LOCUS       NM_134091               3013 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus small G protein signaling modulator 3 (Sgsm3),
            transcript variant 1, mRNA.
ACCESSION   NM_134091
VERSION     NM_134091.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3013)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3013)
  AUTHORS   Jung,S.E., Choi,J.W., Moon,H., Oh,S., Lim,S., Lee,S., Kim,S.W. and
            Hwang,K.C.
  TITLE     Small G protein signaling modulator 3 (SGSM3) knockdown attenuates
            apoptosis and cardiogenic differentiation in rat mesenchymal stem
            cells exposed to hypoxia
  JOURNAL   PLoS One 15 (4), e0231272 (2020)
   PUBMED   32271805
  REMARK    GeneRIF: SGSM3/Sgsm3 probably has an effect on mesenchymal stem
            cells (MSC) survival and thus therapeutic potential in diseased
            hearts, but SGSM3 may worsen the development of MSC-based
            therapeutic approaches in regenerative medicine.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3013)
  AUTHORS   Yang,H., Sasaki,T., Minoshima,S. and Shimizu,N.
  TITLE     Identification of three novel proteins (SGSM1, 2, 3) which modulate
            small G protein (RAP and RAB)-mediated signaling pathway
  JOURNAL   Genomics 90 (2), 249-260 (2007)
   PUBMED   17509819
REFERENCE   4  (bases 1 to 3013)
  AUTHORS   Itoh,T., Satoh,M., Kanno,E. and Fukuda,M.
  TITLE     Screening for target Rabs of TBC (Tre-2/Bub2/Cdc16)
            domain-containing proteins based on their Rab-binding activity
  JOURNAL   Genes Cells 11 (9), 1023-1037 (2006)
   PUBMED   16923123
REFERENCE   5  (bases 1 to 3013)
  AUTHORS   Lan,Z., Kurata,W.E., Martyn,K.D., Jin,C. and Lau,A.F.
  TITLE     Novel rab GAP-like protein, CIP85, interacts with connexin43 and
            induces its degradation
  JOURNAL   Biochemistry 44 (7), 2385-2396 (2005)
   PUBMED   15709751
  REMARK    GeneRIF: Functional importance of the interaction between CIP85 and
            connexin 43 (Cx43) is suggested by the observation that CIP85
            appears to induce the turnover of Cx43 through the lysosomal
            pathway. (CIP85; Cx43-interacting protein of 85-kDa)
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY242851.1, BC018197.1, AK142314.1 and AI844026.1.
            
            On Mar 14, 2009 this sequence version replaced NM_134091.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC018197.1, AK170806.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on conservation,
                                                expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-40                BY242851.1         2-41
            41-2778             BC018197.1         1-2738
            2779-2994           AK142314.1         2747-2962
            2995-3013           AI844026.1         1-19                c
FEATURES             Location/Qualifiers
     source          1..3013
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 37.96 cM"
     gene            1..3013
                     /gene="Sgsm3"
                     /gene_synonym="1810012I01Rik; Cip85; RUSC3; Rutbc3"
                     /note="small G protein signaling modulator 3"
                     /db_xref="GeneID:105835"
                     /db_xref="MGI:MGI:1916329"
     exon            1..101
                     /gene="Sgsm3"
                     /gene_synonym="1810012I01Rik; Cip85; RUSC3; Rutbc3"
                     /inference="alignment:Splign:2.1.0"
