LOCUS       NM_001379585            5598 bp    mRNA    linear   ROD 24-OCT-2024
DEFINITION  Mus musculus sphingomyelin synthase 2 (Sgms2), transcript variant
            5, mRNA.
ACCESSION   NM_001379585 XM_006502193
VERSION     NM_001379585.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5598)
  AUTHORS   Jiang,X., Yuan,Z., Ding,T., Yu,K. and Dong,J.
  TITLE     SMS2 siRNA inhibits pancreatic tumor growth by tumor
            microenvironment modulation
  JOURNAL   Int Immunopharmacol 142 (Pt A), 113111 (2024)
   PUBMED   39255679
  REMARK    GeneRIF: SMS2 siRNA inhibits pancreatic tumor growth by tumor
            microenvironment modulation.
REFERENCE   2  (bases 1 to 5598)
  AUTHORS   Uchiumi,O., Zou,J., Yamaki,S., Hori,Y., Ono,M., Yamamoto,R. and
            Kato,N.
  TITLE     Disruption of sphingomyelin synthase 2 gene alleviates cognitive
            impairment in a mouse model of Alzheimer's disease
  JOURNAL   Brain Res 1835, 148934 (2024)
   PUBMED   38609029
  REMARK    GeneRIF: Disruption of sphingomyelin synthase 2 gene alleviates
            cognitive impairment in a mouse model of Alzheimer's disease.
REFERENCE   3  (bases 1 to 5598)
  AUTHORS   Zhang,D., Deng,W., Jiang,T., Zhao,Y., Bai,D., Tian,Y., Kong,S.,
            Zhang,L., Wang,H., Gao,S. and Lu,Z.
  TITLE     Maternal Ezh1/2 deficiency impairs the function of mitochondria in
            mouse oocytes and early embryos
  JOURNAL   J Cell Physiol 239 (6), e31244 (2024)
   PUBMED   38529784
REFERENCE   4  (bases 1 to 5598)
  AUTHORS   Chiang,Y.P., Li,Z., He,M., Jones,Q., Pan,M., Han,X. and Jiang,X.C.
  TITLE     Sphingomyelin synthase-related protein SMSr is a
            phosphatidylethanolamine phospholipase C that promotes nonalcoholic
            fatty liver disease
  JOURNAL   J Biol Chem 299 (9), 105162 (2023)
   PUBMED   37586586
  REMARK    Erratum:[J Biol Chem. 2024 Apr;300(4):107204. doi:
            10.1016/j.jbc.2024.107204. PMID: 38552502]
REFERENCE   5  (bases 1 to 5598)
  AUTHORS   He,S., Gu,X., Yang,J., Xu,F., Hu,J., Wang,W., Huang,Y., Lou,B.,
            Ding,T., Zhou,L., Ye,D., Yu,K. and Dong,J.
  TITLE     Sphingomyelin synthase 2 is a positive regulator of the CSF1R-STAT3
            pathway in pancreatic cancer-associated macrophage
  JOURNAL   Front Pharmacol 13, 902016 (2022)
   PUBMED   36324684
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5598)
  AUTHORS   Hailemariam,T.K., Huan,C., Liu,J., Li,Z., Roman,C., Kalbfeisch,M.,
            Bui,H.H., Peake,D.A., Kuo,M.S., Cao,G., Wadgaonkar,R. and
            Jiang,X.C.
  TITLE     Sphingomyelin synthase 2 deficiency attenuates NFkappaB activation
  JOURNAL   Arterioscler Thromb Vasc Biol 28 (8), 1519-1526 (2008)
   PUBMED   18566297
  REMARK    GeneRIF: SMS2 (Sphingomyelin synthase 2) physiologically
            contributes to de novo Sphingomyelin biosynthesis and plasma
            membrane Sphingomyelin levels
REFERENCE   7  (bases 1 to 5598)
  AUTHORS   Hecht,J., Seitz,V., Urban,M., Wagner,F., Robinson,P.N., Stiege,A.,
            Dieterich,C., Kornak,U., Wilkening,U., Brieske,N., Zwingman,C.,
            Kidess,A., Stricker,S. and Mundlos,S.
  TITLE     Detection of novel skeletogenesis target genes by comprehensive
            analysis of a Runx2(-/-) mouse model
  JOURNAL   Gene Expr Patterns 7 (1-2), 102-112 (2007)
   PUBMED   16829211
REFERENCE   8  (bases 1 to 5598)
  AUTHORS   Dong,J., Liu,J., Lou,B., Li,Z., Ye,X., Wu,M. and Jiang,X.C.
