LOCUS       NM_177547               5410 bp    mRNA    linear   ROD 03-SEP-2024
DEFINITION  Mus musculus serum/glucocorticoid regulated kinase 3 (Sgk3),
            transcript variant 2, mRNA.
ACCESSION   NM_177547
VERSION     NM_177547.3
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5410)
  AUTHORS   Ren,J., Che,Y., Li,H., Gao,H., Wang,Y., Wang,Y., Su,H., Li,Z.,
            Li,J. and Qu,P.
  TITLE     SGK3 deficiency in macrophages suppresses angiotensin II-induced
            cardiac remodeling via regulating Ndufa13-mediated mitochondrial
            oxidative stress
  JOURNAL   Cell Mol Life Sci 81 (1), 359 (2024)
   PUBMED   39158709
  REMARK    GeneRIF: SGK3 deficiency in macrophages suppresses angiotensin
            II-induced cardiac remodeling via regulating Ndufa13-mediated
            mitochondrial oxidative stress.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5410)
  AUTHORS   Dong,Q.Q., Tu,Y.C., Gao,P., Liao,Q.Q., Zhou,P., Zhang,H., Shu,H.P.,
            Sun,L.L., Feng,L. and Yao,L.J.
  TITLE     SGK3 promotes vascular calcification via Pit-1 in chronic kidney
            disease
  JOURNAL   Theranostics 14 (2), 861-878 (2024)
   PUBMED   38169564
  REMARK    GeneRIF: SGK3 promotes vascular calcification via Pit-1 in chronic
            kidney disease.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5410)
  AUTHORS   Cui,Y., Liu,R., Hong,Y., Wang,Y., Zhu,Y., Wen,T., Lu,J., Mao,S.,
            Wang,X., Pan,J. and Luo,Y.
  TITLE     MicroRNA-92a-3p Regulates Retinal Angiogenesis by Targeting SGK3 in
            Vascular Endothelial Cells
  JOURNAL   Invest Ophthalmol Vis Sci 63 (11), 19 (2022)
   PUBMED   36269185
  REMARK    GeneRIF: MicroRNA-92a-3p Regulates Retinal Angiogenesis by
            Targeting SGK3 in Vascular Endothelial Cells.
REFERENCE   4  (bases 1 to 5410)
  AUTHORS   Sun,J., Yang,T., Wei,T., Zhou,L., Shan,T., Chen,J., Gu,L., Chen,B.,
            Liu,L., Jiang,Q., Du,C., Ma,Y., Wang,H., Chen,F., Guo,X., Ji,Y. and
            Wang,L.
  TITLE     CDK9 binds and activates SGK3 to promote cardiac repair after
            injury via the GSK-3beta/beta-catenin pathway
  JOURNAL   Front Cardiovasc Med 9, 970745 (2022)
   PUBMED   36082129
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5410)
  AUTHORS   Ahuja,N., Hiltabidle,M.S., Rajasekhar,H., Voss,S., Lu,S.Z.,
            Barlow,H.R., Cowdin,M.A., Daniel,E., Vaddaraju,V., Anandakumar,T.,
            Black,E., Cleaver,O. and Maynard,C.
  TITLE     Endothelial Cyp26b1 restrains murine heart valve growth during
            development
  JOURNAL   Dev Biol 486, 81-95 (2022)
   PUBMED   35364055
REFERENCE   6  (bases 1 to 5410)
  AUTHORS   Hogan,M.E., King,L.E. Jr. and Sundberg,J.P.
  TITLE     Defects of pelage hairs in 20 mouse mutations
  JOURNAL   J Invest Dermatol 104 (5 Suppl), 31S-32S (1995)
   PUBMED   7738386
REFERENCE   7  (bases 1 to 5410)
  AUTHORS   Borodin,P.M., Gorlov,I.P. and Ladygina,T.Yu.
  TITLE     Double insertion of homogeneously staining regions in chromosome 1
            of wild Mus musculus musculus: effects on chromosome pairing and
            recombination
  JOURNAL   J Hered 81 (2), 91-95 (1990)
   PUBMED   2159965
REFERENCE   8  (bases 1 to 5410)
  AUTHORS   Novak,E.K., Hui,S.W. and Swank,R.T.
  TITLE     Platelet storage pool deficiency in mouse pigment mutations
            associated with seven distinct genetic loci
  JOURNAL   Blood 63 (3), 536-544 (1984)
   PUBMED   6696991
REFERENCE   9  (bases 1 to 5410)
  AUTHORS   Taylor,B.A. and O'Brien,A.D.
