LOCUS       NM_133220               5517 bp    mRNA    linear   ROD 03-SEP-2024
DEFINITION  Mus musculus serum/glucocorticoid regulated kinase 3 (Sgk3),
            transcript variant 1, mRNA.
ACCESSION   NM_133220
VERSION     NM_133220.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5517)
  AUTHORS   Ren,J., Che,Y., Li,H., Gao,H., Wang,Y., Wang,Y., Su,H., Li,Z.,
            Li,J. and Qu,P.
  TITLE     SGK3 deficiency in macrophages suppresses angiotensin II-induced
            cardiac remodeling via regulating Ndufa13-mediated mitochondrial
            oxidative stress
  JOURNAL   Cell Mol Life Sci 81 (1), 359 (2024)
   PUBMED   39158709
  REMARK    GeneRIF: SGK3 deficiency in macrophages suppresses angiotensin
            II-induced cardiac remodeling via regulating Ndufa13-mediated
            mitochondrial oxidative stress.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5517)
  AUTHORS   Dong,Q.Q., Tu,Y.C., Gao,P., Liao,Q.Q., Zhou,P., Zhang,H., Shu,H.P.,
            Sun,L.L., Feng,L. and Yao,L.J.
  TITLE     SGK3 promotes vascular calcification via Pit-1 in chronic kidney
            disease
  JOURNAL   Theranostics 14 (2), 861-878 (2024)
   PUBMED   38169564
  REMARK    GeneRIF: SGK3 promotes vascular calcification via Pit-1 in chronic
            kidney disease.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5517)
  AUTHORS   Cui,Y., Liu,R., Hong,Y., Wang,Y., Zhu,Y., Wen,T., Lu,J., Mao,S.,
            Wang,X., Pan,J. and Luo,Y.
  TITLE     MicroRNA-92a-3p Regulates Retinal Angiogenesis by Targeting SGK3 in
            Vascular Endothelial Cells
  JOURNAL   Invest Ophthalmol Vis Sci 63 (11), 19 (2022)
   PUBMED   36269185
  REMARK    GeneRIF: MicroRNA-92a-3p Regulates Retinal Angiogenesis by
            Targeting SGK3 in Vascular Endothelial Cells.
REFERENCE   4  (bases 1 to 5517)
  AUTHORS   Sun,J., Yang,T., Wei,T., Zhou,L., Shan,T., Chen,J., Gu,L., Chen,B.,
            Liu,L., Jiang,Q., Du,C., Ma,Y., Wang,H., Chen,F., Guo,X., Ji,Y. and
            Wang,L.
  TITLE     CDK9 binds and activates SGK3 to promote cardiac repair after
            injury via the GSK-3beta/beta-catenin pathway
  JOURNAL   Front Cardiovasc Med 9, 970745 (2022)
   PUBMED   36082129
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5517)
  AUTHORS   Ahuja,N., Hiltabidle,M.S., Rajasekhar,H., Voss,S., Lu,S.Z.,
            Barlow,H.R., Cowdin,M.A., Daniel,E., Vaddaraju,V., Anandakumar,T.,
            Black,E., Cleaver,O. and Maynard,C.
  TITLE     Endothelial Cyp26b1 restrains murine heart valve growth during
            development
  JOURNAL   Dev Biol 486, 81-95 (2022)
   PUBMED   35364055
REFERENCE   6  (bases 1 to 5517)
  AUTHORS   Hogan,M.E., King,L.E. Jr. and Sundberg,J.P.
  TITLE     Defects of pelage hairs in 20 mouse mutations
  JOURNAL   J Invest Dermatol 104 (5 Suppl), 31S-32S (1995)
   PUBMED   7738386
REFERENCE   7  (bases 1 to 5517)
  AUTHORS   Borodin,P.M., Gorlov,I.P. and Ladygina,T.Yu.
  TITLE     Double insertion of homogeneously staining regions in chromosome 1
            of wild Mus musculus musculus: effects on chromosome pairing and
            recombination
  JOURNAL   J Hered 81 (2), 91-95 (1990)
   PUBMED   2159965
REFERENCE   8  (bases 1 to 5517)
  AUTHORS   Novak,E.K., Hui,S.W. and Swank,R.T.
  TITLE     Platelet storage pool deficiency in mouse pigment mutations
            associated with seven distinct genetic loci
  JOURNAL   Blood 63 (3), 536-544 (1984)
   PUBMED   6696991
REFERENCE   9  (bases 1 to 5517)
  AUTHORS   Taylor,B.A. and O'Brien,A.D.
