LOCUS       NM_011363               3436 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus SH2B adaptor protein 1 (Sh2b1), transcript variant 2,
            mRNA.
ACCESSION   NM_011363
VERSION     NM_011363.3
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3436)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3436)
  AUTHORS   Argetsinger,L.S., Flores,A., Svezhova,N., Ellis,M., Reynolds,C.,
            Cote,J.L., Cline,J.M., Myers,M.G. and Carter-Su,C.
  TITLE     Role of the Beta and Gamma Isoforms of the Adapter Protein SH2B1 in
            Regulating Energy Balance
  JOURNAL   Endocrinology 164 (5) (2023)
   PUBMED   36799031
  REMARK    GeneRIF: Role of the Beta and Gamma Isoforms of the Adapter Protein
            SH2B1 in Regulating Energy Balance.
REFERENCE   3  (bases 1 to 3436)
  AUTHORS   Han,X., Liu,Y., Dai,Y., Xu,T., Hu,Q., Yi,X., Rui,L., Hu,G. and
            Hu,J.
  TITLE     Neuronal SH2B1 attenuates apoptosis in an MPTP mouse model of
            Parkinson's disease via promoting PLIN4 degradation
  JOURNAL   Redox Biol 52, 102308 (2022)
   PUBMED   35390677
  REMARK    GeneRIF: Neuronal SH2B1 attenuates apoptosis in an MPTP mouse model
            of Parkinson's disease via promoting PLIN4 degradation.
REFERENCE   4  (bases 1 to 3436)
  AUTHORS   Miyamoto,Y., Torii,T., Homma,K., Oizumi,H., Ohbuchi,K.,
            Mizoguchi,K., Takashima,S. and Yamauchi,J.
  TITLE     The adaptor SH2B1 and the phosphatase PTP4A1 regulate the
            phosphorylation of cytohesin-2 in myelinating Schwann cells in mice
  JOURNAL   Sci Signal 15 (718), eabi5276 (2022)
   PUBMED   35077201
  REMARK    GeneRIF: The adaptor SH2B1 and the phosphatase PTP4A1 regulate the
            phosphorylation of cytohesin-2 in myelinating Schwann cells in
            mice.
REFERENCE   5  (bases 1 to 3436)
  AUTHORS   Zhang,M., Deng,Y. and Riedel,H.
  TITLE     PSM/SH2B1 splice variants: critical role in src catalytic
            activation and the resulting STAT3s-mediated mitogenic response
  JOURNAL   J Cell Biochem 104 (1), 105-118 (2008)
   PUBMED   18247337
  REMARK    GeneRIF: an essential role of the SH2B1 variants in the activation
            of the Src kinase and the resulting mitogenic response--extending
            to phenotypic cell transformation and involving the established Src
            substrate STAT3
REFERENCE   6  (bases 1 to 3436)
  AUTHORS   Yousaf,N., Deng,Y., Kang,Y. and Riedel,H.
  TITLE     Four PSM/SH2-B alternative splice variants and their differential
            roles in mitogenesis
  JOURNAL   J Biol Chem 276 (44), 40940-40948 (2001)
   PUBMED   11502739
REFERENCE   7  (bases 1 to 3436)
  AUTHORS   Riedel,H., Yousaf,N., Zhao,Y., Dai,H., Deng,Y. and Wang,J.
  TITLE     PSM, a mediator of PDGF-BB-, IGF-I-, and insulin-stimulated
            mitogenesis
  JOURNAL   Oncogene 19 (1), 39-50 (2000)
   PUBMED   10644978
REFERENCE   8  (bases 1 to 3436)
  AUTHORS   Nelms,K., O'Neill,T.J., Li,S., Hubbard,S.R., Gustafson,T.A. and
            Paul,W.E.
  TITLE     Alternative splicing, gene localization, and binding of SH2-B to
            the insulin receptor kinase domain
  JOURNAL   Mamm Genome 10 (12), 1160-1167 (1999)
   PUBMED   10594240
REFERENCE   9  (bases 1 to 3436)
  AUTHORS   Wang,J. and Riedel,H.
  TITLE     Insulin-like growth factor-I receptor and insulin receptor
            association with a Src homology-2 domain-containing putative
            adapter
  JOURNAL   J Biol Chem 273 (6), 3136-3139 (1998)
   PUBMED   9452421
REFERENCE   10 (bases 1 to 3436)
  AUTHORS   Riedel,H., Wang,J., Hansen,H. and Yousaf,N.
