LOCUS       NM_030750               3324 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus sphingosine-1-phosphate phosphatase 1 (Sgpp1), mRNA.
ACCESSION   NM_030750
VERSION     NM_030750.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3324)
  AUTHORS   Li,S., Teegarden,A., Bauer,E.M., Choi,J., Messaddeq,N.,
            Hendrix,D.A., Ganguli-Indra,G., Leid,M. and Indra,A.K.
  TITLE     Transcription Factor CTIP1/ BCL11A Regulates Epidermal
            Differentiation and Lipid Metabolism During Skin Development
  JOURNAL   Sci Rep 7 (1), 13427 (2017)
   PUBMED   29044125
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3324)
  AUTHORS   Kilbey,A., Terry,A., Wotton,S., Borland,G., Zhang,Q., Mackay,N.,
            McDonald,A., Bell,M., Wakelam,M.J., Cameron,E.R. and Neil,J.C.
  TITLE     Runx1 Orchestrates Sphingolipid Metabolism and Glucocorticoid
            Resistance in Lymphomagenesis
  JOURNAL   J Cell Biochem 118 (6), 1432-1441 (2017)
   PUBMED   27869314
  REMARK    GeneRIF: Results show that Runx1 regulates glucocorticoid
            sensitivity in lymphoma cells and identify an established direct
            target gene, Sgpp1, as an integrator of sphingolipid metabolism and
            responses to glucocorticoids.
REFERENCE   3  (bases 1 to 3324)
  AUTHORS   Steinmetz,C.C., Tatavarty,V., Sugino,K., Shima,Y., Joseph,A.,
            Lin,H., Rutlin,M., Lambo,M., Hempel,C.M., Okaty,B.W., Paradis,S.,
            Nelson,S.B. and Turrigiano,G.G.
  TITLE     Upregulation of mu3A Drives Homeostatic Plasticity by Rerouting
            AMPAR into the Recycling Endosomal Pathway
  JOURNAL   Cell Rep 16 (10), 2711-2722 (2016)
   PUBMED   27568566
REFERENCE   4  (bases 1 to 3324)
  AUTHORS   Taguchi,Y., Allende,M.L., Mizukami,H., Cook,E.K., Gavrilova,O.,
            Tuymetova,G., Clarke,B.A., Chen,W., Olivera,A. and Proia,R.L.
  TITLE     Sphingosine-1-phosphate Phosphatase 2 Regulates Pancreatic Islet
            beta-Cell Endoplasmic Reticulum Stress and Proliferation
  JOURNAL   J Biol Chem 291 (23), 12029-12038 (2016)
   PUBMED   27059959
REFERENCE   5  (bases 1 to 3324)
  AUTHORS   Allende,M.L., Sipe,L.M., Tuymetova,G., Wilson-Henjum,K.L., Chen,W.
            and Proia,R.L.
  TITLE     Sphingosine-1-phosphate phosphatase 1 regulates keratinocyte
            differentiation and epidermal homeostasis
  JOURNAL   J Biol Chem 288 (25), 18381-18391 (2013)
   PUBMED   23637227
  REMARK    GeneRIF: Data indicate that sphingosine-1-phosphate phosphatases 1
            (Sgpp1) deficiency in keratinocytes causes sphingosine-1-phosphate
            (S1P) elevation and accelerates their differentiation.
REFERENCE   6  (bases 1 to 3324)
  AUTHORS   Johnson,K.R., Johnson,K.Y., Becker,K.P., Bielawski,J., Mao,C. and
            Obeid,L.M.
  TITLE     Role of human sphingosine-1-phosphate phosphatase 1 in the
            regulation of intra- and extracellular sphingosine-1-phosphate
            levels and cell viability
  JOURNAL   J Biol Chem 278 (36), 34541-34547 (2003)
   PUBMED   12815058
  REMARK    GeneRIF: sphingosine-1-phosphate phosphatase 1 plays roles in the
            regulation of intra- and extracellular sphingosine-1-phosphate
            levels and cell viability
REFERENCE   7  (bases 1 to 3324)
  AUTHORS   Le Stunff,H., Galve-Roperh,I., Peterson,C., Milstien,S. and
            Spiegel,S.
  TITLE     Sphingosine-1-phosphate phosphohydrolase in regulation of
            sphingolipid metabolism and apoptosis
  JOURNAL   J Cell Biol 158 (6), 1039-1049 (2002)
   PUBMED   12235122
  REMARK    GeneRIF: regulation of sphingolipid metabolism and apoptosis by
            SPP1
REFERENCE   8  (bases 1 to 3324)
  AUTHORS   Brindley,D.N., English,D., Pilquil,C., Buri,K. and Ling,Z.C.
  TITLE     Lipid phosphate phosphatases regulate signal transduction through
            glycerolipids and sphingolipids
  JOURNAL   Biochim Biophys Acta 1582 (1-3), 33-44 (2002)
   PUBMED   12069808
  REMARK    Review article
REFERENCE   9  (bases 1 to 3324)
  AUTHORS   Le Stunff,H., Peterson,C., Thornton,R., Milstien,S., Mandala,S.M.
            and Spiegel,S.
