LOCUS       NM_001358550            2081 bp    mRNA    linear   ROD 09-FEB-2024
DEFINITION  Mus musculus small glutamine-rich tetratricopeptide repeat
            (TPR)-containing, alpha (Sgta), transcript variant 3, mRNA.
ACCESSION   NM_001358550 XM_006513876
VERSION     NM_001358550.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2081)
  AUTHORS   Kubota,S., Doi,H., Koyano,S., Tanaka,K., Komiya,H., Katsumoto,A.,
            Ikeda,S., Hashiguchi,S., Nakamura,H., Fukai,R., Takahashi,K.,
            Kunii,M., Tada,M., Takeuchi,H. and Tanaka,F.
  TITLE     SGTA associates with intracellular aggregates in neurodegenerative
            diseases
  JOURNAL   Mol Brain 14 (1), 59 (2021)
   PUBMED   33757575
  REMARK    GeneRIF: SGTA associates with intracellular aggregates in
            neurodegenerative diseases.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2081)
  AUTHORS   Sundberg,J.P., Dadras,S.S., Silva,K.A., Kennedy,V.E., Garland,G.,
            Murray,S.A., Sundberg,B.A., Schofield,P.N. and Pratt,C.H.
  TITLE     Systematic screening for skin, hair, and nail abnormalities in a
            large-scale knockout mouse program
  JOURNAL   PLoS One 12 (7), e0180682 (2017)
   PUBMED   28700664
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2081)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. PMID: 29144450]
REFERENCE   4  (bases 1 to 2081)
  AUTHORS   Philp,L.K., Day,T.K., Butler,M.S., Laven-Law,G., Jindal,S.,
            Hickey,T.E., Scher,H.I., Butler,L.M. and Tilley,W.D.
  TITLE     Small Glutamine-Rich Tetratricopeptide Repeat-Containing Protein
            Alpha (SGTA) Ablation Limits Offspring Viability and Growth in Mice
  JOURNAL   Sci Rep 6, 28950 (2016)
   PUBMED   27358191
  REMARK    GeneRIF: In conclusion, this thorough investigation of SGTA-null
            mutation reports a mild phenotype of reduced body size.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2081)
  AUTHORS   Leznicki,P., Korac-Prlic,J., Kliza,K., Husnjak,K., Nyathi,Y.,
            Dikic,I. and High,S.
  TITLE     Binding of SGTA to Rpn13 selectively modulates protein quality
            control
  JOURNAL   J Cell Sci 128 (17), 3187-3196 (2015)
   PUBMED   26169395
  REMARK    GeneRIF: the binding of SGTA to Rpn13 enables specific polypeptides
            to escape proteasomal degradation and/or selectively modulates
            substrate degradation.
REFERENCE   6  (bases 1 to 2081)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   7  (bases 1 to 2081)
  AUTHORS   Sharma,M., Burre,J. and Sudhof,T.C.
  TITLE     CSPalpha promotes SNARE-complex assembly by chaperoning SNAP-25
            during synaptic activity
  JOURNAL   Nat Cell Biol 13 (1), 30-39 (2011)
   PUBMED   21151134
  REMARK    Erratum:[Nat Cell Biol. 2011 Feb;13(2):182]
REFERENCE   8  (bases 1 to 2081)
  AUTHORS   Tobaben,S., Varoqueaux,F., Brose,N., Stahl,B. and Meyer,G.
  TITLE     A brain-specific isoform of small glutamine-rich tetratricopeptide
            repeat-containing protein binds to Hsc70 and the cysteine string
            protein
  JOURNAL   J Biol Chem 278 (40), 38376-38383 (2003)
   PUBMED   12878599
REFERENCE   9  (bases 1 to 2081)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC152500.7, BY084509.1, AK051005.1 and CD775676.1.
            
            [WARNING] On Apr 1, 2024 this sequence was replaced by
            NM_001358550.2.
