LOCUS       NM_177364               7409 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Mus musculus SH3 and PX domains 2B (Sh3pxd2b), mRNA.
ACCESSION   NM_177364
VERSION     NM_177364.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7409)
  AUTHORS   Mehes,E., Barath,M., Gulyas,M., Bugyik,E., Geiszt,M., Szoor,A.,
            Lanyi,A. and Czirok,A.
  TITLE     Enhanced endothelial motility and multicellular sprouting is
            mediated by the scaffold protein TKS4
  JOURNAL   Sci Rep 9 (1), 14363 (2019)
   PUBMED   31591456
  REMARK    GeneRIF: Enhanced endothelial motility and multicellular sprouting
            is mediated by the scaffold protein TKS4.
            Erratum:[Sci Rep. 2020 Jul 20;10(1):12293. doi:
            10.1038/s41598-020-68536-8.. PMID: 32686692]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7409)
  AUTHORS   Vas,V., Hahner,T., Kudlik,G., Ernszt,D., Kvell,K., Kuti,D.,
            Kovacs,K.J., Tovari,J., Trexler,M., Mero,B.L., Szeder,B.,
            Koprivanacz,K. and Buday,L.
  TITLE     Analysis of Tks4 Knockout Mice Suggests a Role for Tks4 in Adipose
            Tissue Homeostasis in the Context of Beigeing
  JOURNAL   Cells 8 (8), 831 (2019)
   PUBMED   31387265
  REMARK    GeneRIF: Beigeing process was more robust in the WAT of Tks4-KO
            mice compared to the wild-type animals.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7409)
  AUTHORS   Daniel,S., Meyer,K.J., Clark,A.F., Anderson,M.G. and McDowell,C.M.
  TITLE     Effect of ocular hypertension on the pattern of retinal ganglion
            cell subtype loss in a mouse model of early-onset glaucoma
  JOURNAL   Exp Eye Res 185, 107703 (2019)
   PUBMED   31211954
REFERENCE   4  (bases 1 to 7409)
  AUTHORS   Vas,V., Kovacs,T., Kormendi,S., Brody,A., Kudlik,G., Szeder,B.,
            Mezo,D., Kallai,D., Koprivanacz,K., Mero,B.L., Dulk,M., Tovari,J.,
            Vajdovich,P., Senel,S.N., Ozcan,I., Helyes,Z., Dobo-Nagy,C. and
            Buday,L.
  TITLE     Significance of the Tks4 scaffold protein in bone tissue
            homeostasis
  JOURNAL   Sci Rep 9 (1), 5781 (2019)
   PUBMED   30962481
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7409)
  AUTHORS   Iizuka,S., Abdullah,C., Buschman,M.D., Diaz,B. and Courtneidge,S.A.
  TITLE     The role of Tks adaptor proteins in invadopodia formation, growth
            and metastasis of melanoma
  JOURNAL   Oncotarget 7 (48), 78473-78486 (2016)
   PUBMED   27802184
  REMARK    GeneRIF: Suggest the importance of Tks adaptor proteins in melanoma
            growth and metastasis in vivo is likely via functional invadopodia
            formation.
REFERENCE   6  (bases 1 to 7409)
  AUTHORS   Iqbal,Z., Cejudo-Martin,P., de Brouwer,A., van der Zwaag,B.,
            Ruiz-Lozano,P., Scimia,M.C., Lindsey,J.D., Weinreb,R., Albrecht,B.,
            Megarbane,A., Alanay,Y., Ben-Neriah,Z., Amenduni,M., Artuso,R.,
            Veltman,J.A., van Beusekom,E., Oudakker,A., Millan,J.L.,
            Hennekam,R., Hamel,B., Courtneidge,S.A. and van Bokhoven,H.
