LOCUS       NM_017400               1593 bp    mRNA    linear   ROD 14-JUN-2024
DEFINITION  Mus musculus SH3-domain GRB2-like 3 (Sh3gl3), transcript variant 1,
            mRNA.
ACCESSION   NM_017400
VERSION     NM_017400.8
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1593)
  AUTHORS   Gowrisankaran,S., Houy,S., Del Castillo,J.G.P., Steubler,V.,
            Gelker,M., Kroll,J., Pinheiro,P.S., Schwitters,D., Halbsgut,N.,
            Pechstein,A., van Weering,J.R.T., Maritzen,T., Haucke,V.,
            Raimundo,N., Sorensen,J.B. and Milosevic,I.
  TITLE     Endophilin-A coordinates priming and fusion of neurosecretory
            vesicles via intersectin
  JOURNAL   Nat Commun 11 (1), 1266 (2020)
   PUBMED   32152276
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1593)
  AUTHORS   Watanabe,S., Mamer,L.E., Raychaudhuri,S., Luvsanjav,D., Eisen,J.,
            Trimbuch,T., Sohl-Kielczynski,B., Fenske,P., Milosevic,I.,
            Rosenmund,C. and Jorgensen,E.M.
  TITLE     Synaptojanin and Endophilin Mediate Neck Formation during Ultrafast
            Endocytosis
  JOURNAL   Neuron 98 (6), 1184-1197 (2018)
   PUBMED   29953872
REFERENCE   3  (bases 1 to 1593)
  AUTHORS   Murdoch,J.D., Rostosky,C.M., Gowrisankaran,S., Arora,A.S.,
            Soukup,S.F., Vidal,R., Capece,V., Freytag,S., Fischer,A.,
            Verstreken,P., Bonn,S., Raimundo,N. and Milosevic,I.
  TITLE     Endophilin-A Deficiency Induces the Foxo3a-Fbxo32 Network in the
            Brain and Causes Dysregulation of Autophagy and the
            Ubiquitin-Proteasome System
  JOURNAL   Cell Rep 17 (4), 1071-1086 (2016)
   PUBMED   27720640
REFERENCE   4  (bases 1 to 1593)
  AUTHORS   Yang,Y., Wei,M., Xiong,Y., Du,X., Zhu,S., Yang,L., Zhang,C. and
            Liu,J.J.
  TITLE     Endophilin A1 regulates dendritic spine morphogenesis and stability
            through interaction with p140Cap
  JOURNAL   Cell Res 25 (4), 496-516 (2015)
   PUBMED   25771685
REFERENCE   5  (bases 1 to 1593)
  AUTHORS   Cao,M., Milosevic,I., Giovedi,S. and De Camilli,P.
  TITLE     Upregulation of Parkin in endophilin mutant mice
  JOURNAL   J Neurosci 34 (49), 16544-16549 (2014)
   PUBMED   25471590
REFERENCE   6  (bases 1 to 1593)
  AUTHORS   Lee,C.G., Morse,H.C. 3rd, Kay,B.K. and Kozak,C.A.
  TITLE     Genetic mapping of eight SH3 domain genes on seven mouse
            chromosomes
  JOURNAL   Mamm Genome 10 (4), 402-404 (1999)
   PUBMED   10087302
REFERENCE   7  (bases 1 to 1593)
  AUTHORS   Zechner,U., Scheel,S., Hemberger,M., Hopp,M., Haaf,T., Fundele,R.,
            Wanker,E.E., Lehrach,H., Wedemeyer,N. and Himmelbauer,H.
  TITLE     Characterization of the mouse Src homology 3 domain gene Sh3d2c on
            Chr 7 demonstrates coexpression with huntingtin in the brain and
            identifies the processed pseudogene Sh3d2c-ps1 on Chr 2
  JOURNAL   Genomics 54 (3), 505-510 (1998)
   PUBMED   9878254
REFERENCE   8  (bases 1 to 1593)
  AUTHORS   Micheva,K.D., Kay,B.K. and McPherson,P.S.
  TITLE     Synaptojanin forms two separate complexes in the nerve terminal.
            Interactions with endophilin and amphiphysin
  JOURNAL   J Biol Chem 272 (43), 27239-27245 (1997)
   PUBMED   9341169
REFERENCE   9  (bases 1 to 1593)
  AUTHORS   Hoffman,N.G., Sparks,A.B., Carter,J.M. and Kay,B.K.
