LOCUS       NM_028232               3609 bp    mRNA    linear   ROD 01-AUG-2024
DEFINITION  Mus musculus shugoshin 1 (Sgo1), mRNA.
ACCESSION   NM_028232
VERSION     NM_028232.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3609)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3609)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3609)
  AUTHORS   Ulmke,P.A., Sakib,M.S., Ditte,P., Sokpor,G., Kerimoglu,C., Pham,L.,
            Xie,Y., Mao,X., Rosenbusch,J., Teichmann,U., Nguyen,H.P.,
            Fischer,A., Eichele,G., Staiger,J.F. and Tuoc,T.
  TITLE     Molecular Profiling Reveals Involvement of ESCO2 in Intermediate
            Progenitor Cell Maintenance in the Developing Mouse Cortex
  JOURNAL   Stem Cell Reports 16 (4), 968-984 (2021)
   PUBMED   33798452
REFERENCE   4  (bases 1 to 3609)
  AUTHORS   Rao,C.V., Farooqui,M., Madhavaram,A., Zhang,Y., Asch,A.S. and
            Yamada,H.Y.
  TITLE     GSK3-ARC/Arg3.1 and GSK3-Wnt signaling axes trigger amyloid-beta
            accumulation and neuroinflammation in middle-aged Shugoshin 1 mice
  JOURNAL   Aging Cell 19 (10), e13221 (2020)
   PUBMED   32857910
  REMARK    GeneRIF: GSK3-ARC/Arg3.1 and GSK3-Wnt signaling axes trigger
            amyloid-beta accumulation and neuroinflammation in middle-aged
            Shugoshin 1 mice.
REFERENCE   5  (bases 1 to 3609)
  AUTHORS   Previato de Almeida,L., Evatt,J.M., Chuong,H.H., Kurdzo,E.L.,
            Eyster,C.A., Gladstone,M.N., Gomez-H,L., Llano,E., Meyer,R.,
            Pendas,A.M., Pezza,R.J. and Dawson,D.S.
  TITLE     Shugoshin protects centromere pairing and promotes segregation of
            nonexchange partner chromosomes in meiosis
  JOURNAL   Proc Natl Acad Sci U S A 116 (19), 9417-9422 (2019)
   PUBMED   31019073
  REMARK    GeneRIF: The results show that shugoshin protects the centromeric
            synaptonemal complex in meiotic prophase and, in anaphase, promotes
            the proper segregation of partner chromosomes that are not linked
            by a crossover.
REFERENCE   6  (bases 1 to 3609)
  AUTHORS   Wang,X., Yang,Y., Duan,Q., Jiang,N., Huang,Y., Darzynkiewicz,Z. and
            Dai,W.
  TITLE     sSgo1, a major splice variant of Sgo1, functions in centriole
            cohesion where it is regulated by Plk1
  JOURNAL   Dev Cell 14 (3), 331-341 (2008)
   PUBMED   18331714
REFERENCE   7  (bases 1 to 3609)
  AUTHORS   Lee,J., Kitajima,T.S., Tanno,Y., Yoshida,K., Morita,T., Miyano,T.,
            Miyake,M. and Watanabe,Y.
  TITLE     Unified mode of centromeric protection by shugoshin in mammalian
            oocytes and somatic cells
  JOURNAL   Nat Cell Biol 10 (1), 42-52 (2008)
   PUBMED   18084284
REFERENCE   8  (bases 1 to 3609)
  AUTHORS   Yin,S., Ai,J.S., Shi,L.H., Wei,L., Yuan,J., Ouyang,Y.C., Hou,Y.,
            Chen,D.Y., Schatten,H. and Sun,Q.Y.
  TITLE     Shugoshin1 may play important roles in separation of homologous
            chromosomes and sister chromatids during mouse oocyte meiosis
  JOURNAL   PLoS One 3 (10), e3516 (2008)
   PUBMED   18949044
  REMARK    GeneRIF: Prevention of premature separation of sister chromatids in
            meiosis I requires the retention of centromeric Sgo1, while normal
            separation of sister chromatids in meiosis II requires loss of
            centromeric Sgo1.
