LOCUS       NM_001135727            5168 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus SH3-domain kinase binding protein 1 (Sh3kbp1),
            transcript variant 1, mRNA.
ACCESSION   NM_001135727
VERSION     NM_001135727.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5168)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5168)
  AUTHORS   Horak,I.R., Latyshko,N.V., Hudkova,O.O., Tokarchuk,K.O.,
            Kishko,T.O., Yusova,O.I., Drobot,L.B. and Tykhomyrov,A.A.
  TITLE     ADAPTOR PROTEIN Ruk/CIN85REGULATES REDOX BALANCE IN 4T1MOUSE BREAST
            CANCER CELLS EXPOSED TO PLASMIN(OGEN)
  JOURNAL   Exp Oncol 44 (1), 31-38 (2022)
   PUBMED   35548969
  REMARK    GeneRIF: ADAPTOR PROTEIN Ruk/CIN85REGULATES REDOX BALANCE IN
            4T1MOUSE BREAST CANCER CELLS EXPOSED TO PLASMIN(OGEN).
REFERENCE   3  (bases 1 to 5168)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5168)
  AUTHORS   Whiley,P.A.F., O'Donnell,L., Moody,S.C., Handelsman,D.J.,
            Young,J.C., Richards,E.A., Almstrup,K., Western,P.S. and
            Loveland,K.L.
  TITLE     Activin A Determines Steroid Levels and Composition in the Fetal
            Testis
  JOURNAL   Endocrinology 161 (7) (2020)
   PUBMED   32274496
REFERENCE   5  (bases 1 to 5168)
  AUTHORS   Kong,M.S., Hashimoto-Tane,A., Kawashima,Y., Sakuma,M., Yokosuka,T.,
            Kometani,K., Onishi,R., Carpino,N., Ohara,O., Kurosaki,T.,
            Phua,K.K. and Saito,T.
  TITLE     Inhibition of T cell activation and function by the adaptor protein
            CIN85
  JOURNAL   Sci Signal 12 (567) (2019)
   PUBMED   30723173
  REMARK    GeneRIF: Data show that Cbl-interacting protein of 85 kDa (CIN85)
            limited T cell responses to T cell receptor (TCR) stimulation.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5168)
  AUTHORS   Buchman,V.L., Luke,C., Borthwick,E.B., Gout,I. and Ninkina,N.
  TITLE     Organization of the mouse Ruk locus and expression of isoforms in
            mouse tissues
  JOURNAL   Gene 295 (1), 13-17 (2002)
   PUBMED   12242006
  REMARK    GeneRIF: Analysis of cDNA clones, ESTs and products of RT-PCR
            amplifications with different combinations of primers revealed how
            alternative splicing and promoter usage generate a variety of Ruk
            transcripts and encoded protein isoforms in different mouse
            tissues.
REFERENCE   7  (bases 1 to 5168)
  AUTHORS   Soubeyran,P., Kowanetz,K., Szymkiewicz,I., Langdon,W.Y. and
            Dikic,I.
  TITLE     Cbl-CIN85-endophilin complex mediates ligand-induced downregulation
            of EGF receptors
  JOURNAL   Nature 416 (6877), 183-187 (2002)
   PUBMED   11894095
  REMARK    Erratum:[Nature 2002 May 2;417(6884):102]
REFERENCE   8  (bases 1 to 5168)
  AUTHORS   Borinstein,S.C., Hyatt,M.A., Sykes,V.W., Straub,R.E., Lipkowitz,S.,
            Boulter,J. and Bogler,O.
  TITLE     SETA is a multifunctional adapter protein with three SH3 domains
            that binds Grb2, Cbl, and the novel SB1 proteins
  JOURNAL   Cell Signal 12 (11-12), 769-779 (2000)
   PUBMED   11152963
REFERENCE   9  (bases 1 to 5168)
  AUTHORS   Chen,B., Borinstein,S.C., Gillis,J., Sykes,V.W. and Bogler,O.
