LOCUS       NM_133816               5014 bp    mRNA    linear   ROD 24-DEC-2022
DEFINITION  Mus musculus SH3-domain binding protein 4 (Sh3bp4), mRNA.
ACCESSION   NM_133816
VERSION     NM_133816.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5014)
  AUTHORS   Butterfield NC, Curry KF, Steinberg J, Dewhurst H, Komla-Ebri D,
            Mannan NS, Adoum AT, Leitch VD, Logan JG, Waung JA, Ghirardello E,
            Southam L, Youlten SE, Wilkinson JM, McAninch EA, Vancollie VE,
            Kussy F, White JK, Lelliott CJ, Adams DJ, Jacques R, Bianco AC,
            Boyde A, Zeggini E, Croucher PI, Williams GR and Bassett JHD.
  TITLE     Accelerating functional gene discovery in osteoarthritis
  JOURNAL   Nat Commun 12 (1), 467 (2021)
   PUBMED   33473114
  REMARK    Erratum:[Nat Commun. 2021 May 28;12(1):3302. PMID: 34050183]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5014)
  AUTHORS   Antas P, Novellasdemunt L, Kucharska A, Massie I, Carvalho J,
            Oukrif D, Nye E, Novelli M and Li VSW.
  TITLE     SH3BP4 Regulates Intestinal Stem Cells and Tumorigenesis by
            Modulating beta-Catenin Nuclear Localization
  JOURNAL   Cell Rep 26 (9), 2266-2273 (2019)
   PUBMED   30811977
REFERENCE   3  (bases 1 to 5014)
  AUTHORS   Kim YM, Stone M, Hwang TH, Kim YG, Dunlevy JR, Griffin TJ and Kim
            DH.
  TITLE     SH3BP4 is a negative regulator of amino acid-Rag GTPase-mTORC1
            signaling
  JOURNAL   Mol Cell 46 (6), 833-846 (2012)
   PUBMED   22575674
  REMARK    GeneRIF: SH3BP4 is a negative regulator of the Rag GTPase complex
            and amino acid-dependent mTORC1 signaling
REFERENCE   4  (bases 1 to 5014)
  AUTHORS   Chiba S, Tokuhara M, Morita EH and Abe S.
  TITLE     TTP at Ser245 phosphorylation by AKT is required for binding to
            14-3-3
  JOURNAL   J Biochem 145 (3), 403-409 (2009)
   PUBMED   19122209
  REMARK    GeneRIF: TTP Ser(245) is the principal target for the modulation of
            this protein via the AKT signalling cascade.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC126024.3, AC153647.4 and AC133168.3.
            
            [WARNING] On May 6, 2023 this sequence was replaced by NM_133816.4.
            
            On Apr 11, 2018 this sequence version replaced NM_133816.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK041504.1, BC012284.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-183               AC126024.3         14082-14264         c
            184-262             AC153647.4         31166-31244         c
            263-507             AC153647.4         699-943             c
            508-2864            AC133168.3         55085-57441
            2865-3053           AC133168.3         63735-63923
            3054-5014           AC133168.3         64662-66622
FEATURES             Location/Qualifiers
     source          1..5014
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1"
     gene            1..5014
                     /gene="Sh3bp4"
                     /gene_synonym="BOG25"