            
            On Dec 1, 2017 this sequence version replaced XM_006513876.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK051005.1, AK039966.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-41                AC152500.7         37975-38015
            42-115              BY084509.1         4-77
            116-2056            AK051005.1         1-1941
            2057-2081           CD775676.1         1-25                c
FEATURES             Location/Qualifiers
     source          1..2081
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 39.72 cM"
     gene            1..2081
                     /gene="Sgta"
                     /gene_synonym="5330427H01Rik; D10Ertd190e; Sgt; Stg"
                     /note="small glutamine-rich tetratricopeptide repeat
                     (TPR)-containing, alpha"
                     /db_xref="GeneID:52551"
                     /db_xref="MGI:MGI:1098703"
     exon            1..144
                     /gene="Sgta"
                     /gene_synonym="5330427H01Rik; D10Ertd190e; Sgt; Stg"
                     /inference="alignment:Splign:2.1.0"
     exon            145..280
                     /gene="Sgta"
                     /gene_synonym="5330427H01Rik; D10Ertd190e; Sgt; Stg"
                     /inference="alignment:Splign:2.1.0"
     CDS             181..1125
                     /gene="Sgta"
                     /gene_synonym="5330427H01Rik; D10Ertd190e; Sgt; Stg"
                     /note="isoform 2 is encoded by transcript variant 3; small
                     glutamine-rich tetratricopeptide repeat (TPR) containing
                     protein; small glutamine-rich tetratricopeptide
                     repeat-containing protein alpha; alpha-SGT"
                     /codon_start=1
                     /product="small glutamine-rich tetratricopeptide
                     repeat-containing protein alpha isoform 2"
                     /protein_id="NP_001345479.1"
                     /db_xref="CCDS:CCDS88056.1"
                     /db_xref="GeneID:52551"
                     /db_xref="MGI:MGI:1098703"
                     /translation="MDNRKRLAYAIIQFLHGQLRHGGLSCDAQESLEVAIQCLETAFG
                     VTLEDSDLALPQTLPEIFEAATSSKEMPQDPRAPDRTPPSEEDSAEAERLKTEGNEQM
                     KLENFEAAVHLYGKAIELNPANAVYFCNRAAAYSKLGNYVGAVQDCERAIGIDPGYSK
                     AYGRMGLALSSLNKHAEAVAYYKKALELDPDNDTYKSNLKIAELKLREAPSPTGGVGS
                     LDIAGLLNNPHFITMASSLMNSPQLQQLMSGMISGGHNPLGTPGSSPQQSDLASLIQA
                     GQQFAQQMQQQNPEFVEQIRSQVVRSRTPSASHEEQQE"
     exon            281..387
                     /gene="Sgta"
                     /gene_synonym="5330427H01Rik; D10Ertd190e; Sgt; Stg"
                     /inference="alignment:Splign:2.1.0"
     exon            388..472
                     /gene="Sgta"
                     /gene_synonym="5330427H01Rik; D10Ertd190e; Sgt; Stg"
                     /inference="alignment:Splign:2.1.0"
     exon            473..572
                     /gene="Sgta"
                     /gene_synonym="5330427H01Rik; D10Ertd190e; Sgt; Stg"
                     /inference="alignment:Splign:2.1.0"
     exon            573..677
                     /gene="Sgta"
                     /gene_synonym="5330427H01Rik; D10Ertd190e; Sgt; Stg"
                     /inference="alignment:Splign:2.1.0"
     exon            678..816
                     /gene="Sgta"
                     /gene_synonym="5330427H01Rik; D10Ertd190e; Sgt; Stg"
                     /inference="alignment:Splign:2.1.0"
     exon            817..879