  TITLE     Disruption of the podosome adaptor protein TKS4 (SH3PXD2B) causes
            the skeletal dysplasia, eye, and cardiac abnormalities of Frank-Ter
            Haar Syndrome
  JOURNAL   Am J Hum Genet 86 (2), 254-261 (2010)
   PUBMED   20137777
  REMARK    GeneRIF: These findings establish a role for TKS4 in Frank-Ter Haar
            syndrome and embryonic development.
REFERENCE   7  (bases 1 to 7409)
  AUTHORS   Mao,M., Thedens,D.R., Chang,B., Harris,B.S., Zheng,Q.Y.,
            Johnson,K.R., Donahue,L.R. and Anderson,M.G.
  TITLE     The podosomal-adaptor protein SH3PXD2B is essential for normal
            postnatal development
  JOURNAL   Mamm Genome 20 (8), 462-475 (2009)
   PUBMED   19669234
  REMARK    GeneRIF: SH3PXD2B is a podosomal-adaptor protein required for
            postnatal growth and development.
REFERENCE   8  (bases 1 to 7409)
  AUTHORS   Hishida,T., Nishizuka,M., Osada,S. and Imagawa,M.
  TITLE     The role of C/EBPdelta in the early stages of adipogenesis
  JOURNAL   Biochimie 91 (5), 654-657 (2009)
   PUBMED   19233245
  REMARK    GeneRIF: Silencing of C/EBPdelta impaired the expression of factor
            for adipocyte differentiation (fad) 49, which is up-regulated and
            plays a crucial role early in adipogenesis.
REFERENCE   9  (bases 1 to 7409)
  AUTHORS   Buschman,M.D., Bromann,P.A., Cejudo-Martin,P., Wen,F., Pass,I. and
            Courtneidge,S.A.
  TITLE     The novel adaptor protein Tks4 (SH3PXD2B) is required for
            functional podosome formation
  JOURNAL   Mol Biol Cell 20 (5), 1302-1311 (2009)
   PUBMED   19144821
  REMARK    GeneRIF: Tks4 has a role in the formation and function of
            podosomes.
REFERENCE   10 (bases 1 to 7409)
  AUTHORS   Hishida,T., Eguchi,T., Osada,S., Nishizuka,M. and Imagawa,M.
  TITLE     A novel gene, fad49, plays a crucial role in the immediate early
            stage of adipocyte differentiation via involvement in mitotic
            clonal expansion
  JOURNAL   FEBS J 275 (22), 5576-5588 (2008)
   PUBMED   18959745
  REMARK    GeneRIF: Induction of the fad49 gene was observed in adipocyte
            differentiable 3T3-L1 cells, but not in non-adipogenic NIH-3T3
            cells.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY197208.1, AK089330.1 and AL662780.20.
            
            On Jul 6, 2018 this sequence version replaced NM_177364.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK171384.1, AK154898.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-148               BY197208.1         30-177
            149-1451            AK089330.1         150-1452
            1452-7409           AL662780.20        163998-169955
FEATURES             Location/Qualifiers
     source          1..7409
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 18.89 cM"
     gene            1..7409
                     /gene="Sh3pxd2b"
                     /gene_synonym="fad49; G431001E03Rik; Tks4; TSK4"
