LOCUS       NM_001358549            2199 bp    mRNA    linear   ROD 08-FEB-2024
DEFINITION  Mus musculus small glutamine-rich tetratricopeptide repeat
            (TPR)-containing, alpha (Sgta), transcript variant 2, mRNA.
ACCESSION   NM_001358549 XM_017314029
VERSION     NM_001358549.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2199)
  AUTHORS   Kubota,S., Doi,H., Koyano,S., Tanaka,K., Komiya,H., Katsumoto,A.,
            Ikeda,S., Hashiguchi,S., Nakamura,H., Fukai,R., Takahashi,K.,
            Kunii,M., Tada,M., Takeuchi,H. and Tanaka,F.
  TITLE     SGTA associates with intracellular aggregates in neurodegenerative
            diseases
  JOURNAL   Mol Brain 14 (1), 59 (2021)
   PUBMED   33757575
  REMARK    GeneRIF: SGTA associates with intracellular aggregates in
            neurodegenerative diseases.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2199)
  AUTHORS   Sundberg,J.P., Dadras,S.S., Silva,K.A., Kennedy,V.E., Garland,G.,
            Murray,S.A., Sundberg,B.A., Schofield,P.N. and Pratt,C.H.
  TITLE     Systematic screening for skin, hair, and nail abnormalities in a
            large-scale knockout mouse program
  JOURNAL   PLoS One 12 (7), e0180682 (2017)
   PUBMED   28700664
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2199)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. PMID: 29144450]
REFERENCE   4  (bases 1 to 2199)
  AUTHORS   Philp,L.K., Day,T.K., Butler,M.S., Laven-Law,G., Jindal,S.,
            Hickey,T.E., Scher,H.I., Butler,L.M. and Tilley,W.D.
  TITLE     Small Glutamine-Rich Tetratricopeptide Repeat-Containing Protein
            Alpha (SGTA) Ablation Limits Offspring Viability and Growth in Mice
  JOURNAL   Sci Rep 6, 28950 (2016)
   PUBMED   27358191
  REMARK    GeneRIF: In conclusion, this thorough investigation of SGTA-null
            mutation reports a mild phenotype of reduced body size.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2199)
  AUTHORS   Leznicki,P., Korac-Prlic,J., Kliza,K., Husnjak,K., Nyathi,Y.,
            Dikic,I. and High,S.
  TITLE     Binding of SGTA to Rpn13 selectively modulates protein quality
            control
  JOURNAL   J Cell Sci 128 (17), 3187-3196 (2015)
   PUBMED   26169395
  REMARK    GeneRIF: the binding of SGTA to Rpn13 enables specific polypeptides
            to escape proteasomal degradation and/or selectively modulates
            substrate degradation.
REFERENCE   6  (bases 1 to 2199)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   7  (bases 1 to 2199)
  AUTHORS   Sharma,M., Burre,J. and Sudhof,T.C.
  TITLE     CSPalpha promotes SNARE-complex assembly by chaperoning SNAP-25
            during synaptic activity
  JOURNAL   Nat Cell Biol 13 (1), 30-39 (2011)
   PUBMED   21151134
  REMARK    Erratum:[Nat Cell Biol. 2011 Feb;13(2):182]
REFERENCE   8  (bases 1 to 2199)
  AUTHORS   Tobaben,S., Varoqueaux,F., Brose,N., Stahl,B. and Meyer,G.
  TITLE     A brain-specific isoform of small glutamine-rich tetratricopeptide
            repeat-containing protein binds to Hsc70 and the cysteine string
            protein
  JOURNAL   J Biol Chem 278 (40), 38376-38383 (2003)
   PUBMED   12878599
REFERENCE   9  (bases 1 to 2199)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY287841.1, BY143324.1, AK079168.1, AK051005.1 and CD775676.1.
            
            [WARNING] On Apr 1, 2024 this sequence was replaced by
            NM_001358549.2.
