LOCUS       NM_001004173            3998 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus sphingosine-1-phosphate phosphatase 2 (Sgpp2), mRNA.
ACCESSION   NM_001004173 XM_484883
VERSION     NM_001004173.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3998)
  AUTHORS   Soldatov,R., Kaucka,M., Kastriti,M.E., Petersen,J.,
            Chontorotzea,T., Englmaier,L., Akkuratova,N., Yang,Y., Haring,M.,
            Dyachuk,V., Bock,C., Farlik,M., Piacentino,M.L., Boismoreau,F.,
            Hilscher,M.M., Yokota,C., Qian,X., Nilsson,M., Bronner,M.E.,
            Croci,L., Hsiao,W.Y., Guertin,D.A., Brunet,J.F., Consalez,G.G.,
            Ernfors,P., Fried,K., Kharchenko,P.V. and Adameyko,I.
  TITLE     Spatiotemporal structure of cell fate decisions in murine neural
            crest
  JOURNAL   Science 364 (6444) (2019)
   PUBMED   31171666
REFERENCE   2  (bases 1 to 3998)
  AUTHORS   Taguchi,Y., Allende,M.L., Mizukami,H., Cook,E.K., Gavrilova,O.,
            Tuymetova,G., Clarke,B.A., Chen,W., Olivera,A. and Proia,R.L.
  TITLE     Sphingosine-1-phosphate Phosphatase 2 Regulates Pancreatic Islet
            beta-Cell Endoplasmic Reticulum Stress and Proliferation
  JOURNAL   J Biol Chem 291 (23), 12029-12038 (2016)
   PUBMED   27059959
  REMARK    GeneRIF: Data indicate that beta-cells from untreated
            sphingosine-1-phosphate phosphotase 2 knockout Sgpp2(-/-) mice
            showed significantly increased expression of proteins
            characteristic of the endoplasmic reticulum stress response,
            indicating a basal islet defect.
REFERENCE   3  (bases 1 to 3998)
  AUTHORS   Shalom-Barak,T., Zhang,X., Chu,T., Timothy Schaiff,W., Reddy,J.K.,
            Xu,J., Sadovsky,Y. and Barak,Y.
  TITLE     Placental PPARgamma regulates spatiotemporally diverse genes and a
            unique metabolic network
  JOURNAL   Dev Biol 372 (1), 143-155 (2012)
   PUBMED   22967998
REFERENCE   4  (bases 1 to 3998)
  AUTHORS   Lopez-Juarez,A., Morales-Lazaro,S., Sanchez-Sanchez,R., Sunkara,M.,
            Lomeli,H., Velasco,I., Morris,A.J. and Escalante-Alcalde,D.
  TITLE     Expression of LPP3 in Bergmann glia is required for proper
            cerebellar sphingosine-1-phosphate metabolism/signaling and
            development
  JOURNAL   Glia 59 (4), 577-589 (2011)
   PUBMED   21319224
REFERENCE   5  (bases 1 to 3998)
  AUTHORS   Kirby,R.J., Jin,Y., Fu,J., Cubillos,J., Swertfeger,D. and
            Arend,L.J.
  TITLE     Dynamic regulation of sphingosine-1-phosphate homeostasis during
            development of mouse metanephric kidney
  JOURNAL   Am J Physiol Renal Physiol 296 (3), F634-F641 (2009)
   PUBMED   19073640
REFERENCE   6  (bases 1 to 3998)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124989.7, BY234834.1, BY297240.1, AC115932.11, CK389092.1 and
            AK081023.1.
