LOCUS       NM_001145859            3069 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus SH3-domain binding protein 2 (Sh3bp2), transcript
            variant 2, mRNA.
ACCESSION   NM_001145859
VERSION     NM_001145859.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3069)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3069)
  AUTHORS   Srivastava,T., Garola,R.E., Zhou,J., Boinpelly,V.C.,
            Rezaiekhaligh,M.H., Joshi,T., Jiang,Y., Ebadi,D., Sharma,S.,
            Sethna,C., Staggs,V.S., Sharma,R., Gipson,D.S., Hao,W., Wang,Y.,
            Mariani,L.H., Hodgin,J.B., Rottapel,R., Yoshitaka,T., Ueki,Y. and
            Sharma,M.
  TITLE     Scaffold protein SH3BP2 signalosome is pivotal for immune
            activation in nephrotic syndrome
  JOURNAL   JCI Insight 9 (3), e170055 (2024)
   PUBMED   38127456
  REMARK    GeneRIF: Scaffold protein SH3BP2 signalosome is pivotal for immune
            activation in nephrotic syndrome.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3069)
  AUTHORS   Matsumoto,Y., Dimitriou,I.D., La Rose,J., Lim,M., Camilleri,S.,
            Law,N., Adissu,H.A., Tong,J., Moran,M.F., Chruscinski,A., He,F.,
            Asano,Y., Katsuyama,T., Sada,K.E., Wada,J. and Rottapel,R.
  TITLE     Tankyrase represses autoinflammation through the attenuation of
            TLR2 signaling
  JOURNAL   J Clin Invest 132 (7) (2022)
   PUBMED   35362478
REFERENCE   4  (bases 1 to 3069)
  AUTHORS   Chihara,K., Chihara,Y., Takeuchi,K. and Sada,K.
  TITLE     Adaptor protein 3BP2 regulates dectin-1-mediated cellular
            signalling to induce cytokine expression and NF-kappaB activation
  JOURNAL   Biochem J 479 (4), 503-523 (2022)
   PUBMED   35129602
  REMARK    GeneRIF: Adaptor protein 3BP2 regulates dectin-1-mediated cellular
            signalling to induce cytokine expression and NF-kappaB activation.
REFERENCE   5  (bases 1 to 3069)
  AUTHORS   Kawahara,K., Mukai,T., Iseki,M., Nagasu,A., Nagasu,H., Akagi,T.,
            Tsuji,S., Hiramatsu-Asano,S., Ueki,Y., Ishihara,K., Kashihara,N.
            and Morita,Y.
  TITLE     SH3BP2 Deficiency Ameliorates Murine Systemic Lupus Erythematosus
  JOURNAL   Int J Mol Sci 22 (8), 4169 (2021)
   PUBMED   33920631
  REMARK    GeneRIF: SH3BP2 Deficiency Ameliorates Murine Systemic Lupus
            Erythematosus.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3069)
  AUTHORS   Chen,G., Dimitriou,I.D., La Rose,J., Ilangumaran,S., Yeh,W.C.,
            Doody,G., Turner,M., Gommerman,J. and Rottapel,R.
  TITLE     The 3BP2 adapter protein is required for optimal B-cell activation
            and thymus-independent type 2 humoral response
  JOURNAL   Mol Cell Biol 27 (8), 3109-3122 (2007)
   PUBMED   17283041
  REMARK    GeneRIF: 3BP2 binds via its SH2 domain to the CD19 signaling
            complex and is required for optimum Syk phosphorylation and calcium
            flux.
REFERENCE   7  (bases 1 to 3069)
  AUTHORS   Ueki,Y., Lin,C.Y., Senoo,M., Ebihara,T., Agata,N., Onji,M.,
            Saheki,Y., Kawai,T., Mukherjee,P.M., Reichenberger,E. and
            Olsen,B.R.
