LOCUS       NM_177816               5992 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus SH2 domain containing 4B (Sh2d4b), transcript variant
            1, mRNA.
ACCESSION   NM_177816 XM_127666
VERSION     NM_177816.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5992)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CT025537.7.
            
            On Aug 30, 2022 this sequence version replaced NM_177816.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC138964.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-533               CT025537.7         41521-42053
            534-693             CT025537.7         60596-60755
            694-841             CT025537.7         62158-62305
            842-989             CT025537.7         74096-74243
            990-1206            CT025537.7         92245-92461
            1207-1331           CT025537.7         94486-94610
            1332-1552           CT025537.7         114000-114220
            1553-5992           CT025537.7         118875-123314
FEATURES             Location/Qualifiers
     source          1..5992
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 22.36 cM"
     gene            1..5992
                     /gene="Sh2d4b"
                     /gene_synonym="A430109M18Rik; D030001E08"
                     /note="SH2 domain containing 4B"
                     /db_xref="GeneID:328381"
                     /db_xref="MGI:MGI:1925182"
     exon            1..533
                     /gene="Sh2d4b"
                     /gene_synonym="A430109M18Rik; D030001E08"
                     /inference="alignment:Splign:2.1.0"
     CDS             350..1645
                     /gene="Sh2d4b"
                     /gene_synonym="A430109M18Rik; D030001E08"
                     /note="isoform a is encoded by transcript variant 1; SH2
                     domain-containing protein 4B"
                     /codon_start=1
                     /product="SH2 domain-containing protein 4B isoform a"
                     /protein_id="NP_808484.2"
                     /db_xref="CCDS:CCDS26955.1"
                     /db_xref="GeneID:328381"
                     /db_xref="MGI:MGI:1925182"
                     /translation="MLQQILQDMYIDPELLAELSDVQKHILFYKMREEQLRRWREREA
                     WDALAQAEGLRPAKVKRASNKHLQWLLGADGEVWVWVMGEGPGDKPYEEISEELIAER
                     ARLQAQKEAEELWRQKEAEITKKFRDALANEKARILAEKWKVEMEDRKAAKILEERIH
                     EEFKRKEEEERRRGEEQIRLQEEQRAKELYWTLKQAQLHSQASENEEREWEEQLRRSK
                     AADEERSRRAQRARDEYRRHSLRAIQKGTVAGLSTMFQELGQNHEQEARLYHQLPDTS
                     PPSPLTGPDRTWERPLRPLSREVIVRWFKEEQLPRRAGFERNTKSIAPWFHGIISRES
                     AEDLLENMTEGAFLVRVSEKIWGYTLSYRLQRGFKHFLVDASGDFYSFLGVDPNRHAT
                     LTDLIDFHKEEIITVSGGELLQEPCGQRDSPPDYHLLFE"
     exon            534..693
                     /gene="Sh2d4b"
                     /gene_synonym="A430109M18Rik; D030001E08"
                     /inference="alignment:Splign:2.1.0"
     exon            694..841
                     /gene="Sh2d4b"
                     /gene_synonym="A430109M18Rik; D030001E08"
