LOCUS       NM_199007               5314 bp    mRNA    linear   ROD 16-FEB-2025
DEFINITION  Mus musculus shugoshin 2A (Sgo2a), transcript variant 1, mRNA.
ACCESSION   NM_199007 XM_355200
VERSION     NM_199007.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5314)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5314)
  AUTHORS   Previato de Almeida,L., Evatt,J.M., Chuong,H.H., Kurdzo,E.L.,
            Eyster,C.A., Gladstone,M.N., Gomez-H,L., Llano,E., Meyer,R.,
            Pendas,A.M., Pezza,R.J. and Dawson,D.S.
  TITLE     Shugoshin protects centromere pairing and promotes segregation of
            nonexchange partner chromosomes in meiosis
  JOURNAL   Proc Natl Acad Sci U S A 116 (19), 9417-9422 (2019)
   PUBMED   31019073
REFERENCE   3  (bases 1 to 5314)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5314)
  AUTHORS   Loo,L., Simon,J.M., Xing,L., McCoy,E.S., Niehaus,J.K., Guo,J.,
            Anton,E.S. and Zylka,M.J.
  TITLE     Single-cell transcriptomic analysis of mouse neocortical
            development
  JOURNAL   Nat Commun 10 (1), 134 (2019)
   PUBMED   30635555
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5314)
  AUTHORS   Krishnan,S., Smits,A.H., Vermeulen,M. and Reinberg,D.
  TITLE     Phospho-H1 Decorates the Inter-chromatid Axis and Is Evicted along
            with Shugoshin by SET during Mitosis
  JOURNAL   Mol Cell 67 (4), 579-593 (2017)
   PUBMED   28781233
  REMARK    GeneRIF: Molecular chaperone SET-assisted eviction of linker
            histones and Shugoshins is a fundamental step in mammalian mitotic
            progression.
REFERENCE   6  (bases 1 to 5314)
  AUTHORS   Llano,E., Gomez,R., Gutierrez-Caballero,C., Herran,Y.,
            Sanchez-Martin,M., Vazquez-Quinones,L., Hernandez,T., de Alava,E.,
            Cuadrado,A., Barbero,J.L., Suja,J.A. and Pendas,A.M.
  TITLE     Shugoshin-2 is essential for the completion of meiosis but not for
            mitotic cell division in mice
  JOURNAL   Genes Dev 22 (17), 2400-2413 (2008)
   PUBMED   18765791
  REMARK    GeneRIF: SGOL2 is necessary for protecting centromeric cohesion
            during mammalian meiosis I. In vivo, the loss of SGOL2 promotes a
            premature release of the meiosis-specific REC8 cohesin complexes
            from anaphase I centromeres
REFERENCE   7  (bases 1 to 5314)
  AUTHORS   Lee,J., Kitajima,T.S., Tanno,Y., Yoshida,K., Morita,T., Miyano,T.,
            Miyake,M. and Watanabe,Y.
  TITLE     Unified mode of centromeric protection by shugoshin in mammalian
            oocytes and somatic cells
  JOURNAL   Nat Cell Biol 10 (1), 42-52 (2008)
   PUBMED   18084284
  REMARK    GeneRIF: Results show that shugoshin Sgo2 is expressed in germ
            cells.
REFERENCE   8  (bases 1 to 5314)
  AUTHORS   Gomez,R., Valdeolmillos,A., Parra,M.T., Viera,A., Carreiro,C.,
            Roncal,F., Rufas,J.S., Barbero,J.L. and Suja,J.A.
  TITLE     Mammalian SGO2 appears at the inner centromere domain and
            redistributes depending on tension across centromeres during
            meiosis II and mitosis
  JOURNAL   EMBO Rep 8 (2), 173-180 (2007)
   PUBMED   17205076
REFERENCE   9  (bases 1 to 5314)
  AUTHORS   Kitajima,T.S., Kawashima,S.A. and Watanabe,Y.