     exon            102..197
                     /gene="Sgsm3"
                     /gene_synonym="1810012I01Rik; Cip85; RUSC3; Rutbc3"
                     /inference="alignment:Splign:2.1.0"
     CDS             191..2443
                     /gene="Sgsm3"
                     /gene_synonym="1810012I01Rik; Cip85; RUSC3; Rutbc3"
                     /note="isoform 1 is encoded by transcript variant 1;
                     Cx43-interacting protein of 85-kDa; RUN and TBC1
                     domain-containing protein 3"
                     /codon_start=1
                     /product="small G protein signaling modulator 3 isoform 1"
                     /protein_id="NP_598852.3"
                     /db_xref="CCDS:CCDS49673.2"
                     /db_xref="GeneID:105835"
                     /db_xref="MGI:MGI:1916329"
                     /translation="MSGNHTPSASGPFSALTPSIWPQEILAKYSQKEESSEQPELCYD
                     EFGFRVDKEGSEPGCSQMTGSPLVEDPPQRLRWQAHLEFTHNHDVGDLTWDKIAVSLP
                     RSEKLRSLVLAGIPHGMRPQLWMRLSGALQKKKNSELSYREIIKNSSNDETIAAKQIE
                     KDLLRTMPSNACFANVNSIGVPRLRRVLRALAWLYPEIGYCQGTGMVAACLLLFLEEE
                     DAFWMMCAIIEDLLPASYFSTTLLGVQTDQRVLRHLIVQYLPRLDKLLQEHDIELSLI
                     TLHWFLTAFASVVHIRLLLRIWDLFFYEGSLVLFQTTLGMLRLKEEELIQSENSASIF
                     NTLSDIPAQMDDAELLLGEAMRLAGSLTDVAVETQRRKHLAYLIADQGQTLGTGTTTN
                     LSQVVRRRTQRRKSGITSLLFGEDDLEALKAKNIKQTELVADLREAILRVARHFQCTD
                     PKNCSVELTPDYSMESHQRDHENYVACLRSHRRRAKALLDFERHDDDELGFRKNDIIT
                     IISQKDEHCWVGELNGLRGWFPAKFVEVLDERSKEYSIAGDDSVTEGVTDLVRGTLCP
                     ALKALFEHGLKKPSLLGGACHPWLFIEEAAGREVERDFDSVYSRLVLCKTYRLDEDGK
                     VLTPEELLYRAVQSVNVTHDAAHAQMDVKLRSLICVGLNEQVLHLWLEVLCSSLPTVE
                     KWYQPWSFLRSPGWVQIKCELRVLCCFAFSLSQDWELPARREEEKQPLKEGVQDMLVK
                     HHLFSWDIDG"
     exon            198..283
                     /gene="Sgsm3"
                     /gene_synonym="1810012I01Rik; Cip85; RUSC3; Rutbc3"
                     /inference="alignment:Splign:2.1.0"
     exon            284..350
                     /gene="Sgsm3"
                     /gene_synonym="1810012I01Rik; Cip85; RUSC3; Rutbc3"
                     /inference="alignment:Splign:2.1.0"
     exon            351..556
                     /gene="Sgsm3"
                     /gene_synonym="1810012I01Rik; Cip85; RUSC3; Rutbc3"
                     /inference="alignment:Splign:2.1.0"
     exon            557..664
                     /gene="Sgsm3"
                     /gene_synonym="1810012I01Rik; Cip85; RUSC3; Rutbc3"
                     /inference="alignment:Splign:2.1.0"
     exon            665..808
                     /gene="Sgsm3"
                     /gene_synonym="1810012I01Rik; Cip85; RUSC3; Rutbc3"
                     /inference="alignment:Splign:2.1.0"
     exon            809..1004
                     /gene="Sgsm3"
                     /gene_synonym="1810012I01Rik; Cip85; RUSC3; Rutbc3"
                     /inference="alignment:Splign:2.1.0"
     exon            1005..1150
                     /gene="Sgsm3"
                     /gene_synonym="1810012I01Rik; Cip85; RUSC3; Rutbc3"
                     /inference="alignment:Splign:2.1.0"
     exon            1151..1375
                     /gene="Sgsm3"
                     /gene_synonym="1810012I01Rik; Cip85; RUSC3; Rutbc3"
                     /inference="alignment:Splign:2.1.0"
