LOCUS       NM_001316684            2484 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus SH3-domain binding protein 1 (Sh3bp1), transcript
            variant 1, mRNA.
ACCESSION   NM_001316684 XM_006520661
VERSION     NM_001316684.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2484)
  AUTHORS   Elbediwy,A., Zihni,C., Terry,S.J., Clark,P., Matter,K. and
            Balda,M.S.
  TITLE     Epithelial junction formation requires confinement of Cdc42
            activity by a novel SH3BP1 complex
  JOURNAL   J Cell Biol 198 (4), 677-693 (2012)
   PUBMED   22891260
REFERENCE   2  (bases 1 to 2484)
  AUTHORS   Cicchetti,P., Ridley,A.J., Zheng,Y., Cerione,R.A. and Baltimore,D.
  TITLE     3BP-1, an SH3 domain binding protein, has GAP activity for Rac and
            inhibits growth factor-induced membrane ruffling in fibroblasts
  JOURNAL   EMBO J 14 (13), 3127-3135 (1995)
   PUBMED   7621827
REFERENCE   3  (bases 1 to 2484)
  AUTHORS   Ren,R., Mayer,B.J., Cicchetti,P. and Baltimore,D.
  TITLE     Identification of a ten-amino acid proline-rich SH3 binding site
  JOURNAL   Science 259 (5098), 1157-1161 (1993)
   PUBMED   8438166
REFERENCE   4  (bases 1 to 2484)
  AUTHORS   Cicchetti,P., Mayer,B.J., Thiel,G. and Baltimore,D.
  TITLE     Identification of a protein that binds to the SH3 region of Abl and
            is similar to Bcr and GAP-rho
  JOURNAL   Science 257 (5071), 803-806 (1992)
   PUBMED   1379745
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL592169.14.
            
            On Sep 1, 2022 this sequence version replaced NM_001316684.1.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17253013.2439554.1,
                                           SRR7345562.3395662.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-168               AL592169.14        25025-25192         c
            169-211             AL592169.14        23798-23840         c
            212-316             AL592169.14        23483-23587         c
            317-393             AL592169.14        22355-22431         c
            394-505             AL592169.14        22021-22132         c
            506-582             AL592169.14        21851-21927         c
            583-727             AL592169.14        21289-21433         c
            728-796             AL592169.14        20648-20716         c
            797-887             AL592169.14        20432-20522         c
            888-1033            AL592169.14        19811-19956         c
            1034-1145           AL592169.14        19104-19215         c
            1146-1227           AL592169.14        18649-18730         c
            1228-1308           AL592169.14        18483-18563         c
            1309-1425           AL592169.14        17656-17772         c
            1426-1523           AL592169.14        16928-17025         c
            1524-1683           AL592169.14        16474-16633         c
            1684-1775           AL592169.14        14887-14978         c
            1776-2484           AL592169.14        12939-13647         c
FEATURES             Location/Qualifiers
     source          1..2484
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 37.7 cM"
     gene            1..2484
                     /gene="Sh3bp1"
                     /gene_synonym="3BP-1"
                     /note="SH3-domain binding protein 1"
                     /db_xref="GeneID:20401"
                     /db_xref="MGI:MGI:104603"
     exon            1..168
                     /gene="Sh3bp1"
                     /gene_synonym="3BP-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             110..2152