  TITLE     Position on mouse chromosome 1 of a gene that controls resistance
            to Salmonella typhimurium
  JOURNAL   Infect Immun 36 (3), 1257-1260 (1982)
   PUBMED   7047397
REFERENCE   10 (bases 1 to 5410)
  AUTHORS   Mayer,T.C., Mittelberger,J.A. and Green,M.C.
  TITLE     The site of action of the fuzzy locus (fz) in the mouse, as
            determined by dermal-epidermal recombinations
  JOURNAL   J Embryol Exp Morphol 32 (3), 707-713 (1974)
   PUBMED   4618567
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB856423.1, AK031133.1, AC158928.6 and AC102570.8.
            
            On Dec 15, 2005 this sequence version replaced NM_177547.2.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1, 2 and 3 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK171678.1, AK171120.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-117               BB856423.1         25-141
            118-2466            AK031133.1         206-2554
            2467-4236           AC158928.6         1-1770              c
            4237-5410           AC102570.8         193198-194371       c
FEATURES             Location/Qualifiers
     source          1..5410
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 2.08 cM"
     gene            1..5410
                     /gene="Sgk3"
                     /gene_synonym="2510015P22Rik; A330005P07Rik; Cisk; fy; fz"
                     /note="serum/glucocorticoid regulated kinase 3"
                     /db_xref="GeneID:170755"
                     /db_xref="MGI:MGI:2182368"
     exon            1..117
                     /gene="Sgk3"
                     /gene_synonym="2510015P22Rik; A330005P07Rik; Cisk; fy; fz"
                     /inference="alignment:Splign:2.1.0"
     exon            118..335
                     /gene="Sgk3"
                     /gene_synonym="2510015P22Rik; A330005P07Rik; Cisk; fy; fz"
                     /inference="alignment:Splign:2.1.0"
     CDS             240..1730
                     /gene="Sgk3"
                     /gene_synonym="2510015P22Rik; A330005P07Rik; Cisk; fy; fz"
                     /EC_number="2.7.11.1"
                     /note="cytokine-independent survival kinase"
                     /codon_start=1
                     /product="serine/threonine-protein kinase Sgk3"
                     /protein_id="NP_808215.2"
                     /db_xref="CCDS:CCDS14816.1"
                     /db_xref="GeneID:170755"
                     /db_xref="MGI:MGI:2182368"
                     /translation="MQRDCIMDYKESCPSVSIPSSDEHREKKKRFTVYKVLVSVGRSE
                     WFVFRRYAEFDKLYNSLKKQFPAMALKIPAKRIFGDNFDPDFIKQRRAGLNEFIQNLV
                     RYPELYNHPDVRAFLQMDSPRHQSDPSEDEDERSTSKPHSTSRNINLGPTGNPHAKPT
                     DFDFLKVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNV
                     KHPFLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEPRARFYAAEIASALGY
                     LHSIKIVYRDLKPENILLDSMGHVVLTDFGLCKEGIAISDTTTTFCGTPEYLAPEVIR
                     KQPYDNTVDWWCLGAVLYEMLYGLPPFYCRDVAEMYDNILHKPLNLRPGVSLTAWSIL
                     EELLEKNRQNRLGAKEDFLEIQNHPFFESLSWTDLVQKKIPPPFNPNVAGPDDIRNFD
                     AVFTEETVPYSVCVSSDYSIVNASVLEADDAFVGFSYAPPSEDLFL"
     exon            336..419
                     /gene="Sgk3"
                     /gene_synonym="2510015P22Rik; A330005P07Rik; Cisk; fy; fz"
                     /inference="alignment:Splign:2.1.0"
     exon            420..492
                     /gene="Sgk3"
                     /gene_synonym="2510015P22Rik; A330005P07Rik; Cisk; fy; fz"
