LOCUS       NM_011892               3515 bp    mRNA    linear   ROD 06-NOV-2024
DEFINITION  Mus musculus sarcoglycan, gamma (dystrophin-associated
            glycoprotein) (Sgcg), mRNA.
ACCESSION   NM_011892
VERSION     NM_011892.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3515)
  AUTHORS   O'Brien,J.G., Willis,A.B., Long,A.M., Kwon,J., Lee,G., Li,F.W.,
            Page,P.G., Vo,A.H., Hadhazy,M., Spencer,M.J., Crosbie,R.H.,
            Demonbreun,A.R. and McNally,E.M.
  TITLE     The super-healing MRL strain promotes muscle growth in muscular
            dystrophy through a regenerative extracellular matrix
  JOURNAL   JCI Insight 9 (3), e173246 (2024)
   PUBMED   38175727
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3515)
  AUTHORS   Wu,T., Xu,Y., Zhang,L., Liang,Z., Zhou,X., Evans,S.M. and Chen,J.
  TITLE     Filamin C is Essential for mammalian myocardial integrity
  JOURNAL   PLoS Genet 19 (1), e1010630 (2023)
   PUBMED   36706168
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3515)
  AUTHORS   Kuhn,T., Kaiser,K., Lebek,S., Altenhofen,D., Knebel,B., Herwig,R.,
            Rasche,A., Pelligra,A., Gorigk,S., Khuong,J.M., Vogel,H.,
            Schurmann,A., Bluher,M., Chadt,A. and Al-Hasani,H.
  TITLE     Comparative genomic analyses of multiple backcross mouse
            populations suggest SGCG as a novel potential obesity-modifier gene
  JOURNAL   Hum Mol Genet 31 (23), 4019-4033 (2022)
   PUBMED   35796564
  REMARK    GeneRIF: Comparative genomic analyses of multiple backcross mouse
            populations suggest SGCG as a novel potential obesity-modifier
            gene.
REFERENCE   4  (bases 1 to 3515)
  AUTHORS   Smith,T.C., Vasilakos,G., Shaffer,S.A., Puglise,J.M., Chou,C.H.,
            Barton,E.R. and Luna,E.J.
  TITLE     Novel gamma-sarcoglycan interactors in murine muscle membranes
  JOURNAL   Skelet Muscle 12 (1), 2 (2022)
   PUBMED   35065666
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3515)
  AUTHORS   Wurmser,M., Chaverot,N., Madani,R., Sakai,H., Negroni,E.,
            Demignon,J., Saint-Pierre,B., Mouly,V., Amthor,H., Tapscott,S.,
            Birchmeier,C., Tajbakhsh,S., Le Grand,F., Sotiropoulos,A. and
            Maire,P.
  TITLE     SIX1 and SIX4 homeoproteins regulate PAX7+ progenitor cell
            properties during fetal epaxial myogenesis
  JOURNAL   Development 147 (19) (2020)
   PUBMED   32591430
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3515)
  AUTHORS   Coral-Vazquez,R., Cohn,R.D., Moore,S.A., Hill,J.A., Weiss,R.M.,
            Davisson,R.L., Straub,V., Barresi,R., Bansal,D., Hrstka,R.F.,
            Williamson,R. and Campbell,K.P.
  TITLE     Disruption of the sarcoglycan-sarcospan complex in vascular smooth
            muscle: a novel mechanism for cardiomyopathy and muscular dystrophy
  JOURNAL   Cell 98 (4), 465-474 (1999)
   PUBMED   10481911
REFERENCE   7  (bases 1 to 3515)
  AUTHORS   Noguchi,S., Wakabayashi,E., Imamura,M., Yoshida,M. and Ozawa,E.
  TITLE     Developmental expression of sarcoglycan gene products in cultured
            myocytes
  JOURNAL   Biochem Biophys Res Commun 262 (1), 88-93 (1999)
   PUBMED   10448073
REFERENCE   8  (bases 1 to 3515)
  AUTHORS   Chan,Y.M., Bonnemann,C.G., Lidov,H.G. and Kunkel,L.M.