  TITLE     The conserved kinetochore protein shugoshin protects centromeric
            cohesion during meiosis
  JOURNAL   Nature 427 (6974), 510-517 (2004)
   PUBMED   14730319
REFERENCE   10 (bases 1 to 5314)
  AUTHORS   Sharov,A.A., Piao,Y., Matoba,R., Dudekula,D.B., Qian,Y.,
            VanBuren,V., Falco,G., Martin,P.R., Stagg,C.A., Bassey,U.C.,
            Wang,Y., Carter,M.G., Hamatani,T., Aiba,K., Akutsu,H., Sharova,L.,
            Tanaka,T.S., Kimber,W.L., Yoshikawa,T., Jaradat,S.A., Pantano,S.,
            Nagaraja,R., Boheler,K.R., Taub,D., Hodes,R.J., Longo,D.L.,
            Schlessinger,D., Keller,J., Klotz,E., Kelsoe,G., Umezawa,A.,
            Vescovi,A.L., Rossant,J., Kunath,T., Hogan,B.L., Curci,A.,
            D'Urso,M., Kelso,J., Hide,W. and Ko,M.S.
  TITLE     Transcriptome analysis of mouse stem cells and early embryos
  JOURNAL   PLoS Biol 1 (3), E74 (2003)
   PUBMED   14691545
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK042448.1, BC052742.1 and AK138621.1.
            
            On May 7, 2009 this sequence version replaced NM_199007.1.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC052742.1, SRR9219380.53909.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN00849390
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2121              AK042448.1         5-2125
            2122-4385           BC052742.1         2030-4293
            4386-5314           AK138621.1         1775-2703
FEATURES             Location/Qualifiers
     source          1..5314
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 28.86 cM"
     gene            1..5314
                     /gene="Sgo2a"
                     /gene_synonym="1110007N04Rik; 4932411A20Rik;
                     5730576N04Rik; D1Ertd8e; Sgol2; Sgol2a; Tripin"
                     /note="shugoshin 2A"
                     /db_xref="GeneID:68549"
                     /db_xref="MGI:MGI:1098767"
     exon            1..339
                     /gene="Sgo2a"
                     /gene_synonym="1110007N04Rik; 4932411A20Rik;
                     5730576N04Rik; D1Ertd8e; Sgol2; Sgol2a; Tripin"
                     /inference="alignment:Splign:2.1.0"
     exon            340..465
                     /gene="Sgo2a"
                     /gene_synonym="1110007N04Rik; 4932411A20Rik;
                     5730576N04Rik; D1Ertd8e; Sgol2; Sgol2a; Tripin"
                     /inference="alignment:Splign:2.1.0"
     CDS             342..3836
                     /gene="Sgo2a"
                     /gene_synonym="1110007N04Rik; 4932411A20Rik;
                     5730576N04Rik; D1Ertd8e; Sgol2; Sgol2a; Tripin"
                     /note="isoform 1 is encoded by transcript variant 1; sgo2;
                     shugoshin-like 2; shugoshin 2; shugoshin-like 2a"
                     /codon_start=1
                     /product="shugoshin 2A isoform 1"
