LOCUS       NM_018822               4324 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus N-sulfoglucosamine sulfohydrolase (sulfamidase)
            (Sgsh), mRNA.
ACCESSION   NM_018822
VERSION     NM_018822.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4324)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4324)
  AUTHORS   Hemsley,K.M., Beard,H., Chidlow,G., Mammone,T., Winner,L.K.,
            Neumann,D., King,B., Snel,M.F., Trim,P.J. and Casson,R.J.
  TITLE     Repetitive, non-invasive imaging of neurodegeneration, and
            prevention of it with gene replacement, in mice with Sanfilippo
            syndrome
  JOURNAL   Exp Neurol 371, 114610 (2024)
   PUBMED   37944880
REFERENCE   3  (bases 1 to 4324)
  AUTHORS   Pollock,K., Noritake,S., Imai,D.M., Pastenkos,G., Olson,M.,
            Cary,W., Yang,S., Fierro,F.A., White,J., Graham,J., Dahlenburg,H.,
            Johe,K. and Nolta,J.A.
  TITLE     An immune deficient mouse model for mucopolysaccharidosis IIIA
            (Sanfilippo syndrome)
  JOURNAL   Sci Rep 13 (1), 18439 (2023)
   PUBMED   37891179
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4324)
  AUTHORS   Pericleous,K., McIntyre,C. and Fuller,M.
  TITLE     Neurocognitive testing in a murine model of mucopolysaccharidosis
            type IIIA
  JOURNAL   Mol Genet Metab Rep 36, 100985 (2023)
   PUBMED   37332488
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4324)
  AUTHORS   Magat,J., Jones,S., Baridon,B., Agrawal,V., Wong,H., Giaramita,A.,
            Mangini,L., Handyside,B., Vitelli,C., Parker,M., Yeung,N., Zhou,Y.,
            Pungor,E., Slabodkin,I., Gorostiza,O., Aguilera,A., Lo,M.J.,
            Alcozie,S., Christianson,T.M., Tiger,P.M.N., Vincelette,J.,
            Fong,S., Gil,G., Hague,C., Lawrence,R., Wendt,D.J., Lebowitz,J.H.,
            Bunting,S., Bullens,S., Crawford,B.E., Roy,S.M. and Woloszynek,J.C.
  TITLE     Intracerebroventricular dosing of N-sulfoglucosamine sulfohydrolase
            in mucopolysaccharidosis IIIA mice reduces markers of brain
            lysosomal dysfunction
  JOURNAL   J Biol Chem 298 (12), 102625 (2022)
   PUBMED   36306823
REFERENCE   6  (bases 1 to 4324)
  AUTHORS   Costanzi,E., Beccari,T., Aisa,M.C., Tiribuzi,R., Hopwood,J.J. and
            Orlacchio,A.
  TITLE     Mouse sulphamidase gene: characterization of the promoter region of
            the gene and expression in mouse tissues
  JOURNAL   Gene 310, 143-149 (2003)
   PUBMED   12801641
REFERENCE   7  (bases 1 to 4324)
  AUTHORS   Frisella,W.A., O'Connor,L.H., Vogler,C.A., Roberts,M., Walkley,S.,
            Levy,B., Daly,T.M. and Sands,M.S.
  TITLE     Intracranial injection of recombinant adeno-associated virus
            improves cognitive function in a murine model of
            mucopolysaccharidosis type VII
  JOURNAL   Mol Ther 3 (3), 351-358 (2001)
   PUBMED   11273777
REFERENCE   8  (bases 1 to 4324)
  AUTHORS   Bhattacharyya,R., Gliddon,B., Beccari,T., Hopwood,J.J. and
            Stanley,P.
  TITLE     A novel missense mutation in lysosomal sulfamidase is the basis of
            MPS III A in a spontaneous mouse mutant
  JOURNAL   Glycobiology 11 (1), 99-103 (2001)
   PUBMED   11181566
REFERENCE   9  (bases 1 to 4324)
  AUTHORS   Costanzi,E., Beccari,T., Stinchi,S., Bibi,L., Hopwood,J.J. and
            Orlacchio,A.
