LOCUS       NM_001033499             399 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus SH2 domain containing 1B2 (Sh2d1b2), mRNA.
ACCESSION   NM_001033499 XM_619693
VERSION     NM_001033499.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 399)
  AUTHORS   Guo,H., Cranert,S.A., Lu,Y., Zhong,M.C., Zhang,S., Chen,J., Li,R.,
            Mahl,S.E., Wu,N., Davidson,D., Waggoner,S.N. and Veillette,A.
  TITLE     Deletion of Slam locus in mice reveals inhibitory role of SLAM
            family in NK cell responses regulated by cytokines and LFA-1
  JOURNAL   J Exp Med 213 (10), 2187-2207 (2016)
   PUBMED   27573813
  REMARK    Erratum:[J Exp Med. 2016 Sep 19;213(10):2227. doi:
            10.1084/jem.2016055209072016c.. PMID: 27621421]
REFERENCE   2  (bases 1 to 399)
  AUTHORS   Wu,N., Zhong,M.C., Roncagalli,R., Perez-Quintero,L.A., Guo,H.,
            Zhang,Z., Lenoir,C., Dong,Z., Latour,S. and Veillette,A.
  TITLE     A hematopoietic cell-driven mechanism involving SLAMF6 receptor,
            SAP adaptors and SHP-1 phosphatase regulates NK cell education
  JOURNAL   Nat Immunol 17 (4), 387-396 (2016)
   PUBMED   26878112
REFERENCE   3  (bases 1 to 399)
  AUTHORS   van Driel,B., Liao,G., Romero,X., O'Keeffe,M.S., Wang,G.,
            Faubion,W.A., Berger,S.B., Magelky,E.M., Manocha,M., Azcutia,V.,
            Grisham,M., Luscinskas,F.W., Mizoguchi,E., de Waal Malefyt,R.,
            Reinecker,H.C., Bhan,A.K., Wang,N. and Terhorst,C.
  TITLE     Signaling lymphocyte activation molecule regulates development of
            colitis in mice
  JOURNAL   Gastroenterology 143 (6), 1544-1554 (2012)
   PUBMED   22960654
REFERENCE   4  (bases 1 to 399)
  AUTHORS   Ma,C., Wang,N., Detre,C., Wang,G., O'Keeffe,M. and Terhorst,C.
  TITLE     Receptor signaling lymphocyte-activation molecule family 1 (Slamf1)
            regulates membrane fusion and NADPH oxidase 2 (NOX2) activity by
            recruiting a Beclin-1/Vps34/ultraviolet radiation
            resistance-associated gene (UVRAG) complex
  JOURNAL   J Biol Chem 287 (22), 18359-18365 (2012)
   PUBMED   22493499
REFERENCE   5  (bases 1 to 399)
  AUTHORS   Wang,N., Calpe,S., Westcott,J., Castro,W., Ma,C., Engel,P.,
            Schatzle,J.D. and Terhorst,C.
  TITLE     Cutting edge: The adapters EAT-2A and -2B are positive regulators
            of CD244- and CD84-dependent NK cell functions in the C57BL/6 mouse
  JOURNAL   J Immunol 185 (10), 5683-5687 (2010)
   PUBMED   20962259
  REMARK    GeneRIF: EAT-2A and EAT-2B act as positive regulators of signaling
            lymphocyte activation molecule family receptor-specific NK cell
            functions in C57BL/6 mice.
REFERENCE   6  (bases 1 to 399)
  AUTHORS   Wu,X., Wang,L., Schroer,S., Choi,D., Chen,P., Okada,H. and Woo,M.
  TITLE     Perinatal survivin is essential for the establishment of pancreatic
            beta cell mass in mice
  JOURNAL   Diabetologia 52 (10), 2130-2141 (2009)
   PUBMED   19644667
REFERENCE   7  (bases 1 to 399)
  AUTHORS   Dong,Z., Cruz-Munoz,M.E., Zhong,M.C., Chen,R., Latour,S. and
            Veillette,A.
  TITLE     Essential function for SAP family adaptors in the surveillance of
            hematopoietic cells by natural killer cells
  JOURNAL   Nat Immunol 10 (9), 973-980 (2009)
   PUBMED   19648922
REFERENCE   8  (bases 1 to 399)
  AUTHORS   Cruz-Munoz,M.E., Dong,Z., Shi,X., Zhang,S. and Veillette,A.
