LOCUS       NM_197943               4749 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus small G protein signaling modulator 2 (Sgsm2),
            transcript variant 1, mRNA.
ACCESSION   NM_197943
VERSION     NM_197943.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4749)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4749)
  AUTHORS   Marubashi,S., Shimada,H., Fukuda,M. and Ohbayashi,N.
  TITLE     RUTBC1 Functions as a GTPase-activating Protein for Rab32/38 and
            Regulates Melanogenic Enzyme Trafficking in Melanocytes
  JOURNAL   J Biol Chem 291 (3), 1427-1440 (2016)
   PUBMED   26620560
REFERENCE   3  (bases 1 to 4749)
  AUTHORS   Yang,H., Sasaki,T., Minoshima,S. and Shimizu,N.
  TITLE     Identification of three novel proteins (SGSM1, 2, 3) which modulate
            small G protein (RAP and RAB)-mediated signaling pathway
  JOURNAL   Genomics 90 (2), 249-260 (2007)
   PUBMED   17509819
REFERENCE   4  (bases 1 to 4749)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Aizawa,H., Yuasa,S.,
            Nakajima,D., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: II. The complete nucleotide sequences of 400 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (1), 35-48 (2003)
   PUBMED   12693553
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL604066.9.
            
            On Mar 19, 2020 this sequence version replaced NM_197943.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC060163.1, AK122273.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-245               AL604066.9         113388-113632       c
            246-321             AL604066.9         108559-108634       c
            322-484             AL604066.9         85578-85740         c
            485-646             AL604066.9         85140-85301         c
            647-714             AL604066.9         84787-84854         c
            715-860             AL604066.9         84544-84689         c
            861-995             AL604066.9         84174-84308         c
            996-1120            AL604066.9         83594-83718         c
            1121-1188           AL604066.9         83132-83199         c
            1189-1349           AL604066.9         81924-82084         c
            1350-1476           AL604066.9         81648-81774         c
            1477-1630           AL604066.9         76309-76462         c
            1631-1695           AL604066.9         75424-75488         c
            1696-1841           AL604066.9         75192-75337         c
            1842-1970           AL604066.9         74614-74742         c
            1971-2153           AL604066.9         74181-74363         c
            2154-2534           AL604066.9         70692-71072         c
            2535-2659           AL604066.9         70349-70473         c
            2660-2742           AL604066.9         69888-69970         c
            2743-2852           AL604066.9         69638-69747         c
            2853-2949           AL604066.9         68303-68399         c
            2950-3117           AL604066.9         67662-67829         c
            3118-4749           AL604066.9         65827-67458         c
FEATURES             Location/Qualifiers
     source          1..4749
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 45.76 cM"
     gene            1..4749
                     /gene="Sgsm2"
                     /gene_synonym="D630003G22Rik; mKIAA0397; Rutbc1"
                     /note="small G protein signaling modulator 2"
                     /db_xref="GeneID:97761"
                     /db_xref="MGI:MGI:2144695"
     exon            1..245
                     /gene="Sgsm2"
                     /gene_synonym="D630003G22Rik; mKIAA0397; Rutbc1"
                     /inference="alignment:Splign:2.1.0"
     CDS             189..3206
                     /gene="Sgsm2"
                     /gene_synonym="D630003G22Rik; mKIAA0397; Rutbc1"
                     /EC_number="5.1.1.18"
                     /note="isoform 1 is encoded by transcript variant 1; RUN