            
            On Dec 1, 2017 this sequence version replaced XM_017314029.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660815.282202.1,
                                           SRR7652917.175207.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139, SAMN01164142
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-149               BY287841.1         1-149
            150-376             BY143324.1         134-360
            377-915             AK079168.1         155-693
            916-2174            AK051005.1         683-1941
            2175-2199           CD775676.1         1-25                c
FEATURES             Location/Qualifiers
     source          1..2199
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 39.72 cM"
     gene            1..2199
                     /gene="Sgta"
                     /gene_synonym="5330427H01Rik; D10Ertd190e; Sgt; Stg"
                     /note="small glutamine-rich tetratricopeptide repeat
                     (TPR)-containing, alpha"
                     /db_xref="GeneID:52551"
                     /db_xref="MGI:MGI:1098703"
     exon            1..259
                     /gene="Sgta"
                     /gene_synonym="5330427H01Rik; D10Ertd190e; Sgt; Stg"
                     /inference="alignment:Splign:2.1.0"
     exon            260..395
                     /gene="Sgta"
                     /gene_synonym="5330427H01Rik; D10Ertd190e; Sgt; Stg"
                     /inference="alignment:Splign:2.1.0"
     CDS             296..1243
                     /gene="Sgta"
                     /gene_synonym="5330427H01Rik; D10Ertd190e; Sgt; Stg"
                     /note="isoform 1 is encoded by transcript variant 2; small
                     glutamine-rich tetratricopeptide repeat (TPR) containing
                     protein; small glutamine-rich tetratricopeptide
                     repeat-containing protein alpha; alpha-SGT"
                     /codon_start=1
                     /product="small glutamine-rich tetratricopeptide
                     repeat-containing protein alpha isoform 1"
                     /protein_id="NP_001345478.1"
                     /db_xref="CCDS:CCDS35990.1"
                     /db_xref="GeneID:52551"
                     /db_xref="MGI:MGI:1098703"
                     /translation="MDNRKRLAYAIIQFLHGQLRHGGLSCDAQESLEVAIQCLETAFG
                     VTLEDSDLALPQTLPEIFEAATSSKQEMPQDPRAPDRTPPSEEDSAEAERLKTEGNEQ
                     MKLENFEAAVHLYGKAIELNPANAVYFCNRAAAYSKLGNYVGAVQDCERAIGIDPGYS
                     KAYGRMGLALSSLNKHAEAVAYYKKALELDPDNDTYKSNLKIAELKLREAPSPTGGVG
                     SLDIAGLLNNPHFITMASSLMNSPQLQQLMSGMISGGHNPLGTPGSSPQQSDLASLIQ
                     AGQQFAQQMQQQNPEFVEQIRSQVVRSRTPSASHEEQQE"
     exon            396..502
                     /gene="Sgta"
                     /gene_synonym="5330427H01Rik; D10Ertd190e; Sgt; Stg"
                     /inference="alignment:Splign:2.1.0"
     exon            503..590
                     /gene="Sgta"
                     /gene_synonym="5330427H01Rik; D10Ertd190e; Sgt; Stg"
                     /inference="alignment:Splign:2.1.0"
     exon            591..690
                     /gene="Sgta"
                     /gene_synonym="5330427H01Rik; D10Ertd190e; Sgt; Stg"
                     /inference="alignment:Splign:2.1.0"
     exon            691..795
                     /gene="Sgta"
                     /gene_synonym="5330427H01Rik; D10Ertd190e; Sgt; Stg"
                     /inference="alignment:Splign:2.1.0"
     exon            796..934
                     /gene="Sgta"
                     /gene_synonym="5330427H01Rik; D10Ertd190e; Sgt; Stg"
                     /inference="alignment:Splign:2.1.0"