                     /note="SH3 and PX domains 2B"
                     /db_xref="GeneID:268396"
                     /db_xref="MGI:MGI:2442062"
     exon            1..129
                     /gene="Sh3pxd2b"
                     /gene_synonym="fad49; G431001E03Rik; Tks4; TSK4"
                     /inference="alignment:Splign:2.1.0"
     CDS             55..2781
                     /gene="Sh3pxd2b"
                     /gene_synonym="fad49; G431001E03Rik; Tks4; TSK4"
                     /note="tyrosine kinase substrate with four SH3 domains;
                     factor for adipocyte differentiation 49"
                     /codon_start=1
                     /product="SH3 and PX domain-containing protein 2B"
                     /protein_id="NP_796338.2"
                     /db_xref="CCDS:CCDS24526.1"
                     /db_xref="GeneID:268396"
                     /db_xref="MGI:MGI:2442062"
                     /translation="MPPRRSIVEVKVLDVQKRRVPNKHYVYIIRVTWSSGATEAIYRR
                     YSKFFDLQMQMLDKFPMEGGQKDPKQRIIPFLPGKILFRRSHIRDVAVKRLIPIDEYC
                     KALIQLPPYISQCDEVLQFFETRPEDLNPPKEEHIGKKKSGNDPTSVDPMVLEQYVVV
                     ADYQKQESSEISLSVGQVVDIIEKNESGWWFVSTAEEQGWVPATCLEGQDGVQDEFSL
                     QPEEEEKYTVIYPYTARDQDEMNLERGAVVEVVQKNLEGWWKIRYQGKEGWAPASYLK
                     KNSGEPLPPKLGPSSPAHSGALDLDGVSRHQNAMGREKELLNNQRDGRFEGRLVPDGD
                     VKQRSPKMRQRPPPRRDMTIPRGLNLPKPPIPPQVEEEYYTIAEFQTTIPDGISFQAG
                     LKVEVIEKSLSGWWYIQMEDKEGWAPATFIDKYKKTSSASRPNFLAPLPHEMTQLRLG
                     DAAATENNTGPEAVGPSRPLPEAPHGAVDSGMLWSKDWKGGKEAPRKASSDLSASTGY
                     EEISDPTQEEKPSLPPRKESIIKSEEELLERERQKMEPLRGSSPKPPGMILPMIPAKH
                     APLARDSRKPEPKLDKSKFPLRNDMGLECGHKVLAKEVKKPNLRPISRSKAELSEEKV
                     DPTSQNLFMKSRPQVRPKPTPSPKTEPAQSEDHVDIYNLRSKLRPAKSQEKALLDGES
                     HHAAGSHDTALSRSFLPGEGPGHGQDRSGRQDGLSPKETPCRAPPRPAKTTDPGPKNV
                     PVPVQEATLQQRPVVPPRRPPPPKKTSSSPLSCRPLPEVRGAQREESRVAPAAGRALL
                     VPPKAKPFLSNSSVGQDDMRGKGGLGPRVTGKVGETREKAASFLNADGPKDSLYVAVA
                     NFEGDEDTSSFQEGTVFEVREKNSSGWWFCQVLSGAPSWEGWIPSNYLRKKP"
     exon            130..210
                     /gene="Sh3pxd2b"
                     /gene_synonym="fad49; G431001E03Rik; Tks4; TSK4"
                     /inference="alignment:Splign:2.1.0"
     exon            211..286
                     /gene="Sh3pxd2b"
                     /gene_synonym="fad49; G431001E03Rik; Tks4; TSK4"
                     /inference="alignment:Splign:2.1.0"
     exon            287..363
                     /gene="Sh3pxd2b"
                     /gene_synonym="fad49; G431001E03Rik; Tks4; TSK4"
                     /inference="alignment:Splign:2.1.0"
     exon            364..455
                     /gene="Sh3pxd2b"
                     /gene_synonym="fad49; G431001E03Rik; Tks4; TSK4"
