LOCUS       NM_019535               2837 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus SH3-domain GRB2-like 2 (Sh3gl2), transcript variant 1,
            mRNA.
ACCESSION   NM_019535
VERSION     NM_019535.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2837)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2837)
  AUTHORS   Liu,M., Ling,Y., Zhang,Y., Liu,L., Qiu,Y., Liu,Y. and Yin,Y.
  TITLE     The role of EndophilinA1 in chronic unpredicted mild stress-induced
            depression model mice
  JOURNAL   Int Immunopharmacol 124 (Pt B), 111023 (2023)
   PUBMED   37837716
  REMARK    GeneRIF: The role of EndophilinA1 in chronic unpredicted mild
            stress-induced depression model mice.
REFERENCE   3  (bases 1 to 2837)
  AUTHORS   Cattaneo,P., Hayes,M.G.B., Baumgarten,N., Hecker,D., Peruzzo,S.,
            Aslan,G.S., Kunderfranco,P., Larcher,V., Zhang,L., Contu,R.,
            Fonseca,G., Spinozzi,S., Chen,J., Condorelli,G., Dimmeler,S.,
            Schulz,M.H., Heinz,S., Guimaraes-Camboa,N. and Evans,S.M.
  TITLE     DOT1L regulates chamber-specific transcriptional networks during
            cardiogenesis and mediates postnatal cell cycle withdrawal
  JOURNAL   Nat Commun 13 (1), 7444 (2022)
   PUBMED   36460641
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2837)
  AUTHORS   Yang,Y., Chen,J., Chen,X., Li,D., He,J., Wang,S., Zhao,S., Yang,X.,
            Deng,S., Tong,C., Wang,D., Guo,Z., Li,D., Ma,C., Liang,X., Shi,Y.S.
            and Liu,J.J.
  TITLE     Endophilin A1 drives acute structural plasticity of dendritic
            spines in response to Ca2+/calmodulin
  JOURNAL   J Cell Biol 220 (6) (2021)
   PUBMED   33988695
REFERENCE   5  (bases 1 to 2837)
  AUTHORS   Gowrisankaran,S., Houy,S., Del Castillo,J.G.P., Steubler,V.,
            Gelker,M., Kroll,J., Pinheiro,P.S., Schwitters,D., Halbsgut,N.,
            Pechstein,A., van Weering,J.R.T., Maritzen,T., Haucke,V.,
            Raimundo,N., Sorensen,J.B. and Milosevic,I.
  TITLE     Endophilin-A coordinates priming and fusion of neurosecretory
            vesicles via intersectin
  JOURNAL   Nat Commun 11 (1), 1266 (2020)
   PUBMED   32152276
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2837)
  AUTHORS   Lee,C.G., Morse,H.C. 3rd, Kay,B.K. and Kozak,C.A.
  TITLE     Genetic mapping of eight SH3 domain genes on seven mouse
            chromosomes
  JOURNAL   Mamm Genome 10 (4), 402-404 (1999)
   PUBMED   10087302
REFERENCE   7  (bases 1 to 2837)
  AUTHORS   Micheva,K.D., Kay,B.K. and McPherson,P.S.
  TITLE     Synaptojanin forms two separate complexes in the nerve terminal.
            Interactions with endophilin and amphiphysin
  JOURNAL   J Biol Chem 272 (43), 27239-27245 (1997)
   PUBMED   9341169
REFERENCE   8  (bases 1 to 2837)
  AUTHORS   Micheva,K.D., Ramjaun,A.R., Kay,B.K. and McPherson,P.S.
  TITLE     SH3 domain-dependent interactions of endophilin with amphiphysin
  JOURNAL   FEBS Lett 414 (2), 308-312 (1997)
   PUBMED   9315708
  REMARK    Erratum:[FEBS Lett 1997 Dec 8;419(1):150]
REFERENCE   9  (bases 1 to 2837)
  AUTHORS   Hoffman,N.G., Sparks,A.B., Carter,J.M. and Kay,B.K.
  TITLE     Binding properties of SH3 peptide ligands identified from
            phage-displayed random peptide libraries
  JOURNAL   Mol Divers 2 (1-2), 5-12 (1996)
   PUBMED   9238627
REFERENCE   10 (bases 1 to 2837)
  AUTHORS   Sparks,A.B., Hoffman,N.G., McConnell,S.J., Fowlkes,D.M. and
            Kay,B.K.
  TITLE     Cloning of ligand targets: systematic isolation of SH3
            domain-containing proteins
  JOURNAL   Nat Biotechnol 14 (6), 741-744 (1996)
   PUBMED   9630982
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL806524.10 and AL805970.8.
