LOCUS       NM_028182               2767 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus SH2 domain containing 4A (Sh2d4a), mRNA.
ACCESSION   NM_028182 XM_001476079 XM_001476415
VERSION     NM_028182.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2767)
  AUTHORS   Lapinski,P.E., Oliver,J.A., Kamen,L.A., Hughes,E.D., Saunders,T.L.
            and King,P.D.
  TITLE     Genetic analysis of SH2D4A, a novel adapter protein related to T
            cell-specific adapter and adapter protein in lymphocytes of unknown
            function, reveals a redundant function in T cells
  JOURNAL   J Immunol 181 (3), 2019-2027 (2008)
   PUBMED   18641339
  REMARK    GeneRIF: SH2D4A is dispensable for TCR signal transduction in T
            cells
REFERENCE   2  (bases 1 to 2767)
  AUTHORS   Patrakka,J., Xiao,Z., Nukui,M., Takemoto,M., He,L., Oddsson,A.,
            Perisic,L., Kaukinen,A., Szigyarto,C.A., Uhlen,M., Jalanko,H.,
            Betsholtz,C. and Tryggvason,K.
  TITLE     Expression and subcellular distribution of novel
            glomerulus-associated proteins dendrin, ehd3, sh2d4a, plekhh2, and
            2310066E14Rik
  JOURNAL   J Am Soc Nephrol 18 (3), 689-697 (2007)
   PUBMED   17251388
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC117792.6, AK008803.1 and AC117740.12.
            
            On or before Sep 26, 2008 this sequence version replaced
            XM_001476415.1, XM_001476079.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK008803.1, BC116682.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-215               AC117792.6         22043-22257         c
            216-2627            AK008803.1         2-2413
            2628-2767           AC117740.12        44067-44206         c
FEATURES             Location/Qualifiers
     source          1..2767
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 33.76 cM"
     gene            1..2767
                     /gene="Sh2d4a"
                     /gene_synonym="2210402M20Rik; SH2A"
                     /note="SH2 domain containing 4A"
                     /db_xref="GeneID:72281"
                     /db_xref="MGI:MGI:1919531"
     exon            1..345
                     /gene="Sh2d4a"
                     /gene_synonym="2210402M20Rik; SH2A"
                     /inference="alignment:Splign:2.1.0"
     exon            346..724
                     /gene="Sh2d4a"
                     /gene_synonym="2210402M20Rik; SH2A"
                     /inference="alignment:Splign:2.1.0"
     CDS             544..1809
                     /gene="Sh2d4a"
                     /gene_synonym="2210402M20Rik; SH2A"
                     /codon_start=1
                     /product="SH2 domain-containing protein 4A"
                     /protein_id="NP_082458.1"
                     /db_xref="CCDS:CCDS52564.1"
                     /db_xref="GeneID:72281"
                     /db_xref="MGI:MGI:1919531"
                     /translation="MLRQILSDMFIDPDLLAELSEEQKQILFYKMREEQIRRWKEREA
                     AMERKESLPVKSRPKKENGKSVHWKLGADKQVWVWVMGEHHLDKPYDVLCDEILAERE
                     HLRAAKDSELRKTQSLELANSLKIKSQNCDLQAMKKTEPQNVTRKAASEEASGQGPRA
                     IPTRKDDKAQTKPVKEKDHEEMKQTEDEKTKQIYKSWKEDSEWQASLRKSKAADEKRR
                     SLAKQAREDYKRLSQRGRSGDGLQNPLTGPQKPRRPPLPPKPQFLQPLGIPPKSLGNQ
                     GVIRTEISSAQMDTIRWFKEEQLPFRAGYQKNSDTIAPWFHGILTLKKANELLSTGVP
                     GSFLIRVSEKIKGYALSYLSEEGCKHFLIDASANSYSFLGVDQLQHATLADLVEYHKE
                     EPITSLGKELLLYPCGQQDKLPDYLELFQ"
     exon            725..881
                     /gene="Sh2d4a"
                     /gene_synonym="2210402M20Rik; SH2A"
                     /inference="alignment:Splign:2.1.0"
     exon            882..1053
                     /gene="Sh2d4a"
                     /gene_synonym="2210402M20Rik; SH2A"
                     /inference="alignment:Splign:2.1.0"
     exon            1054..1162
                     /gene="Sh2d4a"
                     /gene_synonym="2210402M20Rik; SH2A"
                     /inference="alignment:Splign:2.1.0"
     exon            1163..1364
                     /gene="Sh2d4a"
                     /gene_synonym="2210402M20Rik; SH2A"
                     /inference="alignment:Splign:2.1.0"
     exon            1365..1495
                     /gene="Sh2d4a"
