LOCUS       NM_001161845            3121 bp    mRNA    linear   ROD 19-MAR-2025
DEFINITION  Mus musculus serum/glucocorticoid regulated kinase 1 (Sgk1),
            transcript variant 1, mRNA.
ACCESSION   NM_001161845
VERSION     NM_001161845.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3121)
  AUTHORS   Huikang,W., Shiya,C., Di,P., Kiani,F.A., Hao,L., Sha,N., Xuan,L.,
            Abouelfetouh,M.M., Ahmed,Z., Mingxing,D. and Yi,D.
  TITLE     Elucidation of Dexmedetomidine-Induced Analgesic Tolerance
            Mechanisms in Neuropathic Pain With Modulation of SGK1, NR2A, and
            NR2B Expression via the Spinal SGK1/NF-kappaB Signalling Pathway
  JOURNAL   J Cell Mol Med 29 (6), e70372 (2025)
   PUBMED   40099662
REFERENCE   2  (bases 1 to 3121)
  AUTHORS   Lo Giudice,Q., Wagener,R.J., Abe,P., Frangeul,L. and Jabaudon,D.
  TITLE     Developmental emergence of first- and higher-order thalamic neuron
            molecular identities
  JOURNAL   Development 151 (18) (2024)
   PUBMED   39348458
REFERENCE   3  (bases 1 to 3121)
  AUTHORS   Liu,Y., Ye,Q., Dai,Y., Hu,J., Chen,J., Dong,J., Li,H. and Dou,Z.
  TITLE     Integrating analysis of mRNA expression profiles indicates Sgk1 as
            a key mediator in muscle-brain crosstalk during resistance exercise
  JOURNAL   Biochem Biophys Res Commun 719, 150075 (2024)
   PUBMED   38749087
  REMARK    GeneRIF: Integrating analysis of mRNA expression profiles indicates
            Sgk1 as a key mediator in muscle-brain crosstalk during resistance
            exercise.
REFERENCE   4  (bases 1 to 3121)
  AUTHORS   Zhang,L., Sun,Z., Yang,Y., Mack,A., Rodgers,M., Aroor,A., Jia,G.,
            Sowers,J.R. and Hill,M.A.
  TITLE     Endothelial cell serum and glucocorticoid regulated kinase 1 (SGK1)
            mediates vascular stiffening
  JOURNAL   Metabolism 154, 155831 (2024)
   PUBMED   38431129
  REMARK    GeneRIF: Endothelial cell serum and glucocorticoid regulated kinase
            1 (SGK1) mediates vascular stiffening.
REFERENCE   5  (bases 1 to 3121)
  AUTHORS   Wang,D., Zhang,Q., Dong,W., Ren,S., Wang,X., Su,C., Lin,X.,
            Zheng,Z. and Xue,Y.
  TITLE     SGLT2 knockdown restores the Th17/Treg balance and suppresses
            diabetic nephropathy in db/db mice by regulating SGK1 via Na
  JOURNAL   Mol Cell Endocrinol 584, 112156 (2024)
   PUBMED   38278341
  REMARK    GeneRIF: SGLT2 knockdown restores the Th17/Treg balance and
            suppresses diabetic nephropathy in db/db mice by regulating SGK1
            via Na.
REFERENCE   6  (bases 1 to 3121)
  AUTHORS   Huber,S.M., Friedrich,B., Klingel,K., Lenka,N., Hescheler,J. and
            Lang,F.
  TITLE     Protein and mRNA expression of serum and glucocorticoid-dependent
            kinase 1 in metanephrogenesis
  JOURNAL   Dev Dyn 221 (4), 464-469 (2001)
   PUBMED   11500984
REFERENCE   7  (bases 1 to 3121)
  AUTHORS   Lee,E., Lein,E.S. and Firestone,G.L.
  TITLE     Tissue-specific expression of the transcriptionally regulated serum
            and glucocorticoid-inducible protein kinase (Sgk) during mouse
            embryogenesis
  JOURNAL   Mech Dev 103 (1-2), 177-181 (2001)
   PUBMED   11335130
REFERENCE   8  (bases 1 to 3121)
  AUTHORS   Shigaev,A., Asher,C., Latter,H., Garty,H. and Reuveny,E.