  TITLE     Increased myeloid cell responses to M-CSF and RANKL cause bone loss
            and inflammation in SH3BP2 'cherubism' mice
  JOURNAL   Cell 128 (1), 71-83 (2007)
   PUBMED   17218256
  REMARK    GeneRIF: These results indicate that the mutant phenotype reflects
            gain of SH3BP2 function and suggests that SH3BP2 is a critical
            regulator of myeloid cell responses to M-CSF and RANKL stimulation.
REFERENCE   8  (bases 1 to 3069)
  AUTHORS   de la Fuente,M.A., Kumar,L., Lu,B. and Geha,R.S.
  TITLE     3BP2 deficiency impairs the response of B cells, but not T cells,
            to antigen receptor ligation
  JOURNAL   Mol Cell Biol 26 (14), 5214-5225 (2006)
   PUBMED   16809760
  REMARK    GeneRIF: 3BP2(-/-) mice had increased accumulation of pre-B cells
            in the bone marrow and a block in the progression of transitional B
            cells in the spleen from the T1 to the T2 stage, but normal numbers
            of mature B cells.
REFERENCE   9  (bases 1 to 3069)
  AUTHORS   Maeno,K., Sada,K., Kyo,S., Miah,S.M., Kawauchi-Kamata,K., Qu,X.,
            Shi,Y. and Yamamura,H.
  TITLE     Adaptor protein 3BP2 is a potential ligand of Src homology 2 and 3
            domains of Lyn protein-tyrosine kinase
  JOURNAL   J Biol Chem 278 (27), 24912-24920 (2003)
   PUBMED   12709437
  REMARK    GeneRIF: 3BP2 is a potential regulator of Lyn protein-tyrosine
            kinase as a ligand of its SH3/SH2 domains in FcepsilonRI-mediated
            signaling in mast cells
REFERENCE   10 (bases 1 to 3069)
  AUTHORS   Ren,R., Mayer,B.J., Cicchetti,P. and Baltimore,D.
  TITLE     Identification of a ten-amino acid proline-rich SH3 binding site
  JOURNAL   Science 259 (5098), 1157-1161 (1993)
   PUBMED   8438166
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK143548.1 and BC085497.1.
            
            Transcript Variant: This variant (2) represents the longest
            transcript and encodes the longest isoform (b).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC085497.1, AK143548.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-112               AK143548.1         2-113
            113-3069            BC085497.1         1-2957
FEATURES             Location/Qualifiers
     source          1..3069
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 17.89 cM"
     gene            1..3069
                     /gene="Sh3bp2"
                     /gene_synonym="3BP2"
                     /note="SH3-domain binding protein 2"
                     /db_xref="GeneID:24055"
                     /db_xref="MGI:MGI:1346349"
     exon            1..221
                     /gene="Sh3bp2"
                     /gene_synonym="3BP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             58..1905
                     /gene="Sh3bp2"
                     /gene_synonym="3BP2"
                     /note="isoform b is encoded by transcript variant 2"
                     /codon_start=1
                     /product="SH3 domain-binding protein 2 isoform b"
                     /protein_id="NP_001139331.1"
                     /db_xref="CCDS:CCDS51470.1"
                     /db_xref="GeneID:24055"
                     /db_xref="MGI:MGI:1346349"
                     /translation="MAGSGSRPRSWGWRETGSRDEAAAGGPTSGPCRCSQGRRALAAP
