LOCUS       NM_009163               4152 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus sphingosine phosphate lyase 1 (Sgpl1), transcript
            variant 1, mRNA.
ACCESSION   NM_009163
VERSION     NM_009163.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4152)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4152)
  AUTHORS   Butera,A., Agostini,M., Cassandri,M., De Nicola,F., Fanciulli,M.,
            D'Ambrosio,L., Falasca,L., Nardacci,R., Wang,L., Piacentini,M.,
            Knight,R.A., Jia,W., Sun,Q., Shi,Y., Wang,Y., Candi,E. and
            Melino,G.
  TITLE     ZFP750 affects the cutaneous barrier through regulating lipid
            metabolism
  JOURNAL   Sci Adv 9 (17), eadg5423 (2023)
   PUBMED   37115925
REFERENCE   3  (bases 1 to 4152)
  AUTHORS   Afsar,S.Y., Alam,S., Fernandez Gonzalez,C. and van
            Echten-Deckert,G.
  TITLE     Sphingosine-1-phosphate-lyase deficiency affects glucose metabolism
            in a way that abets oncogenesis
  JOURNAL   Mol Oncol 16 (20), 3642-3653 (2022)
   PUBMED   35973936
  REMARK    GeneRIF: Sphingosine-1-phosphate-lyase deficiency affects glucose
            metabolism in a way that abets oncogenesis.
REFERENCE   4  (bases 1 to 4152)
  AUTHORS   De la Garza-Rodea,A.S., Moore,S.A., Zamora-Pineda,J., Hoffman,E.P.,
            Mistry,K., Kumar,A., Strober,J.B., Zhao,P., Suh,J.H. and Saba,J.D.
  TITLE     Sphingosine Phosphate Lyase Is Upregulated in Duchenne Muscular
            Dystrophy, and Its Inhibition Early in Life Attenuates Inflammation
            and Dystrophy in Mdx Mice
  JOURNAL   Int J Mol Sci 23 (14), 7579 (2022)
   PUBMED   35886926
  REMARK    GeneRIF: Sphingosine Phosphate Lyase Is Upregulated in Duchenne
            Muscular Dystrophy, and Its Inhibition Early in Life Attenuates
            Inflammation and Dystrophy in Mdx Mice.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4152)
  AUTHORS   Jackson,J., Wischhof,L., Scifo,E., Pellizzer,A., Wang,Y.,
            Piazzesi,A., Gentile,D., Siddig,S., Stork,M., Hopkins,C.E.,
            Handler,K., Weis,J., Roos,A., Schultze,J.L., Nicotera,P.,
            Ehninger,D. and Bano,D.
  TITLE     SGPL1 stimulates VPS39 recruitment to the mitochondria in MICU1
            deficient cells
  JOURNAL   Mol Metab 61, 101503 (2022)
   PUBMED   35452878
  REMARK    GeneRIF: SGPL1 stimulates VPS39 recruitment to the mitochondria in
            MICU1 deficient cells.
REFERENCE   6  (bases 1 to 4152)
  AUTHORS   Okazaki,N., F-Kikuno,R., Ohara,R., Inamoto,S., Koseki,H.,
            Hiraoka,S., Saga,Y., Seino,S., Nishimura,M., Kaisho,T., Hoshino,K.,
            Kitamura,H., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: IV. The complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (3), 205-218 (2004)
   PUBMED   15368895
REFERENCE   7  (bases 1 to 4152)
  AUTHORS   Mendel,J., Heinecke,K., Fyrst,H. and Saba,J.D.
  TITLE     Sphingosine phosphate lyase expression is essential for normal
            development in Caenorhabditis elegans
  JOURNAL   J Biol Chem 278 (25), 22341-22349 (2003)
   PUBMED   12682045
REFERENCE   8  (bases 1 to 4152)
  AUTHORS   Kihara,A., Ikeda,M., Kariya,Y., Lee,E.Y., Lee,Y.M. and Igarashi,Y.
  TITLE     Sphingosine-1-phosphate lyase is involved in the differentiation of
            F9 embryonal carcinoma cells to primitive endoderm
  JOURNAL   J Biol Chem 278 (16), 14578-14585 (2003)
   PUBMED   12584204
  REMARK    GeneRIF: SPL may be involved in the regulation of intracellular S1P
            levels during this differentiation
REFERENCE   9  (bases 1 to 4152)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   10 (bases 1 to 4152)
  AUTHORS   Zhou,J. and Saba,J.D.