  TITLE     Characterization of murine sphingosine-1-phosphate phosphohydrolase
  JOURNAL   J Biol Chem 277 (11), 8920-8927 (2002)
   PUBMED   11756451
REFERENCE   10 (bases 1 to 3324)
  AUTHORS   Mandala,S.M., Thornton,R., Galve-Roperh,I., Poulton,S.,
            Peterson,C., Olivera,A., Bergstrom,J., Kurtz,M.B. and Spiegel,S.
  TITLE     Molecular cloning and characterization of a lipid phosphohydrolase
            that degrades sphingosine-1- phosphate and induces cell death
  JOURNAL   Proc Natl Acad Sci U S A 97 (14), 7859-7864 (2000)
   PUBMED   10859351
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK149860.1 and AC124742.4.
            
            On Aug 26, 2009 this sequence version replaced NM_030750.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK149860.1, BC026814.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2361              AK149860.1         2-2362
            2362-3324           AC124742.4         189774-190736       c
FEATURES             Location/Qualifiers
     source          1..3324
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 32.95 cM"
     gene            1..3324
                     /gene="Sgpp1"
                     /gene_synonym="SPP; SPP1; Spph1"
                     /note="sphingosine-1-phosphate phosphatase 1"
                     /db_xref="GeneID:81535"
                     /db_xref="MGI:MGI:2135760"
     exon            1..817
                     /gene="Sgpp1"
                     /gene_synonym="SPP; SPP1; Spph1"
                     /inference="alignment:Splign:2.1.0"
     CDS             167..1459
                     /gene="Sgpp1"
                     /gene_synonym="SPP; SPP1; Spph1"
                     /note="SPPase1; sphingosine-1-phosphatase 1"
                     /codon_start=1
                     /product="sphingosine-1-phosphate phosphatase 1"
                     /protein_id="NP_109675.1"
                     /db_xref="CCDS:CCDS25986.1"
                     /db_xref="GeneID:81535"
                     /db_xref="MGI:MGI:2135760"
                     /translation="MSLGQRLALLASRLQEPQRVASFQRLCGVEVPLSSPAADEDAET
                     EVRGAPGEPRRRGRQPGAEDSPAKADCCGAPNGVRNGLAAEPGPTGPRRAGSQRRNSL
                     TGEEGELVKVSNLPLYYLFCLGTELGNELFYILFFPFWIWNLDPFVGRRLVIIWVLVM
                     YLGQCTKDIIRWPRPASPPVIKLEVFYNSEYSMPSTHAMSGTAIPIAMFLLTYGRWQY
                     PLIYGLILIPCWSSLVCLSRIYMGMHSILDVIAGFLYTILILIIFYPLVDLIDNFNQT
                     YKYAPLIIIGLHLILGIFSFTLDTWSTSRGDTAEILGSGAGIACGSHAAYTLGLSLEP
                     SLHMLPLAIPPLTVTLFGKAILRIVLGMLLVLFVRDIMKKITIPLACKLSSIPCHDIR
                     QARQHMEVELPYRYITYGMVGFSITFLVPYVFSFIGIS"
     exon            818..907
                     /gene="Sgpp1"
                     /gene_synonym="SPP; SPP1; Spph1"
                     /inference="alignment:Splign:2.1.0"
     exon            908..3324
                     /gene="Sgpp1"
                     /gene_synonym="SPP; SPP1; Spph1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3281..3286
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sgpp1"
                     /gene_synonym="SPP; SPP1; Spph1"
                     /note="hexamer: AATAAA"
     polyA_site      3307
                     /gene="Sgpp1"
                     /gene_synonym="SPP; SPP1; Spph1"
                     /note="major polyA site"
ORIGIN      
        1 gtgagcgcgc caggggaggg gcgcgcgggg cgcagggcgc gcgcggcggc cgctgcggcc
       61 tgttggcgcg gtcgccggca gcctcgagcg agtcgagcta ggcaccgtgg cggctgtggc
      121 tggcgaggag cgcgtggccg gatcaattcc cgagtggccc gcgaccatgt ccctggggca
      181 gcggctggct ctgctggcca gccgtctgca ggagccgcag cgggtggcga gcttccagcg
      241 tctgtgtggg gtggaggtgc cgctcagcag cccggcggcg gacgaggatg cagagaccga
      301 ggttcgcgga gccccgggag aaccccggcg acggggacgg cagccgggcg ctgaggacag