  TITLE     PSM, an insulin-dependent, pro-rich, PH, SH2 domain containing
            partner of the insulin receptor
  JOURNAL   J Biochem 122 (6), 1105-1113 (1997)
   PUBMED   9498552
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK171328.1, BY749559.1, BC051978.1, AK168439.1 and AI182992.1.
            
            On Jan 23, 2014 this sequence version replaced NM_011363.2.
            
            Transcript Variant: This variant (2) uses an alternate splice site
            and includes an additional exon that results in a frameshift in the
            3' coding region, compared to variant 7. The encoded isoform (2,
            also known as gamma) has a distinct and shorter C-terminus,
            compared to isoform 4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK170444.1, AF421139.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164137, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-354               AK171328.1         4-357
            355-614             BY749559.1         352-611
            615-2542            BC051978.1         158-2085
            2543-3296           AK168439.1         2085-2838
            3297-3436           AI182992.1         1-140
FEATURES             Location/Qualifiers
     source          1..3436
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 69.06 cM"
     gene            1..3436
                     /gene="Sh2b1"
                     /gene_synonym="C530001K22Rik; Irip; mKIAA1299; Psm; SH2-B;
                     SH2-Bb; Sh2bpsm1"
                     /note="SH2B adaptor protein 1"
                     /db_xref="GeneID:20399"
                     /db_xref="MGI:MGI:1201407"
     exon            1..512
                     /gene="Sh2b1"
                     /gene_synonym="C530001K22Rik; Irip; mKIAA1299; Psm; SH2-B;
                     SH2-Bb; Sh2bpsm1"
                     /inference="alignment:Splign:2.1.0"
     exon            513..1534
                     /gene="Sh2b1"
                     /gene_synonym="C530001K22Rik; Irip; mKIAA1299; Psm; SH2-B;
                     SH2-Bb; Sh2bpsm1"
                     /inference="alignment:Splign:2.1.0"
     CDS             596..2644
                     /gene="Sh2b1"
                     /gene_synonym="C530001K22Rik; Irip; mKIAA1299; Psm; SH2-B;
                     SH2-Bb; Sh2bpsm1"
                     /note="isoform 2 is encoded by transcript variant 2; SH2B
                     adapter protein 1; SH2 domain-containing protein 1B;
                     pro-rich, PH and SH2 domain-containing signaling mediator;
                     SH2-B PH domain containing signaling mediator 1"
                     /codon_start=1
                     /product="SH2B adapter protein 1 isoform 2"
                     /protein_id="NP_035493.2"
                     /db_xref="CCDS:CCDS40126.1"
                     /db_xref="GeneID:20399"
                     /db_xref="MGI:MGI:1201407"
                     /translation="MNGAPSPEDGVFPSPPALPPPPPPSWQEFCESHARAAALDLARR
                     FRLYLASHPQYAEPGAEAAFSGRFAELFLQHFEAEVARASGSLSPPVLAPLSPGVEIP
                     PSHDLSLESCRVGGPLAVLGPSRSSEDLAGPLPSSVPSSTTSSKPKLKKRFSLRSVGR
                     SVRGSVRGILQWRGAVDSPSQAGPLETTSGPPVLGGNSNSNSSGGAGTVGRALANDGT
                     SPGERWTHRFERLRLSRGGGTLKDGAGMIQREELLSFMGAEEAAPDPAGVGRGGGAAG
                     LTSGGGGQPQWQKCRLLLRSEGEGGGGSRLEFFVPPKASRPRLSIPCSTITDVRTATA
                     LEMPDRENTFVVKVEGPSEYILETSDALHVKAWVSDIQECLSPGPCPAISPRPMTLPL
                     APGTSFFTKDNTDSLELPCLNHSESLPSQDLLLGPSESNDRLSQGAYGGLSDRPSASF
