LOCUS       NM_019464               5903 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus SH3-domain GRB2-like B1 (endophilin) (Sh3glb1),
            transcript variant 2, mRNA.
ACCESSION   NM_019464 XM_916027
VERSION     NM_019464.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5903)
  AUTHORS   Touyama,K., Khan,M., Aoki,K., Matsuda,M., Hiura,F., Takakura,N.,
            Matsubara,T., Harada,Y., Hirohashi,Y., Tamura,Y., Gao,J., Mori,K.,
            Kokabu,S., Yasuda,H., Fujita,Y., Watanabe,K., Takahashi,Y., Maki,K.
            and Jimi,E.
  TITLE     Bif-1/Endophilin B1/SH3GLB1 regulates bone homeostasis
  JOURNAL   J Cell Biochem 120 (11), 18793-18804 (2019)
   PUBMED   31243813
  REMARK    GeneRIF: Bif-1/Endophilin B1/SH3GLB1 regulates bone homeostasis.
REFERENCE   2  (bases 1 to 5903)
  AUTHORS   Nakano,Y., Wiechert,S. and Banfi,B.
  TITLE     Overlapping Activities of Two Neuronal Splicing Factors Switch the
            GABA Effect from Excitatory to Inhibitory by Regulating REST
  JOURNAL   Cell Rep 27 (3), 860-871 (2019)
   PUBMED   30995482
REFERENCE   3  (bases 1 to 5903)
  AUTHORS   Wild,F., Khan,M.M., Straka,T. and Rudolf,R.
  TITLE     Progress of endocytic CHRN to autophagic degradation is regulated
            by RAB5-GTPase and T145 phosphorylation of SH3GLB1 at mouse
            neuromuscular junctions in vivo
  JOURNAL   Autophagy 12 (12), 2300-2310 (2016)
   PUBMED   27715385
  REMARK    GeneRIF: SH3GLB1 controls nicotinic acetylcholine receptors
            endocytic trafficking in a phosphorylation- and RAB5-dependent
            manner at steps upstream of autophagosome formation.
REFERENCE   4  (bases 1 to 5903)
  AUTHORS   Liu,Y., Takahashi,Y., Desai,N., Zhang,J., Serfass,J.M., Shi,Y.G.,
            Lynch,C.J. and Wang,H.G.
  TITLE     Bif-1 deficiency impairs lipid homeostasis and causes obesity
            accompanied by insulin resistance
  JOURNAL   Sci Rep 6, 20453 (2016)
   PUBMED   26857140
  REMARK    GeneRIF: These findings thus identify Bif-1 as a novel regulator of
            lipid homeostasis to prevent the pathogenesis of obesity and its
            associated metabolic complications.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5903)
  AUTHORS   Wang,D.B., Kinoshita,Y., Kinoshita,C., Uo,T., Sopher,B.L.,
            Cudaback,E., Keene,C.D., Bilousova,T., Gylys,K., Case,A.,
            Jayadev,S., Wang,H.G., Garden,G.A. and Morrison,R.S.
  TITLE     Loss of endophilin-B1 exacerbates Alzheimer's disease pathology
  JOURNAL   Brain 138 (Pt 7), 2005-2019 (2015)
   PUBMED   25981964
  REMARK    GeneRIF: Our findings suggest that endophilin-B1 is a key mediator
            of a feed-forward mechanism of Alzheimer's disease pathogenesis
REFERENCE   6  (bases 1 to 5903)
  AUTHORS   Powles,N., Babbs,C., Ficker,M., Schimmang,T. and Maconochie,M.
  TITLE     Identification and analysis of genes from the mouse otic vesicle
            and their association with developmental subprocesses through in
            situ hybridization
  JOURNAL   Dev Biol 268 (1), 24-38 (2004)
   PUBMED   15031102
REFERENCE   7  (bases 1 to 5903)
  AUTHORS   Modregger,J., Schmidt,A.A., Ritter,B., Huttner,W.B. and Plomann,M.