                     RKPAVPAAWTPFMAAEEMQWPVPMKAIGAQNLLTMPGGVAKAGYLHKKGGTQLQLLKW
                     PLRFVIIHKRCIYYFKSSTSASPQGAFSLSGYNRVMRAAEETTSNNVFPFKIIHISKK
                     HRTWFFSASSEDERKSWMALLRREIGHFHEKKELPLDTSDSSSDTDSFYGAVERPIDI
                     SLSSYPMDNEDYEHEDEDDSYLEPDSPGPMKLEDALTYPPAYPPPPVPVPRKPAFSDL
                     PRAHSFTSKSPSPLLPPPPPKRGLPDTGSAPEDAKDALGLRRVEPGLRVPATPRRMSD
                     PPMSNVPTVPNLRKHPCFRDSVNPGLEPWTPGHGTSSVSSSTTMAVATSRNCDKLKSF
                     HLSSRGPPTSEPPPVPANKPKFLKIAEEPSPREAAKFAPVPPVAPRPPVQKMPMPEAT
                     VRPAVLPRPENTPLPHLQRSPPDGQSFRGFSFEKARQPSQADTGEEDSDEDYEKVPLP
                     NSVFVNTTESCEVERLFKATDPRGEPQDGLYCIRNSSTKSGKVLVVWDESSNKVRNYR
                     IFEKDSKFYLEGEVLFASVGSMVEHYHTHVLPSHQSLLLRHPYGYAGPR"
     exon            222..361
                     /gene="Sh3bp2"
                     /gene_synonym="3BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            362..464
                     /gene="Sh3bp2"
                     /gene_synonym="3BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            465..582
                     /gene="Sh3bp2"
                     /gene_synonym="3BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            583..653
                     /gene="Sh3bp2"
                     /gene_synonym="3BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            654..742
                     /gene="Sh3bp2"
                     /gene_synonym="3BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            743..811
                     /gene="Sh3bp2"
                     /gene_synonym="3BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            812..1460
                     /gene="Sh3bp2"
                     /gene_synonym="3BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1461..1569
                     /gene="Sh3bp2"
                     /gene_synonym="3BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1570..1625
                     /gene="Sh3bp2"
                     /gene_synonym="3BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1626..1707
                     /gene="Sh3bp2"
                     /gene_synonym="3BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1708..1767
                     /gene="Sh3bp2"
                     /gene_synonym="3BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1768..3048
                     /gene="Sh3bp2"
                     /gene_synonym="3BP2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3012..3017
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sh3bp2"
                     /gene_synonym="3BP2"
                     /note="hexamer: AATAAA"
     polyA_site      3035
                     /gene="Sh3bp2"
                     /gene_synonym="3BP2"
                     /note="major polyA site"
ORIGIN      
        1 actaccgccc gcgaggggag gagccagggg cagctccggc ctggggctct acgagctatg
       61 gcgggctcag ggtcgcggcc gcggagctgg ggctggcgag agacaggctc cagggacgag
      121 gctgcggccg gtgggcccac ctcgggaccc tgtcgctgct cacagggaag gcgggcgctg
      181 gccgcccccc ggaagccggc tgtgcccgcc gcgtggacac ccttcatggc ggctgaggag
      241 atgcagtggc ctgtccccat gaaggccatt ggtgcccaga atttgctgac catgcctggt
      301 ggtgtggcga aggctggtta cctgcataag aagggtggca cccaactgca gctgctcaaa
      361 tggcccctcc gctttgtgat catccacaag cgctgcatct actacttcaa gagcagcaca