                     SPSSASIAASHFDSMELLPPELPPRIPIEEGPPAGTVHPLSTPYPPLDTPEAATGSFL
                     FQGESEGGEGDQPLSGYPWFHGMLSRLKAAQLVLEGGTGSHGVFLVRQSETRRGEYVL
                     TFNFQGKAKHLRLSLNEEGQCRVQHLWFQSIFDMLEHFRVHPIPLESGGSSDVVLVSY
                     VPSQRQQGEQSRSAGEEVPVHPRSEAGSRLGAMQGCARATDATPMPPPPSCPSERVTV
                     "
     exon            1535..1636
                     /gene="Sh2b1"
                     /gene_synonym="C530001K22Rik; Irip; mKIAA1299; Psm; SH2-B;
                     SH2-Bb; Sh2bpsm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1637..1728
                     /gene="Sh2b1"
                     /gene_synonym="C530001K22Rik; Irip; mKIAA1299; Psm; SH2-B;
                     SH2-Bb; Sh2bpsm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1729..1904
                     /gene="Sh2b1"
                     /gene_synonym="C530001K22Rik; Irip; mKIAA1299; Psm; SH2-B;
                     SH2-Bb; Sh2bpsm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1905..2108
                     /gene="Sh2b1"
                     /gene_synonym="C530001K22Rik; Irip; mKIAA1299; Psm; SH2-B;
                     SH2-Bb; Sh2bpsm1"
                     /inference="alignment:Splign:2.1.0"
     exon            2109..2320
                     /gene="Sh2b1"
                     /gene_synonym="C530001K22Rik; Irip; mKIAA1299; Psm; SH2-B;
                     SH2-Bb; Sh2bpsm1"
                     /inference="alignment:Splign:2.1.0"
     exon            2321..2542
                     /gene="Sh2b1"
                     /gene_synonym="C530001K22Rik; Irip; mKIAA1299; Psm; SH2-B;
                     SH2-Bb; Sh2bpsm1"
                     /inference="alignment:Splign:2.1.0"
     exon            2543..2642
                     /gene="Sh2b1"
                     /gene_synonym="C530001K22Rik; Irip; mKIAA1299; Psm; SH2-B;
                     SH2-Bb; Sh2bpsm1"
                     /inference="alignment:Splign:2.1.0"
     exon            2643..3423
                     /gene="Sh2b1"
                     /gene_synonym="C530001K22Rik; Irip; mKIAA1299; Psm; SH2-B;
                     SH2-Bb; Sh2bpsm1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3394..3399
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sh2b1"
                     /gene_synonym="C530001K22Rik; Irip; mKIAA1299; Psm; SH2-B;
                     SH2-Bb; Sh2bpsm1"
                     /note="hexamer: AATAAA"
     polyA_site      3423
                     /gene="Sh2b1"
                     /gene_synonym="C530001K22Rik; Irip; mKIAA1299; Psm; SH2-B;
                     SH2-Bb; Sh2bpsm1"
                     /note="major polyA site"
ORIGIN      
        1 cccgtcccag cgcctgcgca gaagcgcgtg ctgggagccc gtcgcggagg cggggggcac
       61 agggagcggg agctgcggcc gtcgccgccg ccgccgctgc cgccgccgga gctaagcgcg
      121 gggaccgaga tgcaggtggg accggaaccg gaacccccct cttcaagtgc ctctttcctc
      181 tccggactcg accctgtcgt ctgagaagcc tgggcggggg tgggcgtggg ggctcggggc
      241 tggaggggtg ctcggctccc gagagggcag cagatagttg gtccctcgga ggctccggcc
      301 caggggcttg tggagggtgt ccaacgacta ggatcgggtc cgagtgatta accacggggc
      361 ccggagggtc cgaacctgga gcgcagcctg caccctccac cacccgccct tctggaatgt
      421 cagaactaag ccaagaggca ggtgcaccgg aaaactgtga ctgagccgtc ttggcagaag
      481 agaaactgag tcaccagtcc aggaaccgca ggctgttgcc gcacatcccg tgtcttctgg
      541 ctgcttccct atttgttccc cgcaggcttc ccttgtcctc ctcctggggc ccatcatgaa
      601 tggtgcccct tccccagagg atggggtctt cccttctccg ccagcgctgc caccaccccc
