LOCUS       NM_012009               2546 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Mus musculus SH2 domain containing 1B1 (Sh2d1b1), transcript
            variant 1, mRNA.
ACCESSION   NM_012009 XM_992334
VERSION     NM_012009.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2546)
  AUTHORS   Chen,J., Zhong,M.C., Guo,H., Davidson,D., Mishel,S., Lu,Y.,
            Rhee,I., Perez-Quintero,L.A., Zhang,S., Cruz-Munoz,M.E., Wu,N.,
            Vinh,D.C., Sinha,M., Calderon,V., Lowell,C.A., Danska,J.S. and
            Veillette,A.
  TITLE     SLAMF7 is critical for phagocytosis of haematopoietic tumour cells
            via Mac-1 integrin
  JOURNAL   Nature 544 (7651), 493-497 (2017)
   PUBMED   28424516
REFERENCE   2  (bases 1 to 2546)
  AUTHORS   Guo,H., Cranert,S.A., Lu,Y., Zhong,M.C., Zhang,S., Chen,J., Li,R.,
            Mahl,S.E., Wu,N., Davidson,D., Waggoner,S.N. and Veillette,A.
  TITLE     Deletion of Slam locus in mice reveals inhibitory role of SLAM
            family in NK cell responses regulated by cytokines and LFA-1
  JOURNAL   J Exp Med 213 (10), 2187-2207 (2016)
   PUBMED   27573813
  REMARK    Erratum:[J Exp Med. 2016 Sep 19;213(10):2227. doi:
            10.1084/jem.2016055209072016c.. PMID: 27621421]
REFERENCE   3  (bases 1 to 2546)
  AUTHORS   Wu,N., Zhong,M.C., Roncagalli,R., Perez-Quintero,L.A., Guo,H.,
            Zhang,Z., Lenoir,C., Dong,Z., Latour,S. and Veillette,A.
  TITLE     A hematopoietic cell-driven mechanism involving SLAMF6 receptor,
            SAP adaptors and SHP-1 phosphatase regulates NK cell education
  JOURNAL   Nat Immunol 17 (4), 387-396 (2016)
   PUBMED   26878112
REFERENCE   4  (bases 1 to 2546)
  AUTHORS   Talaei,N., Yu,T., Manion,K., Bremner,R. and Wither,J.E.
  TITLE     Identification of the SLAM Adapter Molecule EAT-2 as a
            Lupus-Susceptibility Gene That Acts through Impaired Negative
            Regulation of Dendritic Cell Signaling
  JOURNAL   J Immunol 195 (10), 4623-4631 (2015)
   PUBMED   26432891
  REMARK    GeneRIF: EAT-2 negatively regulates cytokine production in
            dendritic cells downstream of SLAM engagement and a genetic
            polymorphism that disturbs this process promotes the development of
            lupus.
REFERENCE   5  (bases 1 to 2546)
  AUTHORS   Guo,H., Cruz-Munoz,M.E., Wu,N., Robbins,M. and Veillette,A.
  TITLE     Immune cell inhibition by SLAMF7 is mediated by a mechanism
            requiring src kinases, CD45, and SHIP-1 that is defective in
            multiple myeloma cells
  JOURNAL   Mol Cell Biol 35 (1), 41-51 (2015)
   PUBMED   25312647
REFERENCE   6  (bases 1 to 2546)
  AUTHORS   Calpe,S., Erdos,E., Liao,G., Wang,N., Rietdijk,S., Simarro,M.,
            Scholtz,B., Mooney,J., Lee,C.H., Shin,M.S., Rajnavolgyi,E.,
            Schatzle,J., Morse,H.C. 3rd, Terhorst,C. and Lanyi,A.
  TITLE     Identification and characterization of two related murine genes,
            Eat2a and Eat2b, encoding single SH2-domain adapters
  JOURNAL   Immunogenetics 58 (1), 15-25 (2006)
   PUBMED   16425036
  REMARK    GeneRIF: Taken together, the data suggest that both EAT-2A and
            EAT-2B are adapters that recruit Src kinases to SLAM family
            receptors using a mechanism that is distinct from that of SAP.
REFERENCE   7  (bases 1 to 2546)
  AUTHORS   Roncagalli,R., Taylor,J.E., Zhang,S., Shi,X., Chen,R.,
            Cruz-Munoz,M.E., Yin,L., Latour,S. and Veillette,A.
  TITLE     Negative regulation of natural killer cell function by EAT-2, a
            SAP-related adaptor
  JOURNAL   Nat Immunol 6 (10), 1002-1010 (2005)
   PUBMED   16127454
REFERENCE   8  (bases 1 to 2546)
  AUTHORS   Tangye,S.G., van de Weerdt,B.C., Avery,D.T. and Hodgkin,P.D.
