LOCUS       NM_001285852            5589 bp    mRNA    linear   ROD 17-DEC-2024
DEFINITION  Mus musculus SH3-domain GRB2-like (endophilin) interacting protein
            1 (Sgip1), transcript variant 1, mRNA.
ACCESSION   NM_001285852
VERSION     NM_001285852.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5589)
  AUTHORS   Durydivka,O., Kuchar,M. and Blahos,J.
  TITLE     SGIP1 Deletion in Mice Attenuates Mechanical Hypersensitivity
            Elicited by Inflammation
  JOURNAL   Cannabis Cannabinoid Res (2024) In press
   PUBMED   38979622
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   2  (bases 1 to 5589)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 5589)
  AUTHORS   Durydivka,O., Gazdarica,M., Vecerkova,K., Radenkovic,S. and
            Blahos,J.
  TITLE     Multiple Sgip1 splice variants inhibit cannabinoid receptor 1
            internalization
  JOURNAL   Gene 892, 147851 (2024)
   PUBMED   37783296
  REMARK    GeneRIF: Multiple Sgip1 splice variants inhibit cannabinoid
            receptor 1 internalization.
REFERENCE   4  (bases 1 to 5589)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5589)
  AUTHORS   Dvorakova,M., Kubik-Zahorodna,A., Straiker,A., Sedlacek,R.,
            Hajkova,A., Mackie,K. and Blahos,J.
  TITLE     SGIP1 is involved in regulation of emotionality, mood, and
            nociception and modulates in vivo signalling of cannabinoid CB1
            receptors
  JOURNAL   Br J Pharmacol 178 (7), 1588-1604 (2021)
   PUBMED   33491188
REFERENCE   6  (bases 1 to 5589)
  AUTHORS   Uezu,A., Horiuchi,A., Kanda,K., Kikuchi,N., Umeda,K., Tsujita,K.,
            Suetsugu,S., Araki,N., Yamamoto,H., Takenawa,T. and Nakanishi,H.
  TITLE     SGIP1alpha is an endocytic protein that directly interacts with
            phospholipids and Eps15
  JOURNAL   J Biol Chem 282 (36), 26481-26489 (2007)
   PUBMED   17626015
REFERENCE   7  (bases 1 to 5589)
  AUTHORS   Munton,R.P., Tweedie-Cullen,R., Livingstone-Zatchej,M.,
            Weinandy,F., Waidelich,M., Longo,D., Gehrig,P., Potthast,F.,
            Rutishauser,D., Gerrits,B., Panse,C., Schlapbach,R. and Mansuy,I.M.
  TITLE     Qualitative and quantitative analyses of protein phosphorylation in
            naive and stimulated mouse synaptosomal preparations
  JOURNAL   Mol Cell Proteomics 6 (2), 283-293 (2007)
   PUBMED   17114649
REFERENCE   8  (bases 1 to 5589)
  AUTHORS   Trinidad,J.C., Specht,C.G., Thalhammer,A., Schoepfer,R. and
            Burlingame,A.L.
  TITLE     Comprehensive identification of phosphorylation sites in
            postsynaptic density preparations
  JOURNAL   Mol Cell Proteomics 5 (5), 914-922 (2006)
   PUBMED   16452087
REFERENCE   9  (bases 1 to 5589)
  AUTHORS   Trevaskis,J., Walder,K., Foletta,V., Kerr-Bayles,L., McMillan,J.,
            Cooper,A., Lee,S., Bolton,K., Prior,M., Fahey,R., Whitecross,K.,
            Morton,G.J., Schwartz,M.W. and Collier,G.R.
  TITLE     Src homology 3-domain growth factor receptor-bound 2-like
            (endophilin) interacting protein 1, a novel neuronal protein that
            regulates energy balance
  JOURNAL   Endocrinology 146 (9), 3757-3764 (2005)
   PUBMED   15919751
  REMARK    GeneRIF: SGIP1 is an important and novel member of the group of
            neuronal molecules required for the regulation of energy
            homeostasis
REFERENCE   10 (bases 1 to 5589)
  AUTHORS   Collins,M.O., Yu,L., Coba,M.P., Husi,H., Campuzano,I.,
            Blackstock,W.P., Choudhary,J.S. and Grant,S.G.