  TITLE     Position on mouse chromosome 1 of a gene that controls resistance
            to Salmonella typhimurium
  JOURNAL   Infect Immun 36 (3), 1257-1260 (1982)
   PUBMED   7047397
REFERENCE   10 (bases 1 to 5517)
  AUTHORS   Mayer,T.C., Mittelberger,J.A. and Green,M.C.
  TITLE     The site of action of the fuzzy locus (fz) in the mouse, as
            determined by dermal-epidermal recombinations
  JOURNAL   J Embryol Exp Morphol 32 (3), 707-713 (1974)
   PUBMED   4618567
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB856423.1, AK031133.1, AC158928.6 and AC102570.8.
            
            On Dec 15, 2005 this sequence version replaced NM_133220.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript. Variants 1, 2 and 3 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660821.165044.1,
                                           SRR1660811.140604.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-117               BB856423.1         25-141
            118-2573            AK031133.1         99-2554
            2574-4343           AC158928.6         1-1770              c
            4344-5517           AC102570.8         193198-194371       c
FEATURES             Location/Qualifiers
     source          1..5517
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 2.08 cM"
     gene            1..5517
                     /gene="Sgk3"
                     /gene_synonym="2510015P22Rik; A330005P07Rik; Cisk; fy; fz"
                     /note="serum/glucocorticoid regulated kinase 3"
                     /db_xref="GeneID:170755"
                     /db_xref="MGI:MGI:2182368"
     exon            1..117
                     /gene="Sgk3"
                     /gene_synonym="2510015P22Rik; A330005P07Rik; Cisk; fy; fz"
                     /inference="alignment:Splign:2.1.0"
     exon            118..224
                     /gene="Sgk3"
                     /gene_synonym="2510015P22Rik; A330005P07Rik; Cisk; fy; fz"
                     /inference="alignment:Splign:2.1.0"
     exon            225..442
                     /gene="Sgk3"
                     /gene_synonym="2510015P22Rik; A330005P07Rik; Cisk; fy; fz"
                     /inference="alignment:Splign:2.1.0"
     CDS             347..1837
                     /gene="Sgk3"
                     /gene_synonym="2510015P22Rik; A330005P07Rik; Cisk; fy; fz"
                     /EC_number="2.7.11.1"
                     /note="cytokine-independent survival kinase"
                     /codon_start=1
                     /product="serine/threonine-protein kinase Sgk3"
                     /protein_id="NP_573483.1"
                     /db_xref="CCDS:CCDS14816.1"
                     /db_xref="GeneID:170755"
                     /db_xref="MGI:MGI:2182368"
                     /translation="MQRDCIMDYKESCPSVSIPSSDEHREKKKRFTVYKVLVSVGRSE
                     WFVFRRYAEFDKLYNSLKKQFPAMALKIPAKRIFGDNFDPDFIKQRRAGLNEFIQNLV
                     RYPELYNHPDVRAFLQMDSPRHQSDPSEDEDERSTSKPHSTSRNINLGPTGNPHAKPT
                     DFDFLKVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNV
                     KHPFLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEPRARFYAAEIASALGY
                     LHSIKIVYRDLKPENILLDSMGHVVLTDFGLCKEGIAISDTTTTFCGTPEYLAPEVIR
                     KQPYDNTVDWWCLGAVLYEMLYGLPPFYCRDVAEMYDNILHKPLNLRPGVSLTAWSIL
                     EELLEKNRQNRLGAKEDFLEIQNHPFFESLSWTDLVQKKIPPPFNPNVAGPDDIRNFD
                     AVFTEETVPYSVCVSSDYSIVNASVLEADDAFVGFSYAPPSEDLFL"
     exon            443..526
                     /gene="Sgk3"
                     /gene_synonym="2510015P22Rik; A330005P07Rik; Cisk; fy; fz"