  TITLE     Identification of the first mammalian sphingosine phosphate lyase
            gene and its functional expression in yeast
  JOURNAL   Biochem Biophys Res Commun 242 (3), 502-507 (1998)
   PUBMED   9464245
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC123530.4, BB854743.1, BB620054.1, AK036747.1 and AI428538.1.
            
            On Oct 21, 2015 this sequence version replaced NM_009163.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript. Variants 1, 2, and 3 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC026135.1, AK036747.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                AC123530.4         86085-86094         c
            11-40               BB854743.1         5-34
            41-132              BB620054.1         2-93
            133-4140            AK036747.1         2-4009
            4141-4152           AI428538.1         5-16                c
FEATURES             Location/Qualifiers
     source          1..4152
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 32.14 cM"
     gene            1..4152
                     /gene="Sgpl1"
                     /gene_synonym="D10Xrf456; S1PL; Spl"
                     /note="sphingosine phosphate lyase 1"
                     /db_xref="GeneID:20397"
                     /db_xref="MGI:MGI:1261415"
     exon            1..162
                     /gene="Sgpl1"
                     /gene_synonym="D10Xrf456; S1PL; Spl"
                     /inference="alignment:Splign:2.1.0"
     exon            163..236
                     /gene="Sgpl1"
                     /gene_synonym="D10Xrf456; S1PL; Spl"
                     /inference="alignment:Splign:2.1.0"
     CDS             210..1916
                     /gene="Sgpl1"
                     /gene_synonym="D10Xrf456; S1PL; Spl"
                     /EC_number="4.1.2.27"
                     /note="SPL 1; SP-lyase 1; sphingosine-1-phosphate
                     aldolase"
                     /codon_start=1
                     /product="sphingosine-1-phosphate lyase 1"
                     /protein_id="NP_033189.2"
                     /db_xref="CCDS:CCDS35914.1"
                     /db_xref="GeneID:20397"
                     /db_xref="MGI:MGI:1261415"
                     /translation="MPGTDLLKLKDFEPYLEILESYSTKAKNYVNGYCTKYEPWQLIA
                     WSVLCTLLIVWVYELIFQPESLWSRFKKKLFKLIRKMPFIGRKIEQQVSKAKKDLVKN
                     MPFLKVDKDYVKTLPAQGMGTAEVLERLKEYSSMDGSWQEGKASGAVYNGEPKLTELL
                     VQAYGEFTWSNPLHPDIFPGLRKLEAEIVRMTCSLFNGGPDSCGCVTSGGTESILMAC
                     KAYRDLALEKGIKTPEIVAPESAHAAFDKAAHYFGMKIVRVALKKNMEVDVQAMKRAI
                     SRNTAMLVCSTPQFPHGVMDPVPEVAKLAVRYKIPLHVDACLGGFLIVFMEKAGYPLE
                     KPFDFRVKGVTSISADTHKYGYAPKGSSVVMYSNEKYRTYQFFVGADWQGGVYASPSI
                     AGSRPGGIIAACWAALMHFGENGYVEATKQIIKTARFLKSELENIKNIFIFGDPQLSV
                     IALGSNDFDIYRLSNMMSAKGWNFNYLQFPRSIHFCITLVHTRKRVAIQFLKDIRESV
                     TQIMKNPKAKTTGMGAIYGMAQATIDRKLVAEISSVFLDCLYTTDPVTQGNQMNGSPK
                     PR"
     exon            237..402
                     /gene="Sgpl1"
                     /gene_synonym="D10Xrf456; S1PL; Spl"
                     /inference="alignment:Splign:2.1.0"
     exon            403..470
                     /gene="Sgpl1"
                     /gene_synonym="D10Xrf456; S1PL; Spl"
                     /inference="alignment:Splign:2.1.0"
     exon            471..618
                     /gene="Sgpl1"
                     /gene_synonym="D10Xrf456; S1PL; Spl"
                     /inference="alignment:Splign:2.1.0"
     exon            619..695
                     /gene="Sgpl1"