  TITLE     Proteomic analysis of in vivo phosphorylated synaptic proteins
  JOURNAL   J Biol Chem 280 (7), 5972-5982 (2005)
   PUBMED   15572359
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY249204.1, AK147926.1, AL732543.8 and BY617051.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN01164131,
                              SAMN01164132 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-42                BY249204.1         2-43
            43-431              AK147926.1         2-390
            432-495             AL732543.8         22664-22727
            496-520             AL732543.8         30551-30575
            521-604             AL732543.8         31637-31720
            605-676             AL732543.8         33443-33514
            677-733             AL732543.8         37421-37477
            734-788             AL732543.8         39535-39589
            789-964             AL732543.8         40330-40505
            965-976             AL732543.8         70307-70318
            977-988             AL732543.8         75346-75357
            989-1013            AL732543.8         78589-78613
            1014-1065           AL732543.8         79519-79570
            1066-1151           AL732543.8         81240-81325
            1152-1244           AL732543.8         84840-84932
            1245-1319           AL732543.8         88562-88636
            1320-1817           AL732543.8         90803-91300
            1818-1942           AL732543.8         97242-97366
            1943-2069           AL732543.8         98567-98693
            2070-2129           AL732543.8         104327-104386
            2130-2241           AL732543.8         125880-125991
            2242-2397           AL732543.8         132156-132311
            2398-2530           AL732543.8         134322-134454
            2531-2733           AL732543.8         135930-136132
            2734-2798           AL732543.8         137392-137456
            2799-2963           AL732543.8         137952-138116
            2964-5542           AL732543.8         139838-142416
            5543-5589           BY617051.1         373-419
FEATURES             Location/Qualifiers
     source          1..5589
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 47.09 cM"
     gene            1..5589
                     /gene="Sgip1"
                     /gene_synonym="3110007P09Rik; gag; SGIP1alpha"
                     /note="SH3-domain GRB2-like (endophilin) interacting
                     protein 1"
                     /db_xref="GeneID:73094"
                     /db_xref="MGI:MGI:1920344"
     exon            1..431
                     /gene="Sgip1"
                     /gene_synonym="3110007P09Rik; gag; SGIP1alpha"
                     /inference="alignment:Splign:2.1.0"
     CDS             422..2986
                     /gene="Sgip1"
                     /gene_synonym="3110007P09Rik; gag; SGIP1alpha"
                     /note="isoform a is encoded by transcript variant 1;
                     SH3-containing GRB2-like protein 3-interacting protein 1;
                     SH3-domain GRB2-like interacting protein 1 alpha;
                     endophilin-3-interacting protein"
                     /codon_start=1
                     /product="SH3-containing GRB2-like protein 3-interacting
                     protein 1 isoform a"
                     /protein_id="NP_001272781.1"
                     /db_xref="GeneID:73094"