                     /gene="Sh3bp1"
                     /gene_synonym="3BP-1"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="SH3 domain-binding protein 1 isoform 1"
                     /protein_id="NP_001303613.1"
                     /db_xref="CCDS:CCDS84176.1"
                     /db_xref="GeneID:20401"
                     /db_xref="MGI:MGI:104603"
                     /translation="MMKRQLHRMRQLAHTGSSGRTPETAEFLGEDLLQVEQRLEPAKR
                     AAHNVHKRLQACLQGQSGADMDKRVKKLPLMALSTTMAESFKELDPDSSMGKALEMTC
                     AIQNQLARILAEFEMTLERDVLQPLSRLSEEELPAILKHKKSLQKLVSDWNTLKSRLS
                     QAAKNSGSNQGLGGASGSHTHTTTANKVEMLKEEEEELKKKVEQCKDEYLADLYHFST
                     KEDSYANYFIHLLEIQADYHRKSLTSLDTALAELRDNHSQADHSPLTTAAPFSRVYGV
                     SLRTHLQDLGRDIALPIEACVLLLLSEGMQEEGLFRLAAGASVLKRLKQTMASDPHSL
                     EEFCSDPHAVAGALKSYLRELPEPLMTSDLYDDWMRAASLKEPGARLEALHDVCSRLP
                     QENFNNLRYLMKFLALLAEEQDVNKMTPSNIAIVLGPNLLWPPEKEGDQAQLDAASVS
                     SIQVVGVVEALIQNADTLFPGDINFNVSGIFPGLAPQEKVSSQQVSEELPPVTVPAPA
                     TTPAPTPAPASMAVRERTEADLPKPTSPKVSRNPTETAASAEDMTRKTKRPAPARPTM
                     PPPQPSSTRSSPPAPSLPPGSVSPGTPQALPRRLVGTSLRAPTMPPPLPPVPPQPARR
                     QSRRLPASPVISNMPAQVDQGVATEDRGGPEAVGGHPPPPALPPQPRPRGLISETE"
     exon            169..211
                     /gene="Sh3bp1"
                     /gene_synonym="3BP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            212..316
                     /gene="Sh3bp1"
                     /gene_synonym="3BP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            317..393
                     /gene="Sh3bp1"
                     /gene_synonym="3BP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            394..505
                     /gene="Sh3bp1"
                     /gene_synonym="3BP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            506..582
                     /gene="Sh3bp1"
                     /gene_synonym="3BP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            583..727
                     /gene="Sh3bp1"
                     /gene_synonym="3BP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            728..796
                     /gene="Sh3bp1"
                     /gene_synonym="3BP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            797..887
                     /gene="Sh3bp1"
                     /gene_synonym="3BP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            888..1033
                     /gene="Sh3bp1"
                     /gene_synonym="3BP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1034..1145
                     /gene="Sh3bp1"
                     /gene_synonym="3BP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1146..1227
                     /gene="Sh3bp1"
                     /gene_synonym="3BP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1228..1308
                     /gene="Sh3bp1"
                     /gene_synonym="3BP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1309..1425
                     /gene="Sh3bp1"
                     /gene_synonym="3BP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1426..1523
                     /gene="Sh3bp1"
                     /gene_synonym="3BP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1524..1683
                     /gene="Sh3bp1"
                     /gene_synonym="3BP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1684..1775
                     /gene="Sh3bp1"
                     /gene_synonym="3BP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1776..2484