            
            On Dec 21, 2006 this sequence version replaced NM_001004173.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BQ943353.1, BC049995.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-20                AC124989.7         28396-28415         c
            21-317              BY234834.1         2-298
            318-403             BY297240.1         317-402
            404-432             AC115932.11        146392-146420
            433-916             CK389092.1         1-484
            917-3998            AK081023.1         773-3854
FEATURES             Location/Qualifiers
     source          1..3998
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 40.23 cM"
     gene            1..3998
                     /gene="Sgpp2"
                     /gene_synonym="Spp2; SPPase2"
                     /note="sphingosine-1-phosphate phosphatase 2"
                     /db_xref="GeneID:433323"
                     /db_xref="MGI:MGI:3589109"
     exon            1..157
                     /gene="Sgpp2"
                     /gene_synonym="Spp2; SPPase2"
                     /inference="alignment:Splign:2.1.0"
     CDS             74..1138
                     /gene="Sgpp2"
                     /gene_synonym="Spp2; SPPase2"
                     /note="sphingosine-1-phosphatase 2"
                     /codon_start=1
                     /product="sphingosine-1-phosphate phosphatase 2"
                     /protein_id="NP_001004173.1"
                     /db_xref="CCDS:CCDS15083.1"
                     /db_xref="GeneID:433323"
                     /db_xref="MGI:MGI:3589109"
                     /translation="MAELLRSLRDSQLVARFQRRCGLFPAREASGEEHVVKNYFYYYL
                     FRFSAALGQEVFYITFLPFTHWNIDPNLSRRLVVIWVLVMYIGQVAKDILKWPRPSFP
                     PVVRLEKRIIAEYGMPSTHAMAATAISFTLLISTMDRYQYPFILGLMMAVVFSTLVCL
                     SRLYTGMHTVLDILGGVLITAVLIALTYPAWTLIDSLDSASPLFPVCVIVVPFLLCYN
                     YPVSDYYSPTRADTTTIVAAGAGVTLGFWINHFFQLVSKPTPSLPVIQNIPPLTTDML
                     VLGLTKFMVGIMLILLVRQLVQKLSLQVLFSWFKVVTRNKEARRRLEIEVPYKFVTYT
                     SVGICATTFVPMLHRFLGLL"
     exon            158..316
                     /gene="Sgpp2"
                     /gene_synonym="Spp2; SPPase2"
                     /inference="alignment:Splign:2.1.0"
     exon            317..496
                     /gene="Sgpp2"
                     /gene_synonym="Spp2; SPPase2"
                     /inference="alignment:Splign:2.1.0"
     exon            497..586
                     /gene="Sgpp2"
                     /gene_synonym="Spp2; SPPase2"
                     /inference="alignment:Splign:2.1.0"
     exon            587..3998
                     /gene="Sgpp2"
                     /gene_synonym="Spp2; SPPase2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgaggccag ggcgcacgct gaggacacgg acgcgcgtgg ctgcgggtcg gaggaacggg
       61 gtcacggctc accatggccg aactgctgcg gagcctgcgg gattcacagc tcgtggcgcg
      121 cttccagcgc cgctgcgggc tcttcccagc gcgggaggct tctggagagg agcatgtggt
      181 gaagaattat ttctactatt acctgttccg gttttcagcc gctttgggcc aggaagtgtt
      241 ctacatcacg tttctccctt tcacccactg gaatatcgac cctaatttgt ccagaagatt
      301 ggttgtgata tgggttttgg tgatgtatat tggccaggtg gccaaggaca tcctgaagtg
      361 gccccggccc tcctttcctc ccgttgtgag acttgaaaag agaattattg cagagtacgg
      421 aatgccatcc acccacgcca tggcggccac cgccatctcc ttcaccctcc tcatctctac
      481 catggaccgg tatcagtacc ctttcatttt aggcctgatg atggctgtgg tgttctctac
      541 gctggtgtgt ctcagcagac tctacacggg gatgcacacg gtcctggata tcctgggtgg
      601 cgttctgatc actgcagtcc tcattgctct gacctaccct gcctggaccc tcatcgattc
      661 cctggactct gccagccccc tcttccctgt gtgtgtcata gttgtaccgt tcctcttgtg
      721 ctacaattac cctgtgtctg actactacag cccgaccagg gcagacacca ccaccatcgt
      781 ggctgctggg gctggagtga ccctgggatt ctggatcaac catttcttcc agctcgtgtc
      841 caagcccacc ccatctcttc ctgtcattca gaacatccca ccccttacca ctgacatgct