  TITLE     Binding properties of SH3 peptide ligands identified from
            phage-displayed random peptide libraries
  JOURNAL   Mol Divers 2 (1-2), 5-12 (1996)
   PUBMED   9238627
REFERENCE   10 (bases 1 to 1593)
  AUTHORS   Sparks,A.B., Hoffman,N.G., McConnell,S.J., Fowlkes,D.M. and
            Kay,B.K.
  TITLE     Cloning of ligand targets: systematic isolation of SH3
            domain-containing proteins
  JOURNAL   Nat Biotechnol 14 (6), 741-744 (1996)
   PUBMED   9630982
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC139213.11, AC175660.3 and AC175489.2.
            
            On Nov 18, 2022 this sequence version replaced NM_017400.7.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC027096.1, U58887.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-179               AC139213.11        74441-74619         c
            180-248             AC175660.3         8809-8877
            249-321             AC175660.3         16957-17029
            322-465             AC175660.3         19450-19593
            466-599             AC175660.3         22538-22671
            600-758             AC175660.3         24804-24962
            759-862             AC175660.3         32732-32835
            863-972             AC175660.3         33698-33807
            973-1593            AC175489.2         4918-5538           c
FEATURES             Location/Qualifiers
     source          1..1593
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 47.15 cM"
     gene            1..1593
                     /gene="Sh3gl3"
                     /gene_synonym="EEN-B2; Sh3d2c; Sh3d2c2; SH3P13"
                     /note="SH3-domain GRB2-like 3"
                     /db_xref="GeneID:20408"
                     /db_xref="MGI:MGI:700011"
     exon            1..179
                     /gene="Sh3gl3"
                     /gene_synonym="EEN-B2; Sh3d2c; Sh3d2c2; SH3P13"
                     /inference="alignment:Splign:2.1.0"
     CDS             135..1178
                     /gene="Sh3gl3"
                     /gene_synonym="EEN-B2; Sh3d2c; Sh3d2c2; SH3P13"
                     /note="isoform 1 is encoded by transcript variant 1;
                     endophilin-A3; endophilin-3; SH3 domain protein 2C; SH3
                     domain-containing GRB2-like protein 3; SH3 domain protein
                     2 C2; endophilin III"
                     /codon_start=1
                     /product="endophilin-A3 isoform 1"
                     /protein_id="NP_059096.3"
                     /db_xref="CCDS:CCDS90263.1"
                     /db_xref="GeneID:20408"
                     /db_xref="MGI:MGI:700011"
                     /translation="MSVAGLKKQFHKASQLFSEKISGAEGTKLDEEFLNMEKKIDITS
                     KAVAEILSKATEYLQPNPAYRAKLGMLNTVSKLRGQVKATGYPQTEGLLGDCMLKYGK
                     ELGEDSAFGNSLVDVGEALKLMAEVKDSLDINVKQTFIDPLQLLQDKDLKEIGHHLRK
                     LEGRRLDYDYKKRRVGKIPEEEIRQAVEKFEESKELAERSMFNFLENDVEQVSQLAVF
                     VEAALDYHRQSTEILQELQSKLELRISLASKVPKREFMPKPVNMSSTDANGVGPSSSS
                     KTPGTDTPSDQPCCRGLYDFEPENEGELGFKEGDIITLTNQIDENWYEGMLRGESGFF
                     PINYVEVIVPLPP"
     exon            180..248
                     /gene="Sh3gl3"
                     /gene_synonym="EEN-B2; Sh3d2c; Sh3d2c2; SH3P13"
                     /inference="alignment:Splign:2.1.0"
     exon            249..321
                     /gene="Sh3gl3"
                     /gene_synonym="EEN-B2; Sh3d2c; Sh3d2c2; SH3P13"
                     /inference="alignment:Splign:2.1.0"