  TITLE     The glioma-associated protein SETA interacts with AIP1/Alix and
            ALG-2 and modulates apoptosis in astrocytes
  JOURNAL   J Biol Chem 275 (25), 19275-19281 (2000)
   PUBMED   10858458
REFERENCE   10 (bases 1 to 5168)
  AUTHORS   Hyatt,M.A., Sykes,V.W., Boyer,A.D., Arden,K.C. and Bogler,O.
  TITLE     Assignment of seta to distal mouse X chromosome by radiation hybrid
            mapping
  JOURNAL   Cytogenet Cell Genet 89 (3-4), 278 (2000)
   PUBMED   10965144
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK049182.1, BB853873.1, AK080930.1, AK028299.1, AK142295.1 and
            AI447724.1.
            
            On Mar 15, 2014 this sequence version replaced NM_001135727.1.
            
            Transcript Variant: This variant (1, also known as Ruk1) represents
            the longest transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK049182.1, SRR1660813.93216.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5                 AK049182.1         1-5
            6-136               BB853873.1         1-131
            137-2078            AK080930.1         2-1943
            2079-4912           AK028299.1         1085-3918
            4913-5165           AK142295.1         3369-3621
            5166-5168           AI447724.1         1-3                 c
FEATURES             Location/Qualifiers
     source          1..5168
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 73.65 cM"
     gene            1..5168
                     /gene="Sh3kbp1"
                     /gene_synonym="1200007H22Rik; 1700125L08Rik;
                     5830464D22Rik; Cin85; IN85; Ruk; Seta"
                     /note="SH3-domain kinase binding protein 1"
                     /db_xref="GeneID:58194"
                     /db_xref="MGI:MGI:1889583"
     exon            1..420
                     /gene="Sh3kbp1"
                     /gene_synonym="1200007H22Rik; 1700125L08Rik;
                     5830464D22Rik; Cin85; IN85; Ruk; Seta"
                     /inference="alignment:Splign:2.1.0"
     CDS             417..2414
                     /gene="Sh3kbp1"
                     /gene_synonym="1200007H22Rik; 1700125L08Rik;
                     5830464D22Rik; Cin85; IN85; Ruk; Seta"
                     /note="isoform 1 is encoded by transcript variant 1; SH3
                     domain-containing kinase-binding protein 1; regulator of
                     ubiquitous kinase; SH3-containing, expressed in
                     tumorigenic astrocytes; Ruk(xl) protein; Ruk(l) protein;
                     Ruk(deltaA) protein; Ruk(m1) protein; Ruk(m3) protein;
                     Ruk(h) protein; Ruk(t) protein"
                     /codon_start=1
                     /product="SH3 domain-containing kinase-binding protein 1
                     isoform 1"
                     /protein_id="NP_001129199.1"
                     /db_xref="CCDS:CCDS53234.1"
                     /db_xref="GeneID:58194"
                     /db_xref="MGI:MGI:1889583"
                     /translation="MVEAIVEFDYQAQHDDELTISVGEVITNIRKEDGGWWEGQINGR
                     RGLFPDNFVREIKKDMKKDLLSNKAPEKPMHDVSSGNALLSSETILRTNKRGERRRRR
                     CQVAFSYLPQNDDELELKVGDIIEVVGEVEEGWWEGVLNGKTGMFPSNFIKELSGESD