            
            On Mar 27, 2023 this sequence version replaced NM_019535.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC018385.1, AK044370.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-196               AL806524.10        111872-112067
            197-265             AL805970.8         9299-9367
            266-338             AL805970.8         17502-17574
            339-482             AL805970.8         38516-38659
            483-616             AL805970.8         39569-39702
            617-775             AL805970.8         41427-41585
            776-879             AL805970.8         43580-43683
            880-1010            AL805970.8         47965-48095
            1011-2837           AL805970.8         49729-51555
FEATURES             Location/Qualifiers
     source          1..2837
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 40.23 cM"
     gene            1..2837
                     /gene="Sh3gl2"
                     /gene_synonym="9530001L19Rik; B930049H17Rik; EEN-B1; EEN1;
                     Sh3d2a; SH3PA"
                     /note="SH3-domain GRB2-like 2"
                     /db_xref="GeneID:20404"
                     /db_xref="MGI:MGI:700009"
     exon            1..196
                     /gene="Sh3gl2"
                     /gene_synonym="9530001L19Rik; B930049H17Rik; EEN-B1; EEN1;
                     Sh3d2a; SH3PA"
                     /inference="alignment:Splign:2.1.0"
     CDS             152..1210
                     /gene="Sh3gl2"
                     /gene_synonym="9530001L19Rik; B930049H17Rik; EEN-B1; EEN1;
                     Sh3d2a; SH3PA"
                     /note="isoform 1 is encoded by transcript variant 1;
                     endophilin-A1; SH3p4; endophilin-1; SH3 domain-containing
                     GRB2-like protein 2; SH3 domain protein 2A; endophilin I"
                     /codon_start=1
                     /product="endophilin-A1 isoform 1"
                     /protein_id="NP_062408.2"
                     /db_xref="CCDS:CCDS18303.1"
                     /db_xref="GeneID:20404"
                     /db_xref="MGI:MGI:700009"
                     /translation="MSVAGLKKQFHKATQKVSEKVGGAEGTKLDDDFKEMERKVDVTS
                     RAVMEIMTKTIEYLQPNPASRAKLSMINTMSKIRGQEKGPGYPQAEALLAEAMLKFGR
                     ELGDDCNFGPALGEVGEAMRELSEVKDSLDMEVKQNFIDPLQNLHDKDLREIQHHLKK
                     LEGRRLDFDYKKKRQGKIPDEELRQALEKFDESKEIAESSMFNLLEMDIEQVSQLSAL
                     VQAQLEYHKQAVQILQQVTVRLEERIRQASSQPRREYQPKPRMSLEFATGDSTQPNGG
                     LSHTGTPKPPGVQMDQPCCRALYDFEPENEGELGFKEGDIITLTNQIDENWYEGMLHG
                     QSGFFPINYVEILVALPH"
     exon            197..265
                     /gene="Sh3gl2"
                     /gene_synonym="9530001L19Rik; B930049H17Rik; EEN-B1; EEN1;
                     Sh3d2a; SH3PA"
                     /inference="alignment:Splign:2.1.0"
     exon            266..338
                     /gene="Sh3gl2"
                     /gene_synonym="9530001L19Rik; B930049H17Rik; EEN-B1; EEN1;
                     Sh3d2a; SH3PA"
                     /inference="alignment:Splign:2.1.0"
     exon            339..482
                     /gene="Sh3gl2"
                     /gene_synonym="9530001L19Rik; B930049H17Rik; EEN-B1; EEN1;
                     Sh3d2a; SH3PA"
                     /inference="alignment:Splign:2.1.0"
     exon            483..616
                     /gene="Sh3gl2"
                     /gene_synonym="9530001L19Rik; B930049H17Rik; EEN-B1; EEN1;
                     Sh3d2a; SH3PA"
                     /inference="alignment:Splign:2.1.0"
     exon            617..775
                     /gene="Sh3gl2"
                     /gene_synonym="9530001L19Rik; B930049H17Rik; EEN-B1; EEN1;
                     Sh3d2a; SH3PA"
                     /inference="alignment:Splign:2.1.0"
     exon            776..879
                     /gene="Sh3gl2"
                     /gene_synonym="9530001L19Rik; B930049H17Rik; EEN-B1; EEN1;
                     Sh3d2a; SH3PA"
                     /inference="alignment:Splign:2.1.0"
     exon            880..1010
                     /gene="Sh3gl2"
                     /gene_synonym="9530001L19Rik; B930049H17Rik; EEN-B1; EEN1;
                     Sh3d2a; SH3PA"
                     /inference="alignment:Splign:2.1.0"