  TITLE     CD84 is up-regulated on a major population of human memory B cells
            and recruits the SH2 domain containing proteins SAP and EAT-2
  JOURNAL   Eur J Immunol 32 (6), 1640-1649 (2002)
   PUBMED   12115647
REFERENCE   9  (bases 1 to 2546)
  AUTHORS   Morra,M., Lu,J., Poy,F., Martin,M., Sayos,J., Calpe,S., Gullo,C.,
            Howie,D., Rietdijk,S., Thompson,A., Coyle,A.J., Denny,C.,
            Yaffe,M.B., Engel,P., Eck,M.J. and Terhorst,C.
  TITLE     Structural basis for the interaction of the free SH2 domain EAT-2
            with SLAM receptors in hematopoietic cells
  JOURNAL   EMBO J 20 (21), 5840-5852 (2001)
   PUBMED   11689425
REFERENCE   10 (bases 1 to 2546)
  AUTHORS   Thompson,A.D., Braun,B.S., Arvand,A., Stewart,S.D., May,W.A.,
            Chen,E., Korenberg,J. and Denny,C.
  TITLE     EAT-2 is a novel SH2 domain containing protein that is up regulated
            by Ewing's sarcoma EWS/FLI1 fusion gene
  JOURNAL   Oncogene 13 (12), 2649-2658 (1996)
   PUBMED   9000139
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC123650.7 and BC116698.1.
            
            On Feb 16, 2018 this sequence version replaced NM_012009.4.
            
            Transcript Variant: This variant (1) represents the longer,
            protein-coding transcript.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK089191.1, BC117508.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-6                 AC123650.7         27348-27353         c
            7-1439              BC116698.1         1-1433
            1440-2546           AC123650.7         17902-19008         c
FEATURES             Location/Qualifiers
     source          1..2546
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 76.84 cM"
     gene            1..2546
                     /gene="Sh2d1b1"
                     /gene_synonym="EAT-2; EAT-2A; Eat2; Eat2a; Sh2d1b"
                     /note="SH2 domain containing 1B1"
                     /db_xref="GeneID:26904"
                     /db_xref="MGI:MGI:1349420"
     exon            1..192
                     /gene="Sh2d1b1"
                     /gene_synonym="EAT-2; EAT-2A; Eat2; Eat2a; Sh2d1b"
                     /inference="alignment:Splign:2.1.0"
     CDS             59..457
                     /gene="Sh2d1b1"
                     /gene_synonym="EAT-2; EAT-2A; Eat2; Eat2a; Sh2d1b"
                     /note="EWS/FLI1 activated transcript 2; SH2 domain protein
                     1B1"
                     /codon_start=1
                     /product="SH2 domain-containing protein 1B"
                     /protein_id="NP_036139.3"
                     /db_xref="CCDS:CCDS35767.1"
                     /db_xref="GeneID:26904"
                     /db_xref="MGI:MGI:1349420"
                     /translation="MDLPYYHGCLTKRECEALLLKGGVDGNFLIRDSESVPGALCLCV
                     SFKKLVYSYRIFREKHGYYRIETNAHTPRTIFPNLQELVSKYGKPGQGLVVHLSNPIM
                     RNNLCQRGRRMELELNVYENTDKEYVDVLP"
     exon            193..256
                     /gene="Sh2d1b1"
                     /gene_synonym="EAT-2; EAT-2A; Eat2; Eat2a; Sh2d1b"
                     /inference="alignment:Splign:2.1.0"
     exon            257..419
                     /gene="Sh2d1b1"
                     /gene_synonym="EAT-2; EAT-2A; Eat2; Eat2a; Sh2d1b"
                     /inference="alignment:Splign:2.1.0"
     exon            420..2546
                     /gene="Sh2d1b1"
                     /gene_synonym="EAT-2; EAT-2A; Eat2; Eat2a; Sh2d1b"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1098..1103
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sh2d1b1"
                     /gene_synonym="EAT-2; EAT-2A; Eat2; Eat2a; Sh2d1b"
                     /note="hexamer: AATAAA"