  TITLE     Molecular organization of sarcoglycan complex in mouse myotubes in
            culture
  JOURNAL   J Cell Biol 143 (7), 2033-2044 (1998)
   PUBMED   9864373
REFERENCE   9  (bases 1 to 3515)
  AUTHORS   Hack,A.A., Ly,C.T., Jiang,F., Clendenin,C.J., Sigrist,K.S.,
            Wollmann,R.L. and McNally,E.M.
  TITLE     Gamma-sarcoglycan deficiency leads to muscle membrane defects and
            apoptosis independent of dystrophin
  JOURNAL   J Cell Biol 142 (5), 1279-1287 (1998)
   PUBMED   9732288
REFERENCE   10 (bases 1 to 3515)
  AUTHORS   Madhavan,R. and Jarrett,H.W.
  TITLE     Interactions between dystrophin glycoprotein complex proteins
  JOURNAL   Biochemistry 34 (38), 12204-12209 (1995)
   PUBMED   7547961
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC138718.3 and AK132610.1.
            
            On Feb 9, 2007 this sequence version replaced NM_011892.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF282901.1, AK132610.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-57                AC138718.3         204929-204985       c
            58-1571             AK132610.1         3-1516
            1572-3515           AC138718.3         165610-167553       c
FEATURES             Location/Qualifiers
     source          1..3515
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 32.27 cM"
     gene            1..3515
                     /gene="Sgcg"
                     /gene_synonym="35kDa; 5430420E18Rik; gamma-SG"
                     /note="sarcoglycan, gamma (dystrophin-associated
                     glycoprotein)"
                     /db_xref="GeneID:24053"
                     /db_xref="MGI:MGI:1346524"
     exon            1..148
                     /gene="Sgcg"
                     /gene_synonym="35kDa; 5430420E18Rik; gamma-SG"
                     /inference="alignment:Splign:2.1.0"
     exon            149..346
                     /gene="Sgcg"
                     /gene_synonym="35kDa; 5430420E18Rik; gamma-SG"
                     /inference="alignment:Splign:2.1.0"
     CDS             152..1027
                     /gene="Sgcg"
                     /gene_synonym="35kDa; 5430420E18Rik; gamma-SG"
                     /note="35DAG; 35 kDa dystrophin-associated glycoprotein;
                     sarcoglycan, gamma (35kD dystrophin-associated
                     glycoprotein)"
                     /codon_start=1
                     /product="gamma-sarcoglycan"
                     /protein_id="NP_036022.1"
                     /db_xref="CCDS:CCDS27181.1"
                     /db_xref="GeneID:24053"
                     /db_xref="MGI:MGI:1346524"
                     /translation="MVREQYTTVTEGTHIERPENQHIYKIGIYGWRKRCLYLFVLLLL
                     AILVVNLALTIWILKVMWFSPIGMGHLHVTADGLRLEGESEFLFPLYAKEIRSRVDSS
                     LLLQSTQNVTVSARNSEGEVTGRVKVGAQMVEVQSQHFQINSEDGKPLFSAEEQDVVV
                     GTGRLRVTGPEGALFEHSVETPLVRADPFQDLRLESPTRSLSMDAPRGVHVKANAGKL
                     EALSQMDIILQSSEGVLVLDAETVGLTKLKQGTQGPAGSSNGFYEICACPDGKLYLSM