      361 ccccgccaag gcggactgct gcggtgcccc gaacggcgtg cgcaacgggc tggcggccga
      421 gccgggcccg accgggcccc gccgcgcggg ctcgcagcgc cgcaactcgt tgacgggcga
      481 ggagggcgag ctggtcaaag tgagcaactt gccgctctac tacctgttct gcttaggcac
      541 ggaactgggc aacgagctct tctacatctt attcttcccc ttctggatct ggaatctcga
      601 cccctttgtg ggccggaggc tggtgatcat ctgggtgctg gtcatgtacc tgggccagtg
      661 caccaaggac atcatccgct ggccacggcc ggcctcgccg cctgtcatca agctggaggt
      721 cttctacaac tcggaataca gcatgccctc cacgcatgcc atgtcaggca ccgccatccc
      781 catcgccatg ttcctgctca cctatggccg ctggcagtat cctcttatct acgggctgat
      841 tctcattccc tgctggagtt cactagtttg cctaagtaga atctacatgg gaatgcattc
      901 tatcctggat gtcattgctg gattcttgta taccatttta atcttaatta tcttctaccc
      961 attggtggac ctgattgaca acttcaacca aacttacaaa tatgcgccgc tcatcatcat
     1021 cgggcttcac ttaattttgg gcatcttctc tttcaccctt gacacctgga gcacatcccg
     1081 aggagacacg gctgagattc tgggaagtgg tgctgggatt gcatgtggct cacacgctgc
     1141 ttataccctg ggcctatcct tagaaccttc tctgcacatg ttacccttag ctatcccccc
     1201 tcttactgta actctgtttg gaaaagccat attacggatc gtcctaggaa tgctgcttgt
     1261 actgttcgtg agggatatca tgaagaagat caccattcct ctagcctgta aactctccag
     1321 tattccgtgt catgacattc gccaagcaag gcagcacatg gaagtggagc tgccataccg
     1381 gtatattacc tacgggatgg ttgggttctc catcacgttt ttggtcccct atgtattttc
     1441 ctttattggt atctcttgat ggaggaacac tgtttgttat aagaaaggag gctaccagct
     1501 atatctaaag ctattctcta ggtaaaactt ggatcagagg cttctgcaag aatttgactt
     1561 aaagaagtaa attctgcagc cagtgcattc tctcattgca caccagatgt tgttttacgt
     1621 gggctgagct ctctcagtgc tgagaaatgg cgcgcccatt tagaatgttc accaaatgtt
     1681 tggggagttc tgtgctgtta caaattgtag ttatatatac catatattaa ggcacacggt
     1741 gtgcaaaggt gtgtctagta tatattatat atacaactgt ttacctaaca acagtggggt
     1801 gtattgaaaa aaatcagtaa caatatgcag ttgtgcccag gtttttggaa ttaatgcagg
     1861 catgttgtta ttaacaaata ggcttagtgt ttctttcctc tgggagccat ttcctagttg
     1921 agttggtaat tagcagacag aaatctgtgt gctaccgcac acttgactta ctgtctctcc
     1981 ccacactgcc agctcccttc atttacccat gaacgagagg catttctaat ggaccaagtt
     2041 ttgggggaag tttgctgttt gagatttttt tttccattct taaagttctg tacactgtgt
     2101 tgaatgtatt ttttttccca actgttttgg tcacaccaat tcaggtactg aattttattg
     2161 cttgctaact gtgcctttct tttcctgaat taagagacac catgtatact gtgatataaa
     2221 agtgacactc taattctatc ataagccaca tcatcaggca aatattttta aaatatatat
     2281 atcaaactaa cagaagtaaa tggcccataa ctcttcagtc gttttttaga aagaaatgtg
     2341 gaattgctaa gttttctcac taatttattg gaaagctaaa tggataagta tttccatttt
     2401 tgtaagtatt tttctgtgca ttgcaagtta ttggaacagt atatatatgt aagtacgttg
     2461 tcttgattgt gtatagtaca aataaatact tccagggagt ggaaacatca ctgaaattta
     2521 tagatgagac agtgtatacc cttcctatgt acacaagcca tttttctaaa ttatttgaaa
     2581 aggattggat ttcctaccgt tatcttttaa taccccactc tttagcaatc taaggtagat
     2641 tataaaatcc aaacgtgaaa tatccgtagc taagattcta ttatttttcc caactaatta
     2701 tttttacagt ggtaaatttg agtgtagtgt taagctattc tttcctgtct gtgcctttat
     2761 attttgaagt gtgattgcaa ttaggttaac attacgttta tttgtggtga ggttttttgt
     2821 aaagaagaga attaattttc catacaaatg aacaccaggt ggaggtaatg attttagtgc
     2881 aataatctct gattatttag aaggaaaacg tttctatttt ggacaaggaa agtatctgag
     2941 cttcttattt tttataattc tcattgaaag cttgggggct tggtagtttt tacccacaaa
     3001 gaatctgatc aactttaagc aagtaaattt ggaccctttg gccaccagga gaagaaagcg
     3061 aggtgcttag aaaagaatcg gtacgcaggg agctcagaag ctgcggagag cagggattgc
     3121 tccacagatg tgctctgtga gttgagctat agacagggtc ccccactttg ggtctgttat
     3181 gctattaatt tttgtgtgtc acttaaaaag aattagaaaa gattctattt ctctgtgttt
     3241 gtttttgttt gatgacagtt ctatgctaaa tgtattttaa aataaaagcc gagatcaata
     3301 ccgaaaagat ctttcttctt tttg
//
