LOCUS       NM_145841               2389 bp    mRNA    linear   ROD 30-JUL-2024
DEFINITION  Mus musculus sarcoglycan zeta (Sgcz), mRNA.
ACCESSION   NM_145841
VERSION     NM_145841.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2389)
  AUTHORS   Levy,R., Mott,R.F., Iraqi,F.A. and Gabet,Y.
  TITLE     Collaborative cross mice in a genetic association study reveal new
            candidate genes for bone microarchitecture
  JOURNAL   BMC Genomics 16, 1013 (2015)
   PUBMED   26611327
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2389)
  AUTHORS   Shiga,K., Yoshioka,H., Matsumiya,T., Kimura,I., Takeda,S. and
            Imamura,M.
  TITLE     Zeta-sarcoglycan is a functional homologue of gamma-sarcoglycan in
            the formation of the sarcoglycan complex
  JOURNAL   Exp Cell Res 312 (11), 2083-2092 (2006)
   PUBMED   16635485
REFERENCE   3  (bases 1 to 2389)
  AUTHORS   Wheeler,M.T., Zarnegar,S. and McNally,E.M.
  TITLE     Zeta-sarcoglycan, a novel component of the sarcoglycan complex, is
            reduced in muscular dystrophy
  JOURNAL   Hum Mol Genet 11 (18), 2147-2154 (2002)
   PUBMED   12189167
  REMARK    GeneRIF: Zeta-sarcoglycan is an integral component of the
            sarcoglycan complex and is important in the pathogenesis of
            muscular dystrophy.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK136779.1.
            
            On Apr 1, 2008 this sequence version replaced NM_145841.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK136779.1, AK048960.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1948              AK136779.1         2-1949
            1949-2389           AK136779.1         1951-2391
FEATURES             Location/Qualifiers
     source          1..2389
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 23.31 cM"
     gene            1..2389
                     /gene="Sgcz"
                     /gene_synonym="C230085N17Rik"
                     /note="sarcoglycan zeta"
                     /db_xref="GeneID:244431"
                     /db_xref="MGI:MGI:2388820"
     exon            1..784
                     /gene="Sgcz"
                     /gene_synonym="C230085N17Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             746..1681
                     /gene="Sgcz"
                     /gene_synonym="C230085N17Rik"
                     /note="ZSG1; zeta-SG"
                     /codon_start=1
                     /product="zeta-sarcoglycan"
                     /protein_id="NP_665840.2"
                     /db_xref="CCDS:CCDS22251.2"
                     /db_xref="GeneID:244431"
                     /db_xref="MGI:MGI:2388820"
                     /translation="MDRSTDLDIQELKMTREQYILATQQNNLPRPENAQLYPVGIYGW
                     RKRCLYFFVLLLLVTMIVNLAMTIWILKVMNFTVDGMGNLRVTKKGIRLEGISEFLLP
                     LYVKEIHSRKDSPLVLQSDRNVTVNARNHMGQLTGQLTVGAEAVEAQCKRFEVRASED
                     GRVLFSADEDEITIGAEKLKVTGTEGAVFGHSVETPHIRAEPSQDLRLESPTRSLKME
                     APRGVQVSAAAGDFKATCRKELHLQSTEGEIFLNADSIRLGNLPIGSFSSSTSSSNSR
                     QTVYELCVCPNGKLYLSPAGVGSTCQSSSSICLWN"
     exon            785..979
                     /gene="Sgcz"
                     /gene_synonym="C230085N17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            980..1081
                     /gene="Sgcz"
                     /gene_synonym="C230085N17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1082..1169
                     /gene="Sgcz"
                     /gene_synonym="C230085N17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1170..1292
                     /gene="Sgcz"
                     /gene_synonym="C230085N17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1293..1365
                     /gene="Sgcz"