                     /db_xref="MGI:MGI:1920344"
                     /translation="MMEGLKKRTRKAFGIRKKEKDTDSTGSPDRDGMQGKKKAQKTQL
                     LLTSCFWLRALSLTLSQQPSPHEPPYHSKAECAREGGKKASKKSNGAPNGFYAEIDWE
                     RYNSPELDEEGYSIRPEEPGSTKGKHFYSSSESEEEEESHKKFNIKIKPLQSKDVLKN
                     AATVDELKASIGNIALSPSPVRKSPRRSPGAIKRNLSSEEVARPRRSTPTPELTSKKP
                     LDDTLALAPLFGPPLESAFDEQKTEVLLDQPEIWGSGQPMNPSTESPELARPFPTGTP
                     PPLPPKTVPATPPRTGSPLTVATGNDQAATEAKIEKLPSISDLDSIFGPVLSPKSVAV
                     NTEEKWVHFSDASPEHVTPELTPREQVVTPPAASDIPADSPAPAPPGPTGSAGPPGPP
                     GPRHVPSPLNLEEVQKKVAEQTFIKDDYLETLSSPKECGLGQRATPPPPPPPTYRTVV
                     SSPGPGSGSGTGTTSGASSPARPATPLVPCSTTPPPPPPRPPSRPKLPPGKPGVGDVS
                     RPFSPPIHSSSPPPIAPLARAESTSSISSTNSLSAATTPTVENEQPSLVWFDRGKFYL
                     TFEGSSRGPSPLTMGAQDTLPVAAAFTETVNAYFKGADPSKCIVKITGEMVLSFPAGI
                     TRHFANNPSPAALTFRVVNSSRLEHVLPNPQLLCCDNTQNDANTKEFWVNMPNLMTHL
                     KKVSEQKPQATYYNVDMLKYQVSAQGIQSTPLNLAVNWRCEPASTDLRIDYKYNTDAM
                     STAVALNNVQFLVPIDGGVTKLQAVLPPAVWNAEQQRILWKIPDISQKSENGGVGSLL
                     ARFQLSEGPSKPSPLVVQFTSEGSTLSGCDIELVGAGYRFSLIKKRFAAGKYLADN"
     exon            432..495
                     /gene="Sgip1"
                     /gene_synonym="3110007P09Rik; gag; SGIP1alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            496..520
                     /gene="Sgip1"
                     /gene_synonym="3110007P09Rik; gag; SGIP1alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            521..604
                     /gene="Sgip1"
                     /gene_synonym="3110007P09Rik; gag; SGIP1alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            605..676
                     /gene="Sgip1"
                     /gene_synonym="3110007P09Rik; gag; SGIP1alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            677..733
                     /gene="Sgip1"
                     /gene_synonym="3110007P09Rik; gag; SGIP1alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            734..788
                     /gene="Sgip1"
                     /gene_synonym="3110007P09Rik; gag; SGIP1alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            789..964
                     /gene="Sgip1"
                     /gene_synonym="3110007P09Rik; gag; SGIP1alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            965..976
                     /gene="Sgip1"
                     /gene_synonym="3110007P09Rik; gag; SGIP1alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            977..988
                     /gene="Sgip1"
                     /gene_synonym="3110007P09Rik; gag; SGIP1alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            989..1013
                     /gene="Sgip1"
                     /gene_synonym="3110007P09Rik; gag; SGIP1alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            1014..1065
                     /gene="Sgip1"
                     /gene_synonym="3110007P09Rik; gag; SGIP1alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            1066..1151
                     /gene="Sgip1"
                     /gene_synonym="3110007P09Rik; gag; SGIP1alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            1152..1244
                     /gene="Sgip1"