     exon            1376..1430
                     /gene="Sgsm3"
                     /gene_synonym="1810012I01Rik; Cip85; RUSC3; Rutbc3"
                     /inference="alignment:Splign:2.1.0"
     exon            1431..1558
                     /gene="Sgsm3"
                     /gene_synonym="1810012I01Rik; Cip85; RUSC3; Rutbc3"
                     /inference="alignment:Splign:2.1.0"
     exon            1559..1714
                     /gene="Sgsm3"
                     /gene_synonym="1810012I01Rik; Cip85; RUSC3; Rutbc3"
                     /inference="alignment:Splign:2.1.0"
     exon            1715..1769
                     /gene="Sgsm3"
                     /gene_synonym="1810012I01Rik; Cip85; RUSC3; Rutbc3"
                     /inference="alignment:Splign:2.1.0"
     exon            1770..1819
                     /gene="Sgsm3"
                     /gene_synonym="1810012I01Rik; Cip85; RUSC3; Rutbc3"
                     /inference="alignment:Splign:2.1.0"
     exon            1820..1972
                     /gene="Sgsm3"
                     /gene_synonym="1810012I01Rik; Cip85; RUSC3; Rutbc3"
                     /inference="alignment:Splign:2.1.0"
     exon            1973..2043
                     /gene="Sgsm3"
                     /gene_synonym="1810012I01Rik; Cip85; RUSC3; Rutbc3"
                     /inference="alignment:Splign:2.1.0"
     exon            2044..2092
                     /gene="Sgsm3"
                     /gene_synonym="1810012I01Rik; Cip85; RUSC3; Rutbc3"
                     /inference="alignment:Splign:2.1.0"
     exon            2093..2178
                     /gene="Sgsm3"
                     /gene_synonym="1810012I01Rik; Cip85; RUSC3; Rutbc3"
                     /inference="alignment:Splign:2.1.0"
     exon            2179..2301
                     /gene="Sgsm3"
                     /gene_synonym="1810012I01Rik; Cip85; RUSC3; Rutbc3"
                     /inference="alignment:Splign:2.1.0"
     exon            2302..2362
                     /gene="Sgsm3"
                     /gene_synonym="1810012I01Rik; Cip85; RUSC3; Rutbc3"
                     /inference="alignment:Splign:2.1.0"
     exon            2363..2997
                     /gene="Sgsm3"
                     /gene_synonym="1810012I01Rik; Cip85; RUSC3; Rutbc3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2761..2766
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sgsm3"
                     /gene_synonym="1810012I01Rik; Cip85; RUSC3; Rutbc3"
                     /note="hexamer: AATAAA"
     polyA_site      2778
                     /gene="Sgsm3"
                     /gene_synonym="1810012I01Rik; Cip85; RUSC3; Rutbc3"
                     /note="major polyA site"
     regulatory      2976..2981
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sgsm3"
                     /gene_synonym="1810012I01Rik; Cip85; RUSC3; Rutbc3"
                     /note="hexamer: AATACA"
     polyA_site      2997
                     /gene="Sgsm3"
                     /gene_synonym="1810012I01Rik; Cip85; RUSC3; Rutbc3"
ORIGIN      
        1 ggctctgcgg cccgcgcgtg cgcagaaggg cagcagtgcg cgccgactag gaggcagctg
       61 ctagcctgac ctgccgaggt gctgaggtgg ccgcgagaca gggctgatga agcctcagga
      121 cagtcagaga agccaatgat gaccgcttgt gcctagacct atgaagtcct gccgtcgtcc
      181 acagcacatg atgtcaggaa accacacgcc ttctgccagt ggccctttct ctgccctgac
      241 tccaagcata tggccccagg agatcctggc aaaatactca cagaaagaag aatcctcaga
