LOCUS       NM_013731               2554 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus serum/glucocorticoid regulated kinase 2 (Sgk2),
            transcript variant 1, mRNA.
ACCESSION   NM_013731 XM_984083 XM_984112
VERSION     NM_013731.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2554)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2554)
  AUTHORS   Park,C.H., Moon,J., Park,M., Cheng,H., Lee,J. and Chang,J.S.
  TITLE     Protein Kinase SGK2 Is Induced by the beta3 Adrenergic
            Receptor-cAMP-PKA-PGC-1alpha/NT-PGC-1alpha Axis but Dispensable for
            Brown/Beige Adipose Tissue Thermogenesis
  JOURNAL   Front Physiol 12, 780312 (2021)
   PUBMED   34899399
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2554)
  AUTHORS   Gotoh,S., Miyauchi,Y., Moore,R. and Negishi,M.
  TITLE     Glucose elicits serine/threonine kinase VRK1 to phosphorylate
            nuclear pregnane X receptor as a novel hepatic gluconeogenic signal
  JOURNAL   Cell Signal 40, 200-209 (2017)
   PUBMED   28911860
  REMARK    GeneRIF: VRK1 self-represses its activity to phosphorylate PXR
            through cyclin-dependent kinase 2 (CDK2) in high glucose
            conditions, resulting in the repression of the PCK1 gene. This PXR
            phosphorylation was also observed in fasting mouse livers. Thus,
            the VRK1-CDK2-PXR-PP2Calpha-SGK2 pathway can be a novel
            physiological cell signaling that regulates gluconeogenesis in
            response to glucose.
REFERENCE   4  (bases 1 to 2554)
  AUTHORS   Wu,Y., Wei,F.Y., Kawarada,L., Suzuki,T., Araki,K., Komohara,Y.,
            Fujimura,A., Kaitsuka,T., Takeya,M., Oike,Y., Suzuki,T. and
            Tomizawa,K.
  TITLE     Mtu1-Mediated Thiouridine Formation of Mitochondrial tRNAs Is
            Required for Mitochondrial Translation and Is Involved in
            Reversible Infantile Liver Injury
  JOURNAL   PLoS Genet 12 (9), e1006355 (2016)
   PUBMED   27689697
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2554)
  AUTHORS   Harms,M.J., Ishibashi,J., Wang,W., Lim,H.W., Goyama,S., Sato,T.,
            Kurokawa,M., Won,K.J. and Seale,P.
  TITLE     Prdm16 is required for the maintenance of brown adipocyte identity
            and function in adult mice
  JOURNAL   Cell Metab 19 (4), 593-604 (2014)
   PUBMED   24703692
REFERENCE   6  (bases 1 to 2554)
  AUTHORS   Shalom-Barak,T., Zhang,X., Chu,T., Timothy Schaiff,W., Reddy,J.K.,
            Xu,J., Sadovsky,Y. and Barak,Y.
  TITLE     Placental PPARgamma regulates spatiotemporally diverse genes and a
            unique metabolic network
  JOURNAL   Dev Biol 372 (1), 143-155 (2012)
   PUBMED   22967998
REFERENCE   7  (bases 1 to 2554)
  AUTHORS   Pao,A.C., Bhargava,A., Di Sole,F., Quigley,R., Shao,X., Wang,J.,
            Thomas,S., Zhang,J., Shi,M., Funder,J.W., Moe,O.W. and Pearce,D.
  TITLE     Expression and role of serum and glucocorticoid-regulated kinase 2
            in the regulation of Na+/H+ exchanger 3 in the mammalian kidney
  JOURNAL   Am J Physiol Renal Physiol 299 (6), F1496-F1506 (2010)
   PUBMED   20926631
REFERENCE   8  (bases 1 to 2554)
  AUTHORS   Loffing,J., Flores,S.Y. and Staub,O.
  TITLE     Sgk kinases and their role in epithelial transport
  JOURNAL   Annu Rev Physiol 68, 461-490 (2006)
   PUBMED   16460280
  REMARK    Review article
REFERENCE   9  (bases 1 to 2554)
  AUTHORS   Masujin,K., Okada,T., Tsuji,T., Ishii,Y., Takano,K., Matsuda,J.,
            Ogura,A. and Kunieda,T.
  TITLE     A mutation in the serum and glucocorticoid-inducible kinase-like
            kinase (Sgkl) gene is associated with defective hair growth in mice
  JOURNAL   DNA Res 11 (6), 371-379 (2004)
   PUBMED   15871460
  REMARK    GeneRIF: the nucleotide substitution in the Sgkl gene is the
            causative mutation for defective hair growth in the ypc mutant
            mouse and the signaling pathway involving SGKL plays an essential
            role in mammalian hair development
REFERENCE   10 (bases 1 to 2554)
  AUTHORS   Kobayashi,T., Deak,M., Morrice,N. and Cohen,P.