                     /note="SH3-domain binding protein 4"
                     /db_xref="GeneID:98402"
                     /db_xref="MGI:MGI:2138297"
     exon            1..183
                     /gene="Sh3bp4"
                     /gene_synonym="BOG25"
                     /inference="alignment:Splign:2.1.0"
     exon            184..262
                     /gene="Sh3bp4"
                     /gene_synonym="BOG25"
                     /inference="alignment:Splign:2.1.0"
     exon            263..507
                     /gene="Sh3bp4"
                     /gene_synonym="BOG25"
                     /inference="alignment:Splign:2.1.0"
     CDS             390..3278
                     /gene="Sh3bp4"
                     /gene_synonym="BOG25"
                     /codon_start=1
                     /product="SH3 domain-binding protein 4"
                     /protein_id="NP_598577.1"
                     /db_xref="CCDS:CCDS15147.1"
                     /db_xref="GeneID:98402"
                     /db_xref="MGI:MGI:2138297"
                     /translation="MAAQRIRAANASGLPRCKSEGTLIDLSEGFSETSFNDVKVPSPS
                     ALLVDNPTPFGNAKEVIAIKDYCPNNFTTLKFSKGDHLYVLDTSGGEWWYAHNTTEMG
                     YIPSSYVQPLNYRNSTLSDSGMIDNLPDSPEEVAKELDLLGGGWTDDQKESGRPYSNN
                     PFWNGVRTNPFLNGNAQPSTDELNPKSTVDLLLFDTGTSSFTESSSATTNSTGNIFDE
                     LPATNGLQVEQPVKRDNPFFRSKRSYSLSELSVLQAKSDAPPTSSFFTGLKSPVPEQF
                     QSREDFRTAWLNHRKLARSCHDLDLLGQSPGWGQTQAVETNIVCKLDSSGGSVQLPDT
                     NISIHVPEGHVAPGETQQISMKALLDPPLDLNSDRSTSVSPVVEVKLSNLEVSTFIIL
                     EMKVSAEVKGDIFSKSTVVLQCLRSDSKEGPYVPIPLAYSYGDTIQVQLDNLEPCMYL
                     AIVAQGPNILYPSTVWDFINKRVTVGLYGPKHIHPSFKTVVTIFGHDCAPKTLLVSEV
                     TRQAPSPAPVALQLWGKHQFILSRPQDLRVCMFSNMTNYEVKANEQARVVRGFQMKLG
                     KVSRLIFSVISQNPNELSDFTLRVQVKDDQDTILTQFCVQTPQPPPKSAIKPSGQRRF
                     LKKNEVGKIILSPFVVTTKYPTFQDRPVSSLKFGKLLKTVVRQNKSHYLLEYKKGDVV
                     ALLSEERIRLKGQLWTKEWYIGYYQGKVGLVHTKNVLVVGKARPSLFSGPELSTSVLL
                     EQILRPCKFLTYIYASVRTLLMENISSWRAFADALGYGNLPLTFFCRAELDSEPERVA
                     SVLEKLKEDCNNPDNKDRKSFQKELVMALLKMDCQGLVVRLIQDFVLLTTAVEVAQRW
                     RELAEKLAKVSKQQMDAYESPHRDRNGVVDSEAMWKPAYDFLLTWSHQIGDSYRDVIQ
                     ELHIGLDKMKNPITRRWKHLTGTLILVNSLDILRAAAFSPADHDDFVI"
     exon            508..2864
                     /gene="Sh3bp4"
                     /gene_synonym="BOG25"
                     /inference="alignment:Splign:2.1.0"
     exon            2865..3053
                     /gene="Sh3bp4"
                     /gene_synonym="BOG25"
                     /inference="alignment:Splign:2.1.0"
     exon            3054..5014
                     /gene="Sh3bp4"
                     /gene_synonym="BOG25"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agaccacctc tgcgcccgct ggcgggggcc gagcgctctg ggctgtcgcg gcgtctgggc
       61 acctcaccac ctctgctgcc tcgatcgctg aggccgcggt accgggagtc gcgcgcgccc
      121 ccggccgggt gagccccaca ggacaagaga accgcaggac ccgtggggcg ccatgcgagc