                     ELGISQDEQLSKSSLRETTGSESDGGDSSSTKSEGANGTMATAAIQPKKVKGVGFGDI
                     FKDKPIKLRPRSIEVENDFLPVEKTIGKKLPPATSTPDPSKTEMDSRTKTKDYCKVIF
                     PYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRRGVFPDNFVKLLPSDFDKEG
                     NRPKKPPPPSAPVVKQGAGTTERKHEIKKIPPERPETLPNRTEEKERPEREPKLDLQK
                     PSVPAIPPKKPRPPKTNSLNRPGALPPRRPERPVGPLTHTRGDSPKIDLAGSALSGIL
                     DKDLSDRSNDIDLEGFDSVISSTEKLSHPTTSRPKATGRRPPSQSLTSSSLSSPDIFD
                     SPSPEEDKEEHISLAHRGIDVSKKTSKTVTISQVSDNKTSLPPKPGTMAAASSGPASL
                     SSVASSPMSSSLGTAGQRASSPSLFSTEGKPKMEPAVSSQAAIEELKMQVRELRTIIE
                     TMKDQQKREIKQLLSELDEEKKIRLRLQMEVNDIKKALQSK"
     exon            421..578
                     /gene="Sh3kbp1"
                     /gene_synonym="1200007H22Rik; 1700125L08Rik;
                     5830464D22Rik; Cin85; IN85; Ruk; Seta"
                     /inference="alignment:Splign:2.1.0"
     exon            579..702
                     /gene="Sh3kbp1"
                     /gene_synonym="1200007H22Rik; 1700125L08Rik;
                     5830464D22Rik; Cin85; IN85; Ruk; Seta"
                     /inference="alignment:Splign:2.1.0"
     exon            703..806
                     /gene="Sh3kbp1"
                     /gene_synonym="1200007H22Rik; 1700125L08Rik;
                     5830464D22Rik; Cin85; IN85; Ruk; Seta"
                     /inference="alignment:Splign:2.1.0"
     exon            807..936
                     /gene="Sh3kbp1"
                     /gene_synonym="1200007H22Rik; 1700125L08Rik;
                     5830464D22Rik; Cin85; IN85; Ruk; Seta"
                     /inference="alignment:Splign:2.1.0"
     exon            937..1142
                     /gene="Sh3kbp1"
                     /gene_synonym="1200007H22Rik; 1700125L08Rik;
                     5830464D22Rik; Cin85; IN85; Ruk; Seta"
                     /inference="alignment:Splign:2.1.0"
     exon            1143..1218
                     /gene="Sh3kbp1"
                     /gene_synonym="1200007H22Rik; 1700125L08Rik;
                     5830464D22Rik; Cin85; IN85; Ruk; Seta"
                     /inference="alignment:Splign:2.1.0"
     exon            1219..1313
                     /gene="Sh3kbp1"
                     /gene_synonym="1200007H22Rik; 1700125L08Rik;
                     5830464D22Rik; Cin85; IN85; Ruk; Seta"
                     /inference="alignment:Splign:2.1.0"
     exon            1314..1421
                     /gene="Sh3kbp1"
                     /gene_synonym="1200007H22Rik; 1700125L08Rik;
                     5830464D22Rik; Cin85; IN85; Ruk; Seta"
                     /inference="alignment:Splign:2.1.0"
     exon            1422..1473
                     /gene="Sh3kbp1"
                     /gene_synonym="1200007H22Rik; 1700125L08Rik;
                     5830464D22Rik; Cin85; IN85; Ruk; Seta"
                     /inference="alignment:Splign:2.1.0"
     exon            1474..1554
                     /gene="Sh3kbp1"
                     /gene_synonym="1200007H22Rik; 1700125L08Rik;
                     5830464D22Rik; Cin85; IN85; Ruk; Seta"
                     /inference="alignment:Splign:2.1.0"
