LOCUS       NM_001162533            2234 bp    mRNA    linear   ROD 26-JUN-2024
DEFINITION  Mus musculus SH3 domain containing 21 (Sh3d21), transcript variant
            1, mRNA.
ACCESSION   NM_001162533
VERSION     NM_001162533.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2234)
  AUTHORS   Nguyen,T.T.T., Tokuhiro,K., Shimada,K., Wang,H., Mashiko,D.,
            Tonai,S., Kiyozumi,D. and Ikawa,M.
  TITLE     Gene-deficient mouse model established by CRISPR/Cas9 system
            reveals 15 reproductive organ-enriched genes dispensable for male
            fertility
  JOURNAL   Front Cell Dev Biol 12, 1411162 (2024)
   PUBMED   38835510
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2234)
  AUTHORS   Inoue,K., Hirose,M., Inoue,H., Hatanaka,Y., Honda,A., Hasegawa,A.,
            Mochida,K. and Ogura,A.
  TITLE     The Rodent-Specific MicroRNA Cluster within the Sfmbt2 Gene Is
            Imprinted and Essential for Placental Development
  JOURNAL   Cell Rep 19 (5), 949-956 (2017)
   PUBMED   28467908
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL731780.6.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC019568.1, AK155132.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-117               AL731780.6         65051-65167         c
            118-275             AL731780.6         64792-64949         c
            276-339             AL731780.6         64628-64691         c
            340-458             AL731780.6         64279-64397         c
            459-549             AL731780.6         64002-64092         c
            550-605             AL731780.6         63794-63849         c
            606-651             AL731780.6         63561-63606         c
            652-752             AL731780.6         63349-63449         c
            753-839             AL731780.6         63161-63247         c
            840-882             AL731780.6         62294-62336         c
            883-976             AL731780.6         54167-54260         c
            977-1029            AL731780.6         54032-54084         c
            1030-1124           AL731780.6         53850-53944         c
            1125-1981           AL731780.6         52843-53699         c
            1982-2039           AL731780.6         52703-52760         c
            2040-2234           AL731780.6         52428-52622         c
FEATURES             Location/Qualifiers
     source          1..2234
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 59.97 cM"
     gene            1..2234
                     /gene="Sh3d21"
                     /gene_synonym="1700029G01Rik"
                     /note="SH3 domain containing 21"
                     /db_xref="GeneID:66938"
                     /db_xref="MGI:MGI:1914188"
     exon            1..117
                     /gene="Sh3d21"
                     /gene_synonym="1700029G01Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             114..2111
                     /gene="Sh3d21"
                     /gene_synonym="1700029G01Rik"
                     /note="isoform 1 is encoded by transcript variant 1; SH3
                     domain-containing protein C1orf113 homolog; SH3
                     domain-containing protein 21"
                     /codon_start=1
                     /product="SH3 domain-containing protein 21 isoform 1"
                     /protein_id="NP_001156005.1"
                     /db_xref="CCDS:CCDS51301.1"
                     /db_xref="GeneID:66938"
                     /db_xref="MGI:MGI:1914188"
                     /translation="MEVLVLARYRAQTEDELSLAPGDVIRQVCAGPARGWLLGELRGR
                     RGRFPKRLVQEIPEALRGVTESRPRFPRRSRRHPINSRDPQRWCRVNFNYSPEQADEL
                     TLQTGEILEVIKEIEDGWWLGEKNGQLGAFPSNFVELLDSGPPSLGNTDIPPITPNSQ
                     RPPKLSNLTYDSPPDYLRTVSCPETCRVLFDYQPEAPDELALQKGDLVKVLRKTTEDK
                     GWWEGECQGRRGVFPDNFVIPPPPIRKLIPRKIISRESAPIKETKKLMPKSSLPTVKK
                     LAAAASAPGRAKTLSTPSGDSQKRPSRNSGFNGSCLNGGPRQPGRKGSRTQASQQHSA
                     SSQEDEQKSPGKGPSRSKTPTPEKTRLPDKVLAPETIPAPDKVSIPKDPVPKKAPDSD
                     KIPATEDTTLDKAGTPESTLSGNKPAKDEALDLKMALHEDTAPALVKILTPEHMIFKK
                     EPSRDNDQCQHLPQGGSTQRPESPAPSNNIQVPGEYSPPPDSSERSCCRVRQVNGSFP
                     AQSKAEDVSAMEEANFLEEPLAKDERTLNKALPKKLPSERAGPQKQVLPQESAPTPQV
                     PHTIQQMPVPEEAPTLHPLTPLTSPKSKNDRMDVLESLKEEVGLLRSRLELLELKLEQ
                     KMGDVWEELKTETLLSPEVQMMQRNRKSFKHAETQTETQTE"
     exon            118..275
                     /gene="Sh3d21"
                     /gene_synonym="1700029G01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            276..339
                     /gene="Sh3d21"
                     /gene_synonym="1700029G01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            340..458
                     /gene="Sh3d21"
                     /gene_synonym="1700029G01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            459..549