                     /protein_id="NP_950172.1"
                     /db_xref="CCDS:CCDS35574.1"
                     /db_xref="GeneID:68549"
                     /db_xref="MGI:MGI:1098767"
                     /translation="MEYPGIKVDTVTSGIQRRVKGRIAKTNLNVSLASKIKAKILNNS
                     SIFKISLKHNNRALARALSKEKENSRRITTEKMQLQKEVEKLNFENTFLRLKLNTLNK
                     KLVEIESHVSNDLLTAIEISSLSEFHQGSFLLSATKKQRNSKQCKPAHLPYARVLLTS
                     ENDDDDGADDKWQTKCNNRTISKTSPDSTSSVSRQPSSLHQCNLKAFPPKEDNQKTCG
                     SGHLEHTSSVDILPNESHSDQSPKSSLSEMKTAPSPSLRREKLSHGNVTMRKKCVSST
                     PDILYVTDLDHQPTSSPGSNWNNEIHGHTNETSNNTQRNAECFLDLPSESSSEPDAKR
                     MELVQKNTDSFHFQKTVYDAADMELTATDIGKIVAVSKSKKNQNKKKADCRKETFRKV
                     KGASSDKKRESSKRECKDGSEVGAEEEADAARAERGAGVLDGRGDSEEPNCISSTEQP
                     SQVNTQKKRTLQNSSDQENIQNTKRRQTYTTDEQEETNPFSRHSVKFLQDGKFDLCQK
                     TLHHNLSKPSRQTFVIRKSEKDNLFPNQEDKDTISENLEVTNEFHIDDLSIEANENVC
                     DHETQTMLDLKKSVSAQQNQTKINKTKQKINRRTKIISVMSQVYEDNDKDIHVLEKDN
                     FPFHTQANKETTSGNLESSKEFESPLLFTRDNGSLRDCKTQNVLDLHKQIPDLYPDRN
                     ESQISKIPRQKVNRKTEVISGVKCFSNDQGVHCSEKDKSLLLQKDKDFPGTLKDLSEF
                     DTPAFCNKDSAKSCDYKSEMLLGLKKHDPNMQPACQDDSKAGKKLRQKVNRKTEIISK
                     ITQIHENDRGSTHDSLNKKLCQKVNISKIISQMNQIYETINEDGNGFKSSIKDCEDIK
                     SCDFGEINSNKKENYDPIQDPCTLVKKTKRKGSCKAGSSLAGAKNRCGLQLTDSSQVQ
                     SVPLDSGLRHHPNEADSGPGEQTNLPKMQKQSAGRSLGDAFSVSLGKEGSRPAKAVSK
                     MTPKSKKRKLPLGCSPETHGTVEITPNTDLAKAVDSQQTEKENYLEKEKIAKRKPDFC
                     TKVLKPLSETCSSNIKNSSLDSMCKSSLPLSISSRKTLMLEESSSLESTCIFQVGDAA
                     HEKITTGTRNPHHRTQKSTPGSRTSLVLVDTSSVSDTNPANPENESEGQSSHPMRRKR
                     QCVPLNLTEPSLRSKMRR"
     exon            466..641
                     /gene="Sgo2a"
                     /gene_synonym="1110007N04Rik; 4932411A20Rik;
                     5730576N04Rik; D1Ertd8e; Sgol2; Sgol2a; Tripin"
                     /inference="alignment:Splign:2.1.0"
     exon            642..719
                     /gene="Sgo2a"
                     /gene_synonym="1110007N04Rik; 4932411A20Rik;
                     5730576N04Rik; D1Ertd8e; Sgol2; Sgol2a; Tripin"
                     /inference="alignment:Splign:2.1.0"
     exon            720..805
                     /gene="Sgo2a"
                     /gene_synonym="1110007N04Rik; 4932411A20Rik;
                     5730576N04Rik; D1Ertd8e; Sgol2; Sgol2a; Tripin"
                     /inference="alignment:Splign:2.1.0"
     exon            806..1041
                     /gene="Sgo2a"
                     /gene_synonym="1110007N04Rik; 4932411A20Rik;
                     5730576N04Rik; D1Ertd8e; Sgol2; Sgol2a; Tripin"
                     /inference="alignment:Splign:2.1.0"