  TITLE     Regulation of sgk by aldosterone and its effects on the epithelial
            Na(+) channel
  JOURNAL   Am J Physiol Renal Physiol 278 (4), F613-F619 (2000)
   PUBMED   10751222
REFERENCE   9  (bases 1 to 3121)
  AUTHORS   Naray-Fejes-Toth,A., Canessa,C., Cleaveland,E.S., Aldrich,G. and
            Fejes-Toth,G.
  TITLE     sgk is an aldosterone-induced kinase in the renal collecting duct.
            Effects on epithelial na+ channels
  JOURNAL   J Biol Chem 274 (24), 16973-16978 (1999)
   PUBMED   10358046
REFERENCE   10 (bases 1 to 3121)
  AUTHORS   Maiyar,A.C., Huang,A.J., Phu,P.T., Cha,H.H. and Firestone,G.L.
  TITLE     p53 stimulates promoter activity of the sgk.
            serum/glucocorticoid-inducible serine/threonine protein kinase gene
            in rodent mammary epithelial cells
  JOURNAL   J Biol Chem 271 (21), 12414-12422 (1996)
   PUBMED   8647846
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC070401.1 and BY493368.1.
            
            On Sep 11, 2009 this sequence version replaced NM_001161845.1.
            
            Summary: This gene encodes a serine/threonine protein kinase that
            plays an important role in cellular stress response. This kinase
            activates certain potassium, sodium, and chloride channels,
            suggesting an involvement in the regulation of processes such as
            cell survival, neuronal excitability, and renal sodium excretion.
            This enzyme is activated by protein phosphorylation and degraded
            via the ubiquitination and proteasome pathway. Multiple transcript
            variants encoding different isoforms have been found for this gene.
            A pseudogene of this gene was identified on chromosome 12.
            [provided by RefSeq, Sep 2009].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC070401.1, SRR1660819.13367.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3096              BC070401.1         1-3096
            3097-3121           BY493368.1         489-513
FEATURES             Location/Qualifiers
     source          1..3121
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 9.83 cM"
     gene            1..3121
                     /gene="Sgk1"
                     /gene_synonym="Sgk"
                     /note="serum/glucocorticoid regulated kinase 1"
                     /db_xref="GeneID:20393"
                     /db_xref="MGI:MGI:1340062"
     exon            1..524
                     /gene="Sgk1"
                     /gene_synonym="Sgk"
                     /inference="alignment:Splign:2.1.0"
     CDS             456..2030
                     /gene="Sgk1"
                     /gene_synonym="Sgk"
                     /EC_number="2.7.11.1"
                     /note="isoform a is encoded by transcript variant 1;
                     serine/threonine-protein kinase Sgk1; serum and
                     glucocorticoid-dependent protein kinase"
                     /codon_start=1
                     /product="serine/threonine-protein kinase Sgk1 isoform a"
                     /protein_id="NP_001155317.2"
                     /db_xref="CCDS:CCDS48515.1"
                     /db_xref="GeneID:20393"
                     /db_xref="MGI:MGI:1340062"
                     /translation="MVNKDMNGFPVKKCSAFQFFKKRVRRWIKSPMVSVDKHQSPNLK
                     YTGPAGVHLPPGESDFEAMCQSCLGDHAFQRGMLPPEESCSWEIQPGCEVKEQCNHAN
                     ILTKPDPRTFWTNDDAAFMKQRRMGLNDFIQKIASNTYACKHAEVQSILKMSHPQEPE
                     LMNANPSPPPSPSQQINLGPSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVFYA
                     VKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGE
                     LFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDF
                     GLCKENIEHNGTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYS
                     RNTAEMYDNILNKPLQLKPNITNSARHLLEGLLQKDRTKRLGAKDDFMEIKSHIFFSL
                     INWDDLINKKITPPFNPNVSGPSDLRHFDPEFTEEPVPSSIGRSPDSILVTASVKEAA
                     EAFLGFSYAPPVDSFL"
     exon            525..734
                     /gene="Sgk1"
                     /gene_synonym="Sgk"
                     /inference="alignment:Splign:2.1.0"
     exon            735..810
                     /gene="Sgk1"
                     /gene_synonym="Sgk"
                     /inference="alignment:Splign:2.1.0"
     exon            811..886
                     /gene="Sgk1"
                     /gene_synonym="Sgk"
                     /inference="alignment:Splign:2.1.0"
     exon            887..962
                     /gene="Sgk1"
                     /gene_synonym="Sgk"
                     /inference="alignment:Splign:2.1.0"
     exon            963..1067
                     /gene="Sgk1"
                     /gene_synonym="Sgk"
                     /inference="alignment:Splign:2.1.0"
     exon            1068..1151
                     /gene="Sgk1"
                     /gene_synonym="Sgk"
                     /inference="alignment:Splign:2.1.0"
     exon            1152..1283
                     /gene="Sgk1"
                     /gene_synonym="Sgk"
                     /inference="alignment:Splign:2.1.0"
     exon            1284..1396
                     /gene="Sgk1"
                     /gene_synonym="Sgk"
                     /inference="alignment:Splign:2.1.0"
     exon            1397..1520
                     /gene="Sgk1"
                     /gene_synonym="Sgk"
                     /inference="alignment:Splign:2.1.0"
     exon            1521..1616
                     /gene="Sgk1"
                     /gene_synonym="Sgk"
                     /inference="alignment:Splign:2.1.0"
     exon            1617..1772
                     /gene="Sgk1"
                     /gene_synonym="Sgk"
                     /inference="alignment:Splign:2.1.0"
     exon            1773..1862
                     /gene="Sgk1"
                     /gene_synonym="Sgk"
                     /inference="alignment:Splign:2.1.0"
     exon            1863..3106
                     /gene="Sgk1"
                     /gene_synonym="Sgk"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3078..3083
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sgk1"
                     /gene_synonym="Sgk"
                     /note="hexamer: AATAAA"
     polyA_site      3096
                     /gene="Sgk1"
                     /gene_synonym="Sgk"
                     /note="major polyA site"
ORIGIN      
        1 ggaacctaca caatcaaaaa cagctctcct ccagcagcct ccagcagcgc atcacctgga
       61 gcagagcgag tcgctcgctc cccgctcagc ccgggagcag ctcggtagct gggggcgggg
      121 acggtaccct gctctcgcct gagcgcccgc cagagcatct ctggatagat ttgctgtatc
      181 ccgccatccg gccccggggt cctgttgtgg tgatgcttac gtttcaaagc aatgatggaa
      241 agagaaaagc cattgccagt ggcctctgaa agtggggcga gttactgcag tcgctgccgc
      301 agcaggatga gcgagtgaaa aactgagccc cgttagcctc tccatcccgt tcggtcttca