     exon            1011..2837
                     /gene="Sh3gl2"
                     /gene_synonym="9530001L19Rik; B930049H17Rik; EEN-B1; EEN1;
                     Sh3d2a; SH3PA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2815..2820
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sh3gl2"
                     /gene_synonym="9530001L19Rik; B930049H17Rik; EEN-B1; EEN1;
                     Sh3d2a; SH3PA"
                     /note="hexamer: AATAAA"
     polyA_site      2837
                     /gene="Sh3gl2"
                     /gene_synonym="9530001L19Rik; B930049H17Rik; EEN-B1; EEN1;
                     Sh3d2a; SH3PA"
                     /note="major polyA site"
ORIGIN      
        1 agggtgtctc tccgcacaag cccgcgtccc gcgccgcgcc cccgcgccag cagctcccgc
       61 ggtcgcacga ccagcggcgg cccggcgacc ccagccgcct ctccgcatct gcatctgcat
      121 ctgccggccg cgcagcctcc cgcatcccat catgtcggtg gcagggctga agaagcagtt
      181 ccacaaagcc actcagaaag tgagtgagaa ggtgggagga gcggaaggca ccaagctcga
      241 tgatgacttc aaagagatgg agaggaaagt ggatgtcacc agcagggctg tgatggagat
      301 aatgacaaaa acgattgaat acctccaacc caatccagct tccagggcta agctcagtat
      361 gatcaacacc atgtcgaaaa tccgcggcca agagaagggg ccaggctacc ctcaggcgga
      421 agcactgctg gcagaggcca tgctcaagtt cggcagggag ctgggtgatg attgcaactt
      481 tggtcctgct ctcggtgagg tgggagaagc catgagggag ctctcggagg tcaaggactc
      541 attggacatg gaagtgaagc agaatttcat cgaccccctt cagaatcttc atgacaagga
      601 tctgagggag attcagcatc atctgaaaaa gctggaaggc cgacgcttag actttgatta
      661 taagaagaag cgacaaggca agattccaga tgaagaactc cgccaagctc tggagaaatt
      721 cgatgagtct aaagaaatcg ccgagtcgag catgttcaac ctcttggaga tggatataga
      781 acaggtgagc cagctctccg cacttgttca ggctcagctg gagtaccaca agcaggcagt
      841 gcagatcctg cagcaggtca ctgtcagact ggaagaaaga ataagacaag cttcatctca
      901 gccaagaagg gaatatcagc ccaaaccacg gatgagccta gagtttgcca ctggagacag
      961 tactcagccc aacgggggtc tctcccacac aggcacaccc aaacctccag gtgtccaaat
     1021 ggatcagccc tgctgccgag ctctgtatga ctttgaacct gaaaatgaag gggaattggg
     1081 ttttaaagag ggcgatatca tcacactcac taatcagatt gacgagaact ggtatgaggg
     1141 gatgcttcat ggccagtctg gctttttccc catcaactat gtagaaattc tggttgctct
     1201 gccccattag gatcctgtgc tggctggctc acctccttct gacccagata gttaagttta
     1261 accactgctt tggtaatgct gcttccaata catcacgaat gcaggccgca gtggatgagt
     1321 caccaagccc acacgtgccc tgggttgacc cgtgtgctcc tccaggagac gcggtgatag
     1381 atggtatctt ccaaggccag tgggcctggt acatgcttta aaacaccatc tgagactagc
     1441 caggagtccc agaactggct tcacagttct caggaggctg tggttcctgg taacatgcct
     1501 gtgaaccaca tggcagaaaa actctcctca ctgaagatat tgtctctcac ccaggggcca
     1561 tctcaaggtc tccagttctc catttacaga ggagaaagtc ctttttgttg cactttccct
     1621 tcctaaatat gtgagtcaca gaattgttgg caaaaacatc ccctcaccag caagatgtct
     1681 gctggtttaa gcaacttggt ctcttgatgc cattagcaaa agtattaatt gtccaaagca
     1741 cctttgttca ctaatatcta tctatctatc tatctatcta tctatctatc tatctatcta
     1801 tctatctatc tatcatctat ctacctacct atctacctat catctatcta tctatcatct
     1861 attatctatc tatctatcta tctatctatc tatctatcta tctatccatc tatctatcca
     1921 tcatctatct acctacctat ctactatcca tctatctatc tatccatcat ctatctacct
     1981 acctatctac tatccatcca tttatctatc tatctatcta tctatctatc tatctatctc
     2041 cctcatactt ctgagacatg gccagttttc ttccctccct gctgttaagc acttggcaga
     2101 tgaggggggg ggtcccattt atttctgagt gagatggtga gcaatctgta tgttggctga
     2161 aaagaaaaaa aaatctccag tctgaattgg gaagaaatct ggtctctaag ctcagattcc
     2221 ttgctgtaca gaagctgtgt atatacgtag cccgtttctg aagggtacag gaagggggca
     2281 cggctgtctt cccttctctg tttacttacc caggaatcag tccattccct gagtcccttt
     2341 accacaaaga cgtaggagag aaacactagt aagcatttcc cactccatag aacaagacag
     2401 tgagcatcgc tccttcccac gtttacttgt ttgtgttcct tgaacatcat ttgtgcatat
     2461 tctgccctca atgaggacca aataaagatg atttttgtgc ttagcagttt aaggtatgtg
     2521 gctgcatatg caaacccctt ttccactcca gtcattactt tgaacgcctc ccttcctcat
     2581 tttgtgtgta cagtgctgtg tacgctgatc agtgttgggt tttcgttttg ttctcctttc
     2641 agttatggaa gtcccgatag gcacccagag ttctatttat ctagctgtac aggctccttc
     2701 agaggtttag cgtgctgctt ccgatatgcc acttgcggta gtggatcgtg tggagtgaaa
     2761 ggcaaatctt cctgcttaat gtataaactc accacgggaa gcactgctgt ttccaataaa
     2821 cattgctgaa gacgaaa
//