                     /inference="alignment:Splign:2.1.0"
     exon            527..599
                     /gene="Sgk3"
                     /gene_synonym="2510015P22Rik; A330005P07Rik; Cisk; fy; fz"
                     /inference="alignment:Splign:2.1.0"
     exon            600..675
                     /gene="Sgk3"
                     /gene_synonym="2510015P22Rik; A330005P07Rik; Cisk; fy; fz"
                     /inference="alignment:Splign:2.1.0"
     exon            676..763
                     /gene="Sgk3"
                     /gene_synonym="2510015P22Rik; A330005P07Rik; Cisk; fy; fz"
                     /inference="alignment:Splign:2.1.0"
     exon            764..813
                     /gene="Sgk3"
                     /gene_synonym="2510015P22Rik; A330005P07Rik; Cisk; fy; fz"
                     /inference="alignment:Splign:2.1.0"
     exon            814..871
                     /gene="Sgk3"
                     /gene_synonym="2510015P22Rik; A330005P07Rik; Cisk; fy; fz"
                     /inference="alignment:Splign:2.1.0"
     exon            872..955
                     /gene="Sgk3"
                     /gene_synonym="2510015P22Rik; A330005P07Rik; Cisk; fy; fz"
                     /inference="alignment:Splign:2.1.0"
     exon            956..1087
                     /gene="Sgk3"
                     /gene_synonym="2510015P22Rik; A330005P07Rik; Cisk; fy; fz"
                     /inference="alignment:Splign:2.1.0"
     exon            1088..1200
                     /gene="Sgk3"
                     /gene_synonym="2510015P22Rik; A330005P07Rik; Cisk; fy; fz"
                     /inference="alignment:Splign:2.1.0"
     exon            1201..1237
                     /gene="Sgk3"
                     /gene_synonym="2510015P22Rik; A330005P07Rik; Cisk; fy; fz"
                     /inference="alignment:Splign:2.1.0"
     exon            1238..1324
                     /gene="Sgk3"
                     /gene_synonym="2510015P22Rik; A330005P07Rik; Cisk; fy; fz"
                     /inference="alignment:Splign:2.1.0"
     exon            1325..1420
                     /gene="Sgk3"
                     /gene_synonym="2510015P22Rik; A330005P07Rik; Cisk; fy; fz"
                     /inference="alignment:Splign:2.1.0"
     exon            1421..1576
                     /gene="Sgk3"
                     /gene_synonym="2510015P22Rik; A330005P07Rik; Cisk; fy; fz"
                     /inference="alignment:Splign:2.1.0"
     exon            1577..1666
                     /gene="Sgk3"
                     /gene_synonym="2510015P22Rik; A330005P07Rik; Cisk; fy; fz"
                     /inference="alignment:Splign:2.1.0"
     exon            1667..5517
                     /gene="Sgk3"
                     /gene_synonym="2510015P22Rik; A330005P07Rik; Cisk; fy; fz"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3772..3777
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sgk3"
                     /gene_synonym="2510015P22Rik; A330005P07Rik; Cisk; fy; fz"
                     /note="hexamer: ATTAAA"
     regulatory      3776..3781
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sgk3"
                     /gene_synonym="2510015P22Rik; A330005P07Rik; Cisk; fy; fz"
                     /note="hexamer: AATATA"
     polyA_site      3789
                     /gene="Sgk3"
                     /gene_synonym="2510015P22Rik; A330005P07Rik; Cisk; fy; fz"
     polyA_site      3792
                     /gene="Sgk3"
                     /gene_synonym="2510015P22Rik; A330005P07Rik; Cisk; fy; fz"
                     /note="major polyA site"
     regulatory      5412..5417