  TITLE     Characterization of the structure and regulation of two novel
            isoforms of serum- and glucocorticoid-induced protein kinase
  JOURNAL   Biochem J 344 Pt 1 (Pt 1), 189-197 (1999)
   PUBMED   10548550
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AI747981.1, AK136559.1, AK050009.1, AV370098.2 and BB350718.1.
            
            On Mar 27, 2014 this sequence version replaced NM_013731.2.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK136559.1, AF169033.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849376, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-49                AI747981.1         152-200
            50-1417             AK136559.1         2-1369
            1418-2465           AK050009.1         1913-2960
            2466-2546           AV370098.2         601-681
            2547-2554           BB350718.1         268-275
FEATURES             Location/Qualifiers
     source          1..2554
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 83.93 cM"
     gene            1..2554
                     /gene="Sgk2"
                     /gene_synonym="Sgkl"
                     /note="serum/glucocorticoid regulated kinase 2"
                     /db_xref="GeneID:27219"
                     /db_xref="MGI:MGI:1351318"
     exon            1..115
                     /gene="Sgk2"
                     /gene_synonym="Sgkl"
                     /inference="alignment:Splign:2.1.0"
     exon            116..361
                     /gene="Sgk2"
                     /gene_synonym="Sgkl"
                     /inference="alignment:Splign:2.1.0"
     exon            362..421
                     /gene="Sgk2"
                     /gene_synonym="Sgkl"
                     /inference="alignment:Splign:2.1.0"
     CDS             386..1489
                     /gene="Sgk2"
                     /gene_synonym="Sgkl"
                     /EC_number="2.7.11.1"
                     /note="isoform a is encoded by transcript variant 1;
                     serine/threonine-protein kinase Sgk2"
                     /codon_start=1
                     /product="serine/threonine-protein kinase Sgk2 isoform a"
                     /protein_id="NP_038759.1"
                     /db_xref="CCDS:CCDS17004.1"
                     /db_xref="GeneID:27219"
                     /db_xref="MGI:MGI:1351318"
                     /translation="MASSPVGVPSPQPSRANGNINLGPSANPNARPTDFDFLKVIGKG
                     NYGKVLLAKRKSDGAFYAVKVLQKKSILKNKEQNHIMAERNVLLKNVRHPFLVGLRYS
                     FQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARFYTAEVASAIGYLHSLNIIYRDL
                     KPENILLDCQGHVVLTDFGLCKECVEPEETTSTFCGTPEYLAPEVLRKEPYDRAVDWW
                     CLGAVLYEMLHGLPPFFNTDVAQMYENILHQPLQIPGGRTVAACDLLQGLLHKDQRQR
                     LGSKEDFLDIKNHMFFSPINWDDLYHKRLTPPFNPNVEGPADLKHFDPEFTQEAVSKS
                     IGCTPDTVASSSGASSAFLGFSYAQDDDDILDS"
     exon            422..471
                     /gene="Sgk2"
                     /gene_synonym="Sgkl"
                     /inference="alignment:Splign:2.1.0"
     exon            472..529
                     /gene="Sgk2"
                     /gene_synonym="Sgkl"
                     /inference="alignment:Splign:2.1.0"
     exon            530..613
                     /gene="Sgk2"
                     /gene_synonym="Sgkl"
                     /inference="alignment:Splign:2.1.0"
     exon            614..745
                     /gene="Sgk2"
                     /gene_synonym="Sgkl"
                     /inference="alignment:Splign:2.1.0"
     exon            746..858
                     /gene="Sgk2"
                     /gene_synonym="Sgkl"
                     /inference="alignment:Splign:2.1.0"
     exon            859..895
                     /gene="Sgk2"
                     /gene_synonym="Sgkl"
                     /inference="alignment:Splign:2.1.0"
     exon            896..982
                     /gene="Sgk2"
                     /gene_synonym="Sgkl"
                     /inference="alignment:Splign:2.1.0"
     exon            983..1078
                     /gene="Sgk2"
