LOCUS       NM_001289709            1857 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus SH3-domain GRB2-like endophilin B2 (Sh3glb2),
            transcript variant 1, mRNA.
ACCESSION   NM_001289709 XM_006497936
VERSION     NM_001289709.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1857)
  AUTHORS   Serfass,J.M., Takahashi,Y., Zhou,Z., Kawasawa,Y.I., Liu,Y.,
            Tsotakos,N., Young,M.M., Tang,Z., Yang,L., Atkinson,J.M.,
            Chroneos,Z.C. and Wang,H.G.
  TITLE     Endophilin B2 facilitates endosome maturation in response to growth
            factor stimulation, autophagy induction, and influenza A virus
            infection
  JOURNAL   J Biol Chem 292 (24), 10097-10111 (2017)
   PUBMED   28455444
  REMARK    GeneRIF: Data (including data from studies in knockout mice)
            suggest that Sh3glb2 regulates trafficking of endocytic vesicles
            and autophagosomes to late endosomes or lysosomes; despite having
            an intracellular localization and tissue distribution similar to
            endophilin B1, endophilin B2 is dispensable for mitochondrial
            apoptosis.
REFERENCE   2  (bases 1 to 1857)
  AUTHORS   Cleland,M.M., Norris,K.L., Karbowski,M., Wang,C., Suen,D.F.,
            Jiao,S., George,N.M., Luo,X., Li,Z. and Youle,R.J.
  TITLE     Bcl-2 family interaction with the mitochondrial morphogenesis
            machinery
  JOURNAL   Cell Death Differ 18 (2), 235-247 (2011)
   PUBMED   20671748
REFERENCE   3  (bases 1 to 1857)
  AUTHORS   Fasso,M., Waitz,R., Hou,Y., Rim,T., Greenberg,N.M., Shastri,N.,
            Fong,L. and Allison,J.P.
  TITLE     SPAS-1 (stimulator of prostatic adenocarcinoma-specific T
            cells)/SH3GLB2: A prostate tumor antigen identified by CTLA-4
            blockade
  JOURNAL   Proc Natl Acad Sci U S A 105 (9), 3509-3514 (2008)
   PUBMED   18303116
  REMARK    GeneRIF: the immunodominant SPAS-1 epitope SNC9-H(8) arose from a
            point mutation in one allele of the gene in transgenic
            adenocarcinoma of mouse prostate tumor cells
REFERENCE   4  (bases 1 to 1857)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY317126.1, CX216029.1, AK152409.1, CB249880.1, EF676083.1 and
            BY651947.1.
            
            On Jan 25, 2014 this sequence version replaced XM_006497936.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK155248.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                BY317126.1         2-11
            11-71               CX216029.1         1-61
            72-950              AK152409.1         2-880
            951-989             CB249880.1         663-701
            990-1825            EF676083.1         951-1786
            1826-1857           BY651947.1         413-444
FEATURES             Location/Qualifiers
     source          1..1857
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 21.6 cM"
     gene            1..1857
                     /gene="Sh3glb2"
                     /gene_synonym="SPAS-1"
                     /note="SH3-domain GRB2-like endophilin B2"
                     /db_xref="GeneID:227700"
                     /db_xref="MGI:MGI:2385131"
     exon            1..174
                     /gene="Sh3glb2"
                     /gene_synonym="SPAS-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             112..1314
                     /gene="Sh3glb2"
                     /gene_synonym="SPAS-1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     SH3-containing protein SH3GLB2; endophilin-B2; stimulator
                     of prostatic adenocarcinoma-specific T-cells-1; SH3
                     domain-containing GRB2-like protein B2"
                     /codon_start=1
                     /product="endophilin-B2 isoform 1"
                     /protein_id="NP_001276638.1"
                     /db_xref="CCDS:CCDS71020.1"
                     /db_xref="GeneID:227700"
                     /db_xref="MGI:MGI:2385131"
                     /translation="MDFNMKKLASDAGIFFTRAVQFTEEKFGQAEKTELDAHFENLLA
                     RADSTKNWTERILRQTEVLLQPNPSARVEEFLYEKLDRKVPSRVTNGELLAQYMAEAA
                     SELGPSTPYGKTLIKVSEAEKRLGAAERDFIHTASLSFLTPLRNFLEGDWKTISKERR
                     LLQNRRLDLDACKARLKKAKAAEAKATTVPDFQETRPRNYILSASASALWNDEVDKAE
                     QELRVAQTEFDRQAEVTRLLLEGISSTHVNHLRCLHEFVKSQTTYYAQCYRHMLDLQK
                     QLGSSQGAIFPGTFVGTTEPASPPLSSTSPTTTAATMPVVPTGAVLAPPEEAALCLEE
                     VAPPASGTRKARVLYDYEAADSSELALLADELITVYSLPGMDPDWLIGERGNKKGKVP
                     VTYLELLS"
     exon            175..316