                     /gene_synonym="2210402M20Rik; SH2A"
                     /inference="alignment:Splign:2.1.0"
     exon            1496..1716
                     /gene="Sh2d4a"
                     /gene_synonym="2210402M20Rik; SH2A"
                     /inference="alignment:Splign:2.1.0"
     exon            1717..2767
                     /gene="Sh2d4a"
                     /gene_synonym="2210402M20Rik; SH2A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2743..2748
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sh2d4a"
                     /gene_synonym="2210402M20Rik; SH2A"
                     /note="hexamer: ATTAAA"
     polyA_site      2764
                     /gene="Sh2d4a"
                     /gene_synonym="2210402M20Rik; SH2A"
                     /note="major polyA site"
ORIGIN      
        1 actgtagaca gcgctctaga ttaaccaagg actagtggcc ttgctgtcac tggaccaagg
       61 cagccaagct tgcctactgg ccctggagcg cctccagcac ccgggtgggg ccttgaggga
      121 gcgcccagtc agtcacccca gcatgtgggc gcggcggggc gggccagggc tgcgatctgg
      181 acgctgagtg tccttctggt cccgagtgtt tgtccagaca gcccgcgcgg ctgggtctct
      241 gggaggctgg gtctctgctt gtcctccctt ctcttcccgg acagttgctg taggcaatct
      301 ggaggtggca ggtgcttggg tcaccttgct ccgggtactg agcaggtttg tccatattta
      361 ccgagcagca tttactacag atacagctct gctgaattcc tgcagtgaga gtcatcattt
      421 ctgggctggt caagtctctg caaaggtgca gcagtgcccg agctcctggc tgctggtagc
      481 aaaccggcaa gtggtttcca agaacttctg ctgtaggtgg agaagttcct gtgagcagca
      541 aagatgctga ggcagatact gtcagatatg ttcatagacc ctgacctgct ggcagagctc
      601 agcgaagagc agaaacagat cttgttctac aagatgagag aggaacagat ccgacgatgg
      661 aaagaaagag aagcggccat ggaaagaaag gagtccttgc cagtgaaatc caggccaaaa
      721 aaagagaatg gcaagtctgt ccattggaag ctgggcgccg ataagcaggt gtgggtttgg
      781 gtaatgggcg agcaccatct ggacaaaccc tatgatgtgc tgtgtgatga gatccttgcg
      841 gagagggagc atctgagagc agcgaaggat tcagagctca ggaaaactca gtctctagaa
      901 ctcgccaata gcttaaaaat aaagtcacag aactgtgatc tgcaagcaat gaagaagaca
      961 gagcctcaga atgtcaccag gaaagcagct tcagaagagg catcaggtca aggacccaga
     1021 gcaataccaa ccaggaagga tgacaaagcc caaactaaac ccgtcaagga aaaagaccac
     1081 gaggaaatga agcagacaga ggatgagaaa accaagcaga tatacaagag ctggaaagaa
     1141 gactcagaat ggcaagcatc tctgcgaaaa tctaaggcgg ctgatgagaa gagacgctct
     1201 ttagctaaac aagcacggga agactacaag aggctatccc aaagggggag gagtggggac
     1261 ggactgcaga acccactgac aggtccacag aagcccagaa gacctcctct tcctccgaag
     1321 ccccagttcc tacagccgct gggaatccct ccaaagtctt tagggaatca gggggtgata
     1381 aggaccgaga tcagctccgc ccagatggac accattcgat ggttcaaaga ggaacagttg
     1441 ccattccgtg caggttacca gaaaaactca gacaccattg ctccttggtt ccatgggatt
     1501 ctcacactga agaaagcaaa tgaacttctg agcacaggtg tgccgggaag ttttttgatt
     1561 cgagtcagtg aaaagatcaa gggctatgcc ctgtcctacc tgtctgagga aggctgcaaa
     1621 catttcctta tagatgcatc tgccaactct tacagcttcc tgggtgtgga ccagctgcag
     1681 catgctacac tggcagattt ggtggaatat cacaaggagg agcccataac ctctctgggg
     1741 aaggaactcc ttctgtaccc ctgtggtcaa caagacaagc tgcccgacta cctggagctc
     1801 ttccagtgac aactctcatc cagatcagcc tccaacttcc agctggtttc ccctctggac
     1861 agacacctct gagatggaca tttgtgtgtg atgccaaaat ctctctgtga cagagccaac
     1921 agtgaacaac gtctgaggtc ttcattgaaa cctctcttct gcataaatgc tggattcagt
     1981 ttaagggggt gttacctctc tctcatcctc attctgaaag gaaaaggggg aaggtaccca
     2041 catttgcaac atcctaatat gaaggatagg accttgaagg atatgaccat gatgatgtat
     2101 ataagataaa aaggacaagg gtacactgaa atctttttag caattaagat gttattttaa
     2161 aagaacaagt gaacaatttc atgatctaca cactcccttt ttgttattca ctcaaaggtc
     2221 tcagtattct gtgtgtataa atttttatct tgcttttaga atggtggaaa aatgtcccca
     2281 ctgagggatg agattatctt caaaagacca ccctttctgt gtctgttgga gtgaggttat
     2341 agaagacaga agagaaagac ccaagtgtaa attgaaagac aagtttcaaa acttgagatg
     2401 agagacttac cacatatgaa aaaaaccaac caaccaacca aaggttttat tgtgacagta
     2461 accctgagtg tgatggtttg aatatgcttg gcccacaggg agtggtagta ttaggaggtg
     2521 tggccttgtt ggaggaggtg tggctttgtt ggaagaagtg tgtcactgtg ggggtgggct
     2581 ttgagaccct cctcctagct gcctgagaga ttcagtcttc tggttccctt cggaagaaga
     2641 tgcagaactc tcagctcctc ctctgccatt cctgtctgga aaatgccgcg ctcctgcctt
     2701 gattataaag gactgaaact ctgaagctgt aagccagccc caattaaatg tttttcttta
     2761 aagagtt
//