                     /inference="alignment:Splign:2.1.0"
     exon            842..989
                     /gene="Sh2d4b"
                     /gene_synonym="A430109M18Rik; D030001E08"
                     /inference="alignment:Splign:2.1.0"
     exon            990..1206
                     /gene="Sh2d4b"
                     /gene_synonym="A430109M18Rik; D030001E08"
                     /inference="alignment:Splign:2.1.0"
     exon            1207..1331
                     /gene="Sh2d4b"
                     /gene_synonym="A430109M18Rik; D030001E08"
                     /inference="alignment:Splign:2.1.0"
     exon            1332..1552
                     /gene="Sh2d4b"
                     /gene_synonym="A430109M18Rik; D030001E08"
                     /inference="alignment:Splign:2.1.0"
     exon            1553..5992
                     /gene="Sh2d4b"
                     /gene_synonym="A430109M18Rik; D030001E08"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2583..2588
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sh2d4b"
                     /gene_synonym="A430109M18Rik; D030001E08"
                     /note="hexamer: AATAAA"
     polyA_site      2606
                     /gene="Sh2d4b"
                     /gene_synonym="A430109M18Rik; D030001E08"
                     /note="major polyA site"
     regulatory      5967..5972
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sh2d4b"
                     /gene_synonym="A430109M18Rik; D030001E08"
                     /note="hexamer: AATAAA"
     polyA_site      5992
                     /gene="Sh2d4b"
                     /gene_synonym="A430109M18Rik; D030001E08"
                     /note="major polyA site"
ORIGIN      
        1 attgttgtag aaaccccagg tgaagccaca acactgctga aatgtggtaa tttaatgata
       61 agtgatctta ataggaagcc aggactagac agctctctgc ctctgctacc tctcagagcc
      121 ccttggttct tgctgcttgg gtgaataatg ctgtcctggc cgatatgaat ccatcattgg
      181 ctgggagctg agacaggaca aagatgctgt ccaaggagag gtcatctgga gtgactccaa
      241 agtgaggagc tagggcagaa ttggctcaag gcgctggcct ggcccaggga tcttgtgtag
      301 ccttggagtt ctgactggct gcactccggt gtgcgtcccc cacagcatca tgctgcagca
      361 gatcctgcag gacatgtaca tcgacccgga gctgttggcc gagctcagcg atgtgcagaa
      421 gcacatcctc ttctataaga tgcgagagga gcagctgcgg cgatggaggg aacgggaggc
      481 gtgggatgcc ctggctcagg cagagggcct gaggcccgca aaggtcaaga gagcgagcaa
      541 caagcatctc cagtggcttc tgggagcaga tggtgaggtc tgggtgtggg tcatgggcga
      601 aggccctgga gacaagccct acgaagagat atctgaagaa ctgattgcag agagggcccg
      661 gctgcaagca cagaaagagg ctgaagagct ctggagacag aaggaagcag agatcaccaa
      721 gaagttccgg gatgccttgg ccaatgagaa agctcggatt ctggcagaga agtggaaagt
      781 ggagatggag gaccgcaagg ctgctaaaat tttggaggaa cgtatacacg aggaattcaa
      841 gaggaaagag gaagaagaga ggcggcgagg ggaagaacag attcggctcc aagaggagca
      901 gagggcaaag gaactctact ggactctgaa gcaggcccag ctgcacagcc aagccagtga
      961 gaatgaggag cgtgaatggg aagaacagct gcggagatcc aaggctgctg atgaagagag
     1021 gagccgtcgt gctcagcgag cccgggatga gtaccggcgc cattcactcc gagccatcca