                     /inference="alignment:Splign:2.1.0"
     exon            456..481
                     /gene="Sh3pxd2b"
                     /gene_synonym="fad49; G431001E03Rik; Tks4; TSK4"
                     /inference="alignment:Splign:2.1.0"
     exon            482..616
                     /gene="Sh3pxd2b"
                     /gene_synonym="fad49; G431001E03Rik; Tks4; TSK4"
                     /inference="alignment:Splign:2.1.0"
     exon            617..721
                     /gene="Sh3pxd2b"
                     /gene_synonym="fad49; G431001E03Rik; Tks4; TSK4"
                     /inference="alignment:Splign:2.1.0"
     exon            722..839
                     /gene="Sh3pxd2b"
                     /gene_synonym="fad49; G431001E03Rik; Tks4; TSK4"
                     /inference="alignment:Splign:2.1.0"
     exon            840..1066
                     /gene="Sh3pxd2b"
                     /gene_synonym="fad49; G431001E03Rik; Tks4; TSK4"
                     /inference="alignment:Splign:2.1.0"
     exon            1067..1116
                     /gene="Sh3pxd2b"
                     /gene_synonym="fad49; G431001E03Rik; Tks4; TSK4"
                     /inference="alignment:Splign:2.1.0"
     exon            1117..1242
                     /gene="Sh3pxd2b"
                     /gene_synonym="fad49; G431001E03Rik; Tks4; TSK4"
                     /inference="alignment:Splign:2.1.0"
     exon            1243..7409
                     /gene="Sh3pxd2b"
                     /gene_synonym="fad49; G431001E03Rik; Tks4; TSK4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7233..7238
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sh3pxd2b"
                     /gene_synonym="fad49; G431001E03Rik; Tks4; TSK4"
                     /note="hexamer: AATAAA"
     polyA_site      7269
                     /gene="Sh3pxd2b"
                     /gene_synonym="fad49; G431001E03Rik; Tks4; TSK4"
                     /note="major polyA site"
     regulatory      7376..7381
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sh3pxd2b"
                     /gene_synonym="fad49; G431001E03Rik; Tks4; TSK4"
                     /note="hexamer: AATAAA"
     polyA_site      7409
                     /gene="Sh3pxd2b"
                     /gene_synonym="fad49; G431001E03Rik; Tks4; TSK4"
ORIGIN      
        1 aaggatcgct ttggcccggc ccggcccgca cggcgctggg cgcggagaac ggccatgccg
       61 ccgcggcgca gtatcgtgga ggtgaaggtg ctggacgtgc agaagcggcg cgtgcccaac
      121 aagcattatg tctacatcat ccgagtcacg tggtccagtg gcgccacgga ggccatctac
      181 cggcgctaca gcaagttctt tgacctccag atgcagatgt tggacaagtt ccccatggaa
      241 ggaggacaga aagaccccaa gcagaggatc attccatttc tgccaggcaa aatcctcttc
      301 cgccgcagcc acatccggga cgtagccgtc aaacgcctga taccaattga tgaatattgt
      361 aaggccctga tccagctgcc cccctacatc tctcagtgtg atgaggttct gcagtttttc
      421 gagacaagac ctgaggacct gaatcctccc aaagaggagc atattgggaa gaagaaatca