REFERENCE   9  (bases 1 to 3609)
  AUTHORS   McGuinness,B.E., Hirota,T., Kudo,N.R., Peters,J.M. and Nasmyth,K.
  TITLE     Shugoshin prevents dissociation of cohesin from centromeres during
            mitosis in vertebrate cells
  JOURNAL   PLoS Biol 3 (3), e86 (2005)
   PUBMED   15737064
REFERENCE   10 (bases 1 to 3609)
  AUTHORS   Kitajima,T.S., Kawashima,S.A. and Watanabe,Y.
  TITLE     The conserved kinetochore protein shugoshin protects centromeric
            cohesion during meiosis
  JOURNAL   Nature 427 (6974), 510-517 (2004)
   PUBMED   14730319
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CR522550.1, AK014357.1, AK049517.1 and BY394301.1.
            
            On Oct 21, 2009 this sequence version replaced NM_028232.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK154188.1, AK014357.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164143 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-55                CR522550.1         126-180             c
            56-2336             AK014357.1         50-2330
            2337-3607           AK049517.1         1701-2971
            3608-3609           BY394301.1         428-429
FEATURES             Location/Qualifiers
     source          1..3609
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 27.92 cM"
     gene            1..3609
                     /gene="Sgo1"
                     /gene_synonym="3300001M08Rik; Sgol1"
                     /note="shugoshin 1"
                     /db_xref="GeneID:72415"
                     /db_xref="MGI:MGI:1919665"
     exon            1..105
                     /gene="Sgo1"
                     /gene_synonym="3300001M08Rik; Sgol1"
                     /inference="alignment:Splign:2.1.0"
     exon            106..236
                     /gene="Sgo1"
                     /gene_synonym="3300001M08Rik; Sgol1"
                     /inference="alignment:Splign:2.1.0"
     exon            237..384
                     /gene="Sgo1"
                     /gene_synonym="3300001M08Rik; Sgol1"
                     /inference="alignment:Splign:2.1.0"
     CDS             243..1796
                     /gene="Sgo1"
                     /gene_synonym="3300001M08Rik; Sgol1"
                     /note="shugoshin 1A protein; shugoshin-like 1"
                     /codon_start=1
                     /product="shugoshin 1"
                     /protein_id="NP_082508.1"
                     /db_xref="CCDS:CCDS28881.1"
                     /db_xref="GeneID:72415"
                     /db_xref="MGI:MGI:1919665"
                     /translation="MAKERCQKRSFQDTLEDIKNRMKEKRNKNLAGIGKRKSFIVAPG
                     QVPTNTATLLRYYQDNNRLLVLALENEKSKVREAQDVILQLRKECYYLTCQLYALKEK
                     LTSRQSEETTQNWKGRPSDVVSSIDNTTRDLSGKSLQQIAVEETDCPYQTTEPSPAVT
                     PETQGCDFDSGKVESTDEVLPRTISIRRHLRKDFSNISHSTTLEDCKASPRVAQSLEV
                     KGSRCREVTVTLHRLENVCLWNKDQISLCSRLINPAKITETEVILSSKPEQIESKHKR
                     ARKRRAEQRRTKQRCKSKSSLRSKGNKNKDKQGLPPTTLDGGIGSCDAYDFNLKGTVH
                     PTPFRQKMNNGCNKETDSSNSEVSDLECSTSEDESDDLYLPPSKRLRDYRESERAVTR