     exon            1042..3666
                     /gene="Sgo2a"
                     /gene_synonym="1110007N04Rik; 4932411A20Rik;
                     5730576N04Rik; D1Ertd8e; Sgol2; Sgol2a; Tripin"
                     /inference="alignment:Splign:2.1.0"
     exon            3667..3820
                     /gene="Sgo2a"
                     /gene_synonym="1110007N04Rik; 4932411A20Rik;
                     5730576N04Rik; D1Ertd8e; Sgol2; Sgol2a; Tripin"
                     /inference="alignment:Splign:2.1.0"
     exon            3821..5314
                     /gene="Sgo2a"
                     /gene_synonym="1110007N04Rik; 4932411A20Rik;
                     5730576N04Rik; D1Ertd8e; Sgol2; Sgol2a; Tripin"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4041..4046
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sgo2a"
                     /gene_synonym="1110007N04Rik; 4932411A20Rik;
                     5730576N04Rik; D1Ertd8e; Sgol2; Sgol2a; Tripin"
                     /note="hexamer: AATAAA"
     polyA_site      4062
                     /gene="Sgo2a"
                     /gene_synonym="1110007N04Rik; 4932411A20Rik;
                     5730576N04Rik; D1Ertd8e; Sgol2; Sgol2a; Tripin"
                     /note="major polyA site"
     regulatory      4913..4918
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sgo2a"
                     /gene_synonym="1110007N04Rik; 4932411A20Rik;
                     5730576N04Rik; D1Ertd8e; Sgol2; Sgol2a; Tripin"
                     /note="hexamer: ATTAAA"
     polyA_site      4936
                     /gene="Sgo2a"
                     /gene_synonym="1110007N04Rik; 4932411A20Rik;
                     5730576N04Rik; D1Ertd8e; Sgol2; Sgol2a; Tripin"
                     /note="major polyA site"
ORIGIN      
        1 ttctcggaat ctgattggct ggagcataaa cgctaactgc cgcgcagttt aaacctgaat
       61 cctggtcttc gcggattgtc gcgcttccct ggcaagtgtg ggcacccaca gctgaagggg
      121 tcgctggtag gcgtggacga ggccagcgcg gccagcaagg cctgcgaagc cggaaccctt
      181 ctcggtagcc actcctggcg cctcagtcct cgccgccgcg cgtcggcttg cagggccggg
      241 acgcggagcc gggacgcgga gccgccttcg gatcggggcg gtaacctctg ttctgacttt
      301 gagctcccag ctgggcgagg ggtcgccact agttttcaga aatggagtac ccagggataa
      361 aagttgacac tgttacctct ggaattcaga gacgagtgaa gggcagaatt gcaaagacaa
      421 atttgaatgt ttctcttgct tcaaagatca aagcaaaaat attaaacaat tcttctattt
      481 tcaagatctc tctaaagcac aacaacagag cattagcgcg ggcccttagt aaagagaaag
      541 agaattctcg aagaattact accgaaaaga tgcaattaca gaaagaagta gagaaactga
      601 attttgagaa tacctttctt cgcttaaagt taaatacctt gaataagaag cttgtagaaa
      661 tagaatcgca tgtgagcaat gatttgttaa ctgcaattga aataagcagt ctttctgagt
      721 tccaccaagg ttcttttctc ctgtcagcta ccaagaaaca aaggaacagt aagcagtgca
      781 agcctgcgca tcttccatat gcaagagttc tgttaacttc agaaaatgat gatgatgatg