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sgk3"
                     /gene_synonym="2510015P22Rik; A330005P07Rik; Cisk; fy; fz"
                     /note="hexamer: ATTAAA"
     polyA_site      5442
                     /gene="Sgk3"
                     /gene_synonym="2510015P22Rik; A330005P07Rik; Cisk; fy; fz"
ORIGIN      
        1 gaggagccgc cgtgacgcgt cagggaggaa acgccggcgc ccggccgcgc cgccgggaag
       61 aagaaactgc cagcgctctg ggctccgcgc ccgggcgccc ggacgccgca cagccggtgc
      121 tggagactga attcagggct tcacaggagt gaataagcac tgtgccagtg agctttgttg
      181 ccagtcctgg aacactgttc ttcaccggca ggagagtgga aggggttcca tgatggagtt
      241 tgaacattac ctcaagaggt ttcatatttt ggatttgtga attatattta ccctctgctg
      301 agaactttga aacttcagac tcaatttctg tccttcaaga cattaaatgc agagggattg
      361 tatcatggac tacaaggaga gctgcccaag tgtaagcatt cccagctctg acgaacacag
      421 agagaaaaag aagaggttca cggtttataa agttctggtc tctgtgggca gaagcgagtg
      481 gtttgtcttc aggagatacg cagagtttga caaactttac aattctttaa agaagcagtt
      541 tcctgctatg gctctgaaga ttcctgccaa gagaatattt ggtgataatt ttgatccaga
      601 ttttattaaa caaagaagag caggattgaa tgagttcatt cagaacttgg tcagatatcc
      661 agagctttac aaccatccag atgtccgagc attccttcaa atggacagcc caagacatca
      721 gtcagatcca tctgaagatg aggatgaaag aagtacttcg aagccacatt ctacctcacg
      781 gaacatcaac ctgggaccaa ctggaaatcc tcatgctaaa ccaactgact tcgatttttt
      841 aaaagttatt ggaaagggca gctttggcaa ggttcttctt gcaaaacgga aactggatgg
      901 aaaattttat gctgtcaaag tgttacagaa aaaaatagtt ctcaacagaa aagagcaaaa
      961 acatattatg gctgaacgca atgtgctctt gaaaaatgtg aagcacccat ttttggttgg
     1021 attgcactat tctttccaaa caactgaaaa gctttatttt gttctggatt ttgttaatgg
     1081 aggggagctc ttctttcacc tccaaaggga aaggtctttt cctgaaccca gagcgaggtt
     1141 ttatgccgcg gagatcgcca gtgccttggg ctacctgcac tccatcaaaa tagtgtacag
     1201 agacttgaag ccagaaaata ttcttttgga ttcaatggga catgttgtct taacggattt
     1261 tggactttgc aaagaaggaa tcgctatttc tgataccacc acaacttttt gtggtacacc
     1321 agagtacctt gcacctgaag taatcagaaa acagccctat gacaacactg tggactggtg
     1381 gtgcctgggc gctgttctgt atgagatgct gtacgggctg cctccttttt actgccgaga
     1441 tgttgctgaa atgtatgaca atattcttca caagccctta aacttgagac caggagtgag
     1501 tctcaccgcc tggtccattc tggaagaact tctagaaaaa aacagacaaa atcgacttgg
     1561 tgccaaagaa gactttcttg aaatccagaa tcatcctttt tttgagtcac tcagctggac
     1621 tgacctcgta caaaaaaaga ttccacctcc atttaaccct aatgtggctg gaccagatga
     1681 tatcagaaac tttgatgccg tcttcactga agaaacggtt ccctattcag tgtgtgtgtc
     1741 ttctgactat tccatcgtga atgccagtgt tctggaggca gatgatgcat ttgttggttt
     1801 ttcttacgcc cctccttcgg aagacttatt tttgtgaaca ctttgacatt cagaaaccaa
     1861 tgaacaacct ctagcttgca gaagaaatgg aaacacctat ttgcgtgaat atattcaact
     1921 atgtataaca gtgcctcatt tttatatgta atagtgaaaa ctaagaaata cgtattttct
     1981 gctgtatgca agaaataggg catttcaaag agctaagttt tgaactgaaa tttgtattct
     2041 tgtttattaa gcttattttt aaacaaaaat ttgaagctat tcttagcatt aacctatttt
     2101 taaaaataac tttttgctat tgactgtttt ttttttcctg ttaagtttac actaacacat
     2161 ccaaggtaga cttttactag tctgttacag ttaagataag atgtattact atctttataa
     2221 ttctatgact tttttatcat agcagaacta tgcaggttgg tttatgatgg tacaggatgg
     2281 tttatgatga aaccctatct tcccatgata aatcactatt tgcttagtag gattaaaatg
     2341 caagggcaga tgaagcacac tggctgctag tggacgactg cagccactca cctgcagccc
     2401 cagaagacaa ggaaaaggca ggcatttgct ttgaaatgct cagtccccat ccatgcacca
     2461 tttttttctc tagaggaaaa gaaaatattt aatggccaga attttttaga attcctaacg
     2521 aactgagaag tgtaataaaa tgctaccaga tgttttttta aggtggtacc caccataatg
     2581 tctctgtcac atatttatat tacaaatgtt ttctatttat gttcctttga ctctttgaag