     1081 gaagggcact gttgctggcc taagcaccat gttccaagag cttggccaga accacgagca
     1141 agaggcaaga ctttatcacc aacttcctga caccagtcca ccatcacccc tcacaggacc
     1201 tgacaggacc tgggagcgac ctctgcgtcc actctccaga gaagtcatcg tgcgctggtt
     1261 caaggaggaa cagctgcctc gccgagcagg ctttgagagg aacaccaagt ccatcgcccc
     1321 ttggtttcat ggaattatta gccgagagag tgcagaagac cttctggaga atatgaccga
     1381 gggagcattt ctggtccggg tcagtgagaa gatctggggt tataccctgt cctaccgcct
     1441 gcagagaggc ttcaaacact tccttgtgga tgcttctggg gacttctaca gctttctggg
     1501 agtggaccct aatcgccatg ccaccctaac agatctcatt gatttccaca aggaggagat
     1561 catcactgtt tcagggggag agttgctaca ggaaccctgt ggacagaggg atagcccacc
     1621 agactatcac ctgttgtttg aatgattttt cccctcctct ttggactcct ttgagtatcc
     1681 tgattttgaa ctgagcttaa gaatatccaa actcaaagcc tcatgacgtt ttggaagatc
     1741 caccattctt cagatgaaca attatattag taagcctcca gaatgtgacc tataaaacgt
     1801 gactgcattc gtgagactgt tcccattcca aagttcaaga cagaaacctc gaataatgat
     1861 gctcctggag gcctgtctgt catggctgtg ctaagttgaa ttcctagggt gaatgggtca
     1921 tattttaata acccaaagca aatccagtgc cgaacctccc acttaatgta gggccagcac
     1981 tcaataagtc tttgttgaat gaatgccctc ctaaaaaact cctaacactg atggtttcta
     2041 gcaaattact ttgtatatta cttcataaag tcacagagat agcagaccag gcttgtgact
     2101 aacttacatg gaagacacac atgttatatc tttcctagta ttcatgaact tgttgatatt
     2161 ctcatgggca ttgctcaagg ttgttatgtt tgactttcag tatgggatat tggtgttgtg
     2221 ctggctgctt ggtttgacta cttctacctc tctcttatgt ctcatcttac atgtggctct
     2281 ggttttgcaa attgaggtaa tgatgtcatg taaatgcgca gaatatctgg aatggattat
     2341 aaacccaagg atagtgttta gatacttgat gaggcaggtc tttgctctct agaatgttct
     2401 ctgtgtgctc tctacttaaa ggcgtagcta tgctttgatt ttaattcttc cacctcctta
     2461 atttgaacat gttcttcata ttaatgagag taacctccct gtaactcagt aactctcaag
     2521 gatggagtct tccttagggt tttattgttg caaagagaca ccatgaacac agccactcat
     2581 aaaataaaat atttaattgg ggactagctt atggcttcag aggttcagtc aattgtcatt
     2641 atgatgggaa gcatggcagc ttgtaagcag acatggttca ggagaaggag ataagagttc
     2701 tataccttga tctgaaggca actgggagag agactgtctt ctaggcacct aggtggatct
     2761 gaatgcctac ccctacagtg agacacttcc ttccaacaag gccatacctc ctaataatgg
     2821 accaaccata ttcgaaccac cacagtgtct aatgcaagca taatcatgtt gtttccttat
     2881 ggtgatagac aaggagatag cagatgttgc agcaagatgg caggttctga agtctggaag
     2941 gcttcagtta tagtccatac tctgaaactt tgtggcatta taatccttgc agcactgggt
     3001 ttggcatata taaaaggata tatggactct ggaaacacca gaaaactgtt ttatctgcct
     3061 tgagagttgt gtagtaagaa gaataaggtg tctttattct ccactcaacc tcttggctct
     3121 tctgtttctt gtatccttgg ccacttgtga catcatccac cctcatggct attgttacag
     3181 ccagttttgt gtggacgact ctgctttctg cattgaccat attcttctgc ctcacatgta
     3241 catatgacaa tgggactttg ccacacatgg ttctttggga tcatttattt ttatctttta
     3301 aactgacttt tctttatttt tgagaatttt gtacatctat acaatgaaaa atgatattta
     3361 ctgttcccct tccctattct attccccaga tctatcccag tatgctctca acatcatgta
     3421 ttcataaaaa ataactcata ggtacaagta atggtaccat atgagtatga gtgtagcctt
     3481 tctctgagca ccatagaaac cttactagga gtcacatctc caaaggaaag tgactctgtc