     exon            1555..1714
                     /gene="Sh3kbp1"
                     /gene_synonym="1200007H22Rik; 1700125L08Rik;
                     5830464D22Rik; Cin85; IN85; Ruk; Seta"
                     /inference="alignment:Splign:2.1.0"
     exon            1715..1800
                     /gene="Sh3kbp1"
                     /gene_synonym="1200007H22Rik; 1700125L08Rik;
                     5830464D22Rik; Cin85; IN85; Ruk; Seta"
                     /inference="alignment:Splign:2.1.0"
     exon            1801..1910
                     /gene="Sh3kbp1"
                     /gene_synonym="1200007H22Rik; 1700125L08Rik;
                     5830464D22Rik; Cin85; IN85; Ruk; Seta"
                     /inference="alignment:Splign:2.1.0"
     exon            1911..2039
                     /gene="Sh3kbp1"
                     /gene_synonym="1200007H22Rik; 1700125L08Rik;
                     5830464D22Rik; Cin85; IN85; Ruk; Seta"
                     /inference="alignment:Splign:2.1.0"
     exon            2040..2308
                     /gene="Sh3kbp1"
                     /gene_synonym="1200007H22Rik; 1700125L08Rik;
                     5830464D22Rik; Cin85; IN85; Ruk; Seta"
                     /inference="alignment:Splign:2.1.0"
     exon            2309..2372
                     /gene="Sh3kbp1"
                     /gene_synonym="1200007H22Rik; 1700125L08Rik;
                     5830464D22Rik; Cin85; IN85; Ruk; Seta"
                     /inference="alignment:Splign:2.1.0"
     exon            2373..5168
                     /gene="Sh3kbp1"
                     /gene_synonym="1200007H22Rik; 1700125L08Rik;
                     5830464D22Rik; Cin85; IN85; Ruk; Seta"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3394..3399
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sh3kbp1"
                     /gene_synonym="1200007H22Rik; 1700125L08Rik;
                     5830464D22Rik; Cin85; IN85; Ruk; Seta"
                     /note="hexamer: AATAAA"
     regulatory      3401..3406
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sh3kbp1"
                     /gene_synonym="1200007H22Rik; 1700125L08Rik;
                     5830464D22Rik; Cin85; IN85; Ruk; Seta"
                     /note="hexamer: AATAAA"
     polyA_site      3414
                     /gene="Sh3kbp1"
                     /gene_synonym="1200007H22Rik; 1700125L08Rik;
                     5830464D22Rik; Cin85; IN85; Ruk; Seta"
     polyA_site      3419
                     /gene="Sh3kbp1"
                     /gene_synonym="1200007H22Rik; 1700125L08Rik;
                     5830464D22Rik; Cin85; IN85; Ruk; Seta"
                     /note="major polyA site"
     regulatory      5148..5153
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sh3kbp1"
                     /gene_synonym="1200007H22Rik; 1700125L08Rik;
                     5830464D22Rik; Cin85; IN85; Ruk; Seta"
                     /note="hexamer: ATTAAA"
     polyA_site      5168
                     /gene="Sh3kbp1"
                     /gene_synonym="1200007H22Rik; 1700125L08Rik;
                     5830464D22Rik; Cin85; IN85; Ruk; Seta"
ORIGIN      
        1 ggaggggaga gcaggctccg aggcggctgc agggcactgg gctgggcggt gctttttttc