                     /gene_synonym="3110007P09Rik; gag; SGIP1alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            1245..1319
                     /gene="Sgip1"
                     /gene_synonym="3110007P09Rik; gag; SGIP1alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            1320..1817
                     /gene="Sgip1"
                     /gene_synonym="3110007P09Rik; gag; SGIP1alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            1818..1942
                     /gene="Sgip1"
                     /gene_synonym="3110007P09Rik; gag; SGIP1alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            1943..2069
                     /gene="Sgip1"
                     /gene_synonym="3110007P09Rik; gag; SGIP1alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            2070..2129
                     /gene="Sgip1"
                     /gene_synonym="3110007P09Rik; gag; SGIP1alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            2130..2241
                     /gene="Sgip1"
                     /gene_synonym="3110007P09Rik; gag; SGIP1alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            2242..2397
                     /gene="Sgip1"
                     /gene_synonym="3110007P09Rik; gag; SGIP1alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            2398..2530
                     /gene="Sgip1"
                     /gene_synonym="3110007P09Rik; gag; SGIP1alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            2531..2733
                     /gene="Sgip1"
                     /gene_synonym="3110007P09Rik; gag; SGIP1alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            2734..2798
                     /gene="Sgip1"
                     /gene_synonym="3110007P09Rik; gag; SGIP1alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            2799..2963
                     /gene="Sgip1"
                     /gene_synonym="3110007P09Rik; gag; SGIP1alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            2964..5589
                     /gene="Sgip1"
                     /gene_synonym="3110007P09Rik; gag; SGIP1alpha"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2985..2990
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sgip1"
                     /gene_synonym="3110007P09Rik; gag; SGIP1alpha"
                     /note="hexamer: AATAAA"
     polyA_site      3026
                     /gene="Sgip1"
                     /gene_synonym="3110007P09Rik; gag; SGIP1alpha"
                     /note="major polyA site"
     regulatory      4060..4065
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sgip1"
                     /gene_synonym="3110007P09Rik; gag; SGIP1alpha"
                     /note="hexamer: AATAAA"
     polyA_site      4079
                     /gene="Sgip1"
                     /gene_synonym="3110007P09Rik; gag; SGIP1alpha"
                     /note="major polyA site"
     regulatory      4865..4870
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sgip1"
                     /gene_synonym="3110007P09Rik; gag; SGIP1alpha"
                     /note="hexamer: ATTAAA"
     polyA_site      4885
                     /gene="Sgip1"
                     /gene_synonym="3110007P09Rik; gag; SGIP1alpha"
                     /note="major polyA site"
ORIGIN      
        1 aggtggggaa ggggctgtgt gtttggagag gagcgggagg cagtgggggt agcgagcaat
       61 ggggacggga aatgggttcc gtgcgctctc cgggggtatt gtgtcaggag atgcaggctg