  TITLE     Gene encoding the mouse sulphamidase: cDNA cloning, structure, and
            chromosomal mapping
  JOURNAL   Mamm Genome 11 (6), 436-439 (2000)
   PUBMED   10818207
REFERENCE   10 (bases 1 to 4324)
  AUTHORS   Bhaumik,M., Muller,V.J., Rozaklis,T., Johnson,L., Dobrenis,K.,
            Bhattacharyya,R., Wurzelmann,S., Finamore,P., Hopwood,J.J.,
            Walkley,S.U. and Stanley,P.
  TITLE     A mouse model for mucopolysaccharidosis type III A (Sanfilippo
            syndrome)
  JOURNAL   Glycobiology 9 (12), 1389-1396 (1999)
   PUBMED   10561464
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK076267.1, AK141266.1 and AL645911.14.
            
            On Sep 21, 2006 this sequence version replaced NM_018822.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK076267.1, AK141266.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-486               AK076267.1         30-515
            487-2385            AK141266.1         435-2333
            2386-4324           AL645911.14        50424-52362         c
FEATURES             Location/Qualifiers
     source          1..4324
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 83.36 cM"
     gene            1..4324
                     /gene="Sgsh"
                     /gene_synonym="4632406A19Rik"
                     /note="N-sulfoglucosamine sulfohydrolase (sulfamidase)"
                     /db_xref="GeneID:27029"
                     /db_xref="MGI:MGI:1350341"
     exon            1..114
                     /gene="Sgsh"
                     /gene_synonym="4632406A19Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             27..1535
                     /gene="Sgsh"
                     /gene_synonym="4632406A19Rik"
                     /EC_number="3.10.1.1"
                     /note="sulphamidase"
                     /codon_start=1
                     /product="N-sulphoglucosamine sulphohydrolase precursor"
                     /protein_id="NP_061292.2"
                     /db_xref="CCDS:CCDS36384.1"
                     /db_xref="GeneID:27029"
                     /db_xref="MGI:MGI:1350341"
                     /translation="MHCPGLACCTILLVLGLCGAHSRNVLLIVADDGGFESGVYNNTA
                     IATPHLDALSRHSLIFRNAFTSVSSCSPSRASLLTGLPQHQNGMYGLHQDVHHFNSFD
                     KVQSLPLLLNQAGVRTGIIGKKHVGPETVYPFDFAFTEENSSVMQVGRNITRIKQLVQ
                     KFLQTQDDRPFFLYVAFHDPHRCGHSQPQYGTFCEKFGNGESGMGYIPDWTPQIYDPQ
                     DVMVPYFVPDTPAARADLAAQYTTIGRMDQGVGLVLQELRGAGVLNDTLIIFTSDNGI
                     PFPSGRTNLYWPGTAEPLLVSSPEHPQRWGQVSDAYVSLLDLTPTILDWFSIPYPSYA
                     IFGSKTIQLTGRSLLPALEAEPLWATVFSSQSHHEVTMSYPMRSVYHQNFRLIHNLSF
                     KMPFPIDQDFYVSPTFQDLLNRTTTGRPTGWYKDLHRYYYRERWELYDISRDPRETRN
                     LAADPDLAQVLEMLKAQLVKWQWETHDPWVCAPDGVLEEKLTPQCRPLHNEL"
     exon            115..275
                     /gene="Sgsh"
                     /gene_synonym="4632406A19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            276..381
                     /gene="Sgsh"
                     /gene_synonym="4632406A19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            382..532
                     /gene="Sgsh"
