LOCUS       NP_001129199             665 aa            linear   ROD 27-APR-2025
DEFINITION  SH3 domain-containing kinase-binding protein 1 isoform 1 [Mus
            musculus].
ACCESSION   NP_001129199
VERSION     NP_001129199.1
DBSOURCE    REFSEQ: accession NM_001135727.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 665)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 665)
  AUTHORS   Horak,I.R., Latyshko,N.V., Hudkova,O.O., Tokarchuk,K.O.,
            Kishko,T.O., Yusova,O.I., Drobot,L.B. and Tykhomyrov,A.A.
  TITLE     ADAPTOR PROTEIN Ruk/CIN85REGULATES REDOX BALANCE IN 4T1MOUSE BREAST
            CANCER CELLS EXPOSED TO PLASMIN(OGEN)
  JOURNAL   Exp Oncol 44 (1), 31-38 (2022)
   PUBMED   35548969
  REMARK    GeneRIF: ADAPTOR PROTEIN Ruk/CIN85REGULATES REDOX BALANCE IN
            4T1MOUSE BREAST CANCER CELLS EXPOSED TO PLASMIN(OGEN).
REFERENCE   3  (residues 1 to 665)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 665)
  AUTHORS   Whiley,P.A.F., O'Donnell,L., Moody,S.C., Handelsman,D.J.,
            Young,J.C., Richards,E.A., Almstrup,K., Western,P.S. and
            Loveland,K.L.
  TITLE     Activin A Determines Steroid Levels and Composition in the Fetal
            Testis
  JOURNAL   Endocrinology 161 (7) (2020)
   PUBMED   32274496
REFERENCE   5  (residues 1 to 665)
  AUTHORS   Kong,M.S., Hashimoto-Tane,A., Kawashima,Y., Sakuma,M., Yokosuka,T.,
            Kometani,K., Onishi,R., Carpino,N., Ohara,O., Kurosaki,T.,
            Phua,K.K. and Saito,T.
  TITLE     Inhibition of T cell activation and function by the adaptor protein
            CIN85
  JOURNAL   Sci Signal 12 (567) (2019)
   PUBMED   30723173
  REMARK    GeneRIF: Data show that Cbl-interacting protein of 85 kDa (CIN85)
            limited T cell responses to T cell receptor (TCR) stimulation.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 665)
  AUTHORS   Buchman,V.L., Luke,C., Borthwick,E.B., Gout,I. and Ninkina,N.
  TITLE     Organization of the mouse Ruk locus and expression of isoforms in
            mouse tissues
  JOURNAL   Gene 295 (1), 13-17 (2002)
   PUBMED   12242006
  REMARK    GeneRIF: Analysis of cDNA clones, ESTs and products of RT-PCR
            amplifications with different combinations of primers revealed how
            alternative splicing and promoter usage generate a variety of Ruk
            transcripts and encoded protein isoforms in different mouse
            tissues.
REFERENCE   7  (residues 1 to 665)
  AUTHORS   Soubeyran,P., Kowanetz,K., Szymkiewicz,I., Langdon,W.Y. and
            Dikic,I.
  TITLE     Cbl-CIN85-endophilin complex mediates ligand-induced downregulation
            of EGF receptors
  JOURNAL   Nature 416 (6877), 183-187 (2002)
   PUBMED   11894095
  REMARK    Erratum:[Nature 2002 May 2;417(6884):102]
REFERENCE   8  (residues 1 to 665)
  AUTHORS   Borinstein,S.C., Hyatt,M.A., Sykes,V.W., Straub,R.E., Lipkowitz,S.,
            Boulter,J. and Bogler,O.
  TITLE     SETA is a multifunctional adapter protein with three SH3 domains
            that binds Grb2, Cbl, and the novel SB1 proteins
  JOURNAL   Cell Signal 12 (11-12), 769-779 (2000)
   PUBMED   11152963
REFERENCE   9  (residues 1 to 665)
  AUTHORS   Chen,B., Borinstein,S.C., Gillis,J., Sykes,V.W. and Bogler,O.
  TITLE     The glioma-associated protein SETA interacts with AIP1/Alix and
            ALG-2 and modulates apoptosis in astrocytes
  JOURNAL   J Biol Chem 275 (25), 19275-19281 (2000)
   PUBMED   10858458
REFERENCE   10 (residues 1 to 665)
  AUTHORS   Hyatt,M.A., Sykes,V.W., Boyer,A.D., Arden,K.C. and Bogler,O.
  TITLE     Assignment of seta to distal mouse X chromosome by radiation hybrid
            mapping
  JOURNAL   Cytogenet Cell Genet 89 (3-4), 278 (2000)
   PUBMED   10965144
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK049182.1, BB853873.1, AK080930.1, AK028299.1, AK142295.1 and
            AI447724.1.