  TITLE     Adenovirus-mediated overexpression of sphingomyelin synthases 1 and
            2 increases the atherogenic potential in mice
  JOURNAL   J Lipid Res 47 (6), 1307-1314 (2006)
   PUBMED   16508036
REFERENCE   9  (bases 1 to 5598)
  AUTHORS   Wang,S., Yehya,N., Schadt,E.E., Wang,H., Drake,T.A. and Lusis,A.J.
  TITLE     Genetic and genomic analysis of a fat mass trait with complex
            inheritance reveals marked sex specificity
  JOURNAL   PLoS Genet 2 (2), e15 (2006)
   PUBMED   16462940
REFERENCE   10 (bases 1 to 5598)
  AUTHORS   Huitema,K., van den Dikkenberg,J., Brouwers,J.F. and Holthuis,J.C.
  TITLE     Identification of a family of animal sphingomyelin synthases
  JOURNAL   EMBO J 23 (1), 33-44 (2004)
   PUBMED   14685263
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC165333.4 and AC165416.12.
            
            On Apr 9, 2020 this sequence version replaced XM_006502193.3.
            
            Summary: Sphingomyelin, a major component of cell and Golgi
            membranes, is made by the transfer of phosphocholine from
            phosphatidylcholine onto ceramide, with diacylglycerol as a side
            product. The protein encoded by this gene is an enzyme that
            catalyzes this reaction primarily at the cell membrane. The
            synthesis is reversible, and this enzyme can catalyze the reaction
            in either direction. The encoded protein is required for cell
            growth. [provided by RefSeq, Oct 2008].
            
            Transcript Variant: This variant (5) differs in the 5' UTR compared
            to variant 1. All seven variants encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17253012.2549968.1,
                                           SRR10223971.4378.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-141               AC165333.4         24082-24222         c
            142-833             AC165416.12        21700-22391
            834-951             AC165416.12        27878-27995
            952-1105            AC165416.12        33684-33837
            1106-1272           AC165416.12        39055-39221
            1273-5598           AC165416.12        40850-45175
FEATURES             Location/Qualifiers
     source          1..5598
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 60.91 cM"
     gene            1..5598
                     /gene="Sgms2"
                     /gene_synonym="4933405A16Rik; 5133401H06Rik"
                     /note="sphingomyelin synthase 2"
                     /db_xref="GeneID:74442"
                     /db_xref="MGI:MGI:1921692"
     exon            1..141
                     /gene="Sgms2"
                     /gene_synonym="4933405A16Rik; 5133401H06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            142..833
                     /gene="Sgms2"
                     /gene_synonym="4933405A16Rik; 5133401H06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            834..951
                     /gene="Sgms2"
                     /gene_synonym="4933405A16Rik; 5133401H06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            952..1105
                     /gene="Sgms2"
                     /gene_synonym="4933405A16Rik; 5133401H06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1106..1272
                     /gene="Sgms2"
                     /gene_synonym="4933405A16Rik; 5133401H06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1273..5598
                     /gene="Sgms2"
                     /gene_synonym="4933405A16Rik; 5133401H06Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5574..5579
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sgms2"
