LOCUS       NM_018825               2904 bp    mRNA    linear   ROD 05-AUG-2023
DEFINITION  Mus musculus SH2B adaptor protein 2 (Sh2b2), transcript variant 1,
            mRNA.
ACCESSION   NM_018825
VERSION     NM_018825.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2904)
  AUTHORS   Sheng L, Liu Y, Jiang L, Chen Z, Zhou Y, Cho KW and Rui L.
  TITLE     Hepatic SH2B1 and SH2B2 regulate liver lipid metabolism and VLDL
            secretion in mice
  JOURNAL   PLoS One 8 (12), e83269 (2013)
   PUBMED   24358267
  REMARK    GeneRIF: Deletion of liver SH2B1 in SH2B2 null mice attenuated very
            low-density lipoprotein (VLDL) secretion.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2904)
  AUTHORS   Wu Y and Smas CM.
  TITLE     Wdnm1-like, a new adipokine with a role in MMP-2 activation
  JOURNAL   Am J Physiol Endocrinol Metab 295 (1), E205-E215 (2008)
   PUBMED   18492766
REFERENCE   3  (bases 1 to 2904)
  AUTHORS   Onnockx S, De Schutter J, Blockmans M, Xie J, Jacobs C,
            Vanderwinden JM, Erneux C and Pirson I.
  TITLE     The association between the SH2-containing inositol polyphosphate
            5-Phosphatase 2 (SHIP2) and the adaptor protein APS has an impact
            on biochemical properties of both partners
  JOURNAL   J Cell Physiol 214 (1), 260-272 (2008)
   PUBMED   17620296
  REMARK    GeneRIF: The association between SHIP2 and the adaptor protein Aps
            has an impact on biochemical properties of both partners.
REFERENCE   4  (bases 1 to 2904)
  AUTHORS   Li M, Li Z, Morris DL and Rui L.
  TITLE     Identification of SH2B2beta as an inhibitor for SH2B1- and
            SH2B2alpha-promoted Janus kinase-2 activation and insulin signaling
  JOURNAL   Endocrinology 148 (4), 1615-1621 (2007)
   PUBMED   17204555
  REMARK    GeneRIF: SH2B2beta is an endogenous inhibitor of SH2B1 and/or
            SH2B2alpha, negatively regulating insulin signaling and/or
            JAK2-mediated cellular responses.
REFERENCE   5  (bases 1 to 2904)
  AUTHORS   Kishi K, Mawatari K, Sakai-Wakamatsu K, Yuasa T, Wang M, Ogura-Sawa
            M, Nakaya Y, Hatakeyama S and Ebina Y.
  TITLE     APS-mediated ubiquitination of the insulin receptor enhances its
            internalization, but does not induce its degradation
  JOURNAL   Endocr J 54 (1), 77-88 (2007)
   PUBMED   17102568
  REMARK    GeneRIF: APS enhanced ligand-dependent multi-ubiquitination of the
            insulin receptor (IR) in CHO cells.
REFERENCE   6  (bases 1 to 2904)
  AUTHORS   Liu J, Kimura A, Baumann CA and Saltiel AR.
  TITLE     APS facilitates c-Cbl tyrosine phosphorylation and GLUT4
            translocation in response to insulin in 3T3-L1 adipocytes
  JOURNAL   Mol Cell Biol 22 (11), 3599-3609 (2002)
   PUBMED   11997497
  REMARK    GeneRIF: APS facilitates c-Cbl tyrosine phosphorylation and GLUT4
            translocation in response to insulin in 3T3-L1 adipocytes
REFERENCE   7  (bases 1 to 2904)
  AUTHORS   Kong M, Wang CS and Donoghue DJ.
  TITLE     Interaction of fibroblast growth factor receptor 3 and the adapter
            protein SH2-B. A role in STAT5 activation
  JOURNAL   J Biol Chem 277 (18), 15962-15970 (2002)
   PUBMED   11827956
REFERENCE   8  (bases 1 to 2904)
  AUTHORS   Iseki M, Takaki S and Takatsu K.
  TITLE     Molecular cloning of the mouse APS as a member of the Lnk family
            adaptor proteins
  JOURNAL   Biochem Biophys Res Commun 272 (1), 45-54 (2000)
   PUBMED   10872802
REFERENCE   9  (bases 1 to 2904)
  AUTHORS   Moodie SA, Alleman-Sposeto J and Gustafson TA.
  TITLE     Identification of the APS protein as a novel insulin receptor
            substrate
  JOURNAL   J Biol Chem 274 (16), 11186-11193 (1999)
   PUBMED   10196204
REFERENCE   10 (bases 1 to 2904)
  AUTHORS   Yokouchi M, Wakioka T, Sakamoto H, Yasukawa H, Ohtsuka S, Sasaki A,
            Ohtsubo M, Valius M, Inoue A, Komiya S and Yoshimura A.
  TITLE     APS, an adaptor protein containing PH and SH2 domains, is
            associated with the PDGF receptor and c-Cbl and inhibits
            PDGF-induced mitogenesis
  JOURNAL   Oncogene 18 (3), 759-767 (1999)
   PUBMED   9989826
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC083890.4, CV561895.1, AK140319.1 and BC057334.1.
