LOCUS       NM_011894               3889 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus SH3-domain binding protein 5 (BTK-associated)
            (Sh3bp5), transcript variant 1, mRNA.
ACCESSION   NM_011894
VERSION     NM_011894.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3889)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3889)
  AUTHORS   Win,S., Min,R.W.M., Zhang,J., Kanel,G., Wanken,B., Chen,Y., Li,M.,
            Wang,Y., Suzuki,A., Aung,F.W.M., Murray,S.F., Aghajan,M., Than,T.A.
            and Kaplowitz,N.
  TITLE     Hepatic Mitochondrial SAB Deletion or Knockdown Alleviates
            Diet-Induced Metabolic Syndrome, Steatohepatitis, and Hepatic
            Fibrosis
  JOURNAL   Hepatology 74 (6), 3127-3145 (2021)
   PUBMED   34331779
  REMARK    GeneRIF: Hepatic Mitochondrial SAB Deletion or Knockdown Alleviates
            Diet-Induced Metabolic Syndrome, Steatohepatitis, and Hepatic
            Fibrosis.
REFERENCE   3  (bases 1 to 3889)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3889)
  AUTHORS   Win,S., Min,R.W., Chen,C.Q., Zhang,J., Chen,Y., Li,M., Suzuki,A.,
            Abdelmalek,M.F., Wang,Y., Aghajan,M., Aung,F.W., Diehl,A.M.,
            Davis,R.J., Than,T.A. and Kaplowitz,N.
  TITLE     Expression of mitochondrial membrane-linked SAB determines severity
            of sex-dependent acute liver injury
  JOURNAL   J Clin Invest 129 (12), 5278-5293 (2019)
   PUBMED   31487267
  REMARK    GeneRIF: SAB expression levels determine the severity of
            JNK1-dependent liver injury
REFERENCE   5  (bases 1 to 3889)
  AUTHORS   Zhang,J., Min,R.W.M., Le,K., Zhou,S., Aghajan,M., Than,T.A., Win,S.
            and Kaplowitz,N.
  TITLE     The role of MAP2 kinases and p38 kinase in acute murine liver
            injury models
  JOURNAL   Cell Death Dis 8 (6), e2903 (2017)
   PUBMED   28661486
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3889)
  AUTHORS   Gineste,C., De Winter,J.M., Kohl,C., Witt,C.C., Giannesini,B.,
            Brohm,K., Le Fur,Y., Gretz,N., Vilmen,C., Pecchi,E., Jubeau,M.,
            Cozzone,P.J., Stienen,G.J., Granzier,H., Labeit,S.,
            Ottenheijm,C.A., Bendahan,D. and Gondin,J.
  TITLE     In vivo and in vitro investigations of heterozygous nebulin
            knock-out mice disclose a mild skeletal muscle phenotype
  JOURNAL   Neuromuscul Disord 23 (4), 357-369 (2013)
   PUBMED   23375831
REFERENCE   7  (bases 1 to 3889)
  AUTHORS   Win,S., Than,T.A., Han,D., Petrovic,L.M. and Kaplowitz,N.
  TITLE     c-Jun N-terminal kinase (JNK)-dependent acute liver injury from
            acetaminophen or tumor necrosis factor (TNF) requires mitochondrial
            Sab protein expression in mice
  JOURNAL   J Biol Chem 286 (40), 35071-35078 (2011)
   PUBMED   21844199
  REMARK    GeneRIF: JNK-dependent acute liver injury from acetaminophen or
            tumor necrosis factor (TNF) requires mitochondrial Sab protein
            expression in mice
REFERENCE   8  (bases 1 to 3889)
  AUTHORS   Bulfone,A., Carotenuto,P., Faedo,A., Aglio,V., Garzia,L.,
            Bello,A.M., Basile,A., Andre,A., Cocchia,M., Guardiola,O.,
            Ballabio,A., Rubenstein,J.L. and Zollo,M.
  TITLE     Telencephalic embryonic subtractive sequences: a unique collection
            of neurodevelopmental genes
  JOURNAL   J Neurosci 25 (33), 7586-7600 (2005)
   PUBMED   16107646
REFERENCE   9  (bases 1 to 3889)
  AUTHORS   Yamadori,T., Baba,Y., Matsushita,M., Hashimoto,S., Kurosaki,M.,
            Kurosaki,T., Kishimoto,T. and Tsukada,S.
