LOCUS       NM_013664               2089 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus SH3-domain GRB2-like 1 (Sh3gl1), transcript variant 1,
            mRNA.
ACCESSION   NM_013664
VERSION     NM_013664.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2089)
  AUTHORS   Yu,Y.G., Han,J.H., Xue,H.X., Li,W.Z., Wu,W.N. and Yin,Y.Y.
  TITLE     The variations of endophilin A2-FoxO3a-autophagy signal in
            angiotensin II-induced dopaminergic neuron injury mouse model and
            by biochanin A
  JOURNAL   Can J Physiol Pharmacol 99 (12), 1298-1307 (2021)
   PUBMED   34310897
  REMARK    GeneRIF: The variations of endophilin A2-FoxO3a-autophagy signal in
            angiotensin II-induced dopaminergic neuron injury mouse model and
            by biochanin A.
REFERENCE   2  (bases 1 to 2089)
  AUTHORS   Liu,Y., Hu,R., Shen,H., Mo,Q., Wang,X., Zhang,G., Li,S., Liang,G.,
            Hou,N. and Luo,J.
  TITLE     Endophilin A2-mediated alleviation of endoplasmic reticulum
            stress-induced cardiac injury involves the suppression of
            ERO1alpha/IP3R signaling pathway
  JOURNAL   Int J Biol Sci 17 (13), 3672-3688 (2021)
   PUBMED   34512174
  REMARK    GeneRIF: Endophilin A2-mediated alleviation of endoplasmic
            reticulum stress-induced cardiac injury involves the suppression of
            ERO1alpha/IP3R signaling pathway.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2089)
  AUTHORS   Norin,U., Rintisch,C., Meng,L., Forster,F., Ekman,D., Tuncel,J.,
            Klocke,K., Backlund,J., Yang,M., Bonner,M.Y., Lahore,G.F.,
            James,J., Shchetynsky,K., Bergquist,M., Gjertsson,I., Hubner,N.,
            Backdahl,L. and Holmdahl,R.
  TITLE     Endophilin A2 deficiency protects rodents from autoimmune arthritis
            by modulating T cell activation
  JOURNAL   Nat Commun 12 (1), 610 (2021)
   PUBMED   33504785
  REMARK    GeneRIF: Endophilin A2 deficiency protects rodents from autoimmune
            arthritis by modulating T cell activation.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2089)
  AUTHORS   Gowrisankaran,S., Houy,S., Del Castillo,J.G.P., Steubler,V.,
            Gelker,M., Kroll,J., Pinheiro,P.S., Schwitters,D., Halbsgut,N.,
            Pechstein,A., van Weering,J.R.T., Maritzen,T., Haucke,V.,
            Raimundo,N., Sorensen,J.B. and Milosevic,I.
  TITLE     Endophilin-A coordinates priming and fusion of neurosecretory
            vesicles via intersectin
  JOURNAL   Nat Commun 11 (1), 1266 (2020)
   PUBMED   32152276
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2089)
  AUTHORS   Genet,G., Boye,K., Mathivet,T., Ola,R., Zhang,F., Dubrac,A., Li,J.,
            Genet,N., Henrique Geraldo,L., Benedetti,L., Kunzel,S.,
            Pibouin-Fragner,L., Thomas,J.L. and Eichmann,A.
  TITLE     Endophilin-A2 dependent VEGFR2 endocytosis promotes sprouting
            angiogenesis
  JOURNAL   Nat Commun 10 (1), 2350 (2019)
   PUBMED   31138815
  REMARK    GeneRIF: Endophilin-A2 is a critical mediator of endothelial cell
            migration and sprouting angiogenesis. ENDOA2 deficiency reduces
            VEGFR2 internalization and inhibits downstream activation of the
            signaling effector PAK but not ERK, thereby affecting front-rear
            polarity and migration but not proliferation or survival.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2089)
  AUTHORS   Lee,C.G., Morse,H.C. 3rd, Kay,B.K. and Kozak,C.A.
  TITLE     Genetic mapping of eight SH3 domain genes on seven mouse
            chromosomes
  JOURNAL   Mamm Genome 10 (4), 402-404 (1999)
   PUBMED   10087302
REFERENCE   7  (bases 1 to 2089)
  AUTHORS   Torrey,T., Kim,W., Morse,H.C. 3rd and Kozak,C.A.
  TITLE     Cloning, expression and genetic mapping of the mouse SH3 domain
            protein, SH3D2B
  JOURNAL   Mamm Genome 9 (1), 74-75 (1998)
   PUBMED   9434950
REFERENCE   8  (bases 1 to 2089)
  AUTHORS   Micheva,K.D., Kay,B.K. and McPherson,P.S.