     polyA_site      1128
                     /gene="Sh2d1b1"
                     /gene_synonym="EAT-2; EAT-2A; Eat2; Eat2a; Sh2d1b"
                     /note="major polyA site"
     regulatory      2507..2512
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sh2d1b1"
                     /gene_synonym="EAT-2; EAT-2A; Eat2; Eat2a; Sh2d1b"
                     /note="hexamer: AATAAA"
     polyA_site      2530
                     /gene="Sh2d1b1"
                     /gene_synonym="EAT-2; EAT-2A; Eat2; Eat2a; Sh2d1b"
ORIGIN      
        1 ctccttggcc tgggactgat ctcagggtga cagggcggtt taaacataac aaccctccat
       61 ggatctgcct tactaccatg gctgcctgac caagcgagag tgtgaagccc tgctcctcaa
      121 gggaggtgtg gatggcaact ttctgataag agacagcgag tctgtgccag gagccctgtg
      181 cctctgtgtc tcgtttaaaa agcttgtcta cagctaccga atcttcagag agaaacatgg
      241 atattacagg atagagacta atgctcatac tccaagaacg atctttccaa acctacagga
      301 attggtctcc aaatatggaa aaccgggtca aggattggtg gttcaccttt caaacccaat
      361 aatgagaaac aacctatgcc aaagagggag aagaatggag ttagagctga atgtttatga
      421 gaacactgat aaggagtatg tggacgtctt gccttgaaga caaggacatt ggacaaagca
      481 agctagagga gagatggctc tgctctcagc tgccacatct gcaagtgtga atctaaaatg
      541 ccaatttcta gtgagccact gagatcctct gattgggata gcaagatctg ttctgcaacc
      601 ttggaggagt catttctcag acgcctgcct cctggcatat tcctcaagag gctccaaagc
      661 cactccttac ttcttactcc cctatcttga aattggacag ccagaaccca atctcctgtc
      721 tggatagagg cagctcccct cattccttca tggttgacaa cttccgacag gacaatggga
      781 agtgaagtgg aaagagtact tcatacagca gaaagaatac tcaatagtga cttcagagtt
      841 cccatcctgt gactctgtgg ctttggagaa atcaccccct cgttctcagc ttcttcatct
      901 attaaacaat tggttgatac acattacctg gactctctat tgagccaggt ggagcagggg
      961 tttgagcagc aggatcagga tctaaggata ctgaaggagc aaacatgtcc ttcctacctg
     1021 tgaggtcgtg gtcctgatgg gggctgtgac ccaacctgaa actgtaggtt ttttcacctg
     1081 agctccagtt cctgaataat aaatactcct tgacttgtta cttatgaatt aatgcctaaa
     1141 ctttgagcta gaattcttac atagattgta acttactgaa cccatttata ccattctgtt
     1201 ctgttgcatg cctgcttacc tctcctcagt gtcatacctt tgacttcctc ccagacttgg
     1261 tcgtagcaaa tctttccttg cctaattatt tcccagagtt actctcttct ttctctgaca
     1321 gatttccttc cttcaaatcc tgccttaact tcttggccat caggtattta ttgacaggtg
     1381 atacttccac agaatacacg agagattatt cctactctac ccattctccc gttcccttca
     1441 atgtgggctc atcttctgtc tcttctttct aaggtttacc ttctgtccaa cattcctctg
     1501 gccacatttt ccccctaatt tttccaaatt ccacatacgc agccatcact ttgctagctc
     1561 tgccttcagg taaatgtgat taaaatattt atttttatca aattttttgg ttagctcacc
     1621 aagaaatggg tgtcactcca gcccttatat acctataaat cattacactc tgggggtttt
     1681 gtttgcttgc ttgttgtttc tctttttgtt gctatatggt ttgtttgttg ttgttgtttt
     1741 tgtttttggt tttttttgtg acagaatctc agtctagccc aagctagcct taaactggag
     1801 gcaatctttc tgcctcagcc ccctaagtgc aggacttaca ggcacaagtg accatatgtg
     1861 cctaaccctt tcttccattt tgaccttccc ttgacctgca tctttcccat cttgctggca
     1921 ccctcttgtg cccagagagg ccctcttctg cctacatccc ctgccttctc tgttcccctt
     1981 tccctatttg agctcctcct cctgactcat agtccacttt ctaagatctg atgtcctcca
     2041 tatgaatgta tttgcacata ttaatttgaa tctagatttt gcatattaga aaactgtggt
     2101 ttgtcctgaa tctgacaaat gtcacttaac agggtgatct ccatgcctgt ccatctttct
     2161 gtgtgaatgc tgtacgttca tcacatatgt gtaccaatgt gggactactt aaagatgttc
     2221 tcatatggtt ggttctattc ctcctaggtt ctaagagcca tcagagcatg gctgtgccca
     2281 acttatggaa acagatgatg caccgaaata taccctccct gaacctagga attaaggact
     2341 gaaaacattt ttctgaagga ctggctgagt tcactttaag gcccctggaa ttttttttga
     2401 ctagttcata atgttaaact aaaggctgaa tagacatgta actcaatggt cgagaacttg
     2461 cttagcgtgt gcaaaggccc cagggtccaa tcatgagcat atgtaaaata aacagagaaa
     2521 gttaattata ggcctggtta gaactc
//