                     AGEVTTCEEHSHVCL"
     exon            347..448
                     /gene="Sgcg"
                     /gene_synonym="35kDa; 5430420E18Rik; gamma-SG"
                     /inference="alignment:Splign:2.1.0"
     exon            449..536
                     /gene="Sgcg"
                     /gene_synonym="35kDa; 5430420E18Rik; gamma-SG"
                     /inference="alignment:Splign:2.1.0"
     exon            537..656
                     /gene="Sgcg"
                     /gene_synonym="35kDa; 5430420E18Rik; gamma-SG"
                     /inference="alignment:Splign:2.1.0"
     exon            657..729
                     /gene="Sgcg"
                     /gene_synonym="35kDa; 5430420E18Rik; gamma-SG"
                     /inference="alignment:Splign:2.1.0"
     exon            730..853
                     /gene="Sgcg"
                     /gene_synonym="35kDa; 5430420E18Rik; gamma-SG"
                     /inference="alignment:Splign:2.1.0"
     exon            854..3515
                     /gene="Sgcg"
                     /gene_synonym="35kDa; 5430420E18Rik; gamma-SG"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1551..1556
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sgcg"
                     /gene_synonym="35kDa; 5430420E18Rik; gamma-SG"
                     /note="hexamer: AATAAA"
     polyA_site      1573
                     /gene="Sgcg"
                     /gene_synonym="35kDa; 5430420E18Rik; gamma-SG"
                     /note="major polyA site"
ORIGIN      
        1 ggaaacctga gccaaggagc tgagaagggg aactcattgt ttgtctcgcc cttcactaca
       61 cgaaatgaga gtttaaatct ttccaccact gcagagcttg ggccctcatc ggcaatcaag
      121 tcatcggtgt ggttcctgag tggctaagaa gatggttcga gaacagtaca ccacggtcac
      181 cgagggcact cacatagaga ggcccgagaa ccagcacatc tacaagattg gcatttacgg
      241 atggaggaag cgctgcctat acctattcgt tcttctcctg ctcgccatcc tcgttgtgaa
      301 tctcgctctc actatctgga ttctgaaagt gatgtggttt tctccaatag gaatgggtca
      361 cttgcatgtt acagcagatg gacttcgcct ggaaggagag tcggaatttt tatttccgct
      421 gtatgccaaa gaaatacgct ccagagtgga ctcatctctg cttctgcagt caacccagaa
      481 cgtgacagtc agtgctcgca actcagaagg ggaggtcaca ggccgggtga aagtgggtgc
      541 ccagatggta gaagtccaga gccagcactt tcagatcaat tctgaagatg gcaagccact
      601 gttctctgcg gaggagcagg acgttgtggt tggcacaggc agactgcgcg taacagggcc
      661 agaaggagct ctttttgaac actcagtgga gacacccctt gtcagagctg acccatttca
      721 agaccttagg ttagaatccc caactcggag tctaagcatg gatgccccaa ggggggttca
      781 tgttaaagct aacgctggga aattggaggc cctctctcag atggacatca tcttgcagag
      841 tagtgaagga gtgctggtgc tggatgctga aactgtgggt ttgaccaagt tgaagcaggg
      901 gacacagggt cccgctggca gctctaatgg attctatgag atctgtgcgt gtcctgatgg
      961 gaagctgtac ctgtctatgg ctggtgaagt caccacctgc gaggaacaca gccacgtctg
     1021 tctttgacca ctgcctcttc ggcagcacac gtacaatgtc ttggtgagac gacggctgtg
     1081 gcctcagcct tcatgtccag cagctggatt ggagctggag ggctcattgc taaaacactt