                     /gene_synonym="D10Xrf456; S1PL; Spl"
                     /inference="alignment:Splign:2.1.0"
     exon            696..824
                     /gene="Sgpl1"
                     /gene_synonym="D10Xrf456; S1PL; Spl"
                     /inference="alignment:Splign:2.1.0"
     exon            825..913
                     /gene="Sgpl1"
                     /gene_synonym="D10Xrf456; S1PL; Spl"
                     /inference="alignment:Splign:2.1.0"
     exon            914..1019
                     /gene="Sgpl1"
                     /gene_synonym="D10Xrf456; S1PL; Spl"
                     /inference="alignment:Splign:2.1.0"
     exon            1020..1118
                     /gene="Sgpl1"
                     /gene_synonym="D10Xrf456; S1PL; Spl"
                     /inference="alignment:Splign:2.1.0"
     exon            1119..1268
                     /gene="Sgpl1"
                     /gene_synonym="D10Xrf456; S1PL; Spl"
                     /inference="alignment:Splign:2.1.0"
     exon            1269..1507
                     /gene="Sgpl1"
                     /gene_synonym="D10Xrf456; S1PL; Spl"
                     /inference="alignment:Splign:2.1.0"
     exon            1508..1654
                     /gene="Sgpl1"
                     /gene_synonym="D10Xrf456; S1PL; Spl"
                     /inference="alignment:Splign:2.1.0"
     exon            1655..1775
                     /gene="Sgpl1"
                     /gene_synonym="D10Xrf456; S1PL; Spl"
                     /inference="alignment:Splign:2.1.0"
     exon            1776..4142
                     /gene="Sgpl1"
                     /gene_synonym="D10Xrf456; S1PL; Spl"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4122..4127
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sgpl1"
                     /gene_synonym="D10Xrf456; S1PL; Spl"
                     /note="hexamer: AATAAA"
     polyA_site      4142
                     /gene="Sgpl1"
                     /gene_synonym="D10Xrf456; S1PL; Spl"
                     /note="major polyA site"
ORIGIN      
        1 ccgggggcgg cgcacctcca atctctgcgg cggcggcgga agggggaacc cgggtcccgt
       61 ggccagcgag tgagtcgctc gcagaaccga ggcgcgtgag gtgggcggcg gccagcggag
      121 cctctgcggg gaaagaagga gccgggtcca cagcctgagg agacgcagag gcagggcagc
      181 cccggggagg gagccggctg cagaggaaga tgcccggaac cgacctcctc aagctgaagg
      241 acttcgagcc ttatttggag attttggaat catattccac aaaagccaag aattatgtga
      301 atggatattg caccaaatat gagccctggc agctcattgc gtggagtgtc ctgtgtactc
      361 tgctgatagt ctgggtgtat gagcttatct tccagccaga gagtttatgg tctcggttta
      421 aaaaaaaatt atttaagctt atcaggaaga tgccatttat tggacgtaag atcgaacaac
      481 aggtgagcaa agccaagaag gatcttgtca agaacatgcc attcctaaag gtggacaagg
      541 attatgtgaa aactctgcct gctcagggta tgggcacagc tgaggttctg gagagactca
      601 aggagtacag ctccatggat ggttcctggc aagaagggaa agcctcagga gctgtgtaca
      661 atggggaacc gaagctcacg gagctgctgg tgcaggctta tggagaattc acgtggagca
      721 atccactgca tccagatatc ttccctggat tgcggaagtt agaggcagaa atcgttagga
      781 tgacttgttc cctcttcaat gggggaccag attcctgtgg atgtgtgact tctgggggaa
      841 cggaaagcat cctgatggcc tgcaaagctt accgggactt ggcgttagag aaggggatca
      901 aaactccaga aattgtggct cccgagagtg cccatgctgc attcgacaaa gcagctcatt
      961 attttgggat gaagattgtc cgagttgcac tgaaaaagaa catggaggtg gatgtgcagg
     1021 caatgaagag agccatctcc aggaacacag ctatgctggt ctgttctacc ccacagtttc
     1081 ctcatggtgt gatggatcct gtccccgaag tggccaagtt ggctgtcaga tataaaatcc
     1141 cactccatgt ggatgcttgt ctggggggct tcctcattgt cttcatggag aaagcagggt
     1201 acccactgga gaaaccattt gatttccggg tgaaaggtgt gaccagcatt tcagcagata