     exon            322..465
                     /gene="Sh3gl3"
                     /gene_synonym="EEN-B2; Sh3d2c; Sh3d2c2; SH3P13"
                     /inference="alignment:Splign:2.1.0"
     exon            466..599
                     /gene="Sh3gl3"
                     /gene_synonym="EEN-B2; Sh3d2c; Sh3d2c2; SH3P13"
                     /inference="alignment:Splign:2.1.0"
     exon            600..758
                     /gene="Sh3gl3"
                     /gene_synonym="EEN-B2; Sh3d2c; Sh3d2c2; SH3P13"
                     /inference="alignment:Splign:2.1.0"
     exon            759..862
                     /gene="Sh3gl3"
                     /gene_synonym="EEN-B2; Sh3d2c; Sh3d2c2; SH3P13"
                     /inference="alignment:Splign:2.1.0"
     exon            863..972
                     /gene="Sh3gl3"
                     /gene_synonym="EEN-B2; Sh3d2c; Sh3d2c2; SH3P13"
                     /inference="alignment:Splign:2.1.0"
     exon            973..1593
                     /gene="Sh3gl3"
                     /gene_synonym="EEN-B2; Sh3d2c; Sh3d2c2; SH3P13"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1574..1579
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sh3gl3"
                     /gene_synonym="EEN-B2; Sh3d2c; Sh3d2c2; SH3P13"
                     /note="hexamer: AATAAA"
     polyA_site      1593
                     /gene="Sh3gl3"
                     /gene_synonym="EEN-B2; Sh3d2c; Sh3d2c2; SH3P13"
                     /note="major polyA site"
ORIGIN      
        1 agtgtgacag cgccgtggcc gtggccgtgg ccgtggggcg cgcggggacc gcccggggtg
       61 cccgctccgc tcagcgtccg ggccgcgtgg cccggcggag ccccgagacc acccccgggc
      121 ggggcgccgc cgcgatgtcg gtggctgggc tcaagaagca gttccacaaa gccagccagc
      181 tgtttagtga aaaaataagt ggtgccgaag gaacgaagct agatgaagaa tttctgaaca
      241 tggaaaagaa aatagatatc accagtaaag ctgttgcaga aatcctttca aaagccacag
      301 agtatctcca acccaatcca gcatacagag ctaagctagg aatgctgaac actgtgtcga
      361 agctccgagg gcaggtgaag gccactggct acccacagac ggaaggcttg ctgggggact
      421 gcatgctgaa gtatggcaag gagctcggag aagactctgc ttttggcaac tcgttggtag
      481 atgttggtga ggccctgaaa ctcatggctg aggtgaaaga ctctctggat attaatgtga
      541 agcaaacttt tattgaccca ctgcagctac tgcaagacaa agatttaaag gagatcgggc
      601 accacctgag aaagctggaa ggccgtcgcc tggattatga ttataaaaag cggcgggtag
      661 gtaagatccc cgaggaagaa atcagacaag cagtagagaa gtttgaagag tcaaaggagt
      721 tggccgaaag gagcatgttt aattttttag aaaatgatgt agagcaagtg agccagctgg
      781 ctgtgtttgt agaggcggca ttagactatc acaggcagtc cacagagatc ctccaggagc
      841 tgcagagcaa gctggagttg cgaatatctc ttgcatccaa agtccccaag cgagaattca
      901 tgccaaagcc tgtgaacatg agttccaccg atgccaatgg ggtcggaccc agctcttcat
      961 caaagacacc aggtactgac actccctcgg accagccctg ctgtcgtggt ctctatgact
     1021 ttgagccaga aaatgaagga gaattaggat ttaaagaagg ggacatcatt acattaacca
     1081 atcagataga tgaaaactgg tatgaaggga tgcttcgtgg ggaatccggc ttcttcccca
     1141 ttaattacgt ggaagtcatt gtgcctttac ctccgtaaat gtgtcttttg gacctaactt
     1201 cagaactgaa atgaattggc accagtgctc tctcagtgtg gtgttctgtg acatcctcgc
     1261 tctctggccc acttaatcac ttttgtatgt gtgttttctt tataatgtat tttgtatcaa
     1321 tttaatttgt ataactgatt tctttgtcct aactcataaa aatagttttc ttcttgttct
     1381 aaaaagtcat tggttaaatg tatttgcttc ctgttgctaa aacgagtaaa ttgcgcccat
     1441 tcgaatggcc tgggtagtcc ttgactgcag tgggaacgca ccctttgcag ccatgaaagc
     1501 taaaggtttt gtttcctgac attattgatg gcctctggtc ttttcctgtt ttaagcttac
     1561 ctgtgaacag cccaataaac atgacacact gta
//