            
            [WARNING] On Nov 18, 2023 this sequence was replaced by
            NM_018825.5.
            
            On Dec 3, 2014 this sequence version replaced NM_018825.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (1). Variants 1 and 2
            encode the same isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC057334.1, AF234838.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-61                AC083890.4         66383-66443         c
            62-312              CV561895.1         1-251
            313-2884            AK140319.1         224-2795
            2885-2904           BC057334.1         2848-2867
FEATURES             Location/Qualifiers
     source          1..2904
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 75.93 cM"
     gene            1..2904
                     /gene="Sh2b2"
                     /gene_synonym="Aps"
                     /note="SH2B adaptor protein 2"
                     /db_xref="GeneID:23921"
                     /db_xref="MGI:MGI:1345171"
     exon            1..312
                     /gene="Sh2b2"
                     /gene_synonym="Aps"
                     /inference="alignment:Splign:2.1.0"
     exon            313..1046
                     /gene="Sh2b2"
                     /gene_synonym="Aps"
                     /inference="alignment:Splign:2.1.0"
     CDS             339..2204
                     /gene="Sh2b2"
                     /gene_synonym="Aps"
                     /note="isoform 1 is encoded by transcript variant 1;
                     insulin receptor substrate 5; SH2B adapter protein 2; SH2
                     and PH domain-containing adapter protein APS; adapter
                     protein with pleckstrin homology and Src homology 2
                     domains; adaptor protein with pleckstrin homology and src
                     homology 2 domains"
                     /codon_start=1
                     /product="SH2B adapter protein 2 isoform 1"
                     /protein_id="NP_061295.2"
                     /db_xref="CCDS:CCDS39327.1"
                     /db_xref="GeneID:23921"
                     /db_xref="MGI:MGI:1345171"
                     /translation="MNGATPSSAAAPAPVPDWRQFCELHAQVAAVDFAHKFCRFLRDN
                     PTYDTPDAGTSFSRHFAANFLAVFSEEVRRVLGSAADTMEPEPAVTSVTSALKTATYG
                     HSRSSEDVSAHAATKARVRKGFSLRNMSLCVVDGVRDLWHRRSSPEPDGGATPKAAEP
                     ASEPRDKWTRRLRLARTLAAKVELVDIQREGALRFMVADDAASGPGGTAQWQKCRLLL
                     RRAVAGERFRLEFFVPPKASRPKVSIPLSAIIEVRTTMPLEMPEKDNTFVLKVENGAE
                     YILETIDSLQKHSWVADIQGCVDPGDSEEDTGLSCARGGCLASRVASCSCELLTDADM
                     PRPPETTTAVGAVVTAPHGRARDTVGESLAHVPLETFLQTLESSGGVSENNNPGDEGA
                     ELDTDAEAELELSDYPWFHGTLSRVKAAQLVLAGGPRSHGLFVIRQSETRPGECVLTF
                     NFQGKAKHLRLSLNGHGQCHVQHLWFQSVFDMLRHFHTHPIPLESGGSADITLRSYVR
                     AQGPPPDPGPAPNTAAPVPACWTEPAGQHYFSSLATATCPPASPSNGAGASSSSGSSS
                     SATSLPPRPAEGPLSAHSRSNSTEHLLDAASGATEEPTEATLGRARAVENQYSFY"
     exon            1047..1148
                     /gene="Sh2b2"
                     /gene_synonym="Aps"
                     /inference="alignment:Splign:2.1.0"
     exon            1149..1240
                     /gene="Sh2b2"
                     /gene_synonym="Aps"
                     /inference="alignment:Splign:2.1.0"
     exon            1241..1332
                     /gene="Sh2b2"
                     /gene_synonym="Aps"
                     /inference="alignment:Splign:2.1.0"
     exon            1333..1500
                     /gene="Sh2b2"
                     /gene_synonym="Aps"
                     /inference="alignment:Splign:2.1.0"
     exon            1501..1709
                     /gene="Sh2b2"
                     /gene_synonym="Aps"
                     /inference="alignment:Splign:2.1.0"
     exon            1710..1881
                     /gene="Sh2b2"