                     /gene_synonym="4933405A16Rik; 5133401H06Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      5598
                     /gene="Sgms2"
                     /gene_synonym="4933405A16Rik; 5133401H06Rik"
                     /note="major polyA site"
ORIGIN      
        1 gcggcgcccg gactgcggcc tggggcggag cggctaccta tgcgggcgag acccgcgcaa
       61 agtttgcagc tctcgggccc ggtcccccgg gtcctctgcg cccagcgagc gcccccggcg
      121 tgcgagcacc ggctgcgagc gaaggaacaa taacatcatc tgtgggaaag agaaccagct
      181 tccttgtggt gactacacag caggttgttg tatggaagga ctaggaacca gcaggccacc
      241 gactacattt cgtatcagca cacatcatca gttctaagag tccatgttga tctcgcaagt
      301 agaaggattt aaaagagaaa ggttcccaca gaaaccaaga accttaccat ctcctttagc
      361 cctggagggt ggcggacaat ggatatcata gagacagcaa aacttgaagg tcacttggaa
      421 agtcaaacca acgactccac caacacttac acaagcccca ccgaagctgt agaggaagag
      481 ggcaaaaatg gcaagggcaa acccaagacc ttatccaacg ggttacgaaa gggtgccaaa
      541 aaatacccgg actacatcca gatttccatg cccaacgact ccaagaacaa gtttcccctg
      601 gagtggtgga aaacaggcat cgcctttgtg tatgcgctct tcaacctcat cctgacaacc
      661 gtcatgatca ccgtcgtgca cgagagggtc cctcccaagg agctcagccc tccgctccca
      721 gacaagtttt ttgattactt cgaccgggtc aaatgggcat tttctgtatc agaaataaac
      781 gggatggtat tggttgggtt atggatcacc cagtggctct ttctgcgtta caagtcaata
      841 gtggggcgca gattcttctt catcatggga actttatacc tgtatcgctg tataactatg
      901 tatgtcacta cgttacctgt gcccggaatg cacttccagt gtgctcccaa gctcaatgga
      961 gactctcagg caaaaataca gcggattctc cggctgattt ctggcggggg actgtctatc
     1021 acgggatctc acatcctgtg cggagacttc ctcttcagcg gccacactgt cgtgctcaca
     1081 cttacttact tgttcatcaa agaatattca cctcgtcact tctggtggta tcacttggtc
     1141 tgctggctgc tgagtgcggc tgggatcatc tgcattctcg tagcgcatga acactatacc
     1201 gtggacgtca tcattgctta ctatatcaca acacggctgt tttggtggta ccattccatg
     1261 gccaacgaaa agaacttgaa ggtctcttcc cagacgaact tcttgtctcg ggcttggtgg
     1321 ttccccatct tctacttttt tgagaagaat gtgcaaggct caattccttg ctgcttttcc
     1381 tggccgctgt cctggccccc tggctgcttc aagtcatcgt gcagaaagta ttcccgggtc
     1441 cagaagatcg gggaggataa tgagaagtct acctgagctg ccaacccggc agccgctctc
     1501 acaccaaaag agtccgtgct gcaaccgaag gcacgtgcgg ctttatattt attttcagag
     1561 aactgactgg taaaatgaag tggaccaaat tttatgcaaa agattggagc gatgaagtat
     1621 tacctttggc ttttttttat tcatcccaag aaacatatat tttcctgcag ctcttcgttc
     1681 attgatgaca aagcccccac actggagttc tgaagaggtg gcaaagaaca cgccgagcct
     1741 ctcctcgcct tccttcactt ccacgttctt tccagattgc tttttttctc ccttcaaggt
     1801 cagaagagtt tgctaacgtt ttgaataaaa tgtctggata tatacagcca ctgtgtaaat
     1861 acagtcagtt gatggcagtg ggttttcacc acagagctta gtaaggggca gcctgcaggt
     1921 ggggcaaggt cattagggtg atgtctggtg tcccctcccc tcccccgcca cccattatgc
     1981 atgactttta ctctttttgg gggagggggg ttggcttttg gtttttcaag acagggtttc
     2041 tctgtgtagc cttggctgtc ctggaactca ctctgaagac cacacccggc ctcttttttt
     2101 tttttttttt taaacctggt aattttagtt tttaaagaaa gagtattgca aggtcatgtg
     2161 aaagagacac acccatggat attttttccc tgtgtgggga tttttccact ttcaagtgtc
     2221 cgtggcagat aaccggcagg ctccgggctt ttcctgctat acccgttaga tgctgcctgc
     2281 cgggagccca aggcttgtta accgcaccag cacaggctga aaccagtgtg aacagatgct
     2341 cacactggag agcaagcttg tgctctctgc tagcttgggc cctgccgtgc catgccgtga
     2401 tgccgttact tattggaccc tagagaaaca tttgggcaca ttccatgaaa acagcttctt
     2461 tttattttaa tatcgtgtgt ctcgggaatg caagatggat cccaaaggtt ttactgtttc
     2521 cctgcctttt agcaagaccc ccccccccag cgctccttag ggcgtgcacc accgctgagc
     2581 aactcacttc accctgtgca cataacacgc ggtgctgccc ttgaacatgt ccctggcatc
     2641 agctcttaac ctcagccatg taggaatgag ggacaactgt tatctcatgt gaaaagatgg