                     /gene_synonym="Sgkl"
                     /inference="alignment:Splign:2.1.0"
     exon            1079..1234
                     /gene="Sgk2"
                     /gene_synonym="Sgkl"
                     /inference="alignment:Splign:2.1.0"
     exon            1235..1324
                     /gene="Sgk2"
                     /gene_synonym="Sgkl"
                     /inference="alignment:Splign:2.1.0"
     exon            1325..2554
                     /gene="Sgk2"
                     /gene_synonym="Sgkl"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2523..2528
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sgk2"
                     /gene_synonym="Sgkl"
                     /note="hexamer: ATTAAA"
     polyA_site      2542
                     /gene="Sgk2"
                     /gene_synonym="Sgkl"
                     /note="major polyA site"
ORIGIN      
        1 actcctgctt gggaaggttg cagggtgagt caggattggg tttcaggtca gaaggacggt
       61 gcagaggaag agaacacaat tctctaggac ctgcactgga acccggggtt tccagggaga
      121 aatggtgacc ccgggggaac agaggtctcc cgtcccatcc taagaactgc tagatcccgt
      181 gtgacatcac cagtcccctc actgctgcca ctgctagaag ctctgagctc tgtgctgggg
      241 gcaccaggca ctgacacttg gctcttgttg ggagaacaga gagagtctct cttgtccaca
      301 gcctgtgctc agctccaact gctgcatctc ccagaggctc tgccctgccc cagctgcata
      361 gagcctacct gatcacagct ccagaatggc ctccagccca gttggagttc ctagcccaca
      421 gccctctagg gccaatggga acatcaacct ggggccatca gccaacccaa atgcccggcc
      481 cacagacttt gatttcctca aagtcattgg caaagggaac tacgggaagg tcctactggc
      541 caagcgcaag tcggacggag ccttctacgc cgtgaaggtg ctgcagaaga aatccatttt
      601 aaagaacaaa gagcagaacc acatcatggc agagcgcaac gtgctgttga agaacgtgcg
      661 gcatcctttc ctcgtgggcc tgcgctactc cttccagacc ccagagaaac tctactttgt
      721 gcttgactat gtcaacgggg gagagctctt cttccatcta cagcgggaac gcaggttcct
      781 ggagccccgg gcccggttct acactgcaga ggtggcgagc gccattggtt accttcactc
      841 tctcaacatc atctacagag acctgaagcc agaaaacatt ctcttggact gccagggtca
      901 cgtggtactg accgatttcg gcctttgcaa ggaatgtgta gagcctgagg agaccacgtc
      961 caccttctgc ggcacccctg agtacttggc tccagaagtg cttcgtaaag agccttacga
     1021 tcgagcagtg gactggtggt gcttaggggc agtcctctac gagatgctac atggcctgcc
     1081 ccccttcttc aacactgacg tggcccagat gtatgagaat attttacatc agccgctaca
     1141 gatccctgga ggccggacag tggctgcctg tgacctcctg caaggccttc tccacaagga
     1201 ccagaggcag cggctgggct ccaaggaaga ctttctggac ataaagaacc acatgttctt
     1261 cagtcccata aactgggatg atctgtacca caagaggctg actccaccct tcaacccaaa
     1321 cgtggaagga cctgctgact tgaaacactt tgacccagag ttcacccagg aagctgtgtc
     1381 caagtccatt ggctgcaccc ctgacaccgt ggccagcagt tctggggctt caagtgcatt
     1441 ccttggattt tcctatgcac aggatgatga tgacattttg gactcttgag agacgtgcgc
     1501 ttggaaagcc accaagccca gccggtacct gctggaacta tcttctgctg cactaagaca
     1561 caatgagtcc caaagaagta agacacagtg gctcggagaa gaggggaaac acattttcca
     1621 tcatgtgaag gaacagttca ggctccccag tatccagccg tctgcagttc tgacttgccc
     1681 ttcttgagaa atgacttctg tgcttggttt ttcatttttg ttttgtcttg tttgttgttg
     1741 ctgaggcagt gacaaaatat gcaagaaaag taaagaacat ctatttggac tcacgatttt
     1801 agaaggtaaa gcccacagtt ggctcatcta ttgctacggt cttcagccaa agctgagtca
     1861 tctcactgga aggggtggct taccttatga ctaccaggag gcagaaacag aagtccgagc
     1921 tgggaataag ataccttcaa ataagatatc ccaagtggcc tactcccttc cagcctgggg
     1981 tgggggaggc cccacctccg atttatcacc tctccatgct ataaaattac acatctatga
     2041 acggactata ttgctgagga agcctgagcc cctccctcat tggatagtga tccaatcatt
     2101 tactgaaggc tccatcagct ggacacagga accttcagaa aagagactag aaccgtggta
     2161 gctttggatg ttgagttatg agatcacaga gtggttactg gccacttttg tgtgctaagc
     2221 aagagaaaag gaggaacggg acagaggtgg gctgcccaga aaccgtctgg tggcttcctt
     2281 tagtgtgtcg taaatctcca cctctcctgg aatgcagcct gggcacaagc tacctctcgt
     2341 agtaaaaggg ttcaaatgct gagagaaagg ggaggatgta ggtgaccagc actctgggag
     2401 agagcctctt ggtatctgaa tttatatttc agtgtataca ttgatgaaat gtaataagcc
     2461 tgtcatgtgt tgtctttggt ttgaggttgc tctatgtgga cggtgtcttt gtttcaggta
     2521 atattaaatg cactggatat tatttgttac tggg
//