      121 gctaccatgt gacgcggtcc agagctgaag ggattggccg aggcagcgca ggcggtgcag
      181 ctcgccggct tgctgttcct ctctgccttt ctctcacagc atcttcctgg gagactgtag
      241 gtgaagcagc actagctgca tccatggccg gtctttcggg ttaacacttg tctcctttgg
      301 cttggcagca agcagagcag acctcagcgg cagctttgtg aggacttagc tgggacctgg
      361 aagcgtatcc tcctgtgttt tttctgactt cttggaaaat aaggaatgca attctgccac
      421 catgatggaa ggactgaaaa aacgtacaag gaaggccttt ggaatacgga agaaagaaaa
      481 agacactgac tctacaggct cgccagaccg agatggaatg caggggaaaa aaaaggctca
      541 gaagacacag cttctcctca cctcttgctt ctggctcaga gccctctcct taactctgtc
      601 tcagcagccc agcccacacg agccacccta ccatagcaaa gcagagtgtg cgcgggaagg
      661 agggaagaaa gcttcgaaga aaagcaatgg ggcaccaaat ggattttatg cagaaatcga
      721 ttgggaaaga tataactcac ctgagctaga tgaagaaggt tacagcatca gacctgagga
      781 accaggctct accaaaggaa agcactttta ttcctcaagt gaatctgaag aggaagaaga
      841 gtcgcacaag aaattcaaca tcaagattaa acccttgcaa tctaaggacg tcctgaagaa
      901 tgcagcgacg gtagatgagc tgaaggcttc aataggcaac atcgcacttt ccccttcgcc
      961 tgtgaggaaa agtccgaggc gcagcccggg tgcaattaaa aggaacttat ccagtgaaga
     1021 agttgcaaga cccaggcgtt ccaccccaac tccagaactt acaagcaaga agcctctgga
     1081 tgacactctg gcccttgctc ccctctttgg tccaccatta gagtcagctt ttgatgagca
     1141 gaagacggaa gttcttttag atcagcctga gatatggggt tcaggccaac cgatgaaccc
     1201 aagtacggag tcgccagagc tagcaagacc tttccccact ggaacacctc cacctctgcc
     1261 tccaaaaact gtaccagcca ctccgcctcg aacaggctcc cccttaacag ttgcaacagg
     1321 aaatgaccag gcagccacag aggccaaaat tgagaaacta ccatccatca gtgacctgga
     1381 cagcattttt gggccagtgt tgtcgcccaa gtctgttgct gttaatactg aagagaagtg
     1441 ggtccatttt tctgatgcat ccccggaaca tgttactcca gagttgactc caagggaaca
     1501 ggtggtgacc ccaccagctg catcagacat cccagctgac tccccagctc cagccccacc
     1561 tggccccaca ggctccgcag gtcccccagg gcctcctggt cctcgccatg taccatctcc
     1621 gctcaattta gaagaagtcc agaagaaagt tgctgagcag accttcatta aagatgatta
     1681 cttagaaaca ctctcatctc ctaaagagtg tgggttggga cagagagcaa ctccacctcc
     1741 cccaccacca cccacctaca ggactgtggt ctcgtccccc ggacctggct cgggcagtgg
     1801 tacggggacc accagtggtg cgtcttctcc tgctcgacca gccaccccct tagttccttg
     1861 cagcaccact ccgcctccac ctcctccccg gcctccatcc cggccaaagc tacctccagg
     1921 aaagcctgga gttggagatg tgtccagacc ttttagccca cccatacact cctccagccc
     1981 tcctccgata gcacccttag cccgggctga aagcacttct tcaatatcgt caactaactc
     2041 actgagcgca gccaccactc ccacagttga gaatgaacag ccctccctcg tttggtttga
     2101 cagaggaaag ttttatttga cttttgaagg ttcctcccgg gggcccagtc ccctaactat
     2161 gggggcccag gacaccctcc cggtcgcagc agctttcaca gaaactgtca acgcctactt
     2221 caaaggagca gatccaagca agtgcattgt taagatcacg ggagaaatgg tgttgtcctt
     2281 ccctgctggt atcaccagac actttgccaa caacccatcc ccagcagctc tgactttccg
     2341 ggtggtaaat tccagcaggt tagagcacgt cctgccgaac ccccaacttc tctgctgtga
     2401 taatacacaa aatgatgcca ataccaagga attctgggta aacatgccaa atttgatgac
     2461 tcacctaaag aaagtctctg aacaaaaacc ccaggctaca tactataatg tggacatgct
     2521 caaatatcag gtgtctgccc agggcattca gtccacacct ctgaacttgg cggtgaactg
     2581 gcgctgtgag cctgcgagca ctgacctgcg catagactat aagtacaaca cggatgccat
     2641 gtccactgca gtggccctca acaacgtgca gttcctggtc cccatagacg gaggagtgac
     2701 caagcttcag gctgtgcttc ctccagcagt ctggaatgct gaacaacaaa gaatattatg
     2761 gaagattccc gatatctccc agaagtcaga aaatggaggc gtaggttctt tactggcgag
     2821 atttcagtta tccgaaggcc cgagcaaacc ttccccgctg gttgtgcagt tcacgagtga