                     /gene_synonym="Aps"
                     /inference="alignment:Splign:2.1.0"
     exon            1882..2885
                     /gene="Sh2b2"
                     /gene_synonym="Aps"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaggcgcgcg ctgctcaggc aaggaggagg gccaggggcg cgcggcgcgc gagtctggga
       61 tcggagcgcg cggagctcgg gagcctgaag agggagagaa cctcaagggg gccgcaccag
      121 gaccgccaag accgcctcgc aagctgcagg ccagggaagc gggagccacc cccgctgccg
      181 ccgccaccgg ccaccaaggg cggagctacg gcccggaggg ccatgcgcca ccgggtccgg
      241 ggatcccagc cgcggtccgg gcagcgctcc tccggcgccc cagcccgcgc ggccgaagct
      301 gcgcgcctgt agcccgacgc tgccatggga ccaaagccat gaatggtgcc acccccagct
      361 cggccgccgc ccccgcccca gtccccgact ggcggcaatt ctgcgagctg cacgcgcagg
      421 tggctgctgt ggacttcgca cacaagttct gccgcttcct tcgggacaac ccgacctacg
      481 acacgcctga cgctgggacc tcattctccc gccactttgc agccaacttc ttggctgtct
      541 tcagtgagga ggtgcgccgc gtgctggggt cagcagccga cactatggaa cccgagcctg
      601 cggtgacctc ggtgacatct gcgctcaaga ctgcaaccta tggccactcc cgcagctccg
      661 aggatgtgtc tgcccacgcg gctaccaagg cgcgtgtccg aaagggattc tcgctgcgta
      721 acatgagcct gtgtgtggtg gatggagtgc gcgacctgtg gcaccggcgc tcgtccccag
      781 agcccgatgg tggggccacc cccaaggccg ccgagcctgc gtcggagcct cgtgacaaat
      841 ggacgcgacg cctgcggcta gcacgaaccc tggcagccaa agtggagtta gtggacatcc
      901 agcgtgaggg cgccctgcgc ttcatggtgg cagacgacgc ggcctcaggg cctggaggca
      961 ctgcgcagtg gcagaagtgt cgcctgctcc tgcggagggc tgtggctggg gaacgtttcc
     1021 gcctggagtt cttcgtgcca cccaaggctt ccagacccaa ggtcagcatc cccctgtcgg
     1081 ccatcattga ggtccgaacc actatgcccc tggaaatgcc tgaaaaggac aacacatttg
     1141 tgctcaaggt ggagaacgga gcagaataca tcctggaaac gatagactca ctgcagaagc
     1201 actcgtgggt ggctgacatc cagggctgtg tggatcctgg ggacagtgag gaagacacag
     1261 gactgtcttg tgcacgggga ggctgcctgg ccagccgcgt ggcctcctgc agctgtgagc
     1321 tcctgacaga tgcagacatg ccccggcccc ccgagacgac gacagcggtg ggtgctgtgg
     1381 tcacagctcc acatggccga gctcgtgaca ccgtgggaga gtccctggcc cacgttcccc
     1441 tggagacttt cctgcaaacc ctggagtctt caggtggtgt cagtgagaac aataacccag
     1501 gggacgaagg agctgagctg gacaccgatg ctgaggctga gctggaactt tccgactacc
     1561 cctggttcca tgggacattg tcccgggtga aggcggccca gcttgtgctg gccggtggcc
     1621 ctcggagcca tggcctcttt gtgatccgcc aaagtgagac taggcctggg gagtgtgtgc
     1681 tgaccttcaa cttccagggc aaggccaagc acctccgcct ttctctgaac ggtcacggcc
     1741 agtgtcatgt ccagcacctg tggttccagt ccgtgtttga tatgctccgt cacttccaca
     1801 cccaccccat ccccctggag tcaggaggat cggctgatat caccctaaga agctatgtgc
     1861 gtgcccaggg cccgcctcct gatccaggac cagcgcccaa cactgcggcc ccagttccag
     1921 cctgctggac ggagccggct ggccagcact acttctccag cctggccacg gccacttgcc
     1981 cgcccgcttc accgtccaat ggcgctggag cttcgtcttc atccggctca tcgtcctctg
     2041 ccacatccct gcccccacgc ccagccgagg ggccgctcag tgcgcacagc cgcagcaaca
     2101 gcacagagca cctgctggat gctgcatctg gagccactga ggagcccaca gaggccacgc
     2161 tgggccgtgc tcgtgctgtg gagaatcagt actcctttta ctagctgcca tgccttttac
     2221 ccacgggtgt cacgcacatc acagcaggcc aaggacacct gttgtctgtc ctgcccaccc
     2281 acagcctggc tagcccacga tggtcagcaa cacctaatga atggctaaat acacctacct
     2341 atggtctagc atggccaaaa tagctggcca gcctagccac ttcagacccc aggggcccac
     2401 tgtgaccatg tgtggcaggc caaggctata tccacagtcg atcaaacatc atgatagccc
     2461 gccaatgatt tcaggcccca cccactggtg gatggccact cccattagca gctattttta
     2521 taagggccac cgaatccata acaggcagct agctcactga caactaaaca catttggtga
     2581 cttcaggccc tggccactga tagttggtta ctcctacagt ggcatggcct acccactggc
     2641 tgcctgcttc actcaagggc agcaagccac gtctatcaag cccatgaagg cctacccact
     2701 gattcctagc aacctcaggc cctgcccacc agtgttgggt cacatactcc aataacctga
     2761 ccaggctgtg gtctgcctag cctaggacag cctgccacgc ccaccagccc cagcccaatg
     2821 ctggggggaa aagccaagct cttcagtgaa gacaaacatt attaaagagc ctgttttagg
     2881 gactaaaaaa aaaaaaaaaa aaaa
//