                     /gene="Sh3bp1"
                     /gene_synonym="3BP-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2464..2469
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sh3bp1"
                     /gene_synonym="3BP-1"
                     /note="hexamer: AATAAA"
     polyA_site      2484
                     /gene="Sh3bp1"
                     /gene_synonym="3BP-1"
                     /note="major polyA site"
ORIGIN      
        1 agagcgccgc ccacccatcc ggggcgaagc gcgcggggaa gcaggctggg ccgggggctg
       61 ccagcctcaa cccccaaggt gactcctcgg ccccctgccc ggacccaaga tgatgaagag
      121 gcagttgcac cgcatgcggc agctggccca cacgggcagc tcgggacgca ccccggagac
      181 tgccgagttt ttgggtgagg acctgctgca ggtagagcaa cggctggagc cagctaaacg
      241 agcagcccac aatgttcaca aacggctgca ggcctgtctg cagggccaaa gcggggctga
      301 catggacaag cgggtgaaga agcttcctct catggctctt tctaccacga tggcagagag
      361 cttcaaggaa ctggatcctg attccagcat ggggaaggcc ttggagatga cctgcgccat
      421 ccagaaccag ctggcccgaa tcctagccga gtttgagatg accctggaga gggatgtcct
      481 gcagccgctc agcaggctga gcgaggagga gctgcctgcc atcctgaagc acaagaaaag
      541 ccttcagaag ctggtgtctg actggaacac cctcaaaagc aggctcagcc aggcagccaa
      601 gaactcagga agcaaccaag gcctgggtgg tgcctcaggc agtcacaccc acaccaccac
      661 tgccaacaag gtagagatgc tgaaggagga agaggaggag ctcaagaaga aggtggaaca
      721 gtgcaaggac gagtacctgg ccgatctcta ccacttctcc accaaggagg attcttatgc
      781 caactacttt attcatctct tggagattca ggctgactac caccgcaagt cactgacctc
      841 actcgacacg gccctagctg agctgaggga caaccacagc caagcagacc actccccctt
      901 gacgacggct gcccccttct ccagggtata tggggtatct ttgagaaccc acctacaaga
      961 cctaggccgt gacattgccc tgcccatcga ggcctgcgtc ctgttgctgc tgtcagaggg
     1021 catgcaggag gagggcctct tccgtctggc tgctggggcc tctgtgctga agcgccttaa
     1081 gcagaccatg gcctcagatc cccacagcct agaggaattc tgctcagacc cccatgctgt
     1141 agcaggtgcc ctcaagtcct atctccggga gctgccggag cccctgatga cctctgacct
     1201 ctacgatgac tggatgagag cagccagcct gaaggagcca ggagcccgcc tggaagccct
     1261 ccatgatgtt tgcagccgtc taccccaaga gaacttcaac aacctcaggt acctgatgaa
     1321 gttcctggct ctgctggcag aggagcagga tgtaaacaag atgacaccca gcaacatcgc
     1381 cattgtccta ggacccaacc tgctgtggcc tcccgagaaa gaaggggacc aggcccaact
     1441 ggacgctgcc tctgtgtcct ccattcaggt ggtgggtgtt gtcgaggcgc tgatacagaa
     1501 cgcagacacc ctcttccctg gagatatcaa cttcaatgta tcaggcatct tcccaggcct
     1561 ggccccccag gagaaggtca gtagccaaca ggtctcagag gagttgccac ctgttactgt
     1621 gcctgcccca gccacgaccc cagctcccac cccggctcca gcctcaatgg ctgtcagaga
     1681 aaggacagag gctgacttgc ccaaaccaac ttctcccaag gtcagcagga accccaccga
     1741 aacagctgct tcggcggagg acatgacccg taagaccaag cgcccagccc cagcccggcc
     1801 taccatgcca cctccccagc cctccagcac ccgctcatcc cctccagctc catccctgcc
     1861 ccctggctct gtcagccctg gtactcccca agctctgcct cgccgtctgg tgggcaccag
     1921 cctccgggcc cctaccatgc ctcccccgtt accccctgtt cctccacagc ctgcccggcg
     1981 tcagagccgg cgtttaccag cctcccctgt catctcaaat atgcctgctc aggtggacca
     2041 gggagtagct acagaggaca gaggaggccc tgaggctgtg ggtgggcatc cccctccacc
     2101 agctctgcca ccccagcccc ggcccagggg cctcatttca gagacagagt aagcaggccc
     2161 tcctacctgg caggtcctca ttgtcccttt ctctctcctg ccatcctccc tcccttgtcc
     2221 tcccaggatg gcccttgtcc agtgcctggg tgcctgctgg gccggcccct atggccagga
     2281 gggctcaggc cagccctctc atttctaacc ttttcctctt ccactttgag cttggggttc
     2341 ccacctgact ccccactctc cggcagggtc tcaagggagc taccagaagg aagaacagac
     2401 ttgcctgttc ctagaggact tttatttttt ttctcttgcc aatgtatttt tgtaaggctc
     2461 gtaaataaat tattttgaac aaaa
//