                     /inference="alignment:Splign:2.1.0"
     exon            493..568
                     /gene="Sgk3"
                     /gene_synonym="2510015P22Rik; A330005P07Rik; Cisk; fy; fz"
                     /inference="alignment:Splign:2.1.0"
     exon            569..656
                     /gene="Sgk3"
                     /gene_synonym="2510015P22Rik; A330005P07Rik; Cisk; fy; fz"
                     /inference="alignment:Splign:2.1.0"
     exon            657..706
                     /gene="Sgk3"
                     /gene_synonym="2510015P22Rik; A330005P07Rik; Cisk; fy; fz"
                     /inference="alignment:Splign:2.1.0"
     exon            707..764
                     /gene="Sgk3"
                     /gene_synonym="2510015P22Rik; A330005P07Rik; Cisk; fy; fz"
                     /inference="alignment:Splign:2.1.0"
     exon            765..848
                     /gene="Sgk3"
                     /gene_synonym="2510015P22Rik; A330005P07Rik; Cisk; fy; fz"
                     /inference="alignment:Splign:2.1.0"
     exon            849..980
                     /gene="Sgk3"
                     /gene_synonym="2510015P22Rik; A330005P07Rik; Cisk; fy; fz"
                     /inference="alignment:Splign:2.1.0"
     exon            981..1093
                     /gene="Sgk3"
                     /gene_synonym="2510015P22Rik; A330005P07Rik; Cisk; fy; fz"
                     /inference="alignment:Splign:2.1.0"
     exon            1094..1130
                     /gene="Sgk3"
                     /gene_synonym="2510015P22Rik; A330005P07Rik; Cisk; fy; fz"
                     /inference="alignment:Splign:2.1.0"
     exon            1131..1217
                     /gene="Sgk3"
                     /gene_synonym="2510015P22Rik; A330005P07Rik; Cisk; fy; fz"
                     /inference="alignment:Splign:2.1.0"
     exon            1218..1313
                     /gene="Sgk3"
                     /gene_synonym="2510015P22Rik; A330005P07Rik; Cisk; fy; fz"
                     /inference="alignment:Splign:2.1.0"
     exon            1314..1469
                     /gene="Sgk3"
                     /gene_synonym="2510015P22Rik; A330005P07Rik; Cisk; fy; fz"
                     /inference="alignment:Splign:2.1.0"
     exon            1470..1559
                     /gene="Sgk3"
                     /gene_synonym="2510015P22Rik; A330005P07Rik; Cisk; fy; fz"
                     /inference="alignment:Splign:2.1.0"
     exon            1560..5410
                     /gene="Sgk3"
                     /gene_synonym="2510015P22Rik; A330005P07Rik; Cisk; fy; fz"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3665..3670
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sgk3"
                     /gene_synonym="2510015P22Rik; A330005P07Rik; Cisk; fy; fz"
                     /note="hexamer: ATTAAA"
     regulatory      3669..3674
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sgk3"
                     /gene_synonym="2510015P22Rik; A330005P07Rik; Cisk; fy; fz"
                     /note="hexamer: AATATA"
     polyA_site      3682
                     /gene="Sgk3"
                     /gene_synonym="2510015P22Rik; A330005P07Rik; Cisk; fy; fz"
     polyA_site      3685
                     /gene="Sgk3"
                     /gene_synonym="2510015P22Rik; A330005P07Rik; Cisk; fy; fz"
                     /note="major polyA site"
     regulatory      5305..5310
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sgk3"