                     PRSKRGLQYPDGKERKEVLPSTAPTGIPPETQESPRCSLKDVTNILQCPRVKIRKPSL
                     PPKRREDSPAVALTKRRCSTIKSYKEPTLASKLRRGDPFTDLCFLNSPIFKQKRGMRC
                     PKRRTKQTQ"
     exon            385..581
                     /gene="Sgo1"
                     /gene_synonym="3300001M08Rik; Sgol1"
                     /inference="alignment:Splign:2.1.0"
     exon            582..658
                     /gene="Sgo1"
                     /gene_synonym="3300001M08Rik; Sgol1"
                     /inference="alignment:Splign:2.1.0"
     exon            659..702
                     /gene="Sgo1"
                     /gene_synonym="3300001M08Rik; Sgol1"
                     /inference="alignment:Splign:2.1.0"
     exon            703..1494
                     /gene="Sgo1"
                     /gene_synonym="3300001M08Rik; Sgol1"
                     /inference="alignment:Splign:2.1.0"
     exon            1495..1684
                     /gene="Sgo1"
                     /gene_synonym="3300001M08Rik; Sgol1"
                     /inference="alignment:Splign:2.1.0"
     exon            1685..3609
                     /gene="Sgo1"
                     /gene_synonym="3300001M08Rik; Sgol1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2314..2319
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sgo1"
                     /gene_synonym="3300001M08Rik; Sgol1"
                     /note="hexamer: AATAAA"
     polyA_site      2342
                     /gene="Sgo1"
                     /gene_synonym="3300001M08Rik; Sgol1"
                     /note="major polyA site"
ORIGIN      
        1 agccaatgga tacgcgtaac gcagaatttc gaatgtggcg gcggtagctg cggagcgcgg
       61 cggagcggga ggttgcatct gctcgtccgg acctgagtgg ccgagatgaa tttcactatg
      121 tagcccaagc ataaatctat gacccacctg ccttagcctt tttagtagct tggattattc
      181 tacaacacct gacttaatat ttctaagcag aaaatcaaaa tattgctttt tttgaaacaa
      241 agatggctaa ggaaaggtgt cagaaaaggt cctttcaaga tacccttgaa gacattaaga
      301 atcgaatgaa agaaaaaagg aataaaaatt tggcggggat tgggaaacgc aagtccttta
      361 ttgttgcacc gggccaagta cccactaaca ctgctacact actgagatat taccaagata
      421 acaacaggtt gttagtcttg gctttggaaa atgagaaatc caaagtgaga gaagcacagg
      481 atgtcatcct gcaactgaga aaagaatgct actaccttac ttgtcagctg tatgcattga
      541 aagagaagct aacttcccga caaagtgaag aaactactca gaactggaaa ggacgtccct
      601 cagacgtggt ctccagcatt gacaatacga ccagggactt gtcagggaag tccttacagc
      661 aaattgctgt tgaagaaact gattgtcctt accaaaccac agaaccaagt cctgctgtta
      721 ctccagagac acagggttgc gattttgatt caggtaaagt tgagtctact gatgaagtct
      781 tacccagaac tatatctatc cgtcgccatt taaggaaaga ttttagtaat ataagccact
      841 ccacgacttt ggaggattgt aaagccagtc caagagtggc acagtctctg gaagttaaag
      901 gaagtagatg tagagaagta accgtaaccc tgcacagact tgaaaatgtt tgtctgtgga
      961 acaaagacca aattagctta tgttctagac tgattaaccc agcaaagatt actgaaacag
     1021 aagtcatttt atcatctaaa cctgaacaaa tagaaagcaa gcataaacgt gcacgaaaaa
     1081 gaagagcaga gcaaagaaga accaagcaga gatgcaaatc aaaatcctca ttgaggagta
