LOCUS       NM_001374030            1170 bp    mRNA    linear   ROD 04-AUG-2024
DEFINITION  Mus musculus SH2 domain containing 6 (Sh2d6), mRNA.
ACCESSION   NM_001374030 XM_006506833
VERSION     NM_001374030.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1170)
  AUTHORS   Gineste,C., De Winter,J.M., Kohl,C., Witt,C.C., Giannesini,B.,
            Brohm,K., Le Fur,Y., Gretz,N., Vilmen,C., Pecchi,E., Jubeau,M.,
            Cozzone,P.J., Stienen,G.J., Granzier,H., Labeit,S.,
            Ottenheijm,C.A., Bendahan,D. and Gondin,J.
  TITLE     In vivo and in vitro investigations of heterozygous nebulin
            knock-out mice disclose a mild skeletal muscle phenotype
  JOURNAL   Neuromuscul Disord 23 (4), 357-369 (2013)
   PUBMED   23375831
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC154002.8.
            
            On Sep 9, 2019 this sequence version replaced XM_006506833.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189685.47986.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-77                AC154002.8         112232-112308       c
            78-199              AC154002.8         112033-112154       c
            200-257             AC154002.8         111183-111240       c
            258-280             AC154002.8         110210-110232       c
            281-332             AC154002.8         109822-109873       c
            333-411             AC154002.8         109379-109457       c
            412-442             AC154002.8         108814-108844       c
            443-467             AC154002.8         108661-108685       c
            468-526             AC154002.8         108193-108251       c
            527-610             AC154002.8         107814-107897       c
            611-769             AC154002.8         107498-107656       c
            770-1170            AC154002.8         105913-106313       c
FEATURES             Location/Qualifiers
     source          1..1170
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 32.27 cM"
     gene            1..1170
                     /gene="Sh2d6"
                     /note="SH2 domain containing 6"
                     /db_xref="GeneID:71130"
                     /db_xref="MGI:MGI:1918380"
     exon            1..77
                     /gene="Sh2d6"
                     /inference="alignment:Splign:2.1.0"
     exon            78..199
                     /gene="Sh2d6"
                     /inference="alignment:Splign:2.1.0"
     CDS             134..886
                     /gene="Sh2d6"
                     /codon_start=1
                     /product="SH2 domain-containing protein 6"
                     /protein_id="NP_001360959.1"
                     /db_xref="CCDS:CCDS90061.1"
                     /db_xref="GeneID:71130"
                     /db_xref="MGI:MGI:1918380"
                     /translation="MARGLPINPSFPTRPTSGYHFPLKTAMNPQPAKQGPVFGRQGRG
                     TSARMVTKKPDEDIYLECEPDPVPVLTRSLSSKALIPPVPLPRTSGLPKSVAGYQEAR
                     NGAMDGALKAGRRLSASSIAPALSSSVAENGSLLGQPWYSGNCDRQSVERALLHFQKD
                     GAYTVRLSSGPHSSQPFTLAVLLRGRVFNIPIRQLDGGHHYALGREGRNHEELFSSVA
                     AMVQHYTKHPLPLVDGHSGNRGLTYLRFPTKP"
     exon            200..257
                     /gene="Sh2d6"
                     /inference="alignment:Splign:2.1.0"
     exon            258..280
                     /gene="Sh2d6"
                     /inference="alignment:Splign:2.1.0"
     exon            281..332
                     /gene="Sh2d6"
                     /inference="alignment:Splign:2.1.0"
     exon            333..411
                     /gene="Sh2d6"
                     /inference="alignment:Splign:2.1.0"
     exon            412..442
                     /gene="Sh2d6"
                     /inference="alignment:Splign:2.1.0"
     exon            443..467
                     /gene="Sh2d6"
                     /inference="alignment:Splign:2.1.0"
     exon            468..526
                     /gene="Sh2d6"
                     /inference="alignment:Splign:2.1.0"
     exon            527..610
                     /gene="Sh2d6"
                     /inference="alignment:Splign:2.1.0"
     exon            611..769
                     /gene="Sh2d6"
                     /inference="alignment:Splign:2.1.0"
     exon            770..1170
                     /gene="Sh2d6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1139..1144
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sh2d6"
                     /note="hexamer: AATAAA"
     polyA_site      1170
                     /gene="Sh2d6"
                     /note="major polyA site"
ORIGIN      
        1 agttgccatg gagacggagc tgttaagaag ccaataagta gaggagacag gaggagagag
       61 ggagagatga gggctagatc gttctgggcc cctggatcca tccaagccac cactgccccc
      121 gcctcagtct accatggcca gaggactccc cataaaccct tccttcccta cccgccctac
      181 ctctggctac catttcccgc tgaagacagc aatgaaccca cagcctgcaa agcagggacc
      241 tgtttttgga aggcaagggc gaggtacatc tgctagaatg gtaacaaaga aaccagatga
      301 ggacatctac ctggagtgtg agccggatcc agttccagtc ttgactaggt ctctgagctc
      361 caaagccctg atacctccag ttcctctgcc aagaacatct ggattgccca agtcagtggc
      421 tggttaccag gaggctcgga atggagctat ggatggtgcg ttgaaagcag gaaggaggct
      481 gtctgcttcc tccatagccc ctgctctgag tagctctgtt gctgagaatg gtagtctgct
      541 gggtcagcct tggtactctg gaaactgtga ccgtcagtct gttgagagag ccctgcttca
      601 cttccaaaag gatggggcct acacggtgcg cctcagctct gggcctcaca gttcccagcc
      661 cttcactttg gcagtactcc tcagaggccg tgtcttcaac attcccatcc ggcaactgga
      721 cggtgggcac cactatgccc tgggtcggga gggcaggaat catgaggagc tcttctcctc
      781 tgtggccgcc atggttcagc attacacgaa gcaccccctg ccccttgtgg acggacacag
      841 tggcaaccgg ggactcacct acctgcgctt ccccaccaag ccctgaagaa acagcagcac
      901 acagatcccc ctcaggcacg tgatgtgtgc cccattcact ttctctccca ctttaggctg
      961 ttttcttttc cctgccttcc tccaccccaa aagctctgca ggttcaaact gagaggcatg
     1021 aagatggcca cctgggaggc tggcttcctc agagacactg cctctcctta gactgacttc
     1081 ttgtgtgtgg tttgcatctt ctgggaggaa ctaggttccc agcacacagt atactttcaa
     1141 taaacattta ctgactgaat tctctcttaa
//