      361 ttcaccgtct ccaggaaggc ggatcgggat acagatgcag taaaccaagc cggtgccacc
      421 ctggatctat aactgtgaag tcccttctgt ggaagatggt aaacaaagac atgaatggat
      481 tcccggtcaa gaaatgctca gcgttccaat tttttaagaa acgggtacga agatggatca
      541 agagccccat ggtcagcgtg gacaagcatc agagccccaa cttgaagtac actggccctg
      601 ctggggtgca tcttccccct ggggagtcag actttgaggc catgtgtcaa tcatgcctgg
      661 gtgaccatgc tttccaaagg gggatgctcc ctccagagga gtcctgttcc tgggagatcc
      721 aacctgggtg tgaagtgaaa gaacaatgta atcatgccaa catcctgacc aagccggacc
      781 caagaacctt ctggactaat gatgatgcag cttttatgaa acagagaagg atgggcctga
      841 acgattttat tcagaagatt gccagcaaca cctatgcatg caaacacgct gaagttcagt
      901 ccattttgaa aatgtcccat cctcaggagc cggagcttat gaacgctaac ccctctcctc
      961 cgccaagtcc ctctcaacaa atcaacctgg gtccgtcctc caaccctcac gccaaaccct
     1021 ccgactttca cttcttgaaa gtgatcggaa agggcagttt tggaaaggtt cttctggcta
     1081 ggcacaaggc agaagaagta ttctatgcag tcaaagtttt acagaagaaa gccatcctga
     1141 agaagaaaga ggagaagcat attatgtcag agcggaatgt tctgttgaag aatgtgaagc
     1201 accctttcct ggtgggcctt cacttctcat tccagaccgc tgacaagctc tactttgtcc
     1261 tggactacat taatggtgga gagctgttct accatctcca gagggagcgc tgcttcctgg
     1321 aaccacgggc tcgattctac gcagctgaaa tagccagtgc cctgggctat ctgcactccc
     1381 taaacatcgt ttatagagac ttaaaacctg agaatattct cctagactcc caggggcaca
     1441 tcgtcctcac tgactttggg ctctgcaaag agaatattga gcataacggg acaacatcta
     1501 ccttctgtgg cacgcctgag tatctggctc ctgaggtcct ccataagcag ccgtatgacc
     1561 ggacggtgga ctggtggtgt cttggggctg tcctgtatga gatgctctac ggcctgcccc
     1621 cgttttatag ccggaacacg gctgagatgt acgacaatat tctgaacaag cctctccagt
     1681 tgaaaccaaa tattacaaac tcggcaaggc acctcctgga aggcctcctg cagaaggacc
     1741 ggaccaagag gctgggtgcc aaggatgact ttatggagat taagagtcat attttcttct
     1801 ctttaattaa ctgggatgat ctcatcaata agaagattac acccccattt aacccaaatg
     1861 tgagtgggcc cagtgacctt cggcacttcg atcccgagtt taccgaggag ccggtcccca
     1921 gctccatcgg caggtcccct gacagcatcc ttgtcacggc cagtgtgaag gaagcagcag
     1981 aagccttcct cggcttctcc tatgcacctc ctgtggattc cttcctctga gtgctcccgg
     2041 gatggttctg aaggacttcc tcagcgtttc ctaaagtgtt ttcgttagcc tttggtggag
     2101 ttgccagctg acagaacatt ttaaaagaat ttgcacacct ggaagcttgg cagtctcgcc
     2161 tgcccggcgt ggcgcgacgc agcgcgcgct gcttgatggg agctttccga agagcacacc
     2221 ctcctctcaa tgagcttgtg aggtcttctt ttcttctctt ccttccaacg tggtgctagc
     2281 tccaggcgag cgagcgtgag agtgccgcct gagacagaca ccttggtctc agttagaagg
     2341 aagatgcagg tctaagagga atccccgcag gtctgtctga gctgtgatca agaatattct
     2401 gcaatgtgcc ttttctgaga tcgtgttagc tccaaagctt tttcctatcg cagagtgttc
     2461 agtttgtgtt tgtttgtttt tgttttgttt tgtttttccc ttggcggatt tcccgtgtgt
     2521 gcagtggcgt gagtgtgcta tgcctgatca cagacggttt tgttgtgagc atcaatgtga
     2581 cacttgcagg acactacaat gtgggacatt gtttgtttct tccacatttg gaagataaat
     2641 ttatgtgtag actgttttgt aagatatagt taataactaa aacctattga aacggtcttg
     2701 caatgacgag cattcagatg cttaaggaaa gcattgctgc tacaaatatt tctattttta
     2761 gaaagggttt ttatggacca atgccccagt tgtcagtcaa agccgttggt gttttcattg
     2821 tttaaaatgt cacctataaa acgggcatta tttatgtttt ttttcccttt gttcatattc
     2881 ttttgcattc ctgattattg tatgtatcgt gtaaaggaag tctgtacatt gggttataac
     2941 actagatatt taaacttaca ggcttatttg taaaccatca ttttaatgta ctgtaattaa
     3001 catgggttat aatatgtaca attcctcctc cttaccacac aacttttttt gtgtgcgata
     3061 aaccaatttt ggtttgcaat aaaatcttga aaactatttg cataaaaaaa aaaaaaaaaa
     3121 a
//