  TITLE     Synaptojanin forms two separate complexes in the nerve terminal.
            Interactions with endophilin and amphiphysin
  JOURNAL   J Biol Chem 272 (43), 27239-27245 (1997)
   PUBMED   9341169
REFERENCE   9  (bases 1 to 2089)
  AUTHORS   Hoffman,N.G., Sparks,A.B., Carter,J.M. and Kay,B.K.
  TITLE     Binding properties of SH3 peptide ligands identified from
            phage-displayed random peptide libraries
  JOURNAL   Mol Divers 2 (1-2), 5-12 (1996)
   PUBMED   9238627
REFERENCE   10 (bases 1 to 2089)
  AUTHORS   Sparks,A.B., Hoffman,N.G., McConnell,S.J., Fowlkes,D.M. and
            Kay,B.K.
  TITLE     Cloning of ligand targets: systematic isolation of SH3
            domain-containing proteins
  JOURNAL   Nat Biotechnol 14 (6), 741-744 (1996)
   PUBMED   9630982
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CT009719.10, AK162715.1 and AI846378.1.
            
            On Nov 16, 2011 this sequence version replaced NM_013664.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U58885.1, AK154836.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-73                CT009719.10        80753-80825         c
            74-2074             AK162715.1         2-2002
            2075-2089           AI846378.1         1-15                c
FEATURES             Location/Qualifiers
     source          1..2089
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 29.11 cM"
     gene            1..2089
                     /gene="Sh3gl1"
                     /gene_synonym="EEN; Sh3d2b; SH3P8"
                     /note="SH3-domain GRB2-like 1"
                     /db_xref="GeneID:20405"
                     /db_xref="MGI:MGI:700010"
     exon            1..223
                     /gene="Sh3gl1"
                     /gene_synonym="EEN; Sh3d2b; SH3P8"
                     /inference="alignment:Splign:2.1.0"
     CDS             179..1285
                     /gene="Sh3gl1"
                     /gene_synonym="EEN; Sh3d2b; SH3P8"
                     /note="isoform 1 is encoded by transcript variant 1;
                     endophilin II; endophilin-A2; endophilin-2; SH3
                     domain-containing GRB2-like protein 1; SH3 domain protein
                     2B"
                     /codon_start=1
                     /product="endophilin-A2 isoform 1"
                     /protein_id="NP_038692.1"
                     /db_xref="CCDS:CCDS28891.1"
                     /db_xref="GeneID:20405"
                     /db_xref="MGI:MGI:700010"
                     /translation="MSVAGLKKQFYKASQLVSEKVGGAEGTKLDDDFKDMEKKVDVTS
                     KAVAEVLVRTIEYLQPNPASRAKLTMLNTVSKIRGQVKNPGYPQSEGLLGECMVRHGK
                     ELGGESNFGDALLDAGESMKRLAEVKDSLDIEVKQNFIDPLQNLCDKDLKEIQHHLKK
                     LEGRRLDFDYKKKRQGKIPDEELRQALEKFEESKEVAETSMHNLLETDIEQVSQLSAL
                     VDAQLDYHRQAVQILEELADKLKRRVREASSRPKREFKPRPREPFELGELEQPNGGFP
                     CAPAPKITASSSFRSSDKPIRMPSKSMPPLDQPSCKALYDFEPENDGELGFREGDLIT
                     LTNQIDENWYEGMLHGQSGFFPLSYVQVLVPLPQ"
     exon            224..292
                     /gene="Sh3gl1"
                     /gene_synonym="EEN; Sh3d2b; SH3P8"
                     /inference="alignment:Splign:2.1.0"
     exon            293..365
                     /gene="Sh3gl1"
                     /gene_synonym="EEN; Sh3d2b; SH3P8"
                     /inference="alignment:Splign:2.1.0"
     exon            366..509
                     /gene="Sh3gl1"
                     /gene_synonym="EEN; Sh3d2b; SH3P8"
                     /inference="alignment:Splign:2.1.0"
     exon            510..643
                     /gene="Sh3gl1"
                     /gene_synonym="EEN; Sh3d2b; SH3P8"
                     /inference="alignment:Splign:2.1.0"
     exon            644..802
                     /gene="Sh3gl1"