  TITLE     Characterization of Endophilin B1b, a brain-specific
            membrane-associated lysophosphatidic acid acyl transferase with
            properties distinct from endophilin A1
  JOURNAL   J Biol Chem 278 (6), 4160-4167 (2003)
   PUBMED   12456676
  REMARK    GeneRIF: characterization of and function at intracellular
            membranes [endophilin B1b]
REFERENCE   8  (bases 1 to 5903)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 5903)
  AUTHORS   Farsad,K., Ringstad,N., Takei,K., Floyd,S.R., Rose,K. and De
            Camilli,P.
  TITLE     Generation of high curvature membranes mediated by direct
            endophilin bilayer interactions
  JOURNAL   J Cell Biol 155 (2), 193-200 (2001)
   PUBMED   11604418
REFERENCE   10 (bases 1 to 5903)
  AUTHORS   Cuddeback,S.M., Yamaguchi,H., Komatsu,K., Miyashita,T., Yamada,M.,
            Wu,C., Singh,S. and Wang,H.G.
  TITLE     Molecular cloning and characterization of Bif-1. A novel Src
            homology 3 domain-containing protein that associates with Bax
  JOURNAL   J Biol Chem 276 (23), 20559-20565 (2001)
   PUBMED   11259440
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC134404.17, AK172959.1, AK052668.1 and AW050200.1.
            
            On Aug 15, 2013 this sequence version replaced NM_019464.2.
            
            Transcript Variant: This variant (2) lacks two alternate in-frame
            exons in the coding region, compared to variant 1. The encoded
            isoform (2) is shorter, compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF263364.1, SRR10223971.4434.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139, SAMN01164140
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-189               AC134404.17        34234-34422
            190-1737            AK172959.1         1-1548
            1738-3979           AC134404.17        63502-65743
            3980-5588           AK052668.1         474-2082
            5589-5894           AW050200.1         17-322              c
            5895-5903           AC134404.17        67659-67667
FEATURES             Location/Qualifiers
     source          1..5903
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 69.0 cM"
     gene            1..5903
                     /gene="Sh3glb1"
                     /gene_synonym="Bif-1; mKIAA0491"
                     /note="SH3-domain GRB2-like B1 (endophilin)"
                     /db_xref="GeneID:54673"
                     /db_xref="MGI:MGI:1859730"
     exon            1..354
                     /gene="Sh3glb1"
                     /gene_synonym="Bif-1; mKIAA0491"
                     /inference="alignment:Splign:2.1.0"
     CDS             283..1380
                     /gene="Sh3glb1"
                     /gene_synonym="Bif-1; mKIAA0491"
                     /note="isoform 2 is encoded by transcript variant 2;
                     endophilin-B1; SH3 domain-containing GRB2-like protein B1"
                     /codon_start=1
                     /product="endophilin-B1 isoform 2"
                     /protein_id="NP_062337.1"
                     /db_xref="CCDS:CCDS17885.1"
                     /db_xref="GeneID:54673"
                     /db_xref="MGI:MGI:1859730"
                     /translation="MNIMDFNVKKLAADAGTFLSRAVQFTEEKLGQAEKTELDAHLEN