     exon            935..997
                     /gene="Sgta"
                     /gene_synonym="5330427H01Rik; D10Ertd190e; Sgt; Stg"
                     /inference="alignment:Splign:2.1.0"
     exon            998..1035
                     /gene="Sgta"
                     /gene_synonym="5330427H01Rik; D10Ertd190e; Sgt; Stg"
                     /inference="alignment:Splign:2.1.0"
     exon            1036..1125
                     /gene="Sgta"
                     /gene_synonym="5330427H01Rik; D10Ertd190e; Sgt; Stg"
                     /inference="alignment:Splign:2.1.0"
     exon            1126..1248
                     /gene="Sgta"
                     /gene_synonym="5330427H01Rik; D10Ertd190e; Sgt; Stg"
                     /inference="alignment:Splign:2.1.0"
     exon            1249..2181
                     /gene="Sgta"
                     /gene_synonym="5330427H01Rik; D10Ertd190e; Sgt; Stg"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggtgcgcagg cgcagccgtc ggtgggtcgg gtcttcggtc gactgagagg tgaggctggg
       61 ggctccgccg tgccccgtat gggcgtcggg ggtctgtggg tttagcttcg ctgtgctcgg
      121 gagcccctgg gacaaaggtg gcttgtgatc cggacttctg ctctcttcgg ggtcacgtga
      181 gcgggcggcg cagagaggaa actgaggcag acagcgtccc aacccacccc cacccctcgt
      241 cgctttttct cacgaaaaga tcctgagcaa gcagtgtcac ctcactagtc tcgagatgga
      301 caacaggaag cgcctggcct atgccatcat ccagttcctc catggccagt tgcggcacgg
      361 tgggctctcg tgtgacgccc aggagagcct agaggttgcc atccagtgtc tggagacagc
      421 cttcggggtg acgctggagg acagtgacct tgctctcccc cagaccctgc cagagatatt
      481 tgaagcagcc acttccagca agcaggagat gccacaggac ccgcgggccc ctgacaggac
      541 accaccctct gaagaggact cagctgaggc agagcgcctc aaaacggaag gtaatgagca
      601 gatgaagctg gagaacttcg aggcggctgt gcacctctac ggcaaggcca ttgagctcaa
      661 ccctgccaat gctgtctact tctgtaacag agctgcggcc tacagcaagc tggggaacta
      721 cgtgggggcc gtgcaggact gcgagcgcgc cattggcatc gaccctgggt atagcaaggc
      781 ctatggccgc atgggccttg cactatccag cctgaacaag catgcagagg ctgtggcata
      841 ctacaagaag gccctggagc tggaccctga caacgacaca tacaagtcca acctcaagat
      901 tgcagagctg aagttacggg aggcgccaag ccctacgggc ggcgtgggca gcttagacat
      961 cgctggcctg ctgaacaacc cacacttcat caccatggct tcgagcttaa tgaacagccc
     1021 ccagctacag cagctcatgt cgggcatgat ctccggaggc cataaccctc tgggcacgcc
     1081 aggcagcagt ccgcagcaga gtgacctggc cagcctcatc caggcgggcc aacagtttgc
     1141 acagcagatg cagcagcaga acccagagtt tgtggagcag atccggagcc aggtggtgcg
     1201 cagccggaca cccagtgcca gccatgagga gcagcaagag tgacaacggt gacccgagtg
     1261 tcccttcgct ccgcggcctc ctggtgtttt agcattttct ccgtcgggca gctcgagaga
     1321 gaaactggac ctgcatgtta agacggactc gtccccacct tgtgttttcc ttcatccctc
     1381 cccttcggtt ttgtactctt actggcccca cacctccctg gaggagtcta cagaagacga
     1441 cacaccagca ccagttcctc cagccaccta ggagctgcag ggaggggtgg ggtgagtgtg
     1501 agtcactgag tgacagcctg ggccctcagg tctcaggccc caccctgccg ggttcctcct
     1561 aaagggactt gagtagctga ctctcatccc cactgccagc cccagctggg caccagcgtc
     1621 ccacaccctc gcctggttgc aggtcccagc aggtgccccc gcctgcctta ttccagtggc
     1681 ctgtgccaca taggactgag gcctgtgact tctgcccagc gtgtggacca tccgtgtctc
     1741 tttccagctt cccctccatc tttacagcca tcagccaatc ctaactttgt gtccagtcca
     1801 gcaccatcct cagcctgggc agcagacata gacattgacc catctgtgtc atcctatcct
     1861 tgatctcatg ggaattcaat gtctggggtt ggcagggagt ttcggggtat cggccctgaa
     1921 gcagccacca gaaccatctt tgttggggtc agtctgagtg agggtgtgga tgttcccaca
     1981 cacattcttg gccctaggag caggtgatga gatcacagga cagctgaacc cttggggggt
     2041 catgatggca tcaggctttg gcagatagtg tcagagctgt gtgtgtggta ggtagccagt
     2101 aggaagatgg gcccccgagg gcagcagcgc caccttgggc acagagtgcc tggagaataa
     2161 agacagtgat gacgctctgc caaaaaaaaa aaaaaaaaa
//