     1141 aggggaacaa aaacaaagat aagcagggtt taccccctac tacactggat ggaggtattg
     1201 gttcctgtga tgcttacgat tttaatctaa aagggacggt ccaccccacc cctttccgac
     1261 aaaaaatgaa caatggctgc aacaaagaaa cggatagcag caactcagaa gtgagtgacc
     1321 tcgaatgcag tacctctgag gatgagtctg atgacctcta cctgcctccc tccaagcgct
     1381 tgcgagacta cagagagtca gagagagcag ttaccaggcc tcggtctaaa agaggacttc
     1441 agtacccaga tgggaaagag aggaaggagg tgctgccatc tacagctcct actggtatcc
     1501 cacctgagac tcaagagtca cctcgttgta gcctaaagga tgtcaccaat atcctgcagt
     1561 gtcctagagt gaagatcagg aagccttctc tgcctccaaa gcggcgtgaa gacagcccag
     1621 cagtggctct gactaaacgc aggtgtagca ccatcaaaag ctataaagag ccaacactcg
     1681 cttcaaagct aagaagaggg gaccctttca cggacttgtg tttcttgaat tctcctattt
     1741 tcaagcagaa aaggggtatg agatgtccta aaagaagaac caagcaaaca cagtaactca
     1801 tttgattagc tactgtttaa ggtgatcctt cttttttacc taataaaata ttattagaca
     1861 gtgcacaatg ggcagaacct ctaccaggct ctgatcagga gggtctcttg gacatatact
     1921 ttgtatggac tattatatta ccaacatcta aaacttctcc agcatcctta ttttttcctt
     1981 aagcaggaga attgcagagt acaaaacttg catcgtagaa aacttacata ggatgtagat
     2041 ctttcataaa tccttaccat cacagtaaga cataagtggg tgaggatccc ttctgtcatt
     2101 gattctttct gtaaactgtg tatcgaatgg tgattaagag aattaatgaa ttgggttctg
     2161 gaacaaggta actgttgtga actgtgagta ctatgctatt gctcagcaga ataatagcac
     2221 tgtcgtggac ctcaggctag ccctttgtgt ggtcagtcta cagtgtaaat aaaggtgtga
     2281 ataaaggggc ttctggcttt gatatgtgaa caaaataaaa gtatccagtt cagaacattg
     2341 aatctttatg tgtgtatgta tgtcttcaaa cttaaatcgt tgtaactggt ccattgttaa
     2401 aggtgaagcc tatggtgacc gcattgtgtt ttccttttgc tcttaatggt cagttactct
     2461 tgattatctt cctttctggc ctttaccact cccaacttag ctggaacctc ttctgtcttc
     2521 cctggttccc cttttcttcc cattagattt gtcctgtcaa gttttcccaa ctgaagcctc
     2581 cagggccaac atcaaggcat ttcaattttc attaaatcgg aagaacgttt gtctcctatg
     2641 ggcaaggccc agggatagat aaataccact caaacaggag attttaagct atcagaaggg
     2701 ccttctggtg gtcatctcag attttaccca caactgcatg gcttcctaca tttaccatca
     2761 aactgaaagt gtggctctgt cactcacgtg cacccctctc gcccatcaca gccttacatt
     2821 tttagccact gtttacagct ctgaggattg gacccacaac tctgtgtgtg gtaggagtag
     2881 tcacagcaat cctcagccac tccatttatc attttctaat gtcatggtat cttgaaagta
     2941 tccattttag ctaaatataa atgcagttaa aagtctagtt tcagcccagt tagctgcatg
     3001 tagcggtgat taccatagta cagcctacat agagaaaggc cctatctgtt ttggacaagc
     3061 taaatttact ttttctgtag ttaacataaa gtagaaaata tttggattaa attttgctac
     3121 ttggcttgca gaacctcaga tatttatttt ctcccctttt gtcaaaaaag ctttccaaag
     3181 gctgatatgt tgcatacatg taatttcagc aatatagagg ctgagtcagg tactacggat
     3241 ctcaaaaacc aaacaaacaa aaatccactt cctgctatag acatttaaat ggctacttcg
     3301 taggtcagca tgtctagtgt catggtgacg ctcactcact ccatgccagt cacttatctt
     3361 aaagctggta ttaggccttt agtcttcttc atctttcttt attcttgctg tagtgtttac
     3421 tcatgggcta ttaaggggtt tgtgtcaaca tttttatgaa acatgtattt ttataaaata
     3481 tgtattgtat tatttatgtt tataattgac ttaagagttt gagacttccc tggttgatag
     3541 atatagttat ttctgtggtt gtataatatg atataaataa accagactta atgacctctt
     3601 ttgagacat
//