     2701 gtctctaaga tctggtgggt ttaagaacat cggactcagt tagaaggtta ctcagtgctg
     2761 ggatatcata gtccttgcct ttggttgaga tctactgaaa gattagtttg tggaacttgt
     2821 agaaaaactt ctaaggattc acagcatggg agcagccagt ggaaggggtg gttacattct
     2881 catgggtatg gcatagagaa catccctggg ttcgtccctg taagctagtc ggccttgatt
     2941 gtttaaaatt aaactttaaa ttgcttggga gaaaaaaaaa agcacaatac agatgtgttc
     3001 agaagggcca ttgtcttctg gtgctataat tctgtgtgtg tgtttcagag ggtctcgttt
     3061 tctgtgttac tgggtgggta aaggatagga tgctaaaccc aaagacacga gcataaaaat
     3121 ctaagtctga ctatcctcac aagagcagag accctaagtg tctttggcag actttgaaat
     3181 gcagggactt ttttttttca agtattttta tcgagtaagc caataataaa ttcataccca
     3241 gtttaccttg tactagacaa ttcggtacaa ctcctcacgt gttcatttcc tcagctctgt
     3301 ggaaagctct gctccgaaca ctagtttacc ttcagggtct gattatgaga gaatcatttg
     3361 gcgctgaagc ctggcctttg ctctgcgagt ctctcactga aacaaaacac tgaaacaaaa
     3421 cacctgaaaa gccttatcca gcctggctag gattctccat gattcttcaa ccgaggaaaa
     3481 tgcttagaca ttgttacatt tcatgttgat tgttgggaac ccttcaaaca gaaaactttg
     3541 catttagtca ggtaaaccag gctgttggaa acaataccat cactttctta aggtttgaaa
     3601 atacccatga gccctgtgtg gaccctgctg ttccctgttc ttgtagtagc tgtgattcct
     3661 aataggtacc gatggggatg caagatgaca actcattgca gtgcaggaaa gtaagacttc
     3721 ctttaagatg gtctcatctc actgtgtagc ccagattggc ctccaacctt cagccctcct
     3781 gtatcagccc cctgggtgct gggattgcag gtgtgtttcc atgcctaccc aggcacagca
     3841 ggacatggta ccagcacctt ttctttgccc attaagatgc agattttacc cattaagtgt
     3901 gggtaaggcg caagcgggcg cctgtgctcc tgttggaagg ttttccccat aatatagagc
     3961 ttctggaaaa cgtccacaaa tatagaacac acatgttttt cctgaacctt cccaatggga
     4021 ctggagttct ctgagactcc gggtttgagc tcctccacta gatcgggaaa aggaggtatc
     4081 cttcccccag tgacccctga gctaattttg actgtctttt gggttgctgt catcacagga
     4141 agcagctttt tgctggggac acaaggttgg ctgagagtca gctcttgcaa tccctgggca
     4201 ggtttgtggc catccatccc ttgctgtgtt gccagcgccc ccttgtggtg atatgtcatg
     4261 tctgaaatcc aaatgccact ttaaaaatat attttcaagg tttctctaaa gtttatctgt
     4321 tgggcctttt gttgttgctg ttttcagggt tttttgccaa aagttgaaat tcccatggga
     4381 aaggagctat tttaaagaca ttcttatcct tcccaaaggg aaagttctca gaatttgagt
     4441 caaagaaagt tgaaggtcac atttacctct tatgtcacaa tcattcgtgt ctggcccata
     4501 gctacagact ttgtttactt caaaacccaa agtcagctgt ctcattttta tttatgtgcc
     4561 agaactcatc atttcacttg taattgaaag gtcttacctt gttccataaa atattttaaa
     4621 ctctttgtta aatgttttga ttttatacta taaaactgat ttaaaaatta agccagtctt
     4681 aacacactca ccctgtctgt agtgtaagga agtgtgagaa ggaagttctt ttttattgtt
     4741 tgtttgtttg tttgtttgtt tgtttgagac agggtttctt tgtgtagccc tggctgtcct
     4801 ggaactcacg cagtagacca ggctggcctt gaactcagaa atccgcctgc ctctgcctct
     4861 gcctctgcct cctgaatgct aggattaaag gcatatgcca ccaccgcctg acgagaagga
     4921 atttcttaat aaatgagttt acatgtctaa atcaagtgta agttatatgc gttgtgttgg
     4981 aaccttttct acgtttatgt ataaagattt cttatattat tatttttaat gccattgcgt
     5041 tgcaataatt tagctcctga ctcatttgac aaaaatacat cttttatgaa gaagtactct
     5101 tgactttgat atctgtacac tgaaaatcat gtcagaagta cccaaagata agtttttata
     5161 cagatagacg cttcgtaagc gctggcttgt tacccactaa ctaactgtac tgtgttctca
     5221 atgaatcatg aaagacaaga gtgggtcact gtagaattat tttaaactgt cctttaaaag
     5281 agaagaaact ataagctaat ctagttgcca agtaggaatt ccttatttaa tttacctcct
     5341 atgcaatgat taatgctgcg aaatgtatgg ttaataagtt acagtatatt cacagaagaa
     5401 atatctttcc aaggtgtaag aagcagccag ttgcattctt ttggaaattt actatactgt
     5461 ttcaatgtgt taagtgcctt gttgtaaagt aaaattttaa gtctcgagtt cattattttc
     5521 ctgacctata tttttcatta tgattatcta ctgtgtgctg ttgtaatcat tttattaaat
     5581 gcttacattt taatcaaa
//