      841 gtgctgatga taaatggcag acaaagtgta acaacagaac tatatcaaag acctcacctg
      901 atagtacctc ttcagtatca agacaacctt catccttaca tcagtgcaat ttgaaagcat
      961 tccctcctaa agaagataat cagaagacat gtgggtcagg tcatttagaa catacttcaa
     1021 gtgttgatat acttcctaat gagagccact cagatcaaag tcctaagagt tctctgagtg
     1081 agatgaaaac tgctccatct cccagcctca gaagggaaaa attatcacat ggtaatgtga
     1141 ctatgaggaa gaagtgtgtg tcttcaactc cagacattct gtatgtgaca gatttagatc
     1201 accaaccaac ttcaagtcca ggatcaaatt ggaataatga gatacatggt catactaatg
     1261 aaaccagcaa taacacgcaa agaaatgccg agtgttttct tgacttacct tctgagtctt
     1321 ccagtgagcc tgacgcaaag cgcatggagc tagtgcagaa gaacaccgat agctttcact
     1381 tccagaaaac tgtatatgat gccgctgata tggagttaac tgctactgac ataggcaaga
     1441 ttgtagcagt ttcaaaaagc aagaaaaatc aaaataagaa aaaggcagac tgtagaaagg
     1501 agactttcag aaaagtgaaa ggtgcaagct ctgataaaaa gagagaaagc tcaaagagag
     1561 aatgtaaaga tggttcagaa gtaggtgctg aggaagaggc tgatgcagcc agagcagaaa
     1621 gaggcgctgg tgtcctggat ggcagagggg attcagaaga gccaaactgc atttccagta
     1681 ctgagcagcc atctcaggta aacacgcaaa agaaaagaac cctccagaac agctcagatc
     1741 aggagaacat tcaaaatacg aagaggaggc aaacatatac gacagatgag caagaggaaa
     1801 caaacccttt ctccagacat tcagtcaaat ttcttcaaga tggtaaattt gatctgtgtc
     1861 agaaaaccct acatcataat ttaagtaagc cttctcgaca gacatttgtg attcgtaagt
     1921 cagaaaaaga taacttattt ccaaatcaag aagataaaga caccatttct gaaaacctag
     1981 aagttacaaa tgaatttcat atagatgatc tttccatcga agctaatgaa aatgtatgtg
     2041 accatgagac tcagacaatg ttggacttga aaaagtctgt cagtgctcaa caaaatcaaa
     2101 caaaaataaa taagactaag cagaaaataa atcgaaggac aaaaataatt tctgtcatga
     2161 gccaagtata tgaggacaat gataaagata ttcacgtcct agaaaaagac aactttccct
     2221 ttcataccca agcaaataaa gaaaccacca gtggaaacct agaaagttca aaagaatttg
     2281 aatcacctct tcttttcaca agagacaacg gaagcttacg tgactgtaag acccagaatg
     2341 ttctggatct gcacaagcaa attcctgatc tataccctga tcggaatgag tcccagatta
     2401 gcaaaatccc taggcaaaaa gtaaatcgca agacagaagt aatttctgga gtgaaatgtt
     2461 ttagtaatga ccaaggtgtt cattgctcag aaaaggataa gtctttgtta ctacaaaagg
     2521 ataaagactt cccaggaact ttaaaagact taagtgagtt tgatacgcct gctttttgta
     2581 acaaagatag tgcaaagtcg tgtgattata agtctgaaat gctcttgggg ttgaaaaaac
     2641 atgaccctaa tatgcaacct gcttgtcaag atgattcaaa agcaggtaag aaacttagac
     2701 aaaaggtaaa tcgaaaaaca gaaataattt ctaaaatcac ccaaatacat gaaaatgata
     2761 gaggaagtac acatgactca ttaaataaga agctctgtca gaaggttaat atatcaaaaa
     2821 tcatttctca aatgaaccaa atatatgaga ctattaatga agatggaaat ggctttaaaa
     2881 gctctatcaa agattgcgaa gatattaaaa gttgtgactt tggggaaatc aacagtaata
     2941 aaaaggaaaa ttatgatcca attcaagatc cttgcacact ggttaaaaaa acaaagagaa
     3001 agggatcatg taaagcaggg agcagtttgg caggagctaa gaacaggtgt ggtttgcagt