                     /gene="Sh3glb2"
                     /gene_synonym="SPAS-1"
                     /inference="alignment:Splign:2.1.0"
     exon            317..445
                     /gene="Sh3glb2"
                     /gene_synonym="SPAS-1"
                     /inference="alignment:Splign:2.1.0"
     exon            446..579
                     /gene="Sh3glb2"
                     /gene_synonym="SPAS-1"
                     /inference="alignment:Splign:2.1.0"
     exon            580..672
                     /gene="Sh3glb2"
                     /gene_synonym="SPAS-1"
                     /inference="alignment:Splign:2.1.0"
     exon            673..735
                     /gene="Sh3glb2"
                     /gene_synonym="SPAS-1"
                     /inference="alignment:Splign:2.1.0"
     exon            736..759
                     /gene="Sh3glb2"
                     /gene_synonym="SPAS-1"
                     /inference="alignment:Splign:2.1.0"
     exon            760..849
                     /gene="Sh3glb2"
                     /gene_synonym="SPAS-1"
                     /inference="alignment:Splign:2.1.0"
     exon            850..950
                     /gene="Sh3glb2"
                     /gene_synonym="SPAS-1"
                     /inference="alignment:Splign:2.1.0"
     exon            951..965
                     /gene="Sh3glb2"
                     /gene_synonym="SPAS-1"
                     /inference="alignment:Splign:2.1.0"
     exon            966..1206
                     /gene="Sh3glb2"
                     /gene_synonym="SPAS-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1207..1857
                     /gene="Sh3glb2"
                     /gene_synonym="SPAS-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1805..1810
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sh3glb2"
                     /gene_synonym="SPAS-1"
                     /note="hexamer: AATAAA"
     polyA_site      1825
                     /gene="Sh3glb2"
                     /gene_synonym="SPAS-1"
                     /note="major polyA site"
     polyA_site      1856
                     /gene="Sh3glb2"
                     /gene_synonym="SPAS-1"
ORIGIN      
        1 gagggcgggc gcaggcagca ggtgggcggg gtgcggcggg gtgcgtgagg cggggcgggg
       61 ggctgccggc tgctctgggg ccggcgtggc ggccctgcgt acgggcgcgc catggacttc
      121 aacatgaaga agctggcgtc ggacgcgggc atcttcttca ctcgggcggt gcagttcaca
      181 gaggagaagt ttggccaggc tgagaagacg gagcttgacg cccactttga aaacctccta
      241 gctcgggcag acagcaccaa gaactggaca gagcggatcc tgaggcagac cgaggtgctg
      301 ctgcagccca accccagtgc tcgagtggag gagttcctat atgagaagct ggacagaaag
      361 gtgccctcga gagtcaccaa tggggagctg ctggctcagt acatggcgga ggcagccagc
      421 gagctgggcc ccagcactcc ctacgggaag acgctgatca aggtgtcaga agctgagaag
      481 cgcctcggag cagcagagcg ggatttcatt cacactgcct ccctcagctt cctcacaccc
      541 ctgcggaact tcctagaggg ggactggaaa acgatttcga aggagaggcg gctcctgcag
      601 aaccggcgtc ttgacctgga tgcctgcaaa gcccggctaa agaaggccaa ggcagccgaa
      661 gccaaagcca cgacggtgcc tgactttcag gagactagac ctcgtaatta cattctatcg
      721 gccagcgcct ccgcgctttg gaacgatgaa gtcgacaagg ctgagcagga gcttcgagtg
      781 gcgcagacag agtttgaccg gcaggcagaa gtgacccgtc tcctgctgga ggggatcagc
      841 agtactcatg tgaaccacct tcgctgcctc catgagttcg tcaagtctca gacaacctac
      901 tatgcacagt gctaccgcca catgctggat ctgcagaaac agctaggcag ctcccagggt
      961 gccatatttc caggcacctt cgtgggcacc acagagcctg cctccccacc cctgagcagc
     1021 acctcaccta ccaccactgc ggccaccatg cctgtggtac ctactggggc tgtcttggcc
     1081 cctccagaag aggcagccct ctgcctggag gaggtggctc ccccagccag tgggactcga
     1141 aaggcccggg tgctctacga ctacgaggca gctgacagca gtgagctggc cctgctggct
     1201 gatgagctca tcactgtcta cagcctgcca ggcatggatc ccgactggct cattggtgag
     1261 agaggcaaca agaagggcaa ggttcctgtc acctacctgg aacttctcag ctaagcagcc
     1321 ccttcccagg ctctgccact tagagtcgtc tgctggccac agagctgctt aggataaggg
     1381 acctaaccct tttctggctg tgcccgtcat tcagctatta aagagcccac aagacagaat
     1441 ggccccaggc ccctctgcta gtcctgcttc tgacctgcaa ccctgcacac cccaggcttc
     1501 ccagctccct taaggcagaa gggtcactac atttgacacc accatgggcc caggatatgc
     1561 tggggatgga tgctcttggc atgaaagaac atctgccttc tggctgtgga aggttgaggg
     1621 ggacagcagc acacaggcag ggctaggagt gtggcaggaa accagaaggg tcagccagag
     1681 cagcagcacc aagtgctgcc tcccacttcc ctcatggctc tggctgggca cagtggctac
     1741 agcagtcatt ccttcagttt ctaactaaca ttctgacctc tgcctgtctg cttgctctct
     1801 ggcaaataaa tcctttgtgt gcgaatcagg atctcagtcc atgagccacc ctgaaag
//