     1261 ctcataagta tggctatgct cctaaaggtt catcagtggt gatgtactct aacgagaagt
     1321 acaggacgta ccagttcttt gttggtgcag actggcaagg tggtgtctac gcatctccaa
     1381 gcatagctgg ctcacggcct ggtggcatca ttgcagcctg ttgggccgcc ttgatgcact
     1441 tcggtgagaa cggctatgtt gaagctacca aacagatcat caaaactgct cgcttcctga
     1501 agtcagaact ggaaaacatc aaaaacatct tcattttcgg tgatcctcaa ttgtcagtta
     1561 ttgctctggg atccaacgat tttgacattt accgactatc taatatgatg tctgctaagg
     1621 ggtggaattt taactacctg cagttcccaa gaagcattca tttctgcatt acgttagtac
     1681 atactcggaa gcgagtggcg atccagttcc taaaggatat ccgggaatca gtcacacaaa
     1741 tcatgaagaa tcctaaagct aagaccacag gaatgggtgc catctatggc atggcccagg
     1801 caaccattga caggaagctg gttgcagaaa tatcctccgt cttcttggac tgcctttata
     1861 ctacggaccc cgtgactcag ggcaaccaga tgaacggttc tccaaagccc cgctgaactt
     1921 tgacccttgt gagttccttg gagcttcagg ccttcagaag gttcttggcg tttggaacag
     1981 actgcacaca atttgacatc tggactggct ccgtagagca caataggata aaccataaga
     2041 tagcttcagc ctcaggactc ctttgtttcc ttgtggggct tttagtttga agaccctgaa
     2101 ggatcccact gcatagtgag tctgtcctgg ttattaatgt taccctagaa attgctttaa
     2161 ccttattttt ctctaacgtc tttagcatcg tctttactta atcattgtgt ggtggctccg
     2221 acctgtcctg attatttagg gaaagtgtga gatagcaaga gggtgtctct gctgcctcag
     2281 tggggtgttc tggccatcag gcaggaagca gttatgtacc gtgttccctc aggtgggtgt
     2341 ctgtctgtcc cacgcagggg gaggttcagc ctctgcttca ggagatgcct cttgtcctca
     2401 ggatcactgt cattacagct tgctttactt ttccaagcac acgtcggcca gactactggc
     2461 ctcttttttt gttttatttt taaataactg gagtatattc ccttggcagg gtttgaagtg
     2521 ctcctttgtc ttgtgcatga ccatggctgc tgccatcttt ggagatgcct gttggcagtc
     2581 atatacttgt ttgttcttat tactgtaggg taagaaatga acatgttttt cagagaatct
     2641 agggctttct ggctgttggc actgcctctc tggatggagt aggggtagat cactcctgag
     2701 ccctctcctg ggccagagga gccacaacca gaccctttcc cacattttcg tgaatagcca
     2761 cataggtaag cgcctacatc ctgcacatgt gggcagtagt cttccccttg gacattgcct
     2821 taagccttca tgtaatgaga atctgctttt attgaagaaa acactccaca agtgtccttg
     2881 acttcctcat tgggtgtgaa gatgtgcaga ggacacttgc tccatcagtg tgtgttcttc
     2941 ctgccccttc cccccttatt cagcttccaa aggtacgaca gcattttagc ttcaggtact
     3001 ggacgttcct caggccccgc taaaaggaag cagacatttt ggagtagaaa gggatggcta
     3061 cagccattac acttggggcc tggggttcct tcttaagact gattgcccag ggctatacag
     3121 ggacaggacc aatccctggc caatttccca tttgcttctc ccttttaggg attgggggct
     3181 ctgaagtagg cagagccccg ttcagctctg atgaccgtac catgtgcctt tctacccatt
     3241 cagtgagtga caaccctcgt cctcacccag gccctggcag aagtagacca ctctttgagg
     3301 tgtgtctgct tataggagag aacttgggac agatcaccag aagccatgct ctgttccttc
     3361 cccttctcag ggattcctga gtattcagcc tgggcattgc tcgctgggag agccagacca
     3421 ccaggctctt cctcaccctc cttaggaagt ggtcttcagc actgttctga ccccaggtgt
     3481 taccagctgg ttcatcacag ggcatgtgta tatgtccact tccctcctgt atgctctaca
     3541 gtgcattatg aggctcaggg atggttggtg tgtcagagag aggctgaatt cctgagtgta
     3601 cacattaaca gtggttagac tgttggactc ctctgggcct cctctctggc ttacaagtgg
     3661 ctaaaatgga gaagcatcct ttatagtctc agcagagcca gggaccaagc cgctcccttc
     3721 ctttgtggta gcactagcat ggggtgctgg tgtttttcag agggacccgc tgcagccatt
     3781 ttaattcatg attaggaacc ttagtgtgac ttaagagttt cattgtgtgt ttatgtgtgc
     3841 atgacatgcc tagtcagtga caggggtggg tagggtgtct agtatcatgg tatcacgtgg
     3901 cttagtagat gccacagtag cttctgcaaa cactgtactg tcttgtttct gtattagatg
     3961 tcggtaatca tgtgaatata ctgccatgtc acttttaata ttaccagttt tatacttgga
     4021 aaatggtact tgcctctttg aaatctattt tgtctctaat gtccctacca tctctatgtt
     4081 ctttcctaac tgcagcaata acccttcaaa agcaattgaa taataaatgt cccaaactgt
     4141 aaaaaaaaaa aa
//