                     LLSKAECTKIWTEKIMKQTEVLLQPNPNARIEEFVYEKLDRKAPSRINNPELLGQYMI
                     DAGTEFGPGTAYGNALIKCGETQKRIGTADRELIQTSALNFLTPLRNFIEGDYKTIAK
                     ERKLLQNKRLDLDAAKTRLKKAKAAETKSSSEQELRITQSEFDRQAEITRLLLEGISS
                     THAHHLRCLNDFVEAQMTYYAQCYQYMLDLQKQLGSFPSNYLSNNNQTSGTPVPYALS
                     NAIGPSAQASTGSLVITCPSNLNDLKESSNNRKARVLYDYDAANSTELSLLADEVITV
                     FSVVGMDSDWLMGERGNQKGKVPITYLELLN"
     exon            355..496
                     /gene="Sh3glb1"
                     /gene_synonym="Bif-1; mKIAA0491"
                     /inference="alignment:Splign:2.1.0"
     exon            497..625
                     /gene="Sh3glb1"
                     /gene_synonym="Bif-1; mKIAA0491"
                     /inference="alignment:Splign:2.1.0"
     exon            626..759
                     /gene="Sh3glb1"
                     /gene_synonym="Bif-1; mKIAA0491"
                     /inference="alignment:Splign:2.1.0"
     exon            760..852
                     /gene="Sh3glb1"
                     /gene_synonym="Bif-1; mKIAA0491"
                     /inference="alignment:Splign:2.1.0"
     exon            853..942
                     /gene="Sh3glb1"
                     /gene_synonym="Bif-1; mKIAA0491"
                     /inference="alignment:Splign:2.1.0"
     exon            943..1043
                     /gene="Sh3glb1"
                     /gene_synonym="Bif-1; mKIAA0491"
                     /inference="alignment:Splign:2.1.0"
     exon            1044..1272
                     /gene="Sh3glb1"
                     /gene_synonym="Bif-1; mKIAA0491"
                     /inference="alignment:Splign:2.1.0"
     exon            1273..5903
                     /gene="Sh3glb1"
                     /gene_synonym="Bif-1; mKIAA0491"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1719..1724
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sh3glb1"
                     /gene_synonym="Bif-1; mKIAA0491"
                     /note="hexamer: AATAAA"
     polyA_site      1740
                     /gene="Sh3glb1"
                     /gene_synonym="Bif-1; mKIAA0491"
                     /note="major polyA site"
     regulatory      5874..5879
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sh3glb1"
                     /gene_synonym="Bif-1; mKIAA0491"
                     /note="hexamer: AATAAA"
     polyA_site      5894
                     /gene="Sh3glb1"
                     /gene_synonym="Bif-1; mKIAA0491"
                     /note="major polyA site"
ORIGIN      
        1 cggggccttc ctccggacgc gacctcggtc cccgtggctc gcagctgctc ggcgacgcga
       61 caggcccagc gtgtgagcgg agaggcgcgc gctcgcgggc gcccgccctc ttccctcccc
      121 cgcctccccg ccaggaaacg acagctgcgc ggggctggcg ccgcctcccg ccacctacca
      181 cgtccgcccc gccgtcgccg tcgcccggcg ccccagcccg gccgcggcgc tccccgcctc
      241 cccgctagcg cagccggcgg ctctgcccgg ctgccgcccg gcatgaacat catggatttc
      301 aacgtgaaga agctggcggc cgacgcgggc accttcctca gccgggccgt gcagttcaca
      361 gaagaaaagc ttggccaggc agagaagaca gaactggacg ctcacctgga aaacctcctt
      421 agcaaagctg aatgtaccaa aatatggaca gaaaagataa tgaagcagac cgaagtgctg
      481 ttgcagccaa atccaaatgc caggatagaa gaatttgttt atgagaaact ggatagaaaa
      541 gcaccaagtc gtataaacaa cccggaactt ttgggacaat atatgattga tgcaggaact