                     /gene_synonym="EEN; Sh3d2b; SH3P8"
                     /inference="alignment:Splign:2.1.0"
     exon            803..906
                     /gene="Sh3gl1"
                     /gene_synonym="EEN; Sh3d2b; SH3P8"
                     /inference="alignment:Splign:2.1.0"
     exon            907..1031
                     /gene="Sh3gl1"
                     /gene_synonym="EEN; Sh3d2b; SH3P8"
                     /inference="alignment:Splign:2.1.0"
     exon            1032..1088
                     /gene="Sh3gl1"
                     /gene_synonym="EEN; Sh3d2b; SH3P8"
                     /inference="alignment:Splign:2.1.0"
     exon            1089..2075
                     /gene="Sh3gl1"
                     /gene_synonym="EEN; Sh3d2b; SH3P8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2054..2059
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sh3gl1"
                     /gene_synonym="EEN; Sh3d2b; SH3P8"
                     /note="hexamer: ATTAAA"
     polyA_site      2075
                     /gene="Sh3gl1"
                     /gene_synonym="EEN; Sh3d2b; SH3P8"
                     /note="major polyA site"
ORIGIN      
        1 gtaatatccc ggccgcgcgt gcgcgctagc cggccgaggt ggcttcgggg cgggggcgca
       61 gagctggcaa gctgatttgg cggtggcggc gccgacctgc gcgcggagga aagaagtcgg
      121 ttcggcggcg ccggcggaaa ccggagttcg agcgggaggc ctgacggcgg caggcggcat
      181 gtcggtggcg gggctgaaga agcagttcta caaggcgagc cagctggtca gcgagaaggt
      241 tggtggggcc gaagggacca aactggatga tgactttaaa gatatggaaa agaaggtgga
      301 tgtcaccagc aaggccgtgg cagaggtgct ggtcagaacc atagaatatc tgcagcctaa
      361 cccagcctcg agagccaagc tgactatgct gaacaccgta tccaagatcc ggggccaagt
      421 gaagaaccct ggctacccac agtcagaggg tctgttggga gagtgcatgg ttcgccatgg
      481 caaggaacta ggtggagagt ccaacttcgg tgatgccctg ctagatgcag gtgagtccat
      541 gaagcgcctg gctgaggtga aggactcact ggacatcgag gtcaagcaga acttcattga
      601 cccactacag aacctgtgtg acaaggatct gaaggagatc cagcaccacc tgaagaaatt
      661 ggagggccgc cgccttgact ttgactacaa gaagaagcgc cagggcaaga tccccgatga
      721 ggagctgcgc caggccctag agaagttcga ggagtccaag gaggtggcgg agaccagtat
      781 gcacaacctc ctggagactg atatagagca ggtgagccag ctctcggccc tggtggatgc
      841 ccagctggac taccaccggc aggcagtgca gatcctggag gagctggctg acaagctgaa
      901 gcgcagggtt cgggaagcct cctcacgccc caagcgggag ttcaagcccc ggccccggga
      961 gccctttgag cttggagagc tggagcagcc caatggggga ttcccctgtg ccccagcacc
     1021 taagatcaca gcctcctcat catttagatc gtcagacaag cccatcagga tgcccagcaa
     1081 gagcatgcca cccctggacc agccaagctg caaggcgctt tatgattttg agccagagaa
     1141 tgatggcgag ctgggcttcc gtgaggggga cctcatcacg cttaccaacc agatcgacga
     1201 gaactggtat gaggggatgc tgcacggcca atcaggcttc ttcccactca gctacgtgca
     1261 ggtgctggtg cctctgcctc agtgactggg cctttacacc gctgccagtc acagtgcagc
     1321 agcagtctaa tgccaaggtg ctctagaaac actaatgttc ctccaggggg gactcctccc
     1381 cactccctca gccctggggc ccccctatcc taagactcgg aaaggcccac cctgaggttc
     1441 tattgccttc ctggtggtat cagcttccag ctgtttcaac ccttcccagc ccgttgctgg
     1501 cgatgggccc atgccccctc tccaggctct ctagaggcag gcaggtcctt ggaatcccca
     1561 gcctgcaagc agaggctggc cagctcccca gctcagcaca cagagacacc tggcacctgc
     1621 tgctcatgaa gaagtgcaca aggcacaaat gtgtacactt cccatgggac cacagaccca
     1681 gctcagctct gttgaagacc aagcacaaag gccttgaaga gtggacattc ccaggtccct
     1741 ggcaccttcc cttgagccag ctccattgct acttattcat gtgactgaag ctgaccacag
     1801 gcagctggca ggtccttttt tcaaccagca ggctaggctg gccatagacc cagctctgcc
     1861 tcaccctgcc atgttccagt aatggaggcc tccagcctgg gctctattac attcttctct
     1921 acagctgccc cataacccgt ggcttatccc tggcacgtgg ggccacaccc cacgccccct
     1981 ggataggcaa cactgtcctg ctccagcctg tgctgaaatg aactgtactc ctaatttttt
     2041 tttaaaaaaa agtattaaat atctctttct atataaaaaa aaaaaaaaa
//