      181 cagggcatcc ctcttctcga ggatggaagg tggagtcttg gagtttttcc tctgacatca
      241 agaggccaac atcccccagc aggaagaagc acactgccaa gttgaccctg ccgtgcagcg
      301 tgactttatg agacagcagc tgctgtccct gctggaacta ggggaggaga catgagacca
      361 tagtacctca cccacccaag aggctcacca tggcagccca gcgtatccgg gcagccaacg
      421 ccagtggcct ccctcggtgc aagtcggagg ggactctgat agacctgagc gagggcttct
      481 cagagacaag ctttaatgat gtcaaagtgc cttcccccag tgccttgctc gtagacaacc
      541 ccacgccttt tggaaacgca aaggaagtga ttgccatcaa agactattgc ccaaacaact
      601 tcaccaccct gaagttttcc aagggcgacc acctctacgt cttggacacg tctggtgggg
      661 agtggtggta cgctcacaac accaccgaga tgggctacat cccttcctcc tacgtgcagc
      721 cattaaacta ccggaattct accctgagtg acagtggcat gatcgacaat cttccggaca
      781 gccctgaaga agttgccaag gagttagatc tgctaggggg tggctggacc gatgaccaga
      841 aagaatctgg caggccctat agtaacaacc ctttctggaa tggagtccga acgaacccct
      901 ttctgaatgg gaatgcacag cccagtacgg atgagctaaa ccccaagagt accgtggatt
      961 tgctcctgtt tgacacgggc acatcttcct tcactgagtc cagctcggcg accaccaaca
     1021 gcaccggcaa catctttgat gagctcccag ccaccaatgg actccaggtg gagcagcctg
     1081 tcaagcggga caaccccttt ttcagaagca agcgttccta cagcctttcg gaactctccg
     1141 tcctgcaagc caaatcggat gctcccccaa cgtccagctt cttcacaggc ttgaagtcgc
     1201 ctgtcccgga acagtttcaa agccgagaag acttccgaac cgcctggctc aatcaccgga
     1261 agctggcccg ttcctgccat gacttggatc tgctcggcca aagcccaggc tggggccaga
     1321 cccaagcagt ggagacaaat attgtgtgca agctggatag ctctgggggc tccgtgcagc
     1381 ttcctgacac caacatcagt atccatgtgc cagagggcca tgtagctcct ggggagacac
     1441 agcagatttc catgaaagcc ctgctggacc ctccgctgga ccttaacagt gacagatcca
     1501 ccagcgtaag ccctgtggtg gaggtgaagc tgagtaacct agaggtgagt accttcatca
     1561 tcttggagat gaaggtctcc gccgaggtga agggcgacat ctttagcaaa agcacggtgg
     1621 tcctgcagtg cctgagaagt gactcaaagg aggggcctta tgtgcccatc cctctcgcct
     1681 acagctatgg ggacaccata caggtacagc tggacaacct ggaaccctgc atgtacctag
     1741 ccatcgttgc ccagggcccc aacatcctct acccttccac cgtgtgggat ttcatcaata
     1801 agagggtcac cgtgggtctc tatggtccca aacacatcca tccatccttc aagacagtag
     1861 tgaccatttt tggacatgat tgtgccccca agaccctcct ggtgagtgag gtgactcggc
     1921 aggctcccag tcctgccccc gtggccctcc agctgtgggg caaacatcag ttcattctgt
     1981 ccaggcccca ggatctcaga gtgtgtatgt tctccaatat gactaactat gaggtcaagg
     2041 ccaacgagca agcccgagta gtgagagggt ttcagatgaa gctgggcaag gtgagccgtc
     2101 tgatcttctc cgtcatctcc cagaacccca atgagctgtc cgacttcacc ctgagggtcc
     2161 aggtcaagga tgatcaggac acgatcctca cgcagttttg tgtccagact ccgcagccgc
     2221 cccctaaaag cgccattaaa ccgtcgggac agaggaggtt tcttaagaag aacgaggtcg
     2281 ggaagatcat cttgtccccg tttgtcgtta caaccaagta tccaacgttt caggaccgcc
     2341 ccgtgtctag cctcaagttt ggcaagcttc taaagacagt ggtgcggcag aacaagagtc
     2401 actacctgct ggagtacaag aaaggtgacg tcgtggctct gctcagcgag gagcgcatcc
     2461 ggctcaaggg acagctgtgg accaaggagt ggtacatcgg ctactaccag ggcaaggtgg
     2521 gcctggtgca caccaagaac gtgctggtcg tcggcaaggc ccggcccagc ctgttctcgg