     3541 ttcctcagaa gctaccaatt accaatgctc ttcagtaagg ggtaggacca caaaacattt
     3601 tttatagtta gtttcttctg ttagagtcct aataagactt acatgtagca tctgttatgc
     3661 cctcaagtct ctgataacac cctcctcttc ttgacccata actagtttta taaattagag
     3721 ttctataaaa tgacctgtgt tctggacttg ccttattgtt tcctgttgtt atttctgtat
     3781 tgtctctatt tcatatttcc tgacttgatt gagattgaat ttgagggcca gaaaatgttc
     3841 ttagggcatc atgtcacaag gatccttgta acatattggc tcaaattttc tagacttgtc
     3901 agtgggctca gaatgtctca aactgagtac cccagttggc cttcttcacc cttatctttt
     3961 gtttttgctt tttgagatag ggtcttgttg caggaaatat taaaaaagaa tggcacattc
     4021 ctgcccttgt accagcaact cactacccca gaggcctggc cggccatgta ctggtggaca
     4081 atggctgacc tgtttttatc tctcggagac tctgactcag tgctccaaaa tctctccatc
     4141 ctgctcgcta agtttccact ggtgggttgt tgccacacca accctgtgtt tcaaatcccc
     4201 catggccttt gtggtgcacc tcaggcaaac ccagtctttg ccactgtatc tttctctctt
     4261 gaactcagag gagccaccag gtgaaggaaa acacaacaca aacaagttca gaaactcagt
     4321 cattgtgcgc tgcaactaaa atcctaatct tgtaaacctt attaaatcta aatcctctgg
     4381 tggagaatcc tgacagatcc gccattgaaa ctgggagaca ctggcagcta catcttgtcc
     4441 ttatgctatc ccgtccaaaa ggccataact cactcctctt tcctctcttt ctctgtgcag
     4501 cccagaagtc ccacctactc acccaatgat tgacttcttt attaattagg ggattgggtc
     4561 acaagaagtc acctgggtac atgactcacc ccttgtccgc agtccccccc aggagagtgg
     4621 aattagcatg caccaggccc atccacaaca gggtctcata atgcagggta atcttaaatt
     4681 tactacattg aactttgatc ttcctgtctc tacttcccgt ggtctgggat ataggtgagt
     4741 accactatgc ttggcttccc ttttggatcc tctccccctt tcagcaaaaa aaagttaccc
     4801 tatatttctc ccctattgct ccagtgaacc ctaggtcaat gggatgctca tgttggtcag
     4861 tcatttcttc cttcatcctc ctggatgaaa gacagctctt gatgtggcca ctgagaagac
     4921 agtcatgcaa gatggcatag ccagatccat caacacctct gtttccactc attctctgtc
     4981 ttttccctct ctggaaagtt catctgggaa gctacgctgg agcttagtgg ctgtcttagt
     5041 ctataccact tgggaactca aagtaagtgc cttctataca catatatatt ctgacctttt
     5101 gtaacttgag tcagggtctt cccatgtagc tcaggctgtc ttggaaatca ttagcttaag
     5161 tttggttctc aactcatgat cttcttgggt tcatttcctg aatgctagca tgacaggtat
     5221 gtgtcatcac aactggcccc aacacattag gtaatagcgg ttttatgtat cagttccata
     5281 gcttccctcc atcagccggt atcgctgcat gaatgaaatg atgtgatgat ggagggatcc
     5341 tgctttctaa actttatgaa ctctcaagcc atagccaaat tctgttctaa ttacatcagt
     5401 tctaccaggt cttagaagac ctcctcttgt tctgattttg cactgtgtca gccatgtgaa
     5461 tttgttcagg ccactcaatc tctataaacc tctgtgtaac tgggaatagg aatttttgtt
     5521 tttaatgtgg tcatcattag cttcttctgg ctgatcagtt aagtgacaaa tagggaatct
     5581 ctgtccaaat gaaagacctt gctatccaca gccacacagt ggcagcttcc tgccaagcag
     5641 tgctgtgtca ggggatgcca caagatgatt tcccacacac tggaagaaag ttccaaacaa
     5701 cagctttgaa aggagtccaa gatgggttga aaaacctgac atcctggaag gttgttcctg
     5761 ttgcctgcta attaatatgt gagggataac agctgagttt tccatcccta actcatttat
     5821 ttcattttat ttggggcctg cactttttgt acgtctcata tattttaggt tttacctggc
     5881 tttcaaataa attccttgta agttgtcctg caaatgaaat tactgtctgg aaaactgcaa
     5941 tttcatcttg agagttttat tatgctaata aatgtcagaa ttctcaaata aa
//