                     /gene="Sh3d21"
                     /gene_synonym="1700029G01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            550..605
                     /gene="Sh3d21"
                     /gene_synonym="1700029G01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            606..651
                     /gene="Sh3d21"
                     /gene_synonym="1700029G01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            652..752
                     /gene="Sh3d21"
                     /gene_synonym="1700029G01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            753..839
                     /gene="Sh3d21"
                     /gene_synonym="1700029G01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            840..882
                     /gene="Sh3d21"
                     /gene_synonym="1700029G01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            883..976
                     /gene="Sh3d21"
                     /gene_synonym="1700029G01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            977..1029
                     /gene="Sh3d21"
                     /gene_synonym="1700029G01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1030..1124
                     /gene="Sh3d21"
                     /gene_synonym="1700029G01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1125..1981
                     /gene="Sh3d21"
                     /gene_synonym="1700029G01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1982..2039
                     /gene="Sh3d21"
                     /gene_synonym="1700029G01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2040..2234
                     /gene="Sh3d21"
                     /gene_synonym="1700029G01Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2209..2214
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sh3d21"
                     /gene_synonym="1700029G01Rik"
                     /note="hexamer: AGTAAA"
     polyA_site      2234
                     /gene="Sh3d21"
                     /gene_synonym="1700029G01Rik"
                     /note="major polyA site"
ORIGIN      
        1 gactcgagtc tccgcctcat ccacatccag tctaccgcct ggcggcttcg cccgccctcc
       61 gagcacccaa tgcccagcct gacggtcagg ctgcgcaggg agccccagaa gtcatggagg
      121 tcctggtcct ggccagatac cgagcgcaga cggaggacga gctgagtctg gctccggggg
      181 acgtgatccg gcaggtgtgc gcggggcccg ctcggggctg gctgcttggg gagttgcggg
      241 gccgccgcgg tcgcttcccc aagcgcctgg tgcaggagat tccggaggcc ctgcggggcg
      301 tcaccgagtc cagaccgcgc tttccgcgcc gtagtcgccg tcaccccatc aactctcggg
      361 acccccaaag atggtgcaga gtgaacttca actacagccc agagcaggca gacgagctga
      421 cgcttcaaac tggggagatt ttggaagtga taaaggagat tgaggacggc tggtggctgg
      481 gagagaagaa cgggcagttg ggagccttcc catccaactt tgtggaattg ctggacagtg
      541 ggcccccaag ccttggaaat acagacatac cgccaattac cccaaattca cagaggcctc
      601 ctaagttgag caacttgaca tatgacagcc ctccagacta cctgcggaca gtctcctgcc
      661 ctgagacctg cagggtccta tttgactacc aacccgaggc cccagatgag ctggcactgc
      721 agaaggggga cctggtgaaa gttctgagaa agacaactga ggataagggc tggtgggaag
      781 gagaatgcca aggcagaaga ggagtttttc ctgacaactt tgtcatccca ccgcccccaa
      841 tcaggaagct gatccctcgg aaaattattt ctcgggaatc agctcctatt aaggaaacaa
      901 agaaactgat gcctaaatca tctctaccta ctgtaaagaa gctggcagca gcggcctctg
      961 caccgggcag agccaagaca ctttcaacac ccagtggaga cagccagaaa cgcccctccc
     1021 ggaactctgg cttcaatggc agctgcctca atgggggacc caggcagcct gggagaaagg
     1081 gatccagaac ccaggcttcc caacagcact ctgcatccag tcaggaggat gaacagaaaa
     1141 gcccaggaaa gggcccctcc aggagtaaaa ccccgactcc agagaagact cgacttccag
     1201 ataaggtcct tgccccagag acgatcccgg ctcctgacaa agtctccatt ccaaaggacc
     1261 ccgttccaaa gaaagcccca gattctgaca aaattcctgc tacagaggat accactctgg
     1321 acaaggctgg cactccagag agcacccttt ctgggaataa gccagctaag gatgaagccc
     1381 ttgacctgaa gatggccctc catgaggaca ctgcccctgc attagtaaag atcttgactc
     1441 cagagcacat gatttttaaa aaggagcctt ctagagacaa cgatcaatgc cagcacttgc
     1501 ctcagggggg atccacacag aggcctgagt ctcctgcacc ctcaaataac atccaggtgc
     1561 caggagagta ctccccaccg cctgactcct cagagaggtc ctgctgtcgc gtgagacagg
     1621 tgaacggctc cttcccagcc cagtccaagg ctgaggatgt gtctgccatg gaggaggcca
     1681 attttttaga ggagccacta gccaaagatg agaggaccct aaacaaggca ctccccaaaa
     1741 agctgccttc tgaaagggcg ggtccccaaa agcaggtgct tccccaagag tcagccccca
     1801 ccccccaagt gccacacact atccagcaga tgccagtccc tgaagaagct cccacacttc
     1861 atcccttgac cccactaacc tctcccaaga gcaagaatga ccgcatggat gtgttggaat
     1921 ccttaaagga agaggtgggg ttgctaagaa gccggctgga gcttctggag ttgaagctgg
     1981 aacagaagat gggggatgtc tgggaggagc tgaagactga gacgctcctg tcgccggagg
     2041 ttcagatgat gcagaggaac cggaaatcct tcaaacacgc agagacacag acggaaacac
     2101 agacagaatg agagcaggtt caggccgaac ctcaacccaa cctggaggga catctatcct
     2161 gcttgggcca ccccggtcct tgcacacaac tttgacaaac tccatggaag taaaaaaaaa
     2221 actctgaaca ctca
//