       61 ttttcttttc ttttctttct ttcttttttt ttcttcttct tcttcttttt tttttttttt
      121 cgcaatttcc actcgcagag agcaggaaac ccggagcagc cgggtgcagt ggggccgcga
      181 tgcagcagca gcagcagcag gagtcgcccc agggtagcag cggcagcagc agcagaggca
      241 gtagcgggcg gcgctgagct gccaccaccg ccgctgagga cgaagccggc ccagcagcag
      301 ccgcgtcccg acgctcgcgc ccccgatccc tgcgccgcga cctcggcgct ccgaacccaa
      361 cgcccggttc cgccaacttt cacgctgctt cggcggctcg gctcgtcttg gcgccaatgg
      421 tggaggccat agtggagttt gattaccagg cccagcatga tgatgagctg acaatcagcg
      481 tgggtgaggt catcaccaac atcaggaagg aggatggagg ctggtgggag ggacagatca
      541 acggcaggag aggtttgttc cctgacaact ttgtaagaga aataaagaaa gatatgaaga
      601 aagatcttct ctctaacaaa gctccagaga aacccatgca cgatgtatcc agtggaaacg
      661 ctctgctttc ttctgaaacc attttaagaa ccaataaacg aggagaacga cggagacgcc
      721 gatgccaggt ggcattcagc tacctgcccc agaatgacga tgagctggag ctgaaagtcg
      781 gggacatcat agaggttgta ggagaggtag aggaaggatg gtgggaaggt gtgctcaatg
      841 ggaagactgg aatgtttcct tccaacttca tcaaggagct gtcaggggag tcggatgagc
      901 ttggcatctc ccaggatgag cagctttcca agtcaagctt aagagaaacc acaggctccg
      961 agagtgatgg aggcgactcc agcagtacca agtccgaagg tgccaacggg accatggcaa
     1021 ctgcagccat ccagcccaag aaagttaaag gagtggggtt tggagacatt ttcaaagaca
     1081 agccaattaa actaagacca aggtcgattg aagtggaaaa tgacttcctg cccgtcgaaa
     1141 agacaattgg gaagaagtta cctccagcta catcaactcc agacccatcg aagacggaga
     1201 tggacagcag gacaaagacc aaggattact gcaaagtaat atttccatat gaggcacaga
     1261 atgatgatga attgacaatc aaggaaggag atatagtgac tctcatcaat aaggactgca
     1321 tcgacgtagg ctggtgggaa ggagaactca atggcagacg aggcgtgttt cctgacaact
     1381 tcgtgaagtt acttccatcg gactttgaca aggaagggaa tagacccaag aaaccgccac
     1441 ctccatcagc tcctgtcgtc aaacaagggg caggtaccac agagagaaaa catgaaatta
     1501 aaaaaatacc tcctgaaaga ccagaaaccc ttccaaacag aacagaagag aaagaaagac
     1561 cagagagaga gccaaaactg gatttacaga agccttcagt tcctgccatc ccaccaaaaa
     1621 agcctcggcc acctaagacc aattctctga acagacctgg tgcattgccc ccaagaagac
     1681 ctgagcgacc agtgggccca ctgacacaca ccaggggtga cagtccaaag attgacttgg
     1741 caggcagcgc actctctggc atcctggata aggacctctc agaccgcagc aatgatattg
     1801 acttagaagg ttttgactct gtgatatcat ctactgagaa actcagccac ccaaccacaa
     1861 gcagaccaaa agctacagga agacggcctc catcccagtc actcacatct tcttcccttt
     1921 caagccccga tatctttgac tccccaagtc ccgaagaaga taaagaggaa cacatttcgc
     1981 ttgcgcacag aggaatagac gtgtcaaaga agacttccaa gactgttacc atatcccaag
     2041 tgtctgataa caagacatcc ctgccaccca agccagggac catggcagct gccagcagtg
     2101 ggccagcttc tctctcttca gtggcatcct cacccatgtc atcctctttg ggaacagctg
     2161 gacagagagc cagttctcca tctctgttca gcacagaagg aaagccaaag atggagccag
     2221 cagtgagcag ccaggctgct atcgaggagc ttaagatgca agtccgtgag ctgaggacca
     2281 tcattgagac catgaaggac cagcagaaac gtgagattaa gcagttactg tcagaattgg
     2341 atgaagagaa aaagatccgg ctccggttgc agatggaagt gaacgacata aagaaagctc
     2401 ttcaatcaaa gtgattactt gataattgag acatcacatt attcatcctg tgtccaagac
     2461 tcagatattc tgccccagtc aaaatcatct tgtgccaaaa aattagaggt ttgattcatc
     2521 gtgtccctgt ttgaacgttt agcacaaaag tcttaatagc acaacacaaa ttccatccaa
     2581 gaggagactc tttcccatgg tgttgtcctg ggtctggcag tggttgtgat ttatagccaa