                     /gene_synonym="4632406A19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            533..689
                     /gene="Sgsh"
                     /gene_synonym="4632406A19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            690..771
                     /gene="Sgsh"
                     /gene_synonym="4632406A19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            772..975
                     /gene="Sgsh"
                     /gene_synonym="4632406A19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            976..4324
                     /gene="Sgsh"
                     /gene_synonym="4632406A19Rik"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      4168
                     /gene="Sgsh"
                     /gene_synonym="4632406A19Rik"
                     /note="major polyA site"
ORIGIN      
        1 aaccgcttac cctgaccggc gccgccatgc actgcccggg actggcctgc tgcacaattc
       61 tgttggtcct gggactctgc ggcgcgcact cgcgcaacgt gctactgata gttgcggatg
      121 acggaggctt tgagagtggt gtatacaaca acactgccat cgccacccct cacctggatg
      181 ccctgtcccg ccacagcctt atcttccgta acgccttcac gtctgtcagc agctgttccc
      241 cgagccgtgc cagcctcctc accggcctgc cccagcatca gaatggcatg tatgggctgc
      301 accaggatgt gcatcacttc aactcttttg acaaggtaca gagccttccg ctgctgctca
      361 accaggccgg agtgcgcaca ggcatcattg ggaagaagca cgtgggtccg gagacggtgt
      421 atccctttga ctttgcattc acagaggaga acagctctgt gatgcaggtg gggcggaaca
      481 tcactagaat taagcaactg gtccagaaat ttctgcagac tcaggatgac aggcccttct
      541 tcctgtacgt ggctttccat gacccgcacc gctgtgggca ctctcagccc cagtatggaa
      601 ccttctgtga gaagtttggc aacggagaga gtggaatggg gtacattcca gactggacac
      661 cccagatcta cgaccctcag gatgtgatgg tgccctactt tgtcccggac acaccagcag
      721 cccgagcaga cctagctgct cagtacacca ccatcgggcg gatggaccaa ggggtaggtc
      781 tggtgctcca ggagctgcga ggtgctggtg tgctgaacga caccctcatc atcttcacat
      841 ctgacaatgg tatccctttc cccagcggca ggaccaacct gtactggccc ggtacagccg
      901 agcctttgct ggtgtcatct ccagagcacc cacagcgctg gggccaggtc agcgacgcct
      961 acgtgagcct tctagacctc acccctacca tcctggactg gttctccatc ccgtacccca
     1021 gctatgccat ctttggctca aagacgatcc agctcacagg ccgatccctc ctgccggcgc
     1081 tggaggcaga gcccctttgg gccactgtct tcagcagcca gagccaccac gaggtcacca
     1141 tgtcctaccc gatgcgctcg gtgtaccacc agaacttccg cctcattcac aacctgagct
     1201 tcaagatgcc atttcccatc gaccaagatt tctatgtctc gccgaccttc caggacctcc
     1261 tgaaccgaac caccacaggc cggcccacgg gctggtacaa ggacctccac cgttactact
     1321 accgggaacg ctgggaactc tacgacatca gccgggaccc tcgagagaca cggaacctgg
     1381 ccgctgaccc agacttggct caagtgctgg agatgctgaa agctcagctt gtcaagtggc
     1441 aatgggagac acatgacccc tgggtgtgcg ccccagatgg agtcctggag gaaaagctca
     1501 caccccagtg ccgaccgctt cacaatgaac tctgaccatc cccggggcac ctgccagccc
     1561 acctggacat ggagggaggg agcaatggag gcagtaccaa cagctgcacc ttctacatac
     1621 ccatcctagg aggcccctct accatatggg atgccactcc cgcctcctgt agaggacact
     1681 caagcacgca ctccctagtt gctgccatac caaggacacc gttgtcctca tgtctgcctg
     1741 tcctggctca ggagactcta gggggaactc gggcatggca gaaccccaag ttttgatagg