     2641 ggttagtgta ttgttgagca ggtctaaacc ttggtgtctg gttttgcaaa tagctatttc
     2701 aaaactgcct tcctaattga ttgtgttttt aaaatgacag aaaaaagtag ccttctataa
     2761 tgtttaccta gttgtgaatt aaataataaa atggcaagtc tgggttggtg tgaatgtgtg
     2821 tcacctacac attctaacag aaggtaacaa taagttagca gtgacatatt cagtattact
     2881 cattttgtag tgccagggat cagacatgca caaggcctca tgaatgctaa taagagttct
     2941 ccttttctct gaagtacaca catgtctctt ggtgtcttta tgtgtcttag aaatcgtcca
     3001 gaaaactgtg aaattacgtg tcagttaatt cctgtgttca taatggtaaa atgtgttagg
     3061 cacagagaag ctattttgaa agggtgcttc ttgggactcc agttcctgga ggacagtttc
     3121 ccaggtcctt taggggacac tagcatgagc ttattagctg cactaaaagc aaacatccct
     3181 tgtacgtgtt accttgacaa atgagaagta tttctcgtcc ataccttttg gcttaaatat
     3241 gttcagcaga atgggactag accgtgcttc agtttgacag gtagtctttg aatgcatgca
     3301 gtacactgga cctccctcac aggtgagatg ttacgtctac actgtactat aatttgatcc
     3361 agggtactgc tctactttaa tacagagtta cttgttgatt ataaatcaag acaaaaattg
     3421 tacatacatg atttttattc taatatccct taattaaatt gccaaaaatt aaagtgcaat
     3481 attgtatttt taagaacaca ttttagattt ttgttgtttc ttggatcaca taaaattagg
     3541 aaaagattaa tgatcgacat ctaatttcta ttgttatttt aaatttaatt agtaatggtt
     3601 atagtagtaa ctactcaaat gagttatttt tgtgtgggaa aaaggtatac aactttgtga
     3661 aaatacttaa gtagaatgaa ttaccaagtt attttatact gacaaatata tgggttggga
     3721 aaaaattcta attttcaagt ttaatttttc tcctaaactg ttaagtcttt tattaaatat
     3781 atgccttttg aacagttgga ctatttcatg ctaactacca aaataatctc caaggttgtt
     3841 taggaagtca gctctctgcc tgttggtttt ggttttagag atacctctca atgtggccca
     3901 gcctggcttc aaacgccgga tcttcttacc atagcgtcct caacctagga ttacggcttg
     3961 ttatttacaa cttgttgaag tcgttttttt agccattgac ctctaaaggt aatagttact
     4021 tccttgcttt gtcacagact acagggtgag tagaggtttg ttttttagga agagcctctt
     4081 tagagctggg gtttcctgct ggagcctggt aaggtggtag aagaggcttt tagtttcctc
     4141 cggggctatc tccagtaacc acctcgtggc acacacagcc tgtggttcca gcaagcacat
     4201 ggtgcacata catgcagaga ctcacatata cacacaaaag gaaagtaagc acattttttt
     4261 caagtatttg ggctctttgc tactttccat atgtactcaa ttgatactag gaaaaattgt
     4321 tctcagcttc agtgatagaa ttccagttaa agatctgttg tgtttatttc acatttttag
     4381 tatggcaact tgtgtcactg ttcatttgca atcttttaaa cacatcttag tgtgtggtcg
     4441 ggcctacata caaatcatct ttcaggatgg gcacgatggc tcaccaggac acttgccacc
     4501 aacgctgatt accagagttc aatccctgag acccacatag tagaagagaa ccagcatcca
     4561 taaattgtcc tctgaccact gtgggcaccc tcatacacaa atgtaatttt tggaaacttt
     4621 ttttgtattt ttttgtttgt ttgctttccg agacagggtt tctctgtata gccccgactg
     4681 tcctggaact cactctgtag accatgctgg cctcgaactc agaaatctgt ctgcctctgc
     4741 ctcccaagtg ctgggattaa aggcgtgcgc caccactgcc cggctacatt ctttggttct
     4801 taaatgtcta gtttttcaca cagtaaatga actgagaaag aaaaaaaaat gctgtgctgt
     4861 gttcagatac acgttttgaa aatttaatca gaagctgccc ctgctaggga gtcacaatgg
     4921 gcagcaagat ggcttctgcc accagggtcg tgcaggtagt gaagccacac gctccctaac
     4981 agaagagaca aacctaaact cagagtctcc gaagctctgg ggtctgcgct cccctcccac
     5041 tcctctgtcg tttcacagca ttctaaagga agtatgtccc cagatttact gatgcaccag
     5101 gggcccccag acactgcaga aatgataaaa atcattacct cagaaataca gaagaaatcc
     5161 tgtaactcaa caggaaatgg aatttatcca gcgtgggggt ccagagtgat catgtggctg
     5221 ctgcttgtca ccagacagaa gaattagctt tgcaataaag gacttccaca aagtcaaatg
     5281 aaaagtcata cattaaacaa ccttaataaa tattctgtaa gcagaatgaa gtatagaaac
     5341 cccaggtggt cacttgtatc tcctacgttg tgtatcttgc tcagctgccc cacaagctga
     5401 cctgtacact tattaaagtc tacattttta aatgctagcc tgttaactta atcttgatta
     5461 tgaaatgttc ccagagatga gctattaaaa gcacatagta tctaaagaaa aagaaaa
//