                     /gene="Sgta"
                     /gene_synonym="5330427H01Rik; D10Ertd190e; Sgt; Stg"
                     /inference="alignment:Splign:2.1.0"
     exon            880..917
                     /gene="Sgta"
                     /gene_synonym="5330427H01Rik; D10Ertd190e; Sgt; Stg"
                     /inference="alignment:Splign:2.1.0"
     exon            918..1007
                     /gene="Sgta"
                     /gene_synonym="5330427H01Rik; D10Ertd190e; Sgt; Stg"
                     /inference="alignment:Splign:2.1.0"
     exon            1008..1130
                     /gene="Sgta"
                     /gene_synonym="5330427H01Rik; D10Ertd190e; Sgt; Stg"
                     /inference="alignment:Splign:2.1.0"
     exon            1131..2063
                     /gene="Sgta"
                     /gene_synonym="5330427H01Rik; D10Ertd190e; Sgt; Stg"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcacttgagc gcatgcgcaa aaggaaacct acacaggaaa tggttttttt ctgcgcaggc
       61 gtcttggtcc tgagggcgga gcttggctgc gccgcggtgc gcaggcgcag ccgtcggtgg
      121 gtcgggtctt cggtcgactg agagatcctg agcaagcagt gtcacctcac tagtctcgag
      181 atggacaaca ggaagcgcct ggcctatgcc atcatccagt tcctccatgg ccagttgcgg
      241 cacggtgggc tctcgtgtga cgcccaggag agcctagagg ttgccatcca gtgtctggag
      301 acagccttcg gggtgacgct ggaggacagt gaccttgctc tcccccagac cctgccagag
      361 atatttgaag cagccacttc cagcaaggag atgccacagg acccgcgggc ccctgacagg
      421 acaccaccct ctgaagagga ctcagctgag gcagagcgcc tcaaaacgga aggtaatgag
      481 cagatgaagc tggagaactt cgaggcggct gtgcacctct acggcaaggc cattgagctc
      541 aaccctgcca atgctgtcta cttctgtaac agagctgcgg cctacagcaa gctggggaac
      601 tacgtggggg ccgtgcagga ctgcgagcgc gccattggca tcgaccctgg gtatagcaag
      661 gcctatggcc gcatgggcct tgcactatcc agcctgaaca agcatgcaga ggctgtggca
      721 tactacaaga aggccctgga gctggaccct gacaacgaca catacaagtc caacctcaag
      781 attgcagagc tgaagttacg ggaggcgcca agccctacgg gcggcgtggg cagcttagac
      841 atcgctggcc tgctgaacaa cccacacttc atcaccatgg cttcgagctt aatgaacagc
      901 ccccagctac agcagctcat gtcgggcatg atctccggag gccataaccc tctgggcacg
      961 ccaggcagca gtccgcagca gagtgacctg gccagcctca tccaggcggg ccaacagttt
     1021 gcacagcaga tgcagcagca gaacccagag tttgtggagc agatccggag ccaggtggtg
     1081 cgcagccgga cacccagtgc cagccatgag gagcagcaag agtgacaacg gtgacccgag
     1141 tgtcccttcg ctccgcggcc tcctggtgtt ttagcatttt ctccgtcggg cagctcgaga
     1201 gagaaactgg acctgcatgt taagacggac tcgtccccac cttgtgtttt ccttcatccc
     1261 tccccttcgg ttttgtactc ttactggccc cacacctccc tggaggagtc tacagaagac
     1321 gacacaccag caccagttcc tccagccacc taggagctgc agggaggggt ggggtgagtg
     1381 tgagtcactg agtgacagcc tgggccctca ggtctcaggc cccaccctgc cgggttcctc
     1441 ctaaagggac ttgagtagct gactctcatc cccactgcca gccccagctg ggcaccagcg
     1501 tcccacaccc tcgcctggtt gcaggtccca gcaggtgccc ccgcctgcct tattccagtg
     1561 gcctgtgcca cataggactg aggcctgtga cttctgccca gcgtgtggac catccgtgtc
     1621 tctttccagc ttcccctcca tctttacagc catcagccaa tcctaacttt gtgtccagtc
     1681 cagcaccatc ctcagcctgg gcagcagaca tagacattga cccatctgtg tcatcctatc
     1741 cttgatctca tgggaattca atgtctgggg ttggcaggga gtttcggggt atcggccctg
     1801 aagcagccac cagaaccatc tttgttgggg tcagtctgag tgagggtgtg gatgttccca
     1861 cacacattct tggccctagg agcaggtgat gagatcacag gacagctgaa cccttggggg
     1921 gtcatgatgg catcaggctt tggcagatag tgtcagagct gtgtgtgtgg taggtagcca
     1981 gtaggaagat gggcccccga gggcagcagc gccaccttgg gcacagagtg cctggagaat
     2041 aaagacagtg atgacgctct gccaaaaaaa aaaaaaaaaa a
//