      481 gggaatgacc cgacctcagt ggaccctatg gtcctggagc agtatgtggt agtggcagac
      541 tatcagaagc aggagagctc agagatcagc ctcagtgtgg gccaagtagt ggacatcatt
      601 gagaagaatg agtcaggttg gtggttcgtc agcactgctg aagagcaggg ctgggtccct
      661 gcaacctgcc tggaaggcca ggatggcgtg caagatgagt tctccctcca gcctgaggaa
      721 gaggagaaat atacggtcat ctacccgtac acagctcgtg accaggatga aatgaaccta
      781 gagcgagggg ctgtggtgga ggtcgtccag aagaacctgg agggctggtg gaagatcagg
      841 taccagggca aagagggctg ggcccctgct tcctacctaa agaagaacag tggggagccc
      901 ttgcccccaa agcttggccc cagctcacct gctcactcgg gtgccctcga cctggatggt
      961 gtttcccggc atcagaatgc tatgggcagg gagaaggagc tgctgaacaa ccagagggat
     1021 ggccggtttg aaggtcgcct ggtgcccgat ggtgacgtta agcagagatc accaaagatg
     1081 aggcaaagac cccctcctcg ccgagacatg accattcctc gaggcctcaa cctgccgaag
     1141 ccccccatcc caccccaggt ggaggaagag tactacacca tcgctgagtt ccagaccacc
     1201 atcccagatg gcatcagctt ccaggcgggc ctgaaggtgg aggtgattga gaagagccta
     1261 agtggttggt ggtacattca gatggaagat aaggaggggt gggccccagc gaccttcatt
     1321 gacaagtata agaagaccag cagtgcctcg aggcccaact ttctggcccc cttgcctcat
     1381 gagatgaccc agctccggct tggggatgca gctgcaacag agaacaatac gggtccagaa
     1441 gccgtggggc cctccagacc cctgcctgag gcaccacacg gtgctgtgga ctctgggatg
     1501 ctctggtcca aagactggaa aggaggaaaa gaggccccaa gaaaggcatc ttcagacctg
     1561 tctgcgtcaa caggatatga ggagatctcg gaccccacac aggaggagaa gcccagcctc
     1621 cctccacgca aagagtccat catcaagtct gaagaggagt tgctggagag ggaaagacag
     1681 aagatggagc cgctccgggg ctcctccccc aagccccctg gcatgatatt gccaatgatt
     1741 ccagcaaagc atgccccgct ggcccgggac agcaggaaac cagagcccaa acttgacaag
     1801 agcaagttcc cgctgagaaa tgacatgggg ttagagtgtg gccacaaggt gctggccaag
     1861 gaagtgaaaa agcccaacct ccggcccatc tccaggtcta aagctgagct gtccgaggag
     1921 aaggtggacc ccacctccca gaatctgttc atgaagtcta gacctcaggt taggcccaaa
     1981 ccaactcctt cccccaagac agagccagct cagagtgaag accacgtgga tatctacaac
     2041 ctcaggagca agctcagacc tgccaagtct caagagaaag ccttattgga tggagaaagc
     2101 caccatgctg ctgggagcca tgacacagcc ctcagcagaa gcttccttcc cggggaggga
     2161 cctggccatg gccaggacag gtctggcaga caggatgggc tgagtccaaa ggagacaccc
     2221 tgcagagccc ctcccaggcc agccaagacc acagaccctg ggcccaagaa tgtgcctgtg
     2281 cctgtccaag aagcaaccct gcagcaaaga cctgtggtcc cacctcgaag acccccaccc
     2341 cccaagaaaa cctcctcgtc accactgtcg tgcaggcccc ttccagaggt cagaggggca
     2401 cagcgtgaag aaagcagagt cgctcctgct gcaggccggg ccctccttgt ccctccaaaa
     2461 gccaaaccct tcctctctaa ctcctcagtg ggccaagatg acatgcgagg caaaggtggg
     2521 ctggggccac gcgtcactgg caaggtggga gaaaccagag agaaggcggc ttccttcctc
     2581 aatgccgatg gcccaaagga ctcactttac gtggccgtgg ccaactttga aggagatgaa
     2641 gacaccagca gcttccagga agggacagtg tttgaagtcc gggagaagaa cagcagtggc
     2701 tggtggttct gccaggtcct cagtggggct ccttcctggg aaggctggat tccttccaac