                     /gene_synonym="2510015P22Rik; A330005P07Rik; Cisk; fy; fz"
                     /note="hexamer: ATTAAA"
     polyA_site      5335
                     /gene="Sgk3"
                     /gene_synonym="2510015P22Rik; A330005P07Rik; Cisk; fy; fz"
ORIGIN      
        1 gaggagccgc cgtgacgcgt cagggaggaa acgccggcgc ccggccgcgc cgccgggaag
       61 aagaaactgc cagcgctctg ggctccgcgc ccgggcgccc ggacgccgca cagccgggtt
      121 ccatgatgga gtttgaacat tacctcaaga ggtttcatat tttggatttg tgaattatat
      181 ttaccctctg ctgagaactt tgaaacttca gactcaattt ctgtccttca agacattaaa
      241 tgcagaggga ttgtatcatg gactacaagg agagctgccc aagtgtaagc attcccagct
      301 ctgacgaaca cagagagaaa aagaagaggt tcacggttta taaagttctg gtctctgtgg
      361 gcagaagcga gtggtttgtc ttcaggagat acgcagagtt tgacaaactt tacaattctt
      421 taaagaagca gtttcctgct atggctctga agattcctgc caagagaata tttggtgata
      481 attttgatcc agattttatt aaacaaagaa gagcaggatt gaatgagttc attcagaact
      541 tggtcagata tccagagctt tacaaccatc cagatgtccg agcattcctt caaatggaca
      601 gcccaagaca tcagtcagat ccatctgaag atgaggatga aagaagtact tcgaagccac
      661 attctacctc acggaacatc aacctgggac caactggaaa tcctcatgct aaaccaactg
      721 acttcgattt tttaaaagtt attggaaagg gcagctttgg caaggttctt cttgcaaaac
      781 ggaaactgga tggaaaattt tatgctgtca aagtgttaca gaaaaaaata gttctcaaca
      841 gaaaagagca aaaacatatt atggctgaac gcaatgtgct cttgaaaaat gtgaagcacc
      901 catttttggt tggattgcac tattctttcc aaacaactga aaagctttat tttgttctgg
      961 attttgttaa tggaggggag ctcttctttc acctccaaag ggaaaggtct tttcctgaac
     1021 ccagagcgag gttttatgcc gcggagatcg ccagtgcctt gggctacctg cactccatca
     1081 aaatagtgta cagagacttg aagccagaaa atattctttt ggattcaatg ggacatgttg
     1141 tcttaacgga ttttggactt tgcaaagaag gaatcgctat ttctgatacc accacaactt
     1201 tttgtggtac accagagtac cttgcacctg aagtaatcag aaaacagccc tatgacaaca
     1261 ctgtggactg gtggtgcctg ggcgctgttc tgtatgagat gctgtacggg ctgcctcctt
     1321 tttactgccg agatgttgct gaaatgtatg acaatattct tcacaagccc ttaaacttga
     1381 gaccaggagt gagtctcacc gcctggtcca ttctggaaga acttctagaa aaaaacagac
     1441 aaaatcgact tggtgccaaa gaagactttc ttgaaatcca gaatcatcct ttttttgagt
     1501 cactcagctg gactgacctc gtacaaaaaa agattccacc tccatttaac cctaatgtgg
     1561 ctggaccaga tgatatcaga aactttgatg ccgtcttcac tgaagaaacg gttccctatt
     1621 cagtgtgtgt gtcttctgac tattccatcg tgaatgccag tgttctggag gcagatgatg
     1681 catttgttgg tttttcttac gcccctcctt cggaagactt atttttgtga acactttgac
     1741 attcagaaac caatgaacaa cctctagctt gcagaagaaa tggaaacacc tatttgcgtg
     1801 aatatattca actatgtata acagtgcctc atttttatat gtaatagtga aaactaagaa
     1861 atacgtattt tctgctgtat gcaagaaata gggcatttca aagagctaag ttttgaactg
     1921 aaatttgtat tcttgtttat taagcttatt tttaaacaaa aatttgaagc tattcttagc
     1981 attaacctat ttttaaaaat aactttttgc tattgactgt tttttttttc ctgttaagtt
     2041 tacactaaca catccaaggt agacttttac tagtctgtta cagttaagat aagatgtatt
     2101 actatcttta taattctatg acttttttat catagcagaa ctatgcaggt tggtttatga
     2161 tggtacagga tggtttatga tgaaacccta tcttcccatg ataaatcact atttgcttag
     2221 taggattaaa atgcaagggc agatgaagca cactggctgc tagtggacga ctgcagccac
     2281 tcacctgcag ccccagaaga caaggaaaag gcaggcattt gctttgaaat gctcagtccc
     2341 catccatgca ccattttttt ctctagagga aaagaaaata tttaatggcc agaatttttt
     2401 agaattccta acgaactgag aagtgtaata aaatgctacc agatgttttt ttaaggtggt
     2461 acccaccata atgtctctgt cacatattta tattacaaat gttttctatt tatgttcctt
     2521 tgactctttg aagggttagt gtattgttga gcaggtctaa accttggtgt ctggttttgc
     2581 aaatagctat ttcaaaactg ccttcctaat tgattgtgtt tttaaaatga cagaaaaaag