     3061 taacagactc ttcccaggta cagtctgtcc ccttagactc tggcttaaga caccatccaa
     3121 acgaagcaga ttctggtcct ggagagcaga ctaacctgcc aaagatgcag aaacaaagcg
     3181 ctgggaggtc actgggagat gctttctctg tgagtctggg aaaagaagga agccgcccag
     3241 ccaaagcagt tagtaaaatg acacccaaat caaagaagag aaagctccct ctcggttgtt
     3301 ctcctgaaac ccacgggacg gtggagataa cacccaacac tgacctcgct aaggctgttg
     3361 actcccaaca gactgagaag gagaactatt tggagaagga gaaaattgcc aagaggaagc
     3421 cagatttttg tacaaaggtg ttgaaacctt tatctgagac atgttcatct aacataaaga
     3481 attcttcctt ggacagtatg tgtaagagtt cgctaccttt gagtatttct tctagaaaaa
     3541 ccctgatgct ggaagaaagt tcttccctgg agagtacatg catctttcaa gtaggtgatg
     3601 ccgctcatga gaagataacg acaggcacac gtaatcccca ccacaggaca cagaagtcga
     3661 caccgggtag cagaacgtcc ctggtcttgg tggataccag ttctgtttca gataccaacc
     3721 ctgctaaccc cgagaatgag tcagaagggc agtcttcaca cccaatgaga aggaaaagac
     3781 agtgcgtccc tctcaacctg acagagccaa gccttagaag caagatgagg agataaagtc
     3841 gaagtgaagt ggacatggat cctggttttc ccgagttctc aaagcacggg tcagaacaga
     3901 agcacaagaa gaacatgaaa caaagacgga ttcagttgtt tgagttttgt acgtgaagtg
     3961 tttggttttg gttttggggt ttttttggcc tttcttagat tttgcaagat ctatgtgcat
     4021 gaaatagcta tatcttagat aataaacttt tttttaaaaa cattggtcat cacataactt
     4081 gttgatttaa atttctatca aatttatata accaagcaac tattcttatt aaccaaataa
     4141 aatgtatcat tgcattggtt atcttgtata tcaggctatc ttgtcttcct aacattgagg
     4201 atgccatctt tactgctaaa acacaggaac acaccaccct gcctgtgcag tggaggttgg
     4261 aggccttgtt aacagaacat ttactttgtg gggagggttg cctttctgac atctgttcat
     4321 gctccaggaa tactgacctc ctggaatccc tctgacagta tagtttttgt tccttttttt
     4381 tttttctacc ttttatgaga tttcccttta tttctctctc ccatgcaaat tacttcatat
     4441 tttataccaa gtatctttct tttactattg gtagagtttg atcacactta aaaaaaacgt
     4501 tttcaggtta taaagtaccc atggttttaa tttaaaaaat gtttaggttg tgtgcgtgca
     4561 cacattcatg ctacagagca tgtggagagt cggctctgct ttcctcatga ggacctgcta
     4621 gagggtggaa ctcaagtcac ctgctttgct ttttgcccac tgagcggttt ttgtgagccc
     4681 tacatttaaa tttcagacta atacagagtt tgttgtatga tgtgaagtat acctgtaata
     4741 ttttactatt tctcaagtga tttattgact taagagctcg tatctatcta ctgatttgaa
     4801 gtttttagcg ttgtgttgta ttcccatgtg tgtcaattgt tgattttcct gactcctatt
     4861 cacttatgta tcattttatc attaattctc tttatttatt ttttaaatac aaattaaaaa
     4921 aagttttaaa gatttattta tctatctatt tatttattta tctattatat gtgtgtacac
     4981 tgtagctgtc ttcagacact ccagaagagg gcatcagatt tttgttaata gatggttgtg
     5041 agccaccatg tggttgctgg gatctgaact cgggaccttt ggaagagcag tccgtgctct
     5101 taactgctga gccatctcac cagcccaatt aattctcttt agaatgtcag tattttcctc
     5161 ataagttttg aaaatctttt aataaattta ccattaggca ttttgttctt ctgtggggtt
     5221 ggcacaagcg aggctttctc ttcagttttt ctaatttact gtttgcaaat atgaagatta
     5281 ctgaattttg tgttgattaa taaaccctct tatg
//