      901 ggttttaggt ctgaccaaat ttatggtggg aatcatgttg atcctcttgg ttcgccaact
      961 ggtgcaaaag ctctccctgc aagtattatt ctcatggttc aaggtggtta ctaggaacaa
     1021 ggaggccagg cgaagactag agattgaagt cccttacaag tttgttacct acacatctgt
     1081 tggcatctgt gccacaacct ttgtgccaat gttgcacagg tttttgggat tgctctgagc
     1141 ccaagacagt taggaactag tccgctaatg cgagatgcaa aatggagaac gctgtcgatt
     1201 caggtaatct caatgcctcc tgtttaagga aaccctaagt catagttttg ttttgctgat
     1261 gtaacataga tacggctgct gtgggattca cctgtaagga caccaggctc aaaccacagc
     1321 tgagctctgc aagatcaccc ctcccctttc tgttacatgg acttgggaca cggtcttggg
     1381 tggacaggaa ttgtggccca gtttgcaatg gttacaagcc ccaccaagct ccagagaccc
     1441 agtagacttg aggtactatg aaggcaggat agtcttttca gttacaacct tgcctgatgc
     1501 cgagtctcaa tccccaaact ggagtttggt ctgggagtaa gggtggcacc atggaaaatc
     1561 tcaactcatt ggacagaatg gcttcttgtg ctgtcatcag actggactgt ccctgagtgg
     1621 gtggtgagac cattctaaaa taaagtttcc tgtgaggaca ctgaagatag tagcagagcc
     1681 atgaggccac cggaagagct tgctttattt accaactcat ctcctccagg aactattagt
     1741 gaagcaagat gctgatctgc cttgcagaca gtccacagca tccagtgatt cggtttccac
     1801 actagtgtaa gcaacgcacg acgggctgcc agctcctcac aggtggaaat gaggacacgc
     1861 tgcgactcct gccctcacct gcctcgcctt caacaccttc agttgcttga gcttccacat
     1921 aagcctggaa gacactgaat cagcacaaga atggatgagc ttcgtcctct ggaagccctc
     1981 acacactgcc tcatccctgt gactttacct ttcgtcattg cttggctact ttgtataaat
     2041 gtcttcagtt attcaccctc tagacaaaat cagggactcc ctctcagtct tcccactcct
     2101 tcttacctct ttcttggcaa gatttttcag ttaagaactt taagatgttt agacctgaag
     2161 aattttagca caagaaaagc tgcagcctat ttggagagaa taagcgggtt aactgtagct
     2221 cctgttagcc ctagaatggt cctccttatc tccttagagc taagaaggtg tgcaggacac
     2281 ccacagcaga gacctccttc cctgggctca gcacttcgga ataagcacca gatgcaatga
     2341 catcccgaag ggttcgagta agtggtagtc attggtcatt tgagggatgg tgtcagtaag
     2401 ccagtgcttc actatatgct cgtactggac aaatcaccct ctgaccccca aaagagctaa
     2461 ggctccaact tttgcattca gtgtaaacac caaagccaaa attttctctg attttgagta
     2521 tgtcccatgg tctatggttg gaatgatgtt ctttggtact gaatgtagtg ttttaattcc
     2581 tgaagaataa ttcttggact gggcatggtt ttaatcctag aatcagaggc aggtagatct
     2641 ctgagtttaa ggccagcctg gtctacagag tgagtttcag gacagccagg gctacacaga
     2701 gaaaccctgt cttgaaaaac aaacaaaaag aataattctt aacaaaatgc ccatttttaa
     2761 cttgacaatt cttctcttct tcgtcatagt taagaacagg aatgcaaagg cctagcactt
     2821 gccaggtttt gctgacagta tttcagctcc gtggctgggg agcctggagc cctggtttac
     2881 aggtgtgctt gcctaggcca gcctccagtt gtgcatggct gtttctgttg tttctccccc
     2941 aacccccaag ctaccaaact agagcttgta atgctggctt atattcacac aggtgatttt
     3001 agttggtttg tctgaagcct aatgacaaaa ggctcagctt cttctacgtg tatctgcaac
     3061 agaagggctg tatgtattgt cacagcggtg gatgtggtga ttaggaagtt taaggcccaa
     3121 caacatggaa gttgacaact gagtgaatgc attcgaggct gtgtttacat aatttagatg
     3181 gaggatgaat atattagcca cacaacatta aacagtgtcc taagaatttg tcatgactgg
     3241 tcactcttgg atggacttga tacaagaaaa gggagggaga aagtattcac tgtagatgcc
     3301 aagtttagtt ttggattcct acagtactga ttttaaatgc tatggcttga tcacattttg
     3361 cctttggtga gccttctcaa ttcaccaaac tcacttctta cagagcagca ccggcatcct
     3421 agtaaagtct ctcttgggtc tcttttcaaa acactttgtc agtttctctc tggagagaga
     3481 gtgccccctg ctggcttagc ttgtcttagt ccagaggccc tcttgcactg ggctggcctg
     3541 gtcaccagaa tgtgtccctg ttaagtctag gcctgtccta tgcggacacc aaagctttta
     3601 gcttcctctg ggaatcagga agaataacac atccttttct catcttgcta ctactctggg
     3661 ccaagtcatc aatgtagaac cggccttcca agccgctgtc cattttgctc agacctgtac
     3721 cttatgctgg aaaaagacat aggcaagacc cttaacctaa tacctttcat gatagccact
     3781 aaaaccactt gacactgtgc ctggtaactt gggttttctt gccgaaatac acaactcatc
     3841 ttcccaggat aatcacagca tgtggtattt cagaccacgt gtttcaggtt tctattttgg
     3901 aagctttcaa ctgtcttgct tatgcagtgt atgtaaattt attctttttt aaaataaaat
     3961 ctttttgttt gagtatgatt attaaatgct ttaaaatc
//