      301 gcagccagag ctctgctatg atgagtttgg tttccgtgtg gacaaggaag gttctgagcc
      361 tggatgcagc cagatgacag gctcacccct ggtggaggac cccccgcaga ggctacgttg
      421 gcaggctcac ctggagttca cccataacca tgatgttggg gatctcacct gggacaagat
      481 tgcagtctcc ctcccccgct ctgagaaact ccgttcccta gtgctggctg gcatcccaca
      541 tggcatgagg ccacagttgt ggatgcggct ctctggggcg ctgcagaaga agaagaactc
      601 tgagttgtcc taccgtgaga ttataaagaa cagctccaac gatgagacca tcgctgccaa
      661 acagatcgaa aaggacctgc tccgtaccat gcccagcaac gcctgctttg ccaatgtgaa
      721 cagcatcggt gttccccgcc tgcgcagagt cctccgagca ctggcctggc tctacccaga
      781 gattggctac tgccagggca caggcatggt ggctgcttgt ctcctgctgt tcctggagga
      841 ggaggatgcc ttctggatga tgtgtgccat tattgaggac ctgctgcctg cctcctactt
      901 cagcactacc ctgctgggag tccagactga ccagcgggtc ctgcgccacc tgattgtcca
      961 gtacctgcct cgcttagaca aactgttgca ggagcacgac attgagctgt ctcttatcac
     1021 gctgcactgg ttcctcacgg ccttcgccag cgtggtgcac atcagactgc tgctgcgcat
     1081 ctgggacctg tttttctacg agggctccct ggtgttgttc cagactacgc tgggcatgct
     1141 gcgccttaag gaggaagagc tgatacagtc tgagaactca gcttccatct tcaacacgct
     1201 gtcagacatt cctgcacaga tggatgacgc agagctgctg ctgggggagg ccatgaggct
     1261 ggctggctcc ctcactgatg tggccgtgga gacccagcgt cgcaagcacc tggcctacct
     1321 tattgcagac caaggccaaa ccctggggac gggcaccacc actaacctct ctcaggttgt
     1381 acggcgcagg acgcagcgga ggaagtctgg tatcacttcc ctgctttttg gagaggacga
     1441 cctagaagct ctcaaggcaa agaacatcaa gcaaacagag ctggtagccg accttcgcga
     1501 agccattttg cgtgtggcac gccacttcca gtgcacagac cccaagaact gtagtgtgga
     1561 gctgacccca gactacagca tggagagcca ccagcgggac catgagaact acgtggcatg
     1621 cttacgcagc caccggcgcc gggccaaggc cctgctggac tttgagcggc acgatgatga
     1681 tgagctaggc ttccgcaaaa atgacatcat cacgatcatt tcccagaagg atgagcactg
     1741 ctgggtgggt gagctgaacg gcctgagagg ctggtttcca gccaagtttg tggaggtcct
     1801 ggatgagcga agcaaagagt actccattgc gggggacgac tctgtgacag aaggagtaac
     1861 agacctcgtg cgaggaaccc tctgcccagc cctcaaggcc ctgtttgaac acggattgaa
     1921 gaagccatcc ttgcttggag gggcttgtca cccctggctg tttatcgagg aggcagcggg
     1981 ccgtgaagtc gaaagagact ttgattctgt gtactcccgc ctggtgctct gtaagacata
     2041 caggctggac gaagatggca aagtcctgac ccctgaagag ctgctgtacc gggcagtgca
     2101 gtctgtgaat gtgacccatg atgcagcaca cgcacaaatg gatgtcaagc tccgctcact
     2161 tatctgcgtg gggctaaatg aacaggtcct acacctgtgg ctggaggttc tctgctccag
     2221 cctgcccact gtggagaagt ggtaccagcc ctggtccttc ctgcgaagcc ctggctgggt
     2281 ccagatcaag tgtgagctcc gtgtcctctg ctgctttgcc ttcagcctct cccaggactg
     2341 ggagctccct gctaggagag aggaggaaaa gcagcccctg aaggagggtg tgcaggacat
     2401 gctggtgaag caccatctct tcagctggga catagatgga tgatgctcct tccagctgct
     2461 ctgtggctgc caggcccgcc catcatagac tgcctggaag gctcccttca acagaaggca
     2521 gagccctggc cagcctcgag cctccctcag gctaggaggt tcagggaaag acactctcca
     2581 gagcttactc aggacccatg atcagtgtct gggcctcccc agttcaggct accacggctg
     2641 tcaaaagcat acagtggtgg ccagcccagc tgctttcctt aacatggtcc tgaggagtgc
     2701 cagccatatg gtatactata ctaaccaaaa accttgggaa gaggcgggga cattattgta
     2761 aataaacctt ttactagagc aagcctccca tcttttgttg agccaagccc tgagttccac
     2821 aaaagctacc cctcctgaaa tggtctgact cccaggccct tgctcagtgt ttatttcaag
     2881 tacgtctgat gcaattaggg ccactgtgtg gcctctagat gccagcatgg aatagaccca
     2941 ggaccccagc caaacttctc aattctgatg gatcaaatac aacagactgg caagtcaaaa
     3001 aaaaaaaaaa aaa
//