     2641 tagccttcta taatgtttac ctagttgtga attaaataat aaaatggcaa gtctgggttg
     2701 gtgtgaatgt gtgtcaccta cacattctaa cagaaggtaa caataagtta gcagtgacat
     2761 attcagtatt actcattttg tagtgccagg gatcagacat gcacaaggcc tcatgaatgc
     2821 taataagagt tctccttttc tctgaagtac acacatgtct cttggtgtct ttatgtgtct
     2881 tagaaatcgt ccagaaaact gtgaaattac gtgtcagtta attcctgtgt tcataatggt
     2941 aaaatgtgtt aggcacagag aagctatttt gaaagggtgc ttcttgggac tccagttcct
     3001 ggaggacagt ttcccaggtc ctttagggga cactagcatg agcttattag ctgcactaaa
     3061 agcaaacatc ccttgtacgt gttaccttga caaatgagaa gtatttctcg tccatacctt
     3121 ttggcttaaa tatgttcagc agaatgggac tagaccgtgc ttcagtttga caggtagtct
     3181 ttgaatgcat gcagtacact ggacctccct cacaggtgag atgttacgtc tacactgtac
     3241 tataatttga tccagggtac tgctctactt taatacagag ttacttgttg attataaatc
     3301 aagacaaaaa ttgtacatac atgattttta ttctaatatc ccttaattaa attgccaaaa
     3361 attaaagtgc aatattgtat ttttaagaac acattttaga tttttgttgt ttcttggatc
     3421 acataaaatt aggaaaagat taatgatcga catctaattt ctattgttat tttaaattta
     3481 attagtaatg gttatagtag taactactca aatgagttat ttttgtgtgg gaaaaaggta
     3541 tacaactttg tgaaaatact taagtagaat gaattaccaa gttattttat actgacaaat
     3601 atatgggttg ggaaaaaatt ctaattttca agtttaattt ttctcctaaa ctgttaagtc
     3661 ttttattaaa tatatgcctt ttgaacagtt ggactatttc atgctaacta ccaaaataat
     3721 ctccaaggtt gtttaggaag tcagctctct gcctgttggt tttggtttta gagatacctc
     3781 tcaatgtggc ccagcctggc ttcaaacgcc ggatcttctt accatagcgt cctcaaccta
     3841 ggattacggc ttgttattta caacttgttg aagtcgtttt tttagccatt gacctctaaa
     3901 ggtaatagtt acttccttgc tttgtcacag actacagggt gagtagaggt ttgtttttta
     3961 ggaagagcct ctttagagct ggggtttcct gctggagcct ggtaaggtgg tagaagaggc
     4021 ttttagtttc ctccggggct atctccagta accacctcgt ggcacacaca gcctgtggtt
     4081 ccagcaagca catggtgcac atacatgcag agactcacat atacacacaa aaggaaagta
     4141 agcacatttt tttcaagtat ttgggctctt tgctactttc catatgtact caattgatac
     4201 taggaaaaat tgttctcagc ttcagtgata gaattccagt taaagatctg ttgtgtttat
     4261 ttcacatttt tagtatggca acttgtgtca ctgttcattt gcaatctttt aaacacatct
     4321 tagtgtgtgg tcgggcctac atacaaatca tctttcagga tgggcacgat ggctcaccag
     4381 gacacttgcc accaacgctg attaccagag ttcaatccct gagacccaca tagtagaaga
     4441 gaaccagcat ccataaattg tcctctgacc actgtgggca ccctcataca caaatgtaat
     4501 ttttggaaac tttttttgta tttttttgtt tgtttgcttt ccgagacagg gtttctctgt
     4561 atagccccga ctgtcctgga actcactctg tagaccatgc tggcctcgaa ctcagaaatc
     4621 tgtctgcctc tgcctcccaa gtgctgggat taaaggcgtg cgccaccact gcccggctac
     4681 attctttggt tcttaaatgt ctagtttttc acacagtaaa tgaactgaga aagaaaaaaa
     4741 aatgctgtgc tgtgttcaga tacacgtttt gaaaatttaa tcagaagctg cccctgctag
     4801 ggagtcacaa tgggcagcaa gatggcttct gccaccaggg tcgtgcaggt agtgaagcca
     4861 cacgctccct aacagaagag acaaacctaa actcagagtc tccgaagctc tggggtctgc
     4921 gctcccctcc cactcctctg tcgtttcaca gcattctaaa ggaagtatgt ccccagattt
     4981 actgatgcac caggggcccc cagacactgc agaaatgata aaaatcatta cctcagaaat
     5041 acagaagaaa tcctgtaact caacaggaaa tggaatttat ccagcgtggg ggtccagagt
     5101 gatcatgtgg ctgctgcttg tcaccagaca gaagaattag ctttgcaata aaggacttcc
     5161 acaaagtcaa atgaaaagtc atacattaaa caaccttaat aaatattctg taagcagaat
     5221 gaagtataga aaccccaggt ggtcacttgt atctcctacg ttgtgtatct tgctcagctg
     5281 ccccacaagc tgacctgtac acttattaaa gtctacattt ttaaatgcta gcctgttaac
     5341 ttaatcttga ttatgaaatg ttcccagaga tgagctatta aaagcacata gtatctaaag
     5401 aaaaagaaaa
//