      601 gagtttggcc cagggacagc ttatggaaat gcccttatta aatgtggaga aacacagaag
      661 cgaattggaa cagctgaccg agagctgatt caaacatcag ccttaaattt cctcactcct
      721 ttaagaaact ttatagaagg ggattacaaa acaatcgcaa aagaaaggaa actattacag
      781 aataagagac tggatttgga tgctgcaaaa acaagactaa aaaaggcaaa agctgcagaa
      841 actaaaagtt catctgaaca ggaattgaga ataactcaaa gtgaatttga tcgtcaggca
      901 gagattaccc gactcctgct tgagggaatc agcagtacac acgcccatca tctccgctgt
      961 ctgaatgact ttgtagaagc ccagatgact tactatgcac agtgttacca gtatatgcta
     1021 gacctacaga agcaactggg aagttttcca tccaattatc tttctaacaa caatcagacc
     1081 tctgggacac cagtgccata tgctttgtca aatgcaattg gtccttctgc ccaggcttca
     1141 acgggtagcc ttgtaatcac ctgtccttct aacctcaatg accttaaaga atccagcaac
     1201 aacaggaagg ctagggtcct ctatgattat gatgctgcaa atagcactga actgtcactc
     1261 ctggccgatg aggtaatcac tgtgttcagt gtcgttggaa tggactccga ctggctaatg
     1321 ggagagagag gaaatcaaaa gggcaaggtg ccaattacct acttagaact tctcaattaa
     1381 acagggagac cacgagaggt tacccatcac aacaccatat ttatataaat aactctaaag
     1441 caggtttaaa tatcttccaa tgttaatgtc ataagagact gaaaaagaaa aattataagc
     1501 catcagaaac tggccattct gccaataaaa ctgcatggtt aatccttcat tacagaatct
     1561 atgttagcga tttcatgaca ggagtgtttt cttaaacaat tctctttcta ctgaggtttt
     1621 actaacaagc aacttctact tttgagcccc aacttaaaaa tgaaaggatt cttttctact
     1681 gaatttttca ttaacaggaa gctttttctt ttatgcaaaa taaatttatt gtgcatgata
     1741 ccagtgactc atttattaga tacaatagcc aaagaataaa gtaaaaactc ctttttacct
     1801 tgctgcccaa taggaatcag atgacttaaa tactaggcct tactagggtc tcttggcttt
     1861 ggagttttgc ttggtttggg ttgggtttgg tttatttatg tttattacac tactggatag
     1921 tttcttttaa acctgagtct tgaaaagtat taccttattt cataattttg ttaagattgc
     1981 agaacactgg ggacaaattc attcactaag aataatcttc agattattca gttgccaaaa
     2041 tttgatgacc aatcagaatt gcatccattg agaagatact acactacagt aaagatttgt
     2101 tgttgaacaa tgattgtgta taaaatacag attggtgcga cagccttcat tataggccaa
     2161 gtcatgcagt ggatgcagtc tgtcttcagc aggatctttg gttatgtggc gcgcgctctg
     2221 gaggttgcta atgacacatt tggaactaga gaattgctgt gaggaccatg ctatccatca
     2281 gcaaacgttg ctgtgaattg ccagttgagg aattctttgg ttaggtcttc atgtctcact
     2341 cgttcatcat ccatccattc aaaagacatt tattgagggc caggtacttt gttgatcaac
     2401 taagtacacc tctaacagga ttgatattgt gatggaagaa ataaaagtgt tgtgtttagg
     2461 aattacctgg tttgggtctg agaagtcaga agtagaatcc cacgtagaag gaaagacttg
     2521 ttttgggcct agaaccaaca gaacataaaa ttgtccagag taccttagta gcggagtaca
     2581 aaggtgtagt tcacttactc acagagtctt gtaaactttt gagccctaaa gtactattta
     2641 aatagcactt taaagcatcc atttgtgtta agagcttggt aaacatggaa aacttggttc
     2701 ttggtctcag cattaaaaac ccctttctct gcagtcagat aaattcctct gcagttttct
     2761 agttctgtaa gactctgact tacacttgag ttacatactt gagggactcc agagacaact
     2821 gagatgctag tgttctaggg aatcaagtga atgaggtttg ttgttctttt tcttcctcag
     2881 aaaggaagtt ttatagccta aagcgccatc tgttatattt gtccaaaatt aggttttgag
     2941 ggactataga aatttgggtg actttaaaca gcagcttcag ttcagcaaat tcagtttatg
     3001 ggaaatagat cagtgcagga gaaaatataa atatggactg aattggttct ggtttgtatc
     3061 ctcacatatt gggctccctg gagttcaact cagatttaga gctgccattt tttatcagta
     3121 taatgggaat aagcattgtt acctagcagg agactattcc acaagtatta ctttgtgttt
     3181 tgtgctttta ggcaaagacc tggcatatag tacatatgct gtaagcccag atgtcctttt