                     /gene_synonym="C230085N17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1366..1489
                     /gene="Sgcz"
                     /gene_synonym="C230085N17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1490..2389
                     /gene="Sgcz"
                     /gene_synonym="C230085N17Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2195..2200
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sgcz"
                     /gene_synonym="C230085N17Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      2224
                     /gene="Sgcz"
                     /gene_synonym="C230085N17Rik"
                     /note="major polyA site"
ORIGIN      
        1 agtaaaacag caaagcagga ggaaaattgc ggtctccctc tcttctcttc gctcttttct
       61 ctctgtggga gccacctcct attctctcaa ctcttttagc ataaccttca aaggagaacg
      121 gtcccttcag actttattac cgtcttttcc ccactgagag aatacctctt agctacaaga
      181 cattttttaa gtctatgcag gacttcgggg atccagttat cttgccaggg aaattgatga
      241 ttgctaatgt ctgagactca cagcgtgcta aattagctac cagagtatgc ctgacggagg
      301 aaggcttttt atcacatagt cttctctcca gtttgaacac atttgcttga attttgccgc
      361 atgatgctgt ccagggaagc agcttttttt cttgggatgc agcaactcgc tggtttctaa
      421 gcttattgcc gaagaaaaaa ataatctgaa attgagtgga tttttccccc tcctttgctt
      481 gagtcgactg agctgtgtcg cacggcggta aagatcaact gtccctaaat ctttgaagaa
      541 gtaaaacaaa gtgaattctc attaatattt atttatttgt attattttta accggtggag
      601 gcggcgagac cacggaggat gagactgaga gaagctacca gggcttggag gaggataaag
      661 ctgagtttca gctggaaact aaaagactag atcggttcgg ggagcaactt ggccagttcc
      721 tctccacttc ctttagtttc gctccatgga cagatccacg gacctggaca tccaggagct
      781 caagatgact cgagaacaat acatactagc cacacagcag aacaacctgc cgagacctga
      841 aaacgcacaa ctctaccctg tggggattta tggatggcga aagaggtgct tatacttctt
      901 tgtccttctg ctgttggtta ccatgatagt taacttagcc atgacaatat ggatattgaa
      961 ggttatgaat ttcactgtgg atggtatggg gaatctgaga gtcaccaaga agggaatccg
     1021 acttgaaggt atatctgagt ttctactacc attgtatgtg aaagaaattc attcccgaaa
     1081 ggacagtcca ttggtcttac agtctgacag aaatgtaaca gtgaatgcaa ggaaccatat
     1141 ggggcagctc actggacagc tgacagtcgg agctgaagct gttgaggcac agtgcaaaag
     1201 attcgaagtg agagcaagtg aagatggcag ggtgctgttt tctgcagatg aagatgagat
     1261 cactattggg gctgagaagc taaaggttac aggaactgaa ggagcagtat ttggacactc
     1321 tgtggaaaca cctcacatca gagcagagcc atctcaagac ctcaggcttg aatcaccaac
     1381 cagatccttg aaaatggagg ctccacgtgg ggtccaggtg agcgcagctg caggtgactt
     1441 caaggctacc tgcaggaagg agctgcactt acagtccaca gaaggggaga tatttttaaa
     1501 tgcagattca atccggctgg gaaatctacc aatcggttcc ttctcttctt caaccagctc
     1561 ctcaaattct cgacagacag tgtatgaact gtgcgtctgc cccaatggca aactctacct
     1621 ttctccagct ggggtaggct ccacctgtca gtccagtagt agcatttgct tgtggaactg
     1681 aagcgactga tttctcctca caccagaata gccttttgtt cccgtccgtc tgcttcacgg
     1741 ttttgctcgg tttcccctgt gatcagtgca gagcgtcttc agatggacca cagagcaaac
     1801 tgttccagta tccgccggga ttggccttca cctttcctga ttcaccattc tcaacacact
     1861 gagtgggact gactcggccg tgggaaaaac atcttcagca gaaaacctgg atcgcaacct
     1921 ttgctcaaaa gggagaataa tttaggtgcc tttgctacgt ggagtgaagc acacacagtt
     1981 ttagattttt gcagaacctg gctgtgaact acgcacgaac acattaccca gacgaaattc
     2041 ccaaatccac tggtgacatg aaatgcttaa ccccgtcaga agactgattc tgcagtccga
     2101 aagcacaatt ttccattcat cttttttgga cgtaaacttt tatccccgaa ttttaaaatt
     2161 ttgaagcatt atgtaatgct tgctttacta aaaaattaaa ttcaatacgt gatttttaac
     2221 taaatgaaat gacgagacag aatctctccc tgagtttttt ttgtttgttt gtttgtttgt
     2281 ttgtttgttt ccttcaattc aatgtgttgg tactctttgt ctactaagtc tggaattttg
     2341 tacattagat aattttgaaa gctctcagca atataatctt tacaaaatt
//