     1141 agaagcatgc agggggaaca tgcctatgga actgttgggc caacactacc tggcttcaga
     1201 acgacacaaa agaaacacca ggaacatatt cactgtattc atctttccag cctctctcca
     1261 gatctctcac gctgagttgc cacctggaaa caatttatag tactcaacgg cagacatcta
     1321 tctcctccca aacatggctg gctggctgat tctaaaatgc actaactgtg cacacccttt
     1381 cctttagatt aaacctcaag tgctcccttc agctgagtgc aatgtgtcag atttcaccaa
     1441 gagatctcca aggtttgtag gtaatttgtg gttaatatga ttttcagtat gtaattaagg
     1501 aaagaaatta cacaaattta gtcatacttt ttatatacat acttatgagc aataaaaatg
     1561 acacttttct ggaccaaggt gtaaaagggt cttactttct ttggtgctca caactctttg
     1621 ggtaggtact aattttcctc aaattcttgg tgacaaagac tcaggctagc cagtcatgag
     1681 gcccaaggtc tcaggtaact actgagatta acttgaaatg tgaccctaaa ttggtctggt
     1741 cattttccct tggagagagc tctgcagcca aaacaccaac tacagcagct gaatgcatag
     1801 atacctggtg ctaatttgac atctttagct ggtgccccag ggccttcatc tcccagcatc
     1861 ttaggaagtg ctgagcctct gcctgacagg cctagtgctg gcttccacgt acagggaaga
     1921 aggggtgaag ctgtttggaa ccagccatgc aacttctaca aacacgagag gctgggtgca
     1981 gctgcagaga ggcagctatg catgcagtgt gtgaatgtgt gcaatgtgtg gatgcatgca
     2041 gtgtgtggac agtaagcagc actcctccac ggcctctgct tcagtcctta cctccatgtt
     2101 cctgccttga gttcctgccc tgacttccct tcacaacaga ttgtgacggg gacatgtaag
     2161 ctaaaataaa ctctttcctc cctgggttgc ttttgatcat ggtgtttcat cacagcgtta
     2221 gaaactgtga gacagaaatt ggtacagaga gtgggctatt tctatgatag accagaccgt
     2281 gtgattaggg atctttccag gattttggaa ctttgggcta gaaaagccac tgagtgctca
     2341 gagcttagtg cacgcttgtg gggacttaga agataaagct gagagctcac agttgatgga
     2401 agtttgaatt gtaaagtttc agaaggacct ttgaatccct caaaaacaca tgatcaggtc
     2461 tggccatatg attttgaatt aagaactgct aaagtaaaaa ccctactttg ctggaaaaat
     2521 caatactcat catgagaggc tgaagagtca gctgtgagta agaaagggcc agtatcactg
     2581 aggcaaaatg tcccgaagtg ccttgcacca ctctggatct cagcttccct gtgtgttgac
     2641 actgagggaa cagtccatag gttttatttc agttatgctg gcttaattag tttttcaatc
     2701 aagttccgca cattgaggct gtaatacaga ggggtcagac cgtgtcttgt gctggctgat
     2761 gaacttggta atgtgtaaga gtctcccagg tctctgctcc aaaccatgaa ggggtcatgg
     2821 agaacagctg aggctggggg ccatgagagg ccaggagagg ctgttggcga agaagacaca
     2881 gcctcagttg cagtagaagt cccagtatta aaggactcat acaggcacca tgtggcaggg
     2941 tcaggggtcc tgaacagaac ccatcctagt gaagtttcta gtgaaggagc catccaaatg
     3001 cagcagagac cccagcattt tggaggtgcc agtaccacgc gacaaccacc aaggacagct
     3061 gcacctgcag agtgaagcta gcctgagtct agaagataag tcccatgtgc tgtggatggc
     3121 agagccaggg aagaaggctg cactgatact ggttttatag cccagggaaa acagcaaaat
     3181 ggaggctcca cctcccacag cagcctgtag aatggacact ggaggtctga atgaaaatgg
     3241 acccccaaag gctcatatat tttacttctt ggtatcggga ggtggtaata cttgagaggg
     3301 attggggata tggccttgtt ggaggaagtg tgtcactggc tgttttatct ttactgtaaa
     3361 cactacctgg ttcctgtcag tcctttgaag ccactcctcc gtttttgtgt cagatatttc
     3421 aatgtacact gcctgcagtg acaccttact ccattgtttt ctgtattata taagactggt
     3481 gtttgctttg tgaaacaatt acattcagat tcagc
//
