LOCUS       NM_144838               3174 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus small glutamine-rich tetratricopeptide repeat
            (TPR)-containing, beta (Sgtb), transcript variant 1, mRNA.
ACCESSION   NM_144838
VERSION     NM_144838.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3174)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3174)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3174)
  AUTHORS   Vuong,T.A., Lee,S.J., Leem,Y.E., Lee,J.R., Bae,G.U. and Kang,J.S.
  TITLE     SGTb regulates a surface localization of a guidance receptor BOC to
            promote neurite outgrowth
  JOURNAL   Cell Signal 55, 100-108 (2019)
   PUBMED   30639199
  REMARK    GeneRIF: The data suggest that SGTb interacts with BOC (brother of
            CDO protein) and regulates its surface level and consequent JNK
            activation, thereby promoting neuronal differentiation and neurite
            outgrowth.
REFERENCE   4  (bases 1 to 3174)
  AUTHORS   Tobaben,S., Varoqueaux,F., Brose,N., Stahl,B. and Meyer,G.
  TITLE     A brain-specific isoform of small glutamine-rich tetratricopeptide
            repeat-containing protein binds to Hsc70 and the cysteine string
            protein
  JOURNAL   J Biol Chem 278 (40), 38376-38383 (2003)
   PUBMED   12878599
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC154216.1 and BC017611.1.
            
            On Feb 27, 2018 this sequence version replaced NM_144838.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC017611.1, AK049820.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-49                AC154216.1         143556-143604       c
            50-2765             BC017611.1         1-2716
            2766-3174           AC154216.1         111484-111892       c
FEATURES             Location/Qualifiers
     source          1..3174
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 56.23 cM"
     gene            1..3174
                     /gene="Sgtb"
                     /gene_synonym="C630001O05Rik"
                     /note="small glutamine-rich tetratricopeptide repeat
                     (TPR)-containing, beta"
                     /db_xref="GeneID:218544"
                     /db_xref="MGI:MGI:2444615"
     exon            1..229
                     /gene="Sgtb"
                     /gene_synonym="C630001O05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            230..349
                     /gene="Sgtb"
                     /gene_synonym="C630001O05Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             250..1164
                     /gene="Sgtb"
                     /gene_synonym="C630001O05Rik"
                     /note="beta-SGT"
                     /codon_start=1
                     /product="small glutamine-rich tetratricopeptide
                     repeat-containing protein beta"
                     /protein_id="NP_659087.1"
                     /db_xref="CCDS:CCDS26746.1"
                     /db_xref="GeneID:218544"
                     /db_xref="MGI:MGI:2444615"
                     /translation="MSSVKPLVYAVIRFLREQSQMDAYTSDEQESLEVAIQCLETVFK
                     ISPEDTHLAVSQPLTEMFTNSVCKNDIRPLSNSVPEDVGKADQLKDEGNNHMKEENYA
                     AAVDCYTQAIELDPNNAVYYCNRAAAQSKLSHYTDAIKDCEKAIAIDSKYSKAYGRMG
                     LALTAMNKFEEAVTSYQKALDLDPENDSYKSNLKIAEQKLREVSSPTGTGLSFDMASL
                     INNPAFITMAASLMQNPQVQQLMSGMMTNAIGGPAAGVGGLTDLSSLIQAGQQFAQQI
                     QQQNPELIEQLRNHIRSRSFSSSADEHS"
     exon            350..453
                     /gene="Sgtb"
                     /gene_synonym="C630001O05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            454..523
                     /gene="Sgtb"
                     /gene_synonym="C630001O05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            524..623
                     /gene="Sgtb"
                     /gene_synonym="C630001O05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            624..728
                     /gene="Sgtb"
                     /gene_synonym="C630001O05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            729..867
                     /gene="Sgtb"
                     /gene_synonym="C630001O05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            868..930
                     /gene="Sgtb"
                     /gene_synonym="C630001O05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            931..968
                     /gene="Sgtb"
                     /gene_synonym="C630001O05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            969..1052