     2641 ttgtgctaaa ggatttttct accttgagat ctcccgagaa atgaaaactc aggcagttta
     2701 gtccatagta gtactatttt gatgatattt tccattaaca aaatgtaatt tcagattatt
     2761 cgtttatagg ctttataatt ttatggtttt tttttaaaat cgtgttttgt cacagatgcc
     2821 cctagtgttt gtgctaacct agtcagaagc aagtgtctca ctcacttgct gcagatggaa
     2881 caaatgccgc ctggctttgt attccccttt aggattctat tacatatgca atttgaggtc
     2941 taacttgtcc ctttccctgc cagccaaccc ccaccactct aagagaaatt ttagcttata
     3001 tatgacggta tatttgcaaa aagagaaaga aaaatctggt atttgcaatg atctgtgcct
     3061 tctttctacc accctcttga ttggagcttt tgtgatgcag ctaccatgat tccaaataag
     3121 taaaaatcag ccacttctcc ctgtccacta gaggtcgctg tcttcacagc ttctctcacc
     3181 ctagccaaag gtcctaagag gagacccgct gtgaagtctg gcctgctctt tggtaccagc
     3241 tgtgactttt cagtttctcc tgctttgagg ttgttcacga aactagaaat gtcattccag
     3301 cttgattgtt ttatcatcag ccaagttaaa cccctgcttc ctgcctttta cacctattgc
     3361 gtgaacagaa tatgcattat taaagcaaaa ataaataaaa aataaaatgc aagtgaaaac
     3421 agggggggaa ttggattatt tcctgcactg ggttgtgcgt gtgtgtgtgt gtgcgcgtgt
     3481 atgtgcgtgt gtgtgcgcgt gtgtgttatt gtttaaattg tattcacagt gttgtttgcc
     3541 ttgctcactt gtaaccccct cctcggatct aggagaatgg gaggagggtc tcgtggaaat
     3601 gtagctattg gatctttcct gcacttatgg aaatgctttg tctttcccaa tgaaactgat
     3661 gtttgcttgt ctgctttctc tttatagtac atgaacagtt cagccttaga ctatgtaact
     3721 gttttcttat ctttagctga aaatgggggg agggcattct gtactgcaag attgttgatg
     3781 gggtagaggt ggaggagtgg tcccttaatg atcccccaaa tatgtgtgtg atgtgtttct
     3841 aaactgctgc tttgtctatt tcctgcattt tatagtgaaa ctactaaaca taaatagatt
     3901 ttcactacca caaagaatga gaattaatga cactgaagga atgatgcaaa aacttcccat
     3961 gattcatcac tgaaaatatg actaataaat gtctcttcct ttttcttcct gtctccatcc
     4021 ccatgccttg ttctaacttg catacttgtc ctttctgctc gaagctgtca cttccttcta
     4081 aggatttaca gaggcctagg gccctaacct tcaggggtgg ggacacaatt aaaggaaggg
     4141 aatgtataaa gaaattattc ttcattccaa tatatgaaga tacttgcctt ttcagcagcg
     4201 atggtctcag tgtgcttggg gcaggagtac atagtttcta tgagcgatat aaagagttcc
     4261 tgtttccctt cactgggcct aagcctttct gcattacact tgaagccttc agtcatttcc
     4321 taccacttat tacaacagtg aggactggat tcttgatgtc ttaatttctc atttatttgt
     4381 ctagaaaatc cataatgata taggacattt ataccgagtg agatcattaa caatgaaatt
     4441 gagagattag agcatcctca ctgggtgatg gtaacaggga atgtagaggg ctgatatctt
     4501 cccctaagag aggcattagg gttagagaga tggggaggga gatatataaa tggagagacc
     4561 gagacacaca gagagaaaga caccgagaaa gtaattatag agaaataagc tggtacgtcc
     4621 agcttcatta ctatcccttg ggctaaccag caagaagatt gtacatcaca gaactggatg
     4681 agccaaacag ccaccatctt tactcttgac taaatggacc tatcaagaat attaaaaagc
     4741 ttggaaatac cctatccact tttgaaaaat tagaattcct ttgcattcag catggactca
     4801 gccaggaatc tatggaggat tttttttttt gcttcatttt ctaaagttgt atttagaaat
     4861 atcttatgta atgtgctttg taaaagaaga tgaattaaaa tgaaattttg tgaaaatatt
     4921 tttgttcaaa gttgtcacag tccaagagga atggtatctt ggaacacaaa ccccttttct
     4981 ctattttaca caatttgagt actctgtcag aaatatcctt agaagacagg aagtaatcca
     5041 ttaaaatctg tgcctgtgaa tttgattttt aaaattgttc gattttacat tcctatcgaa
     5101 gcgtaaaatg ctagttaggt acaaattctt tttttagtgt gaaaaccatt aaattattat
     5161 tattggaa
//