      421 tctgcctccc cacagggtgc cttctcactg agtggctaca acagagtgat gcgagcagct
      481 gaggagacca cgtccaacaa tgtcttccca ttcaagatca ttcacatcag caagaagcac
      541 cgaacatggt tcttctcagc gtcctctgag gatgagcgca agagctggat ggccttgcta
      601 cgcagggaaa ttggccactt ccatgagaag aaggaactac ctctagacac cagcgactct
      661 agctcagaca cggacagctt ctatggtgca gttgagcgac ctatagatat cagcctgtct
      721 tcatatccca tggacaatga agattacgaa catgaagatg aggacgactc gtacctggag
      781 cctgattccc cggggcccat gaagcttgaa gatgccctga cctatccacc agcctaccca
      841 ccaccccctg tgcctgtacc tcggaagcca gccttctctg acttgccccg tgcccactcg
      901 ttcacctcta aaagtccaag tcccttactg ccacccccac ctcctaagcg aggccttcca
      961 gacactggct ctgcccctga ggatgctaag gacgcattgg gcctgaggcg agtagagcct
     1021 ggcctcaggg tgcctgccac ccctcggagg atgagtgacc ccccaatgag caatgtaccc
     1081 accgtgccca acctccggaa acatccttgc ttccgggaca gtgtgaatcc cggcctagaa
     1141 ccctggaccc ctggccatgg gactagctct gtctccagct ctaccaccat ggccgttgcc
     1201 acctctagga actgtgacaa actcaagtca ttccacctgt cttcccgagg gccacccaca
     1261 tctgagcccc cacccgtgcc tgctaataag cccaagttcc tgaagatagc tgaagaacct
     1321 tccccgaggg aggcagccaa gtttgcacct gtgccccctg tggcccccag gcctcctgtg
     1381 cagaagatgc ccatgcctga ggctactgtt cggcctgcag tgctgcctag accagagaac
     1441 acacctcttc ctcacctcca gcgatccccc cctgatggac agagtttcag gggcttctcc
     1501 tttgaaaagg cccgccagcc ctcacaggct gacactggcg aggaggactc agatgaagac
     1561 tatgagaagg tgccgctgcc taactcggtg tttgtcaaca cgacagagtc ctgcgaggtg
     1621 gaaaggttgt tcaaagctac ggacccccgt ggagagcctc aggatgggct gtattgcatt
     1681 cggaactcct ctaccaagtc agggaaggtt ttggtcgtgt gggatgaatc ttctaacaaa
     1741 gtgaggaatt atcgcatctt tgaaaaggat tctaagttct acctggaagg tgaggttctg
     1801 tttgccagtg tgggcagcat ggtggagcac taccacaccc atgtgctgcc cagccatcag
     1861 agcctgttgc tgcggcaccc atacggctac gctgggccca ggtgacatcc attccacaca
     1921 gctgttgggt ggaagcagcc ccggagccac agctctgcca caaagatgga gaccagctgc
     1981 atgggaagat gaacaggaat gggcttgaca tcagacctca tcgacatgac acctagccgc
     2041 agtgagcagg ctgggttcca gctggagcag gccacaacta ctaaaggagt ggctggatga
     2101 cttggcccat ccagccattc catgacccat ctctcaagaa cccaggtctg gtgactaagt
     2161 gctgcctggg cttcgagggc acatgatcag gtcgctatag catacctact ctgtagtggg
     2221 ctgggaccaa gcaaggctgg gttacttgaa gccttgtcct aggacccata ggaatgctaa
     2281 gacataggaa tgctctagga gggaccattg cctctcaata aatcagagat gacctttgtc
     2341 tcaatgacca gggtttgatt ggcacagagt gggtagcagg ctctactgag caccaccaat
     2401 gtccaggtag agagctactg agagcagccc taatgtgtgg tctttagtgt tcagggcaca
     2461 ggctgctgag tgacctcact ggaagagata gctaaataat ggatcaggat ccacctggat
     2521 ctgtcaatct tggctggagc ctcaatttga aagccccaat tagcaattat tgagcgacta
     2581 tgtaactggc ctggtactgg ggctggttgc tggctgtgag cagcccctag tccagcttgg
     2641 tcaagcttac tctagagcag gtcagtgagt atcaggtgct gctggaggtg ctgtggtctg
     2701 ggaagccaca tgggggatct gggagcttgg aatccagtgt gtgtgggggc agggaagggg
     2761 tgggaggtcg gggaggttcc agtaagactt cttacagatg acctggccag agtgaagtgg
     2821 gacaggccaa ggatgggtgg ggacagtggc atccacgtac ccccaagtag tttggtgatc
     2881 ccaattggtc caggccacac ccctggcaca gccgtctaga ctggactttt tctgtgaaaa
     2941 taaattcatt tggaggtcag ggcagccaga gaccttggca ctatctgatt tcattgcact
     3001 ttatgttaga aaataaagtt tctttttaaa ttttattatt tttatgcaaa aaaaaaaaaa
     3061 aaaaaaaaa
//