                     and TBC1 domain containing 1; RUN and TBC1
                     domain-containing protein 1"
                     /codon_start=1
                     /product="small G protein signaling modulator 2 isoform 1"
                     /protein_id="NP_922934.2"
                     /db_xref="CCDS:CCDS36224.1"
                     /db_xref="GeneID:97761"
                     /db_xref="MGI:MGI:2144695"
                     /translation="MGSAEDAVKEKLLWNVKKEVKQIMEEAVTRKFVHEDSSHIIALC
                     GAVEACLLHQLRRRAAGFLRSDKMAALFTKVGKTCPVAEDICHKVQELQQQAEGRKPS
                     GGSQEALRKQGSTGGKAPALSPQALKHIWVRTALMEKVLDRVVQYLAENCSKYYEKEA
                     LLADPVFGPILACLLVGPCALEYTKLKTADHYWTDPSADELVQRHRIRGPPNRQDSPA
                     KRPALGIRKRHSSGSASEDRLAACAREYVESLHQNSRTRLLYGKNNVLVQPKEDMEAV
                     PGYLSLHQSAENLTLKWTPNQLMNGTLGDSELEKSVYWDYALVVPFSQIVCIHCHQQK
                     SGGTLVLVSQDGIQRPPLHFPQGGHLLSFLSCLENGLLPRGQLEPPLWTQQGKGKVFP
                     KLRKRSSIRSIDVEELGVGRATDYVFRIIYPGHRHEHNAGDMIEMQGFGPSLTAWHLE
                     PLCSQGSSCLSCSSSSSPYATPSHCSCIPDRLPLRLLCESMKRQIVSRAFYGWLAYCR
                     HLSTVRTHLSALVHHNIIPPDRPPGASGGLTKDVWSKYQKDEKNYKELELLRQVYYGG
                     VEHEIRKDVWPFLLGHYKFGMSKKEMEQVDTAVAARYQQVLAEWKACEVVVRQREREA
                     HPATLTKFSSGSSIDSHVQRLVHRDSTISNDVFISVDDLEPSGPQDLEDSKPKREQEP
                     GAGTPGIAAAEQQSVEFDSPDSGLPSSRNYSVASGIQSSLDEAQSVGFEDDGAGEDGS
                     EGPATAAHTFPGPHDPGQETLAPASELEAGQELAAVCAAAYTIELLDTVALNLHRIDK
                     DVQRCDRNYWYFTTSNLERLRDIMCSYVWEHLDMGYVQGMCDLLAPLLVILDNDQLAY
                     SCFSHLMKRMGQNFPSGGAMDSHFANMRSLIQILDSELFELMHQNGDYTHFYFCYRWF
                     LLDFKRELLYEDVFAVWEVIWAARRISSEHFVLFIALALVEAYREIIRDNNMDFTDII
                     KFFNERAERHDAQEILRIARDLVHKVQMLIDNK"
     exon            246..321
                     /gene="Sgsm2"
                     /gene_synonym="D630003G22Rik; mKIAA0397; Rutbc1"
                     /inference="alignment:Splign:2.1.0"
     exon            322..484
                     /gene="Sgsm2"
                     /gene_synonym="D630003G22Rik; mKIAA0397; Rutbc1"
                     /inference="alignment:Splign:2.1.0"
     exon            485..646
                     /gene="Sgsm2"
                     /gene_synonym="D630003G22Rik; mKIAA0397; Rutbc1"
                     /inference="alignment:Splign:2.1.0"
     exon            647..714
                     /gene="Sgsm2"
                     /gene_synonym="D630003G22Rik; mKIAA0397; Rutbc1"
                     /inference="alignment:Splign:2.1.0"
     exon            715..860
                     /gene="Sgsm2"
                     /gene_synonym="D630003G22Rik; mKIAA0397; Rutbc1"
                     /inference="alignment:Splign:2.1.0"
     exon            861..995
                     /gene="Sgsm2"
                     /gene_synonym="D630003G22Rik; mKIAA0397; Rutbc1"
                     /inference="alignment:Splign:2.1.0"
     exon            996..1120
                     /gene="Sgsm2"
                     /gene_synonym="D630003G22Rik; mKIAA0397; Rutbc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1121..1188
                     /gene="Sgsm2"
                     /gene_synonym="D630003G22Rik; mKIAA0397; Rutbc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1189..1349
                     /gene="Sgsm2"
                     /gene_synonym="D630003G22Rik; mKIAA0397; Rutbc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1350..1476
                     /gene="Sgsm2"
                     /gene_synonym="D630003G22Rik; mKIAA0397; Rutbc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1477..1630
                     /gene="Sgsm2"
                     /gene_synonym="D630003G22Rik; mKIAA0397; Rutbc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1631..1695
                     /gene="Sgsm2"
                     /gene_synonym="D630003G22Rik; mKIAA0397; Rutbc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1696..1841