     2881 aggaagtact ctctctggct gtgacattga acttgttgga gcaggctacc ggttttcact
     2941 cattaagaag aggtttgctg caggaaagta cttggcagat aactaataaa aggtcatgca
     3001 aggatttgga agatccatgc cctggagaac tgttgtttga gagacatgtt ttaatctggc
     3061 ttgatgaaca caaaccgatg tccgtacttg gggtctgtca gctggaaagt cccggcattc
     3121 agcagtgact tccggcaccc agtactgtgc tgctcagttc tgcagtattt acttataggt
     3181 gtaatatttg ttaatggttt taaaatgtaa ttattgtatt tgtaaactgt accttcattc
     3241 cagtaaggca gttagacact tgggttttag cattttccat tcctgaaacg gatgtaataa
     3301 tttaatagta gtactgttga acggcacaat gcttacagag atacagcgca ttttgtcaat
     3361 atataaaatt taaatataat gttgatagtt atcataaagg gggtgccaca catcgagaac
     3421 cttaaacaga accagaaaca aaacacccag ctaactttcc ttcactcttt actatgtttc
     3481 cctctagtgc taaagaaaac ttctagcttc agtttagtgg gttaaattca caaactattt
     3541 cagaggaaaa aaaattctaa agttacagcc tattcaaaga gaaacattaa ttaccacttt
     3601 ttaaagagct tttttttcaa actgcaaatt tcataaaaat gcaaactgtg taaacagggc
     3661 ctcttatttt tataacttgt gtaaaaaggg aaaagcaatt catatttaaa gtttaagtat
     3721 attaaattat atccaagagg gcagaggatg ctgaagtctg acctgacccc agccccttct
     3781 gtgccgttta gcaaatgtgg agattgctaa gtcatcgcat taaagccaac atgattttta
     3841 aagtttgaga ctttatgtag ctgaactggt taaaactttt gcacaattgc tcgggacaca
     3901 ggggcctctc tcgtccagca tccaggggtg ggtaccttgt ttcttcttta ctcatgagaa
     3961 tcaaaacaca gagaaggatg gaggaaaaca aatagtcccc tggtccatcc aaaaggagaa
     4021 ttctaaactt atcatttaca tctttggggg gaaggaagaa ataaacttta taaatgaaat
     4081 tctattcacc ttgttatgaa tatttttgaa tgattttaag attcatcata tacaactgtg
     4141 aatctctgcc gctcttgggg aattgaaagc agagtcggga cagtggcttt gaacatagta
     4201 aatgccacag ttctgggagt gggggacggt gtctgcccca ccggagggca atcaaagcag
     4261 tgtcgtgtga ggcctaaaga agaagtcttc cagtaaacca caagttattt taaacagaaa
     4321 agttcctgtt tggggctctc ccactgagtt ggcctgtgta gcatttgctg ctgaatcaca
     4381 ttttgtatcc actcaaatct gacaaggagt ggtcaactcc ttttcaattt tagaatcaaa
     4441 ttaaaaattt tttaagtctt acttcaacag tgagattgtg gttggcagtt gtttctagtg
     4501 agctctgtag atttatctat gttctcttcg atcaacgctt gctaccaaaa ggatgtccaa
     4561 gaggattttt acctgcaaac aattcattta tttaaaatag gctcctgcct aattccccaa
     4621 agcagtccgg ctttgaaggt tttttgaaca aactaatttg ttgaccaaaa agtttggctt
     4681 tgaaaccgaa atagagaaat aaaatgtaaa ttttaaatct aatagaacaa gtggaaatga
     4741 aaacacttaa accaatggag agtatgaagc agaaaaaaaa aaatgaagct gatctaaaat
     4801 gtgattatac aatgttttta agtagtcagt tcatggaaaa atattgaata ttaacacaaa
     4861 gcatattaaa aatatgtaaa tattactgtt tctcatgtct ttctctttat atcttatttt
     4921 gtgaagtttt agaatgaatt ggtcattaag tatgcagtgt ttctttccaa agaataattt
     4981 tgttgatatt gtaaaaatgt aattaaagat agagatttga gtagtctcta acattattca
     5041 aatgtttcca ggaaccaaat tggaaagtat gaagaaatct tgtaatccct taattgacta
     5101 ttgtgaaatg aaacgacagt tggtgatctc aaaattaaga cgtgaaaatt cagagcttca
     5161 gtggggaatg ggtggttcct tccagttcag ataacaacag ttgctcattt cagagatgga
     5221 gatgttggtg ctgtttggtt ttaagcttgt gcaatttcat cttctggtga agctctgtgt
     5281 gcagcactat aggataaaaa ttcatattct gagacaaggt ccaagactag gcagaccagg
     5341 tctcagttat cagtgtcaat cgggtcaggt tcccttttgt ccaaacaaaa tgggttagct
     5401 catagacaga tggttggcag gacagtaagc taaattaaga caattaagag caatttccta
     5461 aacactctga cttttaaggc tgatagaaag tatgcatgtt ttattttggt gacatggaaa
     5521 gtatgtattc ctcttcaaac caatcccata tttttatgaa attttccaaa ataaattcct
     5581 gtttaaact
//