     1801 tgagtttgga gatctgcaga tggaggagca gggtctgggg ctcgaagccc tctggtttcg
     1861 ggaacctgtg gatgttttca agcccttcac cctaagagga gctcaggttt ctgggtgcca
     1921 catgggcagt gggcagaccg cactgactac ttcaaccaac cttgtcctgg agagagcatt
     1981 cagtaggcct tgagcttgct tccgcctcca tgctcccccc ctgaggtaca tgcttagcca
     2041 gggttcatgc tgttctcaga ggagtgagtt tgatcctgtg gtctatctgg gctctgctct
     2101 cctttctgag ggtgactgag gaggacaggg tgggacagtg tgcgctctct ctccctctct
     2161 ctctcccccc tctctctcct ttcattctct ctgagtgaca ccaagcaaac cacctggctc
     2221 catcttttcc cttccttcac ttgccaaggg acagaagcac tgcttagaaa tctagaaaga
     2281 gaggggctgt cccttttgcc cctctgtcaa ctccatcttg gaagggagtg agagttatgg
     2341 gccctagtgt tggaaaatcc tttttacaat agtataatca ttcacagaac ttcatagtag
     2401 cacactgcat cttaggcacc gagacacaaa caccgtgtca aaatgactca gtttatggct
     2461 agatgggggc ttcacccaag tgtggcgcaa tgcagcctgg gaaggactgg gggaaatgtc
     2521 agttttgaga gagagttctt tgctcatgaa gggtcagttg gctctgggat atgcaccaaa
     2581 gcaacctggg gtttggggtt aggcacagag gcagtgagtc aaagagccac tcaagtctgt
     2641 gcactacagc accttcattt gcagatgtct gtggcagcac ttggctgtta gcagctgagt
     2701 cagctgtgcc cacggtgctc cagagtcagg cccccgccct gggcaggaag gactgctcca
     2761 gcgagcttgc aaggttcctt tgacatcaga aacataaaag gaagggccag aacccacaaa
     2821 gctattcctg ttgtcacagg aggttggggc actggctctg agcaggtctc agggagtacc
     2881 cccacacggc agaatatttt ccggtcctcc atcagcccag gccatgctgt gtgaaggtgg
     2941 cttcgtcatt tacaccttga tttctggggg cacctgaggt cagaccccga ccagagaagg
     3001 aagtggggtt gtttgctgac agcattgaca gacacacaga ggtccccaca gtcccaagcc
     3061 aggtctgggc ttcagcaggg gctctctgtc cacaccacct tcttctgctc atctgcaatg
     3121 gccaggcgca cacagctgag caggctgtcc agatcactcc agctgtcggg ggccaggctg
     3181 ctgtacagac acggcactct gtccagctct ccctcctcct gccgggccac ctccaggaac
     3241 tgctcctccg agctgccaag ccgatgcagg cccttcctac aaagcagaga tagatgttca
     3301 gctcgaagac agcaaggtag ccaggaaagc acacagttgg ctttagtaca gcacactgtt
     3361 gtcatccagg ccagggtctg cagaagactc agcatgcacc cttgggcgcg agcatgggag
     3421 tcctatccag ggaagtcatg aaggaaggac ggacttggct gcaagcagca ttcactgatg
     3481 gagtgagcca aagaaattgt acttcccaga agatataggc agtgggatgt ttgtcccagc
     3541 cagacaccaa gtgatggggt gagaccaggc ttcatgagcc ccaggcactg cgcagctttg
     3601 gtgtaactag ggcaggggac aggtccactc cgggggagag caagctggac ctctggcctg
     3661 aggttgcaag gacacaactg gggctggaac ttagagctcc agtgtgcgct agaggcacat
     3721 gacaagcttt ttctggagca caggcacctg tttggaccct gctaccctct ccctgcccag
     3781 ccctccctcc cctggcagct acctgagttt ctttgctgtc ttctcattga cagagacatg
     3841 gatgataatg ggaaacatgt ccatcctatg taggactcgg acgctgtcca gccgcacatc
     3901 cagcagggcg tgggtgctct ttgggagggc atagagaagc aagttaagcc ccgggcctcg
     3961 ggtctgggag ggactgagag gaagctgtgc agcagagcac agggctgtgt ggaagacacc
     4021 cgaacagagg cagtgtggca tgtgccagga cgcctgctgt atatcttcaa gggtgaaacc
     4081 catttgattt gtccctgggg aaatctggat ttgcaagctt ttggcattga gatagatttt
     4141 gcatggagta caaaccttaa gaatcaaaca gtgccagctg ttgccctccg ttgtgcgtgt
     4201 gtgcccgtgt gcatgcacat gtgtgtgtgt gtgtgtgtgt gcgtgtgtgt gtgtgtgttt
     4261 tccttcctac tcctccttat ggaagtgtga aacttgatgg tttactgaga gctgtaaaat
     4321 ctga
//