     2761 tacctccgga agaaacccta gcttccccgc cctgccggga ggcccagcag tccctgctag
     2821 ccttccccac gtatttaata cgcatcttaa tttatcagtc tccacatcat ttcgaggaag
     2881 gtggccattg ggatgctgtg atatcctgta gcctggggtc tgattctcct gttgtggctt
     2941 ctccagaagt ctcaaaagcc acagcctttg ccaggtagaa accacgttac catccttgtc
     3001 tgtggtagaa cccatcctca taggcaacat cttgttatcc agaagcagga tagtgacaca
     3061 gacccccaga actgacacca gccacctgga agacttccag accaccctca atgctcaatt
     3121 tggcatagag ggacagcctc acagcctgtg acaactcgct ctaacttctc catgttacca
     3181 gaagcccagt catggctttg ttcaccgttc tcagaatacc tggtgccagg aagaaccgag
     3241 tcccgaaaga atcagcctcc ggggtttctg cttctaagtc ctgagcagct gcagctgccc
     3301 tcaagtggtc ctagagattc actcggttat cctgccttgg accgtgatca gtcctaaagg
     3361 agcacgcttc acttcactgc taaagccact ggtccattca gggcttttaa attccaattc
     3421 ccacccacct ccctcagtcc ctggaacaag agtctccacg tttgtttaag taaggggcca
     3481 gtccttcaca aggcacatgg tccatgagtg cttctttgcc tagtaggtgc caaactgccc
     3541 ttggccttct gccttcaggt tctgtcaacc aggctccctc ccctgtctat tgcacccatt
     3601 ttctagttga ggaaagtgag gctctacagg ccccaggata tgctaggtag gaagtggctg
     3661 aaggaggctt gagtccaggt ctgcctgacc ccagtatcca tgctcttctc cctgcaagaa
     3721 caaccagaga gggaagagat ggaggttgac tgggtatcag ggtaggtggc ctgggggctt
     3781 ccttatgtta tgagcaaagg gatggtagtg actgccctgg actcacagct gtctctgcag
     3841 gacagggtgt accctggatc cttagtagca gttacaaagc ttatagcctg ataccctgtg
     3901 tgtggaagag aaataaagga agccgaggca ctgtccctct ggtggctaag gaccagcagc
     3961 ttggtctgtg ccaaactaag aacagtaccc aagggcctgt agtgtcctgc cccagcagca
     4021 gctgctgctc cgtgtagaac agttggcttt ttagcgtgct ctttccctgg gagaagccca
     4081 gggtagccct tccctatttt gaccaataga cggctaaggc ctggagaggt ccacttagtt
     4141 attgcagagc taaaaatcag gacccagatt tctagctccc agcccagacc aacttgtacc
     4201 tatgaatggg cttcctgtga aagcggggta gggttgggag ggccaagctc catcccatcc
     4261 cacagtccct acagaagagg ggacagccct gtctggttct acacttcccc agtgttcatt
     4321 tttaatgtgg tttggaaacc acgaagcccc ctttcccaag atgcttgcat cttacttgca
     4381 gtgccaaaga ttttgtgcaa ggggatcctt tctgcacccc acccctgccc aactctctct
     4441 gctttcctct gacccacctg gcgctgtcac tctcttcctc tgttcagcct gcagtcccct
     4501 acgccccacc cccacccccc agcactgggc ctgggtagga ggcacctgaa ggatgaccct
     4561 gcttagtctg tgccctgggc ctcgggggaa agcggcagtt agggagaggg gaagctgaga
     4621 gagtcttcag ctctggagca gcacttgaga gcctcatgcc cacacccacg ctgtgcagga
     4681 atcctcatag ctttctattt gttggtggtt tttgagtttc gacacctctg cttgaccagc
     4741 tttctgaagc cgttttacag gcctttggtt gttgctgttt tgtttttcct gcttgcactt
     4801 ggctctctgt gaccttctca agtattttac aagtcccttc tatgccgcag atgctgggta
     4861 gaccagggag cggggagggg ggcatcaccc tgcactgaag aactgagctt tgcccactag
     4921 ctccagtgaa gaagtcatct gccttctacc ctcctctctg gtcagctgag gcagagcaga
     4981 caggccttcc tgtgggcaat gagagaattt accttttgtc ctatccttgt gctgctgtga
     5041 actgtatgtg tgccgggttc cctttctgtt cactgtcttt ttcttgggtc acacacacag