                     /gene="Sgsm2"
                     /gene_synonym="D630003G22Rik; mKIAA0397; Rutbc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1842..1970
                     /gene="Sgsm2"
                     /gene_synonym="D630003G22Rik; mKIAA0397; Rutbc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1971..2153
                     /gene="Sgsm2"
                     /gene_synonym="D630003G22Rik; mKIAA0397; Rutbc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2154..2534
                     /gene="Sgsm2"
                     /gene_synonym="D630003G22Rik; mKIAA0397; Rutbc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2535..2659
                     /gene="Sgsm2"
                     /gene_synonym="D630003G22Rik; mKIAA0397; Rutbc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2660..2742
                     /gene="Sgsm2"
                     /gene_synonym="D630003G22Rik; mKIAA0397; Rutbc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2743..2852
                     /gene="Sgsm2"
                     /gene_synonym="D630003G22Rik; mKIAA0397; Rutbc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2853..2949
                     /gene="Sgsm2"
                     /gene_synonym="D630003G22Rik; mKIAA0397; Rutbc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2950..3117
                     /gene="Sgsm2"
                     /gene_synonym="D630003G22Rik; mKIAA0397; Rutbc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3118..4749
                     /gene="Sgsm2"
                     /gene_synonym="D630003G22Rik; mKIAA0397; Rutbc1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4729..4734
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sgsm2"
                     /gene_synonym="D630003G22Rik; mKIAA0397; Rutbc1"
                     /note="hexamer: AATAAA"
     polyA_site      4749
                     /gene="Sgsm2"
                     /gene_synonym="D630003G22Rik; mKIAA0397; Rutbc1"
                     /note="major polyA site"
ORIGIN      
        1 gcggggctcg gaagatggct gcggagctga gcaccgggca gtggctgcgg cggctgcagg
       61 cggggagcgc agcgggcggg gactccgcct cgcgtgtggg gcgctgagtc gggaggcgcg
      121 gaggcggtga gggcgcaccg ggggctcggg gggccactcg gtgccacctg cccgccacct
      181 gccgcaccat gggcagcgca gaggacgcgg tcaaagaaaa gctgctgtgg aacgtgaaga
      241 aggaggtgaa acaaatcatg gaggaggctg tcaccaggaa attcgtgcat gaagatagca
      301 gccacatcat tgctctgtgt ggtgctgtgg aggcttgcct cctgcatcag ctaagacgcc
      361 gtgctgctgg ctttctgcga agtgacaaga tggcggccct gttcaccaaa gtggggaaga
      421 catgccccgt ggctgaagat atctgccaca aggtgcagga gttgcagcaa caggcagagg
      481 gcaggaaacc ctcgggaggc agccaagaag cccttcggaa acagggctct accggtggga
      541 aggccccagc tctcagccca caggccttga aacacatatg ggtacgcaca gcactcatgg
      601 agaaagttct ggacagggtt gtacagtacc tggccgaaaa ctgcagcaag tattacgaga
      661 aggaagcatt attggcagat cctgtgtttg gcccaatcct ggcatgtctc ctagtgggac
      721 cctgtgcctt ggaatacacg aagctcaaga cagctgatca ctactggact gacccctctg
      781 ctgatgagct ggttcagagg caccgtatcc ggggtccccc taaccgtcag gactccccgg
      841 caaagcgccc tgccctgggg atccggaagc gccactctag tgggagtgcc tcagaagacc
      901 ggcttgccgc ctgcgcccgt gagtacgtgg agtctctgca ccagaactca agaacacgcc
      961 tgctctatgg caagaacaac gtgttggtgc agccgaagga ggacatggag gcagtccctg
     1021 gctacctctc cctgcaccag tctgcagaga acctaaccct gaagtggact cccaaccaac
     1081 tcatgaacgg gactctcggg gactctgagc tagagaagag tgtttactgg gactatgcct
     1141 tggtggtgcc cttcagtcag atcgtctgca tccactgcca ccagcaaaag agcggtggca
     1201 cgcttgtgct ggtgagccag gatggcatcc agaggccgcc actacacttc ccacagggag
     1261 gacacctgct gtccttcctg tcatgtctgg agaatgggct gctgcctcgt ggacagcttg
     1321 agcccccgct gtggacccag cagggaaagg gcaaggtttt ccccaagcta cggaaacgca
     1381 gcagcattcg gtccattgat gtagaggagc tgggtgtcgg acgggcaacg gactacgtgt
     1441 tccggatcat ctaccccgga cataggcacg agcataatgc tggcgacatg attgagatgc
     1501 agggtttcgg acccagccta acagcctggc acctagagcc cctgtgtagc cagggctcct