                     /gene="Sgtb"
                     /gene_synonym="C630001O05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1053..3174
                     /gene="Sgtb"
                     /gene_synonym="C630001O05Rik"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2041
                     /gene="Sgtb"
                     /gene_synonym="C630001O05Rik"
                     /note="major polyA site"
     polyA_site      2130
                     /gene="Sgtb"
                     /gene_synonym="C630001O05Rik"
                     /note="major polyA site"
ORIGIN      
        1 tgctccgccc ctggggcgga tccagcaagc actgtcgtcc gagagccttg cgagcagccg
       61 ggtgggctga gggggcggcg gcggcggcag cattggagcg ggggaagttt gggagccgtg
      121 gccccctctg cgatccagaa caccgctcaa gccccgagga ccgcggggac aggcggaccc
      181 gcttcccgac gcccccgggc ccgcagccgt catctcgtgt cctctcgtgg agatatttaa
      241 gcgtctaaaa tgtcatctgt gaagccccta gtttatgcag ttattcgttt cttgcgggaa
      301 caaagtcaga tggatgcata tacttctgat gaacaagaaa gtttggaagt tgccatccag
      361 tgtttggaga ccgtttttaa gatcagtcca gaagacacac atctggcagt ttcacagcct
      421 ttgacagaaa tgttcacaaa ctccgtctgt aagaatgaca tacggccgct ttcaaactca
      481 gtgcccgagg atgtgggaaa ggcggaccag ctgaaggatg aaggcaataa ccacatgaaa
      541 gaagaaaatt acgctgcggc agtggactgc tacacgcagg caatagaact ggatcccaac
      601 aatgccgttt attattgcaa cagggctgct gctcaaagca aattaagtca ctacacagac
      661 gcaatcaagg actgcgagaa agccattgca attgactcga aatacagcaa ggcctacgga
      721 aggatggggc tcgccctcac tgccatgaat aagtttgaag aggccgttac aagctaccag
      781 aaggcactgg atctcgatcc tgagaatgat tcgtataagt caaatctgaa aatagcagaa
      841 cagaagttga gagaggtgtc tagccctacg ggaaccgggc tgagctttga catggctagc
      901 ttgataaata acccggcctt catcaccatg gctgcaagtt taatgcagaa ccctcaagtt
      961 cagcagctaa tgtcagggat gatgacaaat gccattggag gaccagctgc cggagttgga
     1021 ggcctaacag acctgtctag cctaatccaa gcggggcagc agtttgcgca gcagatacaa
     1081 cagcagaatc cggaactcat agagcagctg agaaaccaca tccggagcag atcgttcagc
     1141 agcagtgcag acgaacactc ctgacttgac caggaccctc gccccagtac aaacattctg
     1201 acgtgtacac ttgtagataa tagccaaaaa caaagtaaca aaacccaccc tatacagagt
     1261 ctgaacataa cggaggaaag tctcctgtgt aaacctgaga gaatacatct gtttagataa
     1321 tagtttacca caagcagact tgaacgtaat ccagacagac tcctttggaa agcagtgatc
     1381 agtagccttg ttaagggtga atacagcctg gggacaaggg tccatccatt ttaaaacttt
     1441 tatcatcata tttgtatatt agacttagta cagagtatat ttattgaata gtagggctat
     1501 ttattggaaa gttcgttagc tgcaggtttc cctaggcagt ggtcttgagc ggggcgatgc
     1561 tggtttagaa gacacgtgct tggcagcacg tcagagagaa gcgctggcac gcgctaccat
     1621 cagtgacgcg tgtctatcga gagtggcact tggaagatac tgtgaatgcc cagaaagcga
     1681 aggcagtgtg ctcaggtttt ctgcatagat tttttaaact aagcttgtct gtagcttcgt
     1741 gtttatagca ttcgcatggc cagttaagta cataatgaaa catacttaga aatccttaat
     1801 gatgctggtc aggtcagtga cattactgcc ccatttaatt atcacagctt aaatgtcaca
     1861 atttcattgc tggaaaactt acctagggca gtatctcgtt acatttaaag aagccactga
     1921 cgtgtcccca gattccgggt ttcctaagtg ggatttaatt atgtgcccat caaagacgac
     1981 gacgacgatg actatttttc ttgaccatta tttgatggct aacagaagca tccatctcta
     2041 acattgctca cttgtgtaat cctttggtgc agtttggctt ggcatgtcgg ttcttatgct
     2101 taactttaat ttattgcaat ttaaacgtaa caggagactt caactgtctt attttaaatt
     2161 ggatgccaca ctgtgcatct ggcgtgtgct tagtaggaag aaatgacacg agctatcgat
     2221 gggaggactc ttagtgcact gatggataag aaggctcatt tcaaatggaa ctggcttatt
     2281 aaccaaaaac ttggttcgta tcccatcact gcattagaga ggaaataagt aggaacagag
     2341 agtagatgcc ccatggaaca gatcctggag ctgttaaagg acaaccagag cgcctgggaa
     2401 cacagatcag tgcatagtgc ttgcccagca tgtgtgaggc cctgggttac cccttcccta
     2461 gtactgcatg caaagggaat ggcggtgagt cccagcacgt gggaggtaag ggtcaggacc
     2521 aggaattcag catcactctt ggctacacag tgagtacaat gctagcctgg gctacaggac
     2581 ccctgtctcg aaaacaaaaa cccccaaaca ccccagtaga aaaaaaaccc gacccaaaca
     2641 acaacaaaac agacaattag aaaacctcat gacttgctct agatttctgt atttaacaac
     2701 tttgggaaac aaatctttgt gaagaagata agctgaatag gcctgtcttg ttaaaaaaaa
     2761 aaaaataagg ctcagatgat ttcagtggtc ttgggagaga aggatatccc ttctctttaa
     2821 ctctttcggg aagcagacaa ggaagaaaca gcccccaact catgtgagca gtaggactcg
     2881 gataagaatt cccagcttgg gaactctatc ttcatgtgct gatgcccctt gctgaaggca
     2941 gctcttctta ggtgggacac aggaaccagt gcatctttca ctgcacgttt ctagttttgt
     3001 ttctttggga aggaaggacc agacagccag atgttgtctc ccatttccac agattttctt
     3061 tccagtcagg acacccttca ctcttcgggt ctgtccagca catcggaatc atcacactgc
     3121 aagccatttc aataattttt ttggtatggt ctgattgtgc tagctgtctt aaaa
//