     2581 ggcccgagct gagcacctca gtgctgctgg agcagatcct gcggccctgc aagttcctta
     2641 cctacatcta tgcctctgtg cggaccttac tcatggagaa catcagcagc tggcgggcct
     2701 ttgctgatgc cctgggttac ggcaacctgc cgctcacctt cttctgccgg gcagagctgg
     2761 acagcgagcc ggaacgggtg gcttccgttc tggaaaagct caaggaagac tgtaacaacc
     2821 ctgacaacaa ggaccggaag tccttccaga aggagctggt gatggctttg ctgaaaatgg
     2881 actgccaggg cctggtggtg agactcatcc aggactttgt gctcctgacc acagctgtcg
     2941 aagtggccca gcgctggagg gaactggctg agaagctagc caaggtctcc aagcaacaga
     3001 tggatgccta tgagtctcct caccgagaca ggaatggggt agtagacagt gaggccatgt
     3061 ggaaacctgc ctatgacttc ttactcacct ggagccacca gattggggac agctaccgag
     3121 atgtcatcca ggagttgcac ataggcctgg acaagatgaa gaaccccatc accaggcgct
     3181 ggaagcacct cacagggaca ctgatcctgg tgaactcact ggacatcctg agggcagctg
     3241 ccttcagtcc cgcggaccat gatgactttg tgatctgagt gggatccctg ccctactgct
     3301 cactggagtt gggactctgc ccaccagacc tgggactcca cccaccagag cttgggactc
     3361 cacccaccag agctgggact tggcccatca tctctccaca gtgggctgtg ccatcaccgg
     3421 gtggtgcagg gagggatggc tgctcaggtc gaggcctacc tgccagccac gcccaggagg
     3481 gactgaggac ttttgacttt cttcccctcc cctctatcca ggggcaggtc ccaggggctt
     3541 tctacttcca gttgccaatt gtgttgcttt ctatttgttg aaaatgtacg tttaaattta
     3601 aaatcacttt tttaaacaga agacttagaa aggacgtaag aaaggtggta tctaattttt
     3661 taatggactg taaaggttat ttaaaaattt tttcacctta gtaaaggcaa atgctattga
     3721 ggtttttatg ttctttaaag gccttttcaa attatgttcc aggggtatgt agatattgta
     3781 aggccacagg tgtttctgag tcccagacat acttgtattt tgacacgcag agtgggaaag
     3841 gagttggctc tgtgcagaca ttttccactt gtcgcctgtg ggaagacgag cccgtgggcc
     3901 tggtgacttg tacgtggcct tgaggctgcc catccctcct tccttctacc ttgctgtcct
     3961 cagtggccat ccacataaca tgttggtctg tgtgcttcag tgagctgcaa agtccccaca
     4021 tggtagctca gtaccattga gattcttcca acaaataagg aatcagctgg agttaggggg
     4081 ccggggggag gggtccctgt cacctgtcta tttggttatt tgcagtaacc attctgaaga
     4141 acaatgcccc ctgagaacaa ggtggtccct gccactctgg gtcattgaat gctggctccc
     4201 tcagggcaga tccacctctg ctataggtgg gaggaacacc cttgcaccca gccagaacct
     4261 ggtggcccct ggctcttctt atgtccacca tggtcacctg gtgacttttc aggtgacatc
     4321 atatgctggc gtgtagaggt gccatctgcc attgccaaac tccgcacttc atctccacgt
     4381 ttaaccacct ccttcctggt gcgcccacat ctcctaaggg gataacatag ttatccagca
     4441 gtgtaaatat tagcacgagg aacattttcc ctgaatgatg ctctctggaa ggttgggagc
     4501 ttgcagagga ttgtaccgag gtggcgggtt atgtggtcca tgatgacttc cagggtcaca
     4561 cagtatctgg catttgggga ggaaacggga agtagaaaga tcagcagtta agtgaccctg
     4621 gtaatgggaa agacttgggc tgtctgttta cagggccagt tccagagcct ccctctgctt
     4681 tgtaggcaca ggctgatgac cagtgtccaa cttctgcttc cgatcagaac ccgcagacca
     4741 acagacttag aagtaaacag taggtattaa tgctgtagga accaagtcac aggactcgca
     4801 ggtcaccaca gtaatgcccg ttactctgca ccttcatttt gcccagagag catctctttc
     4861 ttgccttttt tccccaaaga agaaacaaaa ccagtcgcac cttaaaccat ggatattttt
     4921 cctcaggggc tttgaatagt ttcctatgca acaagacttg tagcacaaat taaattctac
     4981 aaaagttgca gtaaatttta tttggacatt tcaa
//