     1561 cctgcctttc ctgttcctcc agtagctccc catatgcaac ccccagtcac tgcagctgca
     1621 ttcctgacag gttgcccctc cggctgctgt gtgagagcat gaagaggcag attgtgtccc
     1681 gggccttcta cggctggcta gcctactgtc gccacctgtc cacagtgagg acacacctgt
     1741 ctgcattggt gcatcacaac atcattccac cagacaggcc cccgggggcc tcaggtggcc
     1801 tcaccaagga tgtgtggagc aagtatcaga aggacgaaaa gaactacaag gagctggagc
     1861 tgctgcggca ggtgtactat ggaggcgtgg aacacgagat tcgcaaggac gtctggccct
     1921 tcctacttgg ccactacaag tttggcatga gcaagaagga gatggagcag gtggatacag
     1981 cagtggcagc aaggtaccag caggtgttgg cagagtggaa ggcctgcgag gtggtggtga
     2041 ggcagcggga gcgggaggct cacccagcca cgctcaccaa gttctcctcg ggcagcagca
     2101 tcgatagcca cgtgcagcgc ctcgtgcacc gggattccac catcagcaat gatgtattta
     2161 tctctgtgga tgatcttgag ccctctggac ctcaggacct ggaagattcc aaaccaaagc
     2221 gggaacagga gccaggagct gggaccccgg gcatagcagc tgcagagcag cagtctgtgg
     2281 agtttgactc tccagactca gggctgcctt cctcccgcaa ctactctgtg gcctcaggca
     2341 tccagtccag cctagatgag gcacagagtg tgggctttga agacgacggt gctggagaag
     2401 atggctccga gggtccagcc actgcagccc acactttccc gggaccccac gatccaggcc
     2461 aggagacgct tgcacctgcc agtgagcttg aagcaggcca ggagctcgca gctgtgtgcg
     2521 ccgcagccta tactatagaa ttactggaca ccgtggcctt aaatctgcac cgcatagaca
     2581 aggatgtgca gagatgtgac cgcaactact ggtacttcac gacctccaac ctcgagaggc
     2641 tcagagacat catgtgcagc tacgtgtggg agcacctgga tatgggctac gtgcagggca
     2701 tgtgtgatct cctggcacct ctcctggtca tccttgacaa tgaccagctg gcctacagct
     2761 gcttcagcca cctcatgaag aggatgggcc agaacttccc cagtgggggt gccatggaca
     2821 gccactttgc caacatgcgc tccctcatcc agatcttgga ctcagagcta tttgagctga
     2881 tgcatcaaaa tggagactat acccacttct atttctgtta tcgctggttc ctgctggatt
     2941 ttaaaagaga gctgctgtat gaggacgtgt ttgcagtgtg ggaagtgatc tgggcagcca
     3001 ggcgcatctc ctcagagcac tttgtcctgt tcatcgccct ggccctggtg gaggcctaca
     3061 gagagattat ccgtgacaac aacatggact tcaccgacat catcaaattc ttcaacgagc
     3121 gggctgagcg gcatgatgcc caggagatcc tgcggattgc ccgggacttg gtccacaagg
     3181 tgcagatgct catagacaac aagtgacggc tgcagctggg ggtggcaaag tgcagagccc
     3241 aggtaccagg cccctgagct ccagcaggga gaggcagagg ccatcatagc ccaaactgcc
     3301 tctcccgatc ccttacccca ccctcacccc tgccaacccc acccactcag ctgtgtaacc
     3361 taacaaagtg actgagcctg ggatgtgagt gtgggcagtg ctggccctgc agggcaagtt
     3421 ggggtcagga tgcctgcaga tcacagctgg gtaggagggg tcggcctcag gagactggct
     3481 gccttggggg acccctttct gtgttcccct ctcaaacaac ttagaatagc cccagtgccg
     3541 cctgcagcct cagcctggac tgtttcccaa agcctctttc ctgtcaacct ggggccctgt
     3601 atggttagtg gggtctacag tggcccgcgc ctcatctaac aagagttgca taggaccagg
     3661 ggctctgtgc catatctctc ctgaggcctt ctatggtctc aactagctgc ctgttcaggc
     3721 atgtgtccta ggggcaggag accttggcta cctcccaggc tctcctaaga ctctggggca
     3781 gtcagatgtg ggccctgggt gagagtggcc cacctcagca gcactgccac agcctctggc
     3841 cagagattaa ccccatgatc tccccacagt acacagtgac ccacccactc gtgtgtacag
     3901 tgtcactctc tgcaccctgc ccttgctttc tgcactagaa atccctagga ctgcacataa
     3961 gcaacacact cgccgcccgc tgtgtggtgt ggagggcagt gactgcgctt gccctccaga
     4021 accaccccag aaagtgtagg aagacagtcc tatcacaacc ttcctccaag gacaggcctg
     4081 tgagttccgg ggtacctgtt acctattcca gacatctgag tacctggggc tgagggaggt
     4141 gggagtgcct ggatagtccc agttcatccc cagggagagg caaggccagc tccactttcc
     4201 ataggctttt cagggttctg agaagcctga agacccagaa gggtctctgg aagagtttac
     4261 agggttgtcg ataaaggtcc aacccttgac ctgaggtcta ggcatgctgt ttctttgttc
     4321 tgtcaccccc cccatgtccc caccatctga gcacatgtaa gccaagtctg ggccctgaag
     4381 cccacacctg gcctggctcc tgcctagaag tcaccaaggt ccacagactt gctgcagctg
     4441 aaaaacacga gaaaggacca gccgcattct gcacatagca cagccttccc tgtcccctac
     4501 cccaacccgg gtactgcaca gcctgtgtgg ggccagctta ccccattgcc cacccttgtt
     4561 cctgactcct cagtctccac caagcacggg tggccaatgt gtgcctgcct tagtgactct
     4621 ggttttgtga ggagcagagt gtatggggtt ttgagttttg tttgtttgtt catttggttg
     4681 gttggttttt gttttgctca gaaactatac tcttcaatgt aacagactaa taaaatgcat
     4741 ttggcaatg
//