            
            Transcript Variant: This variant (1, also known as Ruk1) represents
            the longest transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK049182.1, SRR1660813.93216.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..665
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 73.65 cM"
     Protein         1..665
                     /product="SH3 domain-containing kinase-binding protein 1
                     isoform 1"
                     /note="SH3 domain-containing kinase-binding protein 1;
                     regulator of ubiquitous kinase; SH3-containing, expressed
                     in tumorigenic astrocytes; Ruk(xl) protein; Ruk(l)
                     protein; Ruk(deltaA) protein; Ruk(m1) protein; Ruk(m3)
                     protein; Ruk(h) protein; Ruk(t) protein"
                     /calculated_mol_wt=73197
     Region          3..55
                     /region_name="SH3_CIN85_1"
                     /note="First Src Homology 3 domain (SH3A) of
                     Cbl-interacting protein of 85 kDa; cd12052"
                     /db_xref="CDD:212985"
     Site            order(7..13,17,21..22,34..36,46..47,49,51..52)
                     /site_type="other"
                     /note="putative ubiquitin interaction site [polypeptide
                     binding]"
                     /db_xref="CDD:212985"
     Site            order(8,10,13..14,16..17,34,36,47,51..52,54)
                     /site_type="other"
                     /note="peptide ligand binding site [polypeptide binding]"
                     /db_xref="CDD:212985"
     Region          102..154
                     /region_name="SH3_CIN85_2"
                     /note="Second Src Homology 3 domain (SH3B) of
                     Cbl-interacting protein of 85 kDa; cd12055"
                     /db_xref="CDD:212988"
     Site            order(106..112,116,120..121,133..135,145..146,148,
                     150..151)
                     /site_type="other"
                     /note="putative ubiquitin interaction site [polypeptide
                     binding]"
                     /db_xref="CDD:212988"
     Site            order(107,109,112,116,133..135,146,148,150..151)
                     /site_type="other"
                     /note="putative peptide ligand binding site [polypeptide
                     binding]"
                     /db_xref="CDD:212988"
     Region          271..326
                     /region_name="SH3_CIN85_3"
                     /note="Third Src Homology 3 domain (SH3C) of
                     Cbl-interacting protein of 85 kDa; cd12057"
                     /db_xref="CDD:212990"
     Site            order(275..282,284..285,289..290,303..306,316..317,319,
                     321..322,324)
                     /site_type="other"
                     /note="ubiquitin interaction site [polypeptide binding]"
                     /db_xref="CDD:212990"
     Site            order(276,278,281,285,304..306,317,319,321..322)
                     /site_type="other"
                     /note="putative peptide ligand binding site [polypeptide
                     binding]"
                     /db_xref="CDD:212990"
     CDS             1..665
                     /gene="Sh3kbp1"
                     /gene_synonym="1200007H22Rik; 1700125L08Rik;
                     5830464D22Rik; Cin85; IN85; Ruk; Seta"
                     /coded_by="NM_001135727.2:417..2414"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS53234.1"
                     /db_xref="GeneID:58194"
                     /db_xref="MGI:MGI:1889583"
ORIGIN      
        1 mveaivefdy qaqhddelti svgevitnir kedggwwegq ingrrglfpd nfvreikkdm
       61 kkdllsnkap ekpmhdvssg nallssetil rtnkrgerrr rrcqvafsyl pqnddelelk
      121 vgdiievvge veegwwegvl ngktgmfpsn fikelsgesd elgisqdeql sksslrettg
      181 sesdggdsss tksegangtm ataaiqpkkv kgvgfgdifk dkpiklrprs ievendflpv
      241 ektigkklpp atstpdpskt emdsrtktkd yckvifpyea qnddeltike gdivtlinkd
      301 cidvgwwege lngrrgvfpd nfvkllpsdf dkegnrpkkp pppsapvvkq gagtterkhe
      361 ikkipperpe tlpnrteeke rperepkldl qkpsvpaipp kkprppktns lnrpgalppr
      421 rperpvgplt htrgdspkid lagsalsgil dkdlsdrsnd idlegfdsvi ssteklshpt
      481 tsrpkatgrr ppsqsltsss lsspdifdsp speedkeehi slahrgidvs kktsktvtis
      541 qvsdnktslp pkpgtmaaas sgpaslssva sspmssslgt agqrasspsl fstegkpkme
      601 pavssqaaie elkmqvrelr tiietmkdqq kreikqllse ldeekkirlr lqmevndikk
      661 alqsk
//