  TITLE     Bruton's tyrosine kinase activity is negatively regulated by Sab,
            the Btk-SH3 domain-binding protein
  JOURNAL   Proc Natl Acad Sci U S A 96 (11), 6341-6346 (1999)
   PUBMED   10339589
REFERENCE   10 (bases 1 to 3889)
  AUTHORS   Baba,Y., Matsushita,M., Matsuda,Y., Inazawa,J., Yamadori,T.,
            Hashimoto,S., Kishimoto,T. and Tsukada,S.
  TITLE     Assignment of SH3BP5/Sh3bp5 encoding sab, an SH3 domain-binding
            protein which preferentially associates with Bruton's tyrosine
            kinase, to human chromosome 1q43 and mouse chromosome 14B by in
            situ hybridization
  JOURNAL   Cytogenet Cell Genet 87 (3-4), 221-222 (1999)
   PUBMED   10702676
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC154616.2 and AC108416.5.
            
            On Apr 12, 2022 this sequence version replaced NM_011894.3.
            
            Sequence Note:.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC053741.1, AK165033.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-289               AC154616.2         93843-94131         c
            290-352             AC154616.2         92115-92177         c
            353-481             AC154616.2         69573-69701         c
            482-646             AC154616.2         45751-45915         c
            647-777             AC108416.5         222568-222698       c
            778-820             AC108416.5         221457-221499       c
            821-1040            AC108416.5         220570-220789       c
            1041-1301           AC108416.5         218783-219043       c
            1302-3889           AC108416.5         215793-218380       c
FEATURES             Location/Qualifiers
     source          1..3889
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 19.11 cM"
     gene            1..3889
                     /gene="Sh3bp5"
                     /gene_synonym="Sab; SH3BP-5"
                     /note="SH3-domain binding protein 5 (BTK-associated)"
                     /db_xref="GeneID:24056"
                     /db_xref="MGI:MGI:1344391"
     exon            1..289
                     /gene="Sh3bp5"
                     /gene_synonym="Sab; SH3BP-5"
                     /inference="alignment:Splign:2.1.0"
     CDS             143..1519
                     /gene="Sh3bp5"
                     /gene_synonym="Sab; SH3BP-5"
                     /note="isoform 1 is encoded by transcript variant 1; SH3
                     domain-binding protein 5; SH3 domain-binding protein that
                     preferentially associates with BTK"
                     /codon_start=1
                     /product="SH3 domain-binding protein 5 isoform 1"
                     /protein_id="NP_036024.2"
                     /db_xref="CCDS:CCDS36855.1"
                     /db_xref="GeneID:24056"
                     /db_xref="MGI:MGI:1344391"
                     /translation="MDTALKRSRSDEPAELPPPAREVEEKEEEEERMEQGLEEEEEEV
                     DPRIQGELEKLNQSTDDINRRETELEDARQKFRSVLVEATVKLDELAKKIGKAVEDSK
                     PYWEARRVARQAQLEAQKATQDFQRATEVLRAAKETISLAEQRLLEDDKRQFDSAWQE
                     MLNHATQRVMEAEQTKTRSELVHKETAARYNAAMGRMRQLEKKLKRAINKSKPYFELK
                     AKYYVQLEQLKKTVDDLQAKLALAKGEYKAALKSLERISDEIHERRRSNAMGPRGCGV
                     GAEGSIASVENLPVSKPEPDAISVASEAFEDDNCSNLVSEDDSETQSVSSFSSGPTSP
                     SEMPDQFPAVARPGSLDLPSPVSLSEFGMMFPILGPRSECSGASSPECEVERGDRAEG