     5101 tctgaaggtt tctgtggcaa gctccatcgg ccatagtgct tcatcactag cctgggcaac
     5161 cggaagcgag tgggtctgca gagccaagtc actcacccaa tttcccttgc ctgggactta
     5221 gcttttcaac atccaggact gtggtcactc ctgtcgggat ggagcatata tgccagactc
     5281 cccctcaccc cccatccctg cctacttcca aggccagggt agcaatgtct gggccaatca
     5341 cagatcagat caccgacaca aacttgtgcc cctcccctgc aactaacatt cacatcaact
     5401 ctgttgatgt gatggcaggg accacctcaa tacataatgg gaaagttaag gtatggagag
     5461 tgaagtcaca tcctgccttg ttcaggttcg ggccaccagc aaagaaatgt tacagttctg
     5521 attttaggtg tctctccctc aatcccctga ccaaacattg gtcattgacc agatggcccc
     5581 tcttggatga accctgctct ctggctccat ggttgcattg tttctgcctg agagtaagta
     5641 tagtaccctg cctctggaaa cctgggcttg aaaacagcca ttgctagatg gaaactttgc
     5701 ttatattttc tggccagagt cactcttggc catttatgtt aataccatgg ctcccggctg
     5761 aggccagggg tggtctgtgc tccagctact tctagtcctg ccaggaaatg gcaagagcca
     5821 tgctaggcgc tcacaggcgg ggtgttttgt tttgttttgt tttgttttgt ttttgagcct
     5881 ctgccaccag accgccccat agagttgatt tctatggcac agttcttgac cttaaactgt
     5941 ctctgaaccc actggggact tggggagtgg atggaaagtg gggatacatg tgcttcacta
     6001 aagaacaggt gccaaatctc cccacaagaa cttaggacag acagtctagt gtttatcgcc
     6061 aaattctggc ccttagtgag aggaagaaac tgaccatcta aggagagtgg tgtggagttg
     6121 tggtgcagcc agaaagcaat ggcccgaatg tgtgggcccc aggctccatc cccagcatca
     6181 cagataaaca agaaccttaa tggcttagct cctgtccttc cattgagccc agggctcttc
     6241 agtgtcgaca tagtccatac cctgggaagc cttgccattt ctttgaacag tgtggccatc
     6301 tcggcccctt cggtggctgt ctaaactttc cttcagggtt tttcctgtat actatggaca
     6361 gccatatcct accacagacc aaagattccc tgaagtcaga ggggtgtgga ctgaatgggt
     6421 agaaaattaa tttgtatcaa ggcccaaggg tttgcctttg cctggaagaa ttgctcctaa
     6481 cttgctaagg ttctagcagc aggactgacc tgaccccaag cagagctgta cagttaagac
     6541 aatggttcgt actcctcacc tcctggacaa ccgtcccaca gaccagacct tcctgctcta
     6601 gggagtgatg cttggtcccc ggtgctatct agttgaggta ccaagcccct caaatgtgag
     6661 ggttccatct tcttccctgt ctctgtactc cttccccaag gaagccctct tagctcccat
     6721 cagaatgagg gcttagcttc tgtccttcaa aagaccagac ccggtgccat cgccagtggc
     6781 cttccctctc acctctgctt ttaagagcaa aggtgccctg ccaggcttat tacagcaata
     6841 aacaattcta atgcaatgga ggtgtccgga ttatgcctgc aatgcctttg tgccctgtaa
     6901 ttactagtag cacctctcgt acataccaga gagtgtgata aactgtggtc accttagcca
     6961 tacatggttc ctgtttcggg gccactgagg ttgcttctaa catccctcca gaaacagtgg
     7021 gctctagaca gcgtggccca ctgtattcat gggcccacag ctggtgctgg gaacccctgg
     7081 gttctcagcc cttctcacac cccctaggcc aactgacagg tcctggtggt ggcttttatc
     7141 tcccgtgagt gtttaatgtg agggggcagg ggatgaacac ctagctgtag catgtagaga
     7201 ctgtatacca ttagtctttt cttttttaaa ataataaaat gcttgactgg tttcaagctt
     7261 cgttgtaaag atgtagtgtt tgtggatttc atctggctga aagagataca tgccccggtg
     7321 tctggacttc atgcgttggt gtctgcactt gagctctttg tgtctgaaga agagaaataa
     7381 acagaatctg ttcaagcatt gcctagaaa
//