      661 tcccccaagt tggcaagagt tctgtgagtc ccatgcgagg gcagctgccc tggatcttgc
      721 ccgacgtttt cgcctctacc tggcctccca cccacagtat gcagagccgg gagcagaggc
      781 cgctttttct ggccgttttg ctgagctctt cctgcagcac ttcgaagccg aggtggctcg
      841 ggcctcgggc tcactctccc cacctgtcct ggctccattg agccctggtg tggaaatccc
      901 accatcacac gacctgtccc ttgagagctg cagggtgggt gggcccctag cagtgttggg
      961 cccttctcga tcttctgagg acctggctgg cccccttcct tcctcagtcc cttcctctac
     1021 aacatcctca aagccaaagc tcaagaagcg cttctccctc cgctcagtgg gccgttcagt
     1081 cagaggctct gttcgaggca tcctgcagtg gcggggtgcc gttgactcgc cctcccaagc
     1141 tgggcctctg gagaccacat ccggccctcc agttctaggt ggaaacagca actccaactc
     1201 ctcgggtggt gctgggacag ttggtagggc attggctaat gatggcacat cccctgggga
     1261 gagatggact catcgatttg agaggctgag gctaagtcgt ggagggggaa ccctgaaaga
     1321 cggagcagga atgatacaga gagaagagct gctgagtttc atgggggctg aagaggctgc
     1381 ccctgaccca gcaggagtgg gtcgtggagg aggggcagct gggctgacct caggaggagg
     1441 agggcagcct cagtggcaaa agtgtcgctt actgctccgg agtgaaggag aaggaggagg
     1501 aggaagtcgc ttggagttct ttgtaccacc caaggcgtcc cgaccccgtc tcagcattcc
     1561 ctgctctact attactgatg tccgcacagc cacagcccta gagatgcctg acagggagaa
     1621 cacgtttgtg gttaaggtag aaggcccttc agagtacatc ctggagacaa gtgatgcgct
     1681 tcatgtgaag gcctgggtgt ctgacatcca ggaatgccta agccccggac cctgtcctgc
     1741 tatcagcccc cgtcccatga cccttcccct ggcccctggg acctccttct tcacaaagga
     1801 taacacagac agcctggagt tgccctgcct gaatcattca gagagtctgc ctagccagga
     1861 tctgctgctg ggacccagcg agagtaacga ccgcctgtcg cagggagctt atgggggcct
     1921 ctcagaccgg ccatcggcgt ccttctcccc tagttctgcc tccattgctg cctcccattt
     1981 tgattcgatg gaactgcttc ctccagaatt gcctcctcga attcccattg aggaggggcc
     2041 tccagcaggg acagttcatc ccctctctac cccctaccct cccctggata ctccagaagc
     2101 agccacagga tcgttcctgt tccaagggga gtcagagggg ggtgaggggg atcagcccct
     2161 ctcaggctat ccttggttcc acggcatgct ctctcgactc aaagctgccc agttagtgtt
     2221 agaaggaggc actggctccc atggtgtctt cttggtacgc cagagtgaga caaggcgtgg
     2281 tgaatatgtc ctcactttca acttccaggg caaggccaag cacctgcgct tgtcactaaa
     2341 tgaggaggga cagtgccggg tccaacatct gtggttccag tccattttcg atatgcttga
     2401 gcacttccgg gtgcacccca tccctctgga gtctggaggc tccagtgatg ttgtccttgt
     2461 cagctatgtg ccctcccagc ggcagcaggg tgagcagagc aggtctgcag gggaggaggt
     2521 gcccgtgcac ccaagaagtg aggccgggag caggctggga gccatgcagg ggtgtgcgag
     2581 ggcgaccgat gctaccccga tgcctcctcc accctcctgc ccttcggagc gagtgactgt
     2641 gtaacggagc acctcccgtg acccagccca gccctctgaa ccccctccat ggacagatcc
     2701 cccacatcct ggggcagaag aggcgtcggg ggcgccagaa gttgcggcag ccacagccgc
     2761 agcagccaaa gagaggcaag agaaagagaa agcgggcagt ggaggggtcc aggaagagct
     2821 ggtccccgtg gctgagctgg tccccatggt tgaattggaa gaggccatag caccaggcac
     2881 tgaggctcag ggtggtgctg gctctagtgg ggacttggag gtgtccctaa tggtacagct
     2941 ccagcagcta ccactagggg gcaacggaga agaagggggt cacccccgag ccattaataa
     3001 tcagtactca tttgtgtgag atacctgccc accctccatt ttcctgctcc cagccttaag
     3061 ttgtgagact gagctgggta ggaacacaga ggaaagtggg agtcccctcc ctacatgctt
     3121 cctgaccctt gtcagccaag ggtgtgtatg ttggtacaag ttgaggttca tgagccctgt
     3181 taagtcccca gttactacac actacaggtg cccttgcccc aggccaagga cttgggctcc
     3241 gttacctccc tgaggggctc ttatggtcag ccccatccct gggggctgtt tccccactaa
     3301 taacccccaa cccaaccaag ggtgaggggg aagggctgtc agttatatta aggttgttgt
     3361 tgttgtttta aacaaaatgg aaaagcataa ataaataaag ggtttatctc agttccatca
     3421 tgaaaaaaaa aaaaaa
//
