccccg gcctggttac
     3001 cccaggggca gagggaagga ggacacacct gtgtgggttc cgtctctctg ggttctgatg
     3061 tgtaaagtgt gccttgtaat gtctaatgga ctttacagat aaatgtcttt ttttttttaa
     3121 gatgtataac taaaatggac aattgtttac aaggcttaac taatttattt gcttttttaa
     3181 aacttgaact ttcttgtaat agcaaattct ttgggttatg gtttttagaa aatattaatt
     3241 tatgaaatga tggttaagga gaagctgggt tctctcctgt ctgttgagag caagagattc
     3301 tttttgacat agactgcatc tccccctccc ctgcttgctg ccctcctccc tgccgttata
     3361 tttggctccg tttagacaaa aatgccagtt ttccaaacag acagctgaat cagtaccggg
     3421 aaggacctgg ggaggggagc cggcagactc caggtagagg agttagtagg tccccatctg
     3481 tctgctttga tcagaaatca acctgaagac ctaatcctgg atttcttttt tgtgggtttt
     3541 tcattttcct gaaacgaagt gggtaaagaa agacgcaaac taaagcacaa ccattgactg
     3601 gaaatacgcg tttgtctgct agcacaagca gcagcgccgt gggaagtgag agaaagtggt
     3661 agtctctgtg tgtgagtggc tttgaaccgt agttcccatt ctatccccaa gtgatccgca
     3721 tgccccaaga cacagtaaaa gtttgtgaga cagtggtggt aagagatgca ctcgtgttaa
     3781 agtcaaaagg ctgtaagaaa acactgtgaa cgtttccact catccatcgt gatttctccg
     3841 ccatcttgca tgtgataccg gattcccaca gtggtgtgga ctgtgcatgg tgtgtgtatt
     3901 tcatagcaat tttcactcag aactgaccga taacaggagg tttaacatac acagcgatct
     3961 cttccctgcc cctgcccctg cccccaccac caccaccact actgaccgag atgtcttaag
     4021 tatgtttgct ccctctcggg tgaaggcaca cgttagccag cacaccagta gttaaaatgc
     4081 ttatccacat gtgtcctccc agcggacgga tgtgaagggc gagctctggg agaccactcg
     4141 ctcctgggac tgttcggcaa ggcttgctgg gagtggctgt gcccacacct tacaattgtg
     4201 gtagggtctg gctgagccca tctttttata tccatccttt gatgctctct tccaattcca
     4261 ccccagctgt gggtctggct agtcctgaga gcagatagag ggaagacagc ctggtagtga
     4321 atgaccttgt tctacggttc tcttctgggt aagagagtaa ggaagtctta caaccaactt
     4381 ttccttttgt tttttttttt ttttgttttt ttttaacttt aagataaaag tagctgggaa
     4441 atattgacat gaactgaaga gtcacagaat ggcaagagat cccattgtct taaagagata
     4501 cgtaatgtgg ctagaagtgg aatcattcct gttaattgat ttttttttat atatatataa
     4561 aaacactgta tattatgttc ctttgtgttg aatttttttt ttaaagaaat actttacttg
     4621 gatattcatg taatatataa aggtttggtg aaatgaactt tagttagaaa aaagctgaca
     4681 tcagctttca tctgtgtgag tcgacaccaa tgtgtcataa tattctttat tttgggatat
     4741 tagtgtattt tatagaaatt ttaaaaaagc aaaaagacta ctacaagtta agatgatttc
     4801 tttttttacc tgtcttttct ccatattttc agctatgtga ttgaagtatc cgtggtaata
     4861 gcttcctggt ataacgctgg ttaaactctc atctgttggt agatcactag gtgatataat
     4921 gtgtgggttt tgtattgggc tttttggaga cagtagatgg atgttgtaac aagggcttgt
     4981 cacaccgtgg tggggatgag aagtcgacaa tttctcatgc cttttatggt aattttgagg
     5041 actggatgaa aggtttcatt attaaaaatt gatgttcaac cctt
//