                     AENKMSDKANNNRVLGSTNGGSGRSRSQSSTSLESQALETRMKQLSLQCSKGRDGIIA
                     DIKMVQIG"
     exon            290..352
                     /gene="Sh3bp5"
                     /gene_synonym="Sab; SH3BP-5"
                     /inference="alignment:Splign:2.1.0"
     exon            353..481
                     /gene="Sh3bp5"
                     /gene_synonym="Sab; SH3BP-5"
                     /inference="alignment:Splign:2.1.0"
     exon            482..646
                     /gene="Sh3bp5"
                     /gene_synonym="Sab; SH3BP-5"
                     /inference="alignment:Splign:2.1.0"
     exon            647..777
                     /gene="Sh3bp5"
                     /gene_synonym="Sab; SH3BP-5"
                     /inference="alignment:Splign:2.1.0"
     exon            778..820
                     /gene="Sh3bp5"
                     /gene_synonym="Sab; SH3BP-5"
                     /inference="alignment:Splign:2.1.0"
     exon            821..1040
                     /gene="Sh3bp5"
                     /gene_synonym="Sab; SH3BP-5"
                     /inference="alignment:Splign:2.1.0"
     exon            1041..1301
                     /gene="Sh3bp5"
                     /gene_synonym="Sab; SH3BP-5"
                     /inference="alignment:Splign:2.1.0"
     exon            1302..3889
                     /gene="Sh3bp5"
                     /gene_synonym="Sab; SH3BP-5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2688..2693
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sh3bp5"
                     /gene_synonym="Sab; SH3BP-5"
                     /note="hexamer: AATAAA"
     polyA_site      2729
                     /gene="Sh3bp5"
                     /gene_synonym="Sab; SH3BP-5"
                     /note="major polyA site"
     polyA_site      3889
                     /gene="Sh3bp5"
                     /gene_synonym="Sab; SH3BP-5"
ORIGIN      
        1 gccactccgc actcgccggc ggagcacccg gggtggcagc gctgcgcgct cagacctacc
       61 cggctgcggc gaggtggccc tcggtgcgtc cggatcccac cgtgcgcttt gcgacccggc
      121 tgcggcgcgt tcggctgccc gcatggacac ggcgctgaaa cggagccgct ctgacgagcc
      181 ggcggagctc ccgccgcctg cccgggaggt ggaggagaaa gaggaggagg aagagaggat
      241 ggaacagggc ctggaggagg aggaggaaga ggtggacccc cggatccagg gagaactgga
      301 gaagttaaat caatccacgg atgatatcaa ccgacgggag actgagcttg aggatgcacg
      361 ccagaagttc cgatctgtcc tggtcgaggc aacggtgaaa ctagacgaac tggcaaagaa
      421 aatcggcaaa gccgtggagg actcgaagcc ctactgggag gcccggaggg tggcaaggca
      481 ggctcagctg gaggcgcaga aggccacaca ggacttccag agggccaccg aggtactccg
      541 tgcagccaag gaaacaatct ctctggctga gcagcggctg ttggaggatg acaagcggca
      601 gtttgactct gcttggcagg aaatgctgaa ccatgctact cagagggtca tggaggccga
      661 gcagaccaag acaaggagtg agctagtaca caaggagacg gcagccaggt acaacgctgc
      721 catgggtcgc atgcgccagc tggagaagaa actcaagcga gccatcaaca agtccaagcc
      781 ttattttgag ctaaaggcaa agtactacgt gcagcttgag caactgaaga agacggtgga
      841 tgaccttcag gccaagctgg ccctggcaaa gggcgagtac aaggcagccc tgaagagcct
      901 ggagaggatc tcagatgaga tacacgagcg gcggcgttcc aatgccatgg ggccccgggg
      961 ctgtggcgtg ggggcagagg gcagcatcgc ctcagtggag aacctgcctg taagcaaacc
     1021 tgagcctgac gccatttctg tggcatcaga agcctttgaa gatgacaact gcagcaactt
     1081 ggtgtctgaa gatgactcgg aaacccagtc tgtgtccagc tttagttcgg gaccgacgag
     1141 tccgtctgaa atgcctgatc agttccctgc agtggcaagg cctggcagtc tggatctgcc