  TITLE     Influence of CRACC, a SLAM family receptor coupled to the adaptor
            EAT-2, on natural killer cell function
  JOURNAL   Nat Immunol 10 (3), 297-305 (2009)
   PUBMED   19151721
REFERENCE   9  (bases 1 to 399)
  AUTHORS   Calpe,S., Erdos,E., Liao,G., Wang,N., Rietdijk,S., Simarro,M.,
            Scholtz,B., Mooney,J., Lee,C.H., Shin,M.S., Rajnavolgyi,E.,
            Schatzle,J., Morse,H.C. 3rd, Terhorst,C. and Lanyi,A.
  TITLE     Identification and characterization of two related murine genes,
            Eat2a and Eat2b, encoding single SH2-domain adapters
  JOURNAL   Immunogenetics 58 (1), 15-25 (2006)
   PUBMED   16425036
  REMARK    GeneRIF: Taken together, the data suggest that both EAT-2A and
            EAT-2B are adapters that recruit Src kinases to SLAM family
            receptors using a mechanism that is distinct from that of SAP.
REFERENCE   10 (bases 1 to 399)
  AUTHORS   Roncagalli,R., Taylor,J.E., Zhang,S., Shi,X., Chen,R.,
            Cruz-Munoz,M.E., Yin,L., Latour,S. and Veillette,A.
  TITLE     Negative regulation of natural killer cell function by EAT-2, a
            SAP-related adaptor
  JOURNAL   Nat Immunol 6 (10), 1002-1010 (2005)
   PUBMED   16127454
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from DQ140178.1.
            
            On Sep 16, 2005 this sequence version replaced XM_619693.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DQ131181.1, DQ140178.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..399
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="129/Sv"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 76.84 cM"
     gene            1..399
                     /gene="Sh2d1b2"
                     /gene_synonym="EAT-2B; Eat2b; Ert; Sh2d1c"
                     /note="SH2 domain containing 1B2"
                     /db_xref="GeneID:545378"
                     /db_xref="MGI:MGI:3622649"
     CDS             1..399
                     /gene="Sh2d1b2"
                     /gene_synonym="EAT-2B; Eat2b; Ert; Sh2d1c"
                     /note="EAT-2-related transducer; SH2 domain protein 1B2"
                     /codon_start=1
                     /product="SH2 domain-containing protein 1B2"
                     /protein_id="NP_001028671.1"
                     /db_xref="CCDS:CCDS15469.1"
                     /db_xref="GeneID:545378"
                     /db_xref="MGI:MGI:3622649"
                     /translation="MDLPYYHGCLTKRECEALLLKGGVDGNFLIRDSESVPGALCLCV
                     SFKKLVYNYRIFREKNGYYRIETEPSTPKTIFPNLEELISKFKTPGQGMVVHLSNPIM
                     RSGFCPGARRLNLEANVYENTDEEYVDVLP"
     exon            1..134
                     /gene="Sh2d1b2"
                     /gene_synonym="EAT-2B; Eat2b; Ert; Sh2d1c"
                     /inference="alignment:Splign:2.1.0"
     exon            135..198
                     /gene="Sh2d1b2"
                     /gene_synonym="EAT-2B; Eat2b; Ert; Sh2d1c"
                     /inference="alignment:Splign:2.1.0"
     exon            199..361
                     /gene="Sh2d1b2"
                     /gene_synonym="EAT-2B; Eat2b; Ert; Sh2d1c"
                     /inference="alignment:Splign:2.1.0"
     exon            362..399
                     /gene="Sh2d1b2"
                     /gene_synonym="EAT-2B; Eat2b; Ert; Sh2d1c"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggatctgc cttactacca tggctgcctg accaagcgag agtgtgaagc cctgctcctc
       61 aagggaggtg tggatggcaa ctttctgata agagacagcg agtctgtgcc aggagccctg
      121 tgcctctgtg tctcgtttaa aaagcttgtc tacaactacc gaatcttcag agagaaaaat
      181 ggatattaca ggatagagac tgagcccagt actccaaaaa caatctttcc aaacctagag
      241 gaattaatct ccaaatttaa aacgccaggt caaggaatgg tggttcatct ttcaaaccca
      301 ataatgagaa gcggcttctg tccaggagcg agaagactga acttagaggc gaatgtttac
      361 gagaacactg atgaggagta tgtggacgtc ttgccttga
//