     3241 cagtccctga cacatgggca gtgaggaaca tgtctgacct ctgtgctgtg cttgccccct
     3301 tcagcccatt ctccacctcc cggaaacccg agcagagcct cctcaccccg cccacactcc
     3361 tcaccccgcc cacactcctc accccgccca cacccctcac cctgccccac acgctcctct
     3421 gtgtaagctc tgtagcagga cccggtgctt ccagcaggag tgctggttac tgaagatgcg
     3481 cttagacaca agaggaccca cccaggctgt agtgctaaga ggagcaaagg cgctttcctt
     3541 gtacctttgt ctattatcga tccaacgtaa tctttaggcc tgctcttttg ttttcatttt
     3601 tttgttttca tgagctttat tgtttggttg ggagttttct ttaattttgg ttttgactta
     3661 aagttatgag tttagttttt gctcacgtaa aggcccaagg aaattgtgta tcatagaaga
     3721 aaactcttag aaaacccatt aattcgtggt gtaattcaaa gttatttaaa taaactcttg
     3781 gcgcctgagc ataattcagt agcacattaa tgagtggagg gtacatatat tcataaaata
     3841 ataaatgaga tgtttatagg ccctctacaa actgaaaaag aagtggattt taactacctt
     3901 tgtccttaaa ggaatctgac ccacatggtt atagttaaaa cattttttca tggtgctaat
     3961 caaaaaaaaa aaaaaaaaat tcgtgttgca ggagatgagg ttcctaaaat gagaatgtac
     4021 ctcactccga tggaacaagg aaaataaggc ctaagccagc atccccaggt tgccacagcc
     4081 catccttcat agcaggaaaa taaggcctaa gccagcatcc ccaggttgcc acagcccatc
     4141 cttcaagcag gagcgaaagg aagctagtgt tagtcaggaa ggatggttct gaggagaagt
     4201 ggcagcgggg aggagagagg gtggcacaga cttgtttatg cagagagctc tcacagagga
     4261 ctgctttgtc acacagtccc agcacctgaa actttgcaat gaactgccta gtggcacaag
     4321 ccagagtgaa gagctgtgga ggggagctcg gctcacagcc agatctgctt cacgccctct
     4381 gcttccctgt gtgcttccct ccctgtcaca tcataaaact atgacgtaag ggaaagttca
     4441 cacgagactt taaaccagcc gtatcagcat tgctgcgaac ttgttgaaaa tgctaattgc
     4501 tgttttcaaa tattctacct tatttatact tttgtctaca cgggcctgtg gattagtagc
     4561 attaatcttc cctgtgaccg ctttttaaat gttttaagac aaaaacctaa ttttactttc
     4621 tttactgtgt tctaactatt aattgtaatt atgttgttat ttttataatt tatttattta
     4681 gcatgtaact gtcactttag aatgtagcct ttctaagata gagactataa ttctgttaat
     4741 cataaatcac tcttagcaca cagcttggct cttatatgct caataaatac ttgttgggta
     4801 aaagggaaaa aaatgctaat acctgtgtct tcccccacaa aacctactga gccaaattct
     4861 ggaagcaggg ccccacagtt gtccaggaag ccatttgcat ggccctgcgg tagtcagttg
     4921 taagaaccac cgcagggccg acagaagtgg ccattcaccc tcaggcacca acgattgaca
     4981 acacttgaac atttcccctt gcctctgtta gccttaccgc caccctcact ggttgaggtc
     5041 ctttcagacc cgtctaagaa gtgggtccga aggtagaagg atacagtcag tgtcagtgag
     5101 gagaggactg cgtagaagag cagggcctgg gtgacaggag tctgggaatg tggacctacc
     5161 tctacagcag tgttctcacc tgtgtcgtat gaccctttca cagggctcgg ctaaggtcat
     5221 cggaaaacac agatatgtat ttacattatg atttgtaaca ggagcgaaat gacagttatg
     5281 aagtaacagg gaaaagaatg ttacggttgg ggtcaccata acatgaggaa ctgtattaga
     5341 gggccacagc gttacacagg ctgagaatca cagctctaaa gaaagtgagc tctaaccacc
     5401 atacttccat acagtgcctt tgaactgggg tttagcttca agacaccctg agaaaccagt
     5461 gaagcagtat tagactaatg tatgcacacc tctgtacctc agtccctaag ctgtaatcta
     5521 actcctacga cagtagactt tttaagaatt gttaatgctt ttttattaat acaagtcata
     5581 atatgctgac aaaaagaaaa attttagagg ttaaaaataa aacatggcct acagttccac
     5641 tatcagagaa gtgctatgac tgaggtggcc tccaggctct ctgcacactt acagattttt
     5701 ttaacgggat caaattgtac atgctgtttt gtaacttttt cactcaacag tcccatgcct
     5761 atcttgctgt gtcatgtgtg tctacatctt ttttaatgga tgcatgatat ttcctcatat
     5821 gtgccacatt ttgttaaact actgttgaat ttttaggttt ccagtttttc actaataaac
     5881 tgctttgaag agcactgtgc tgc
//