     1201 tagccctgtg tccctgtcag aatttgggat gatgttccca atactgggtc ctcgaagtga
     1261 atgcagtggg gcctcctccc ctgaatgtga ggttgaacga ggagacagag cagaaggggc
     1321 cgagaataaa atgagtgaca aagccaacaa caaccgtgtt ctcggcagca ccaacggtgg
     1381 cagtggcagg agcaggagcc aaagcagcac gtcccttgag agccaggcct tggaaacccg
     1441 gatgaagcag ctctccctac agtgctcaaa aggaagagat ggaattattg ctgacataaa
     1501 aatggtgcag attggctgat ccacccaagg gctatggcct atgtgcagat catatttata
     1561 catgaaattc aagaacattg tgccaataat catttaacat aagccaaata gtatgcattt
     1621 actctaaact gcactaacca agtttcagtg accttgaggg ctaaacattt tccctctggt
     1681 aagagctctt gggctggtgt gcttttcaga gcagagccat tgcaggtaaa ccgtgaccag
     1741 ggagggtcac ggtctttgca gagcattccc tgtagcggca gcgtggaagc aataactagt
     1801 ttctgagaaa gaacctgcag ggccaggagg agagctggac acttagccag actggggtca
     1861 ccagccttca tctctatccc cacttcctct tcttcttggg gaaacagatg ttctctccat
     1921 tacatcacag ggcaccaaga taattttaaa aatcacacac acacacacac acaaactcaa
     1981 gtgttcagaa cacactgctg taactacagt gcaggaacac agttcctcat caccaccact
     2041 ggtgctcgct cagaggggct ttcagaagcg tgtcttctgg gaaacctgtt gaaccatttc
     2101 ctaggaaagc taccaggaac tgcacttttt aggggtgggg acggtgaatg ccaatgtggg
     2161 gacgtagata tcatagaggg gatgtgtggc tgggggcagt ttgtagcctg agcttagcct
     2221 gctagccaag gggctttatt ctaagagaag tgcatgtgag gaatggttgg cattgctctt
     2281 atctagattg acaaggagtt catttctctg tagactgtaa ctcctacaat acctgagatt
     2341 atttaaggtt tatgctgcac ctagtattcc ttagaggaag ctgtccttaa agctaggagg
     2401 gaatgggcat ggttggtaaa tagaagcaat ggatctgtta tgctaatagt agtgtataga
     2461 cttagtgttt atggttatgc atatttagag cactgtattt tatttgtcct gttttattaa
     2521 tctaccattt ctgaaagaaa aaaaaaaaga aaacaactcc ccatttacaa ctattaattt
     2581 tagccatgtg tgtatagctc ttcatacact agtggtttct tttttattga tggacacagt
     2641 atccttatta caaggttatt ttgtacttgt tttattacct tgggtgtaat aaaagccgag
     2701 aagactttgt gacttccgat gagaaagtcc actgttgtct gtcttctcct cttgccttgg
     2761 ttgttggggc atctgctctc cttttcaggt aaggtgatga tggagcctgg aaattttagc
     2821 tcacacacca aggtctggat tagaattccc acttttgctg ttacaaaggt gagcactgag
     2881 aagagacagg cgggcagttc caggtgacag tcccgagaag agaagctttt agtttcactg
     2941 gtcagcatag tcttaggggc agggggacat actgttaaat ggtctcatct actcagtctg
     3001 atttaatttg tggcactaag gtactttttc taatggaaat ctgagagtag ctgtcttcag
     3061 acaaaccaga agagagcatc agattccatt acagatggct gtgagccacc atgtggttgc
     3121 tgggaattga actcaggacc tttggaagag cagtcagtgc tcttaaccat tgaccatctc
     3181 tccagccccc agtagtggac tttataatgt atatgccaca cactgaaatg tgctgtggga
     3241 ttaagtgcca agtgatcata agtgctttgc ctgttaaatt ccatctcaga gttggtggga
     3301 gtccctttca attgctctgt tctggcagtg aggcgctgct cattccccct tcctgtcaac
     3361 atttctgagg taaagttgtg tagtttgtct atttctggca gagactagaa gacagaatat
     3421 tctcgtgttg ggaagtttag tgctatatcc cttctgtggg cacaggcgtt tcacagtatg
     3481 ccttcctgct ttggttcccc tcaccctgtc tcccacagca ggaagtcaga aaccttcgac
     3541 cctgcttcat ggtcacttcc tcgcctgtct cccttcacgc ttctaggtta gagcagtgcc
     3601 actcttgtca tctcagcctc ctctgccatg ttggggactc actctcacac ctgtccttct
     3661 ccatgtctct caagttacca tttctgaaat ttagccaatt tcagtttttg accctccagc
     3721 tctcatgtat tttttgaggt gaccacaata actgaaccat gtactactaa ttctagaata
     3781 ttgataattt cctttacctt gtgtgtgggg tgagggtggg ggataagggg agtttcttct
     3841 ttaagtctga gcatctatgc gtatattgaa attagatacc tgaaccacc
//
